The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.

Animals Male Dopamine / metabolism Mice Corpus Striatum / metabolism Humans Acetylcholine / metabolism Substance-Related Disorders / metabolism Signal Transduction / drug effects Glutamic Acid / metabolism Interneurons / metabolism Feeding and Eating Disorders / metabolism Mice, Inbred C57BL Amino Acid Transport Systems, Acidic / metabolism Mutation Mutation, Missense Vesicular Acetylcholine Transport Proteins

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 Jul 2024
Historique:
received: 24 02 2023
accepted: 07 05 2024
medline: 7 7 2024
pubmed: 7 7 2024
entrez: 6 7 2024
Statut: epublish

Résumé

Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh vesicular stores through vesicular synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients with substance use disorders (SUDs) and eating disorders (EDs). A mouse line was generated to understand the neurochemical and behavioral impact of the p.T8I variant. In VGLUT3

Identifiants

DOI: 10.1038/s41467-024-49371-1 PMID: 38971801
pubmed: 38971801
doi: 10.1038/s41467-024-49371-1
pii: 10.1038/s41467-024-49371-1
doi:

Substances chimiques

Dopamine VTD58H1Z2X
Acetylcholine N9YNS0M02X
SLC18A3 protein, human 0
Glutamic Acid 3KX376GY7L
Amino Acid Transport Systems, Acidic 0
Vesicular Acetylcholine Transport Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5691

Subventions

Organisme : Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)
ID : RGPIN/386431-2012
Organisme : Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)
ID : RGPIN/04682-2017

Informations de copyright

© 2024. The Author(s).

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Auteurs

Mathieu Favier (M)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, H4H 1R3, Canada. mathieu.favier@mail.mcgill.ca.
ORCID: 0000-0002-1680-3751

Elena Martin Garcia (E)

Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain.
ORCID: 0000-0002-4487-3028

Romain Icick (R)

Département de Psychiatrie et de Médecine Addictologique, DMU Neurosciences, APHP.Nord, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, F-75010, France.
INSERM U1144, "Therapeutic optimization in neuropsychopharmacology", Paris, F-75006, France.
Université Paris Cité, Inserm UMR-S1144, Paris, F-75006, France.
Neurobiologie Intégrative des Systèmes Cholinergiques, Département de Neurosciences, Institut Pasteur, Paris, F-75015, France.

Camille de Almeida (C)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Joachim Jehl (J)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.
Brain Plasticity Unit, CNRS UMR 8249, ESPCI Paris, PSL Research University, 75005, Paris, France.
ORCID: 0000-0001-9821-7619

Mazarine Desplanque (M)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Johannes Zimmermann (J)

Neurocure NWFZ, Charite Universitaetsmedizin, Institut für Neurophysiologie, Charitéplatz 1, 10117, Berlin, Germany.

Annabelle Henrion (A)

Fondation FondaMental, Créteil, France.
Université Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, F-94010, Créteil, France.

Nina Mansouri-Guilani (N)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Coline Mounier (C)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, H4H 1R3, Canada.

Svethna Ribeiro (S)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, H4H 1R3, Canada.

Fiona Henderson (F)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.
ORCID: 0000-0002-9865-9326

Andrea Geoffroy (A)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Sebastien Mella (S)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Odile Poirel (O)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Véronique Bernard (V)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.
ORCID: 0000-0003-4748-5167

Véronique Fabre (V)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Yulong Li (Y)

State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
ORCID: 0000-0002-9166-9919

Christian Rosenmund (C)

Neurocure NWFZ, Charite Universitaetsmedizin, Institut für Neurophysiologie, Charitéplatz 1, 10117, Berlin, Germany.
ORCID: 0000-0002-3905-2444

Stéphane Jamain (S)

Fondation FondaMental, Créteil, France.
Université Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, F-94010, Créteil, France.
ORCID: 0000-0002-4321-4100

Florence Vorspan (F)

Département de Psychiatrie et de Médecine Addictologique, DMU Neurosciences, APHP.Nord, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, F-75010, France.
INSERM U1144, "Therapeutic optimization in neuropsychopharmacology", Paris, F-75006, France.
Université Paris Cité, Inserm UMR-S1144, Paris, F-75006, France.

Alexandre Mourot (A)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.
Brain Plasticity Unit, CNRS UMR 8249, ESPCI Paris, PSL Research University, 75005, Paris, France.
ORCID: 0000-0002-8839-7481

Philibert Duriez (P)

GHU Paris Psychiatrie et Neurosciences (CMME, Hospital Sainte-Anne), Institute of Psychiatry and Neuroscience of Paris (INSERM UMR1266), Paris, France.

Leora Pinhas (L)

PHLIP Mental Health and Painless Medicine clinic, Toronto, Canada.

Rafael Maldonado (R)

Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain.
ORCID: 0000-0002-4359-8773

Nicolas Pietrancosta (N)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.
Sorbonne Université, École normale supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005, Paris, France.
LCBPT, Université Paris Descartes, Sorbonne Paris Cité, UMR 8601, CNRS, Paris, 75006, France.

Stéphanie Daumas (S)

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France.

Salah El Mestikawy (S)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, H4H 1R3, Canada. salah.elmestikawy@mcgill.ca.
Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005, Paris, France. salah.elmestikawy@mcgill.ca.
ORCID: 0000-0002-6253-0002

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Cellules › Neurones › Interneurones › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Systèmes de transport d'acides aminés › Systèmes de transport d'acides aminés acides › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › The human VGLUT3-pT8I mutation elicits uneven...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs vésiculaires des neurotransmetteurs › Transporteurs vésiculaires des amines biogènes › Transporteurs vésiculaires de l'acétylcholine › The human VGLUT3-pT8I mutation elicits uneven...