Mutational Landscape of Alzheimer's Disease and Frontotemporal Dementia: Regional Variances in Northern, Central, and Southern Italy.
Humans
Alzheimer Disease
/ genetics
Italy
/ epidemiology
Frontotemporal Dementia
/ genetics
Female
Male
Middle Aged
Aged
Mutation
tau Proteins
/ genetics
Age of Onset
C9orf72 Protein
/ genetics
Presenilin-2
/ genetics
Retrospective Studies
Amyloid beta-Protein Precursor
/ genetics
Presenilin-1
/ genetics
Progranulins
/ genetics
Adult
Aged, 80 and over
Genetic Predisposition to Disease
APP
Alzheimer’s Disease
C9orf72
Frontotemporal Dementia
GRN
MAPT
PSEN1
PSEN2
gene
mutation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jun 2024
27 Jun 2024
Historique:
received:
07
05
2024
revised:
24
06
2024
accepted:
25
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) are the two major neurodegenerative diseases with distinct clinical and neuropathological profiles. The aim of this report is to conduct a population-based investigation in well-characterized
Identifiants
pubmed: 39000146
pii: ijms25137035
doi: 10.3390/ijms25137035
pii:
doi:
Substances chimiques
tau Proteins
0
C9orf72 Protein
0
MAPT protein, human
0
PSEN2 protein, human
0
Presenilin-2
0
Amyloid beta-Protein Precursor
0
Presenilin-1
0
C9orf72 protein, human
0
Progranulins
0
GRN protein, human
0
PSEN1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Funded by the European Union - Next Generation EU - NRRP M6C2 - Investment 2.1 Enhance-ment and strengthening of biomedical research in the NHS
ID : PNRR-MR1-2022-12375654 - Cup Code: C83C22001300001. Title: Genetic and epigenetic modulAtors in Rare neurodegenerative diseases with DEmentia: a National study on autosomal dominant Alzheimer disease and genetic frontotemporal degeneration with dementIA (