Unveiling New Genetic Variants Associated with Age at Onset in Alzheimer's Disease and Frontotemporal Lobar Degeneration Due to
Humans
Alzheimer Disease
/ genetics
C9orf72 Protein
/ genetics
Frontotemporal Lobar Degeneration
/ genetics
Age of Onset
Female
Male
Aged
Middle Aged
DNA Repeat Expansion
/ genetics
Aged, 80 and over
Polymorphism, Single Nucleotide
Transferrin
/ genetics
Genetic Predisposition to Disease
Genetic Variation
Alzheimer’s disease
C9orf72
Frontotemporal lobar degeneration
GRN
age at onset
calsyntenin-1
genetic modulators
transferrin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jul 2024
07 Jul 2024
Historique:
received:
14
06
2024
revised:
04
07
2024
accepted:
05
07
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
Alzheimer's disease (AD) and Frontotemporal lobar degeneration (FTLD) represent the most common forms of neurodegenerative dementias with a highly phenotypic variability. Herein, we investigated the role of genetic variants related to the immune system and inflammation as genetic modulators in AD and related dementias. In patients with sporadic AD/FTLD (n = 300) and
Identifiants
pubmed: 39000564
pii: ijms25137457
doi: 10.3390/ijms25137457
pii:
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
Transferrin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health, Italy, Ricerca Finalizzata
ID : Grant RF-2019-12369272