Modelling Role of Protective and Nonprotective HLA Allele Inducing Different HIV Infection Outcomes.
Bistable viral kinetics
CD8+ cell
HIV
HIV elite controller
HLA diversity
Journal
Bulletin of mathematical biology
ISSN: 1522-9602
Titre abrégé: Bull Math Biol
Pays: United States
ID NLM: 0401404
Informations de publication
Date de publication:
13 Jul 2024
13 Jul 2024
Historique:
received:
24
01
2024
accepted:
25
06
2024
medline:
14
7
2024
pubmed:
14
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
Human immunodeficiency virus (HIV) infects CD4+ cells and causes progressive immune function failure, and CD8+ cells lyse infected CD4+ cell via recognising peptide presented by human leukocyte antigens (HLA). Variations in HLA allele lead to observed different HIV infection outcomes. Within-host HIV dynamics involves virus replication within infected cells and lysing of infected cells by CD8+ cells, but how variations in HLA alleles determine different infection outcomes was far from clear. Here, we used mathematical modelling and parameter inference with a new analysis of published virus inhibition assay data to estimate CD8+ cell lysing efficiency, and found that lysing efficiency fall in the gap between low bound (0.1-0.2 day
Identifiants
pubmed: 39003370
doi: 10.1007/s11538-024-01334-9
pii: 10.1007/s11538-024-01334-9
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107Informations de copyright
© 2024. Crown.
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