Molecular basis for the activation of human spliceosome.

Spliceosomes / metabolism Humans RNA Splicing Cryoelectron Microscopy RNA Precursors / metabolism RNA, Small Nuclear / metabolism Ribonucleoprotein, U2 Small Nuclear / metabolism Models, Molecular DEAD-box RNA Helicases / metabolism Catalytic Domain

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 Jul 2024
Historique:
received: 25 02 2024
accepted: 20 07 2024
medline: 28 7 2024
pubmed: 28 7 2024
entrez: 27 7 2024
Statut: epublish

Résumé

The spliceosome executes pre-mRNA splicing through four sequential stages: assembly, activation, catalysis, and disassembly. Activation of the spliceosome, namely remodeling of the pre-catalytic spliceosome (B complex) into the activated spliceosome (B

Identifiants

DOI: 10.1038/s41467-024-50785-0 PMID: 39068178
pubmed: 39068178
doi: 10.1038/s41467-024-50785-0
pii: 10.1038/s41467-024-50785-0
doi:

Substances chimiques

RNA Precursors 0
RNA, Small Nuclear 0
U6 small nuclear RNA 0
Ribonucleoprotein, U2 Small Nuclear 0
DEAD-box RNA Helicases EC 3.6.4.13

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6348

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Xiechao Zhan (X)

Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. zhanxiechao@westlake.edu.cn.
Research Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. zhanxiechao@westlake.edu.cn.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. zhanxiechao@westlake.edu.cn.
ORCID: 0000-0003-3084-5656

Yichen Lu (Y)

Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Research Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
College of Life Sciences, Fudan University, Shanghai, China.

Yigong Shi (Y)

Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. syg@westlake.edu.cn.
Research Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. syg@westlake.edu.cn.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. syg@westlake.edu.cn.
Beijing Frontier Research Center for Biological Structure, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. syg@westlake.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Structures nucléaires › Espace intranucléaire › Splicéosomes › Molecular basis for the activation of human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular basis for the activation of human...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Molecular basis for the activation of human...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular basis for the activation of human...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Précurseurs des ARN › Molecular basis for the activation of human...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN nucléaire › Molecular basis for the activation of human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Petites ribonucléoprotéines nucléaires U2 › Molecular basis for the activation of human...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Molecular basis for the activation of human...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › Molecular basis for the activation of human...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Molecular basis for the activation of human...