Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase.
RNA modification
dihydrouridine
dihydrouridine synthase
flavoenzyme
rRNA
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
medline:
30
7
2024
pubmed:
30
7
2024
entrez:
30
7
2024
Statut:
ppublish
Résumé
Dihydrouridine (D), a prevalent and evolutionarily conserved base in the transcriptome, primarily resides in tRNAs and, to a lesser extent, in mRNAs. Notably, this modification is found at position 2449 in the
Identifiants
pubmed: 39078675
doi: 10.1073/pnas.2401981121
doi:
Substances chimiques
RNA, Ribosomal, 23S
0
Uridine
WHI7HQ7H85
Escherichia coli Proteins
0
RNA, Bacterial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2401981121Subventions
Organisme : Agence Nationale de la Recherche (ANR)
ID : 20-CE92-0030
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 439669440 - TRR-319-TP C01 and HE 3397/21-1
Organisme : Science Ministry | Forskerakademiet (Danish Research Academy)
ID : FNU-rammebevilling 10-084554
Organisme : Animal Health and Welfare ERA-Net (ANIHWA)
ID : GM132254
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.