Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
16
06
2021
accepted:
03
07
2024
medline:
1
8
2024
pubmed:
1
8
2024
entrez:
31
7
2024
Statut:
epublish
Résumé
Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties. Following prolonged administration of fluoxetine in male mice, we showed that fluoxetine increases the number of muscle stem cells and muscle angiogenesis, associated with positive changes in skeletal muscle function. Fluoxetine also improved skeletal muscle regeneration after single and multiples injuries with an increased muscle stem cells pool and vessel density associated with reduced fibrotic lesions and inflammation. Mice devoid of peripheral serotonin treated with fluoxetine did not exhibit beneficial effects during muscle regeneration. Specifically, pharmacological, and genetic inactivation of the 5-HT1B subtype serotonin receptor also abolished the enhanced regenerative process induced by fluoxetine. We highlight here a regenerative property of serotonin on skeletal muscle.
Identifiants
pubmed: 39085209
doi: 10.1038/s41467-024-50220-4
pii: 10.1038/s41467-024-50220-4
doi:
Substances chimiques
Selective Serotonin Reuptake Inhibitors
0
Fluoxetine
01K63SUP8D
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6457Informations de copyright
© 2024. The Author(s).
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