Poly-GR repeats associated with ALS/FTD gene

C9orf72 Protein / genetics Amyotrophic Lateral Sclerosis / genetics Humans Frontotemporal Dementia / genetics Neurons / metabolism Induced Pluripotent Stem Cells / metabolism DNA Repeat Expansion / genetics Peptide Chain Elongation, Translational p38 Mitogen-Activated Protein Kinases / metabolism Stress, Physiological / genetics Ribosomes / metabolism

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
06 Aug 2024
Historique:
medline: 6 8 2024
pubmed: 6 8 2024
entrez: 6 8 2024
Statut: ppublish

Résumé

Hexanucleotide repeat expansion in the

Identifiants

DOI: 10.1126/scisignal.adl1030 PMID: 39106320
pubmed: 39106320
doi: 10.1126/scisignal.adl1030
doi:

Substances chimiques

C9orf72 Protein 0
C9orf72 protein, human 0
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadl1030

Auteurs

Daoyuan Dong (D)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0009-0000-6892-4857

Zhe Zhang (Z)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0003-3952-2722

Yini Li (Y)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0003-2213-0650

Malgorzata J Latallo (MJ)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Shaopeng Wang (S)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Blake Nelson (B)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-0678-1501

Rong Wu (R)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-4506-3764

Gopinath Krishnan (G)

RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.

Fen-Biao Gao (FB)

RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.

Bin Wu (B)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-9442-3041

Shuying Sun (S)

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0002-8449-7370

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Protéine C9orf72 › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Démence frontotemporale › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Cellules › Neurones › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Expansion de séquence répétée de l'ADN › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Métabolisme › Biosynthèse des peptides › Élongation de la traduction › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Poly-GR repeats associated with ALS/FTD gene
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Poly-GR repeats associated with ALS/FTD gene