Torsemide Crystalline Salts with a Significant Spring-Parachute Effect.
crystalline salt
spring-parachute
torsemide
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
07 Sep 2024
07 Sep 2024
Historique:
received:
15
03
2024
accepted:
26
08
2024
medline:
7
9
2024
pubmed:
7
9
2024
entrez:
6
9
2024
Statut:
epublish
Résumé
Torsemide is a long acting pyridine sulfonylurea diuretic. Torsemide hydrochloride is widely used now, there are only a few organic acid salts reported. Cocrystallization with organic acids is an effective way to improve its solubility. Here, we reported maleate and phthalate of torsemide, in which the organic acid lost a proton transferring to the pyridine of torsemide, and torsemide interacted with organic acid through N
Identifiants
pubmed: 39242368
doi: 10.1208/s12249-024-02926-3
pii: 10.1208/s12249-024-02926-3
doi:
Substances chimiques
Torsemide
W31X2H97FB
Salts
0
Diuretics
0
Maleates
0
maleic acid
91XW058U2C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
210Informations de copyright
© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
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