Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets.
Humans
Leukemia, Myeloid, Acute
/ genetics
Drug Resistance, Neoplasm
/ genetics
Single-Cell Analysis
/ methods
Protein Kinase Inhibitors
/ therapeutic use
Mutation
fms-Like Tyrosine Kinase 3
/ genetics
Staurosporine
/ analogs & derivatives
Aniline Compounds
/ therapeutic use
Male
Middle Aged
Female
Pyrazines
/ therapeutic use
Sequence Analysis, DNA
/ methods
Proto-Oncogene Proteins c-kit
/ genetics
GTP Phosphohydrolases
/ genetics
Membrane Proteins
/ genetics
Adult
Aged
FLT3 mutations
acute myeloid leukemia
clonal architecture
clonal evolution
tyrosine kinase inhibitors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
30
07
2024
revised:
04
09
2024
accepted:
14
09
2024
medline:
29
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the
Identifiants
pubmed: 39337490
pii: ijms251810002
doi: 10.3390/ijms251810002
pii:
doi:
Substances chimiques
Protein Kinase Inhibitors
0
fms-Like Tyrosine Kinase 3
EC 2.7.10.1
Staurosporine
H88EPA0A3N
Aniline Compounds
0
FLT3 protein, human
EC 2.7.10.1
gilteritinib
66D92MGC8M
midostaurin
ID912S5VON
Pyrazines
0
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
NRAS protein, human
EC 3.6.1.-
GTP Phosphohydrolases
EC 3.6.1.-
Membrane Proteins
0
KIT protein, human
EC 2.7.10.1
Types de publication
Journal Article
Case Reports
Langues
eng
Sous-ensembles de citation
IM