Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
received:
30
04
2024
accepted:
23
09
2024
revised:
15
09
2024
medline:
2
10
2024
pubmed:
2
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS. In particular, photoreceptors have a distinctive AS pattern involving the inclusion of microexons not found in other cell types. PROM1 whose encoded protein Prominin-1 is located in photoreceptor outer segments (OSs), undergoes exon 4 inclusion from the 12
Identifiants
pubmed: 39353897
doi: 10.1038/s41419-024-07105-7
pii: 10.1038/s41419-024-07105-7
doi:
Substances chimiques
AC133 Antigen
0
PROM1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
721Informations de copyright
© 2024. The Author(s).
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