Enzymatic Kinetic Resolution of Racemic 1-(Isopropylamine)-3-phenoxy-2-propanol: A Building Block for β-Blockers.

Kinetics Stereoisomerism Lipase / metabolism Adrenergic beta-Antagonists / chemistry Biotransformation Fungal Proteins / metabolism Biocatalysis Saccharomycetales / enzymology Propanols / chemistry
Candida rugosa enantioselective biotransformation ionic liquid lipase β-blockers

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Oct 2024
Historique:
received: 02 09 2024
revised: 25 09 2024
accepted: 30 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

This study aimed to optimize the kinetic resolution of building blocks for the synthesis of β-blockers using

Identifiants

DOI: 10.3390/ijms251910730 PMID: 39409060
pubmed: 39409060
pii: ijms251910730
doi: 10.3390/ijms251910730
pii:
doi:

Substances chimiques

Lipase EC 3.1.1.3
Adrenergic beta-Antagonists 0
Fungal Proteins 0
Propanols 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Science Centre in Poland
ID : 2017/27/N/NZ7/02424

Auteurs

Joanna Chałupka (J)

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical Biotechnology and Laboratory Medicine, Pomeranian Medical University in Szczecin, 71-251 Szczecin, Poland.
Department of Medicinal Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Dr. A. Jurasza 2, 85-089 Bydgoszcz, Poland.
ORCID: 0000-0003-3045-5703

Michał Piotr Marszałł (MP)

Department of Medicinal Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Dr. A. Jurasza 2, 85-089 Bydgoszcz, Poland.

Adam Sikora (A)

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical Biotechnology and Laboratory Medicine, Pomeranian Medical University in Szczecin, 71-251 Szczecin, Poland.
Department of Medicinal Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Dr. A. Jurasza 2, 85-089 Bydgoszcz, Poland.
ORCID: 0000-0001-8449-2134

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes bêta-adrénergiques › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Métabolisme › Biocatalyse › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Saccharomycetales › Enzymatic Kinetic Resolution of Racemic...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Propanols › Enzymatic Kinetic Resolution of Racemic...