Gastrointestinal germinal center B cell depletion and reduction in IgA

Humans HIV Infections / immunology Plasma Cells / immunology Germinal Center / immunology HIV-1 / immunology Immunoglobulin A / immunology B-Lymphocytes / immunology Male Female Adult Intestinal Mucosa / immunology Viremia / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
25 Oct 2024
Historique:
medline: 25 10 2024
pubmed: 25 10 2024
entrez: 25 10 2024
Statut: ppublish

Résumé

Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A-positive (IgA

Identifiants

DOI: 10.1126/sciimmunol.ado0090 PMID: 39454027
pubmed: 39454027
doi: 10.1126/sciimmunol.ado0090
doi:

Substances chimiques

Immunoglobulin A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eado0090

Auteurs

Francesca Cossarini (F)

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8793-5241

Joan Shang (J)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8274-1109

Azra Krek (A)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0009-0001-7845-9984

Zainab Al-Taie (Z)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-2624-2035

Ruixue Hou (R)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-6423-651X

Pablo Canales-Herrerias (P)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-1865-6476

Minami Tokuyama (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6488-9687

Michael Tankelevich (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Adam Tillowitz (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6702-4048

Divya Jha (D)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-5038-241X

Alexandra E Livanos (AE)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8418-3400

Louise Leyre (L)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Mathieu Uzzan (M)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gastroenterology Department, Hôpital Henri Mondor, APHP, Créteil, France.
ORCID: 0000-0002-7761-2879

Gustavo Martinez-Delgado (G)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Matthew D Taylor (MD)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0009-0001-8002-3506

Keshav Sharma (K)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6888-6205

Arno R Bourgonje (AR)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-5754-3821

Michael Cruz (M)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0009-0006-1408-0840

Giorgio Ioannou (G)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Travis Dawson (T)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-9609-793X

Darwin D'Souza (D)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-1943-5173

Seunghee Kim-Schulze (S)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-0192-4400

Ahmed Akm (A)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Judith A Aberg (JA)

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8162-0284

Benjamin K Chen (BK)

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-5404-1997

Douglas S Kwon (DS)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0001-8521-8735

Sacha Gnjatic (S)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-5643-9520

Alexandros D Polydorides (AD)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8604-0756

Andrea Cerutti (A)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain.
ORCID: 0000-0003-3026-4704

Carmen Argmann (C)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ivan Vujkovic-Cvijin (I)

F. Widjaja IBD Institute, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
ORCID: 0000-0002-8611-4900

Mayte Suarez-Fariñas (M)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8712-3553

Francesca Petralia (F)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jeremiah J Faith (JJ)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-2691-4500

Saurabh Mehandru (S)

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-9781-2969

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Plasmocytes › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Gastrointestinal germinal center B cell...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Gastrointestinal germinal center B cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Gastrointestinal germinal center B cell...