Aram Oganesian

Affiliations

Astex Pharmaceuticals Inc., Pleasanton, California.

Publications (15)

A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Amit M Oza , Ursula A Matulonis , Angeles Alvarez Secord , John Nemunaitis , Lynda D Roman , Sarah P Blagden , Susana Banerjee , William P McGuire , Sharad Ghamande , Michael J Birrer , Gini F Fleming , Merry Jennifer Markham , Hal W Hirte , Diane M Provencher , Bristi Basu , Rebecca Kristeleit , Deborah K Armstrong , Benjamin Schwartz , Patricia Braly , Geoff D Hall , Kenneth P Nephew , Simone Jueliger , Aram Oganesian , Sue Naim , Yong Hao , Harold Keer , Mohammad Azab , Daniela Matei

Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Anna Maria Di Giacomo , Alessia Covre , Francesca Finotello , Dietmar Rieder , Riccardo Danielli , Luca Sigalotti , Diana Giannarelli , Florent Petitprez , Laetitia Lacroix , Monica Valente , Ornella Cutaia , Carolina Fazio , Giovanni Amato , Andrea Lazzeri , Santa Monterisi , Clelia Miracco , Sandra Coral , Andrea Anichini , Christoph Bock , Amelie Nemc , Aram Oganesian , James Lowder , Mohammad Azab , Wolf H Fridman , Catherine Sautès-Fridman , Zlatko Trajanoski , Michele Maio

Mass balance and metabolite profiling of

Investigational new drugs

Avec: Jeroen Roosendaal , Hilde Rosing , Luc Lucas , Abadi Gebretensae , Alwin D R Huitema , Marloes G van Dongen , Jos H Beijnen , Aram Oganesian

A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies.

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Vanessa Martins , Lynsey Fazal , Aram Oganesian , Alpesh Shah , Jessie Stow , Hugh Walton , Nicola Wilsher

Role of cedazuridine/decitabine in the management of myelodysplastic syndrome and chronic myelomonocytic leukemia.

Future oncology (London, England)

Avec: Swapna Thota , Aram Oganesian , Mohammad Azab , Elizabeth A Griffiths

Pharmacodynamic and Clinical Results from a Phase I/II Study of the HSP90 Inhibitor Onalespib in Combination with Abiraterone Acetate in Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Susan Slovin , Syed Hussain , Fred Saad , Jorge Garcia , Joel Picus , Roberta Ferraldeschi , Mateus Crespo , Penelope Flohr , Ruth Riisnaes , Chihche Lin , Harold Keer , Aram Oganesian , Paul Workman , Johann de Bono

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Avec: Jeroen Roosendaal , Kai Wang , Hilde Rosing , Luc Lucas , Abadi Gebretensae , Aram Oganesian , Jan H M Schellens , Jos H Beijnen , Zhongping John Lin

Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-methyl-2'-deoxycytidine.

Journal of pharmaceutical and biomedical analysis

Avec: Jeroen Roosendaal , Hilde Rosing , Luc Lucas , Aram Oganesian , Jan H M Schellens , Jos H Beijnen

Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study.

The Lancet. Haematology

Avec: Guillermo Garcia-Manero , James McCloskey , Elizabeth A Griffiths , Karen W L Yee , Amer M Zeidan , Aref Al-Kali , H Joachim Deeg , Prapti A Patel , Mitchell Sabloff , Mary-Margaret Keating , Nancy Zhu , Nashat Y Gabrail , Salman Fazal , Joseph Maly , Olatoyosi Odenike , Hagop Kantarjian , Amy E DeZern , Casey L O'Connell , Gail J Roboz , Lambert Busque , Rena Buckstein , Harshad Amin , Jasleen Randhawa , Brian Leber , Aditi Shastri , Kim-Hien Dao , Aram Oganesian , Yong Hao , Harold N Keer , Mohammad Azab , Michael R Savona

A validated liquid chromatography-tandem mass spectroscopy method for the quantification of tolinapant in human plasma.

Analytical science advances

Avec: Vanessa Martins , Nicola Wilsher , Song Lin , Aram Oganesian

Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study.

British journal of haematology

Avec: Klaus Geissler , Zdenek Koristek , Teresa Bernal Del Castillo , Jan Novák , Gabriela Rodríguez-Macías , Stephan K Metzelder , Arpad Illes , Jiří Mayer , Montserrat Arnan , Mary-Margaret Keating , Jürgen Krauter , Monia Lunghi , Nicola Stefano Fracchiolla , Uwe Platzbecker , Valeria Santini , Yuri Sano , Aram Oganesian , Harold Keer , Michael Lübbert

Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study.

Blood

Avec: Guillermo Garcia-Manero , Elizabeth A Griffiths , David P Steensma , Gail J Roboz , Richard Wells , James McCloskey , Olatoyosi Odenike , Amy E DeZern , Karen Yee , Lambert Busque , Casey O'Connell , Laura C Michaelis , Joseph Brandwein , Hagop Kantarjian , Aram Oganesian , Mohammad Azab , Michael R Savona

Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.

Targeted oncology

Avec: Haley E Ramsey , Aram Oganesian , Agnieszka E Gorska , Londa Fuller , Maria Arrate , Kelli Boyd , Harold Keer , Mohammad Azab , Michael R Savona

A Phase I Study of ASTX660, an Antagonist of Inhibitors of Apoptosis Proteins, in Adults with Advanced Cancers or Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Monica M Mita , Patricia M LoRusso , Kyriakos P Papadopoulos , Michael S Gordon , Alain C Mita , Roberta Ferraldeschi , Harold Keer , Aram Oganesian , Xiang Yao Su , Simone Jueliger , Anthony W Tolcher

An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study.

The Lancet. Haematology

Avec: Michael R Savona , Olatoyosi Odenike , Philip C Amrein , David P Steensma , Amy E DeZern , Laura C Michaelis , Stefan Faderl , Wael Harb , Hagop Kantarjian , James Lowder , Aram Oganesian , Mohammad Azab , Guillermo Garcia-Manero

Réseau de co-auteurs

Mohammad Azab 7 collaborations

Harold Keer 5 collaborations

Michael R Savona 4 collaborations

Jeroen Roosendaal 3 collaborations

Hilde Rosing 3 collaborations

Luc Lucas 3 collaborations

Jos H Beijnen 3 collaborations

Elizabeth A Griffiths 3 collaborations

Guillermo Garcia-Manero 3 collaborations

Olatoyosi Odenike 3 collaborations

Hagop Kantarjian 3 collaborations

Amy E DeZern 3 collaborations

Simone Jueliger 2 collaborations

Yong Hao 2 collaborations

James Lowder 2 collaborations

Abadi Gebretensae 2 collaborations

Vanessa Martins 2 collaborations

Nicola Wilsher 2 collaborations

Roberta Ferraldeschi 2 collaborations

Jan H M Schellens 2 collaborations

James McCloskey 2 collaborations

Mary-Margaret Keating 2 collaborations

Gail J Roboz 2 collaborations

Lambert Busque 2 collaborations

David P Steensma 2 collaborations

Laura C Michaelis 2 collaborations

Amit M Oza 1 collaboration

Ursula A Matulonis 1 collaboration

Angeles Alvarez Secord 1 collaboration

John Nemunaitis 1 collaboration

Lynda D Roman 1 collaboration

Sarah P Blagden 1 collaboration

Susana Banerjee 1 collaboration

William P McGuire 1 collaboration

Sharad Ghamande 1 collaboration

Michael J Birrer 1 collaboration

Gini F Fleming 1 collaboration

Merry Jennifer Markham 1 collaboration

Hal W Hirte 1 collaboration

Diane M Provencher 1 collaboration

Bristi Basu 1 collaboration

Rebecca Kristeleit 1 collaboration

Deborah K Armstrong 1 collaboration

Benjamin Schwartz 1 collaboration

Patricia Braly 1 collaboration

Geoff D Hall 1 collaboration

Kenneth P Nephew 1 collaboration

Sue Naim 1 collaboration

Daniela Matei 1 collaboration

Anna Maria Di Giacomo 1 collaboration

Alessia Covre 1 collaboration

Francesca Finotello 1 collaboration

Dietmar Rieder 1 collaboration

Riccardo Danielli 1 collaboration

Luca Sigalotti 1 collaboration

Diana Giannarelli 1 collaboration

Florent Petitprez 1 collaboration

Laetitia Lacroix 1 collaboration

Monica Valente 1 collaboration

Ornella Cutaia 1 collaboration

Carolina Fazio 1 collaboration

Giovanni Amato 1 collaboration

Andrea Lazzeri 1 collaboration

Santa Monterisi 1 collaboration

Clelia Miracco 1 collaboration

Sandra Coral 1 collaboration

Andrea Anichini 1 collaboration

Christoph Bock 1 collaboration

Amelie Nemc 1 collaboration

Wolf H Fridman 1 collaboration

Catherine Sautès-Fridman 1 collaboration

Zlatko Trajanoski 1 collaboration

Michele Maio 1 collaboration

Alwin D R Huitema 1 collaboration

Marloes G van Dongen 1 collaboration

Lynsey Fazal 1 collaboration

Alpesh Shah 1 collaboration

Jessie Stow 1 collaboration

Hugh Walton 1 collaboration

Swapna Thota 1 collaboration

Susan Slovin 1 collaboration

Syed Hussain 1 collaboration

Fred Saad 1 collaboration

Jorge Garcia 1 collaboration

Joel Picus 1 collaboration

Mateus Crespo 1 collaboration

Penelope Flohr 1 collaboration

Ruth Riisnaes 1 collaboration

Chihche Lin 1 collaboration

Paul Workman 1 collaboration

Johann de Bono 1 collaboration

Kai Wang 1 collaboration

Zhongping John Lin 1 collaboration

Karen W L Yee 1 collaboration

Amer M Zeidan 1 collaboration

Aref Al-Kali 1 collaboration

H Joachim Deeg 1 collaboration

Prapti A Patel 1 collaboration

Mitchell Sabloff 1 collaboration

Nancy Zhu 1 collaboration

Nashat Y Gabrail 1 collaboration

Salman Fazal 1 collaboration

Joseph Maly 1 collaboration

Casey L O'Connell 1 collaboration

Rena Buckstein 1 collaboration

Harshad Amin 1 collaboration

Jasleen Randhawa 1 collaboration

Brian Leber 1 collaboration

Aditi Shastri 1 collaboration

Kim-Hien Dao 1 collaboration

Harold N Keer 1 collaboration

Song Lin 1 collaboration

Klaus Geissler 1 collaboration

Zdenek Koristek 1 collaboration

Teresa Bernal Del Castillo 1 collaboration

Jan Novák 1 collaboration

Gabriela Rodríguez-Macías 1 collaboration

Stephan K Metzelder 1 collaboration

Arpad Illes 1 collaboration

Jiří Mayer 1 collaboration

Montserrat Arnan 1 collaboration

Jürgen Krauter 1 collaboration

Monia Lunghi 1 collaboration

Nicola Stefano Fracchiolla 1 collaboration

Uwe Platzbecker 1 collaboration

Valeria Santini 1 collaboration

Yuri Sano 1 collaboration

Michael Lübbert 1 collaboration

Richard Wells 1 collaboration

Karen Yee 1 collaboration

Casey O'Connell 1 collaboration

Joseph Brandwein 1 collaboration

Haley E Ramsey 1 collaboration

Agnieszka E Gorska 1 collaboration

Londa Fuller 1 collaboration

Maria Arrate 1 collaboration

Kelli Boyd 1 collaboration

Monica M Mita 1 collaboration

Patricia M LoRusso 1 collaboration

Kyriakos P Papadopoulos 1 collaboration

Michael S Gordon 1 collaboration

Alain C Mita 1 collaboration

Xiang Yao Su 1 collaboration

Anthony W Tolcher 1 collaboration

Philip C Amrein 1 collaboration

Stefan Faderl 1 collaboration

Wael Harb 1 collaboration