F Denorme

Affiliations

Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Publications (38)

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke.

Frontiers in immunology

Avec: Frederik Denorme , Karen Vanhoorelbeke , Simon F De Meyer

Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function.

Blood cells, molecules & diseases

Avec: Seema Bhatlekar , Shancy Jacob , Bhanu K Manne , Li Guo , Frederik Denorme , Emilia A Tugolukova , Mark J Cody , Yasuhiro Kosaka , Isidore Rigoutsos , Robert A Campbell , Jesse W Rowley , Ryan M O'Connell , Paul F Bray

Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps.

Frontiers in immunology

Avec: Claudia V de Araujo , Frederik Denorme , W Zac Stephens , Qing Li , Mark J Cody , Jacob L Crandell , Aaron C Petrey , Kimberly A Queisser , John L Rustad , James M Fulcher , Judah L Evangelista , Michael S Kay , Joshua D Schiffman , Robert A Campbell , Christian C Yost

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.

Current opinion in hematology

Avec: Izabella Andrianova , Mia Kowalczyk , Frederik Denorme

Harnessing Twitter to empower scientific engagement and communication: The ISTH 2020 virtual congress experience.

Research and practice in thrombosis and haemostasis

Avec: Maha Othman , Matthew Cormier , Geoffrey D Barnes , Shane P Comer , Jean M Connors , Frederik Denorme , Alok A Khorana , Pedro Henrique Las Casas , Shravan Morla , Joshua Muia , Fionnuala Ní Áinle , Kirk A Taylor , Dianne E van der Wal , Angela C Weyand , Michelle Lavin , Auteur inconnu

Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations.

International journal of stroke : official journal of the International Stroke Society

Avec: S Staessens , S Fitzgerald , T Andersson , F Clarençon , F Denorme , M J Gounis , W Hacke , D S Liebeskind , I Szikora , Acgm van Es , W Brinjikji , K M Doyle , S F De Meyer

Platelet gene expression and function in patients with COVID-19.

Blood

Avec: Bhanu Kanth Manne , Frederik Denorme , Elizabeth A Middleton , Irina Portier , Jesse W Rowley , Chris Stubben , Aaron C Petrey , Neal D Tolley , Li Guo , Mark Cody , Andrew S Weyrich , Christian C Yost , Matthew T Rondina , Robert A Campbell

Paradigms in chronic subdural hematoma pathophysiology: Current treatments and new directions.

The journal of trauma and acute care surgery

Avec: Michael T Bounajem , Robert A Campbell , Frederik Denorme , Ramesh Grandhi

Endovascular mechanical thrombectomy in a child with COVID-19: Clot analysis reveals a novel pathway in the neuroinflammatory cascade resulting in large-vessel occlusion.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Avec: Vijay M Ravindra , Frederik Denorme , Matthew D Alexander , Robert A Campbell , Ramesh Grandhi

MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis.

Blood

Avec: Bhanu Kanth Manne , Robert A Campbell , Seema Bhatlekar , Abigail Ajanel , Frederik Denorme , Irina Portier , Elizabeth A Middleton , Neal D Tolley , Yasuhiro Kosaka , Emilie Montenont , Li Guo , Jesse W Rowley , Paul F Bray , Shancy Jacob , Rikiro Fukanaga , Christopher Proud , Andrew S Weyrich , Matthew T Rondina

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.

Blood

Avec: Elizabeth A Middleton , Xue-Yan He , Frederik Denorme , Robert A Campbell , David Ng , Steven P Salvatore , Maria Mostyka , Amelia Baxter-Stoltzfus , Alain C Borczuk , Massimo Loda , Mark J Cody , Bhanu Kanth Manne , Irina Portier , Estelle S Harris , Aaron C Petrey , Ellen J Beswick , Aleah F Caulin , Anthony Iovino , Lisa M Abegglen , Andrew S Weyrich , Matthew T Rondina , Mikala Egeblad , Joshua D Schiffman , Christian Con Yost

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice.

Haematologica

Avec: Frederik Denorme , Kimberly Martinod , Aline Vandenbulcke , Cécile V Denis , Peter J Lenting , Hans Deckmyn , Karen Vanhoorelbeke , Simon F De Meyer

Platelet necrosis mediates ischemic stroke outcome in mice.

Blood

Avec: Frederik Denorme , Bhanu Kanth Manne , Irina Portier , Alicia S Eustes , Yasuhiro Kosaka , Benjamin T Kile , Matthew T Rondina , Robert A Campbell

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand.

Blood advances

Avec: Michelle L Stoller , Indranil Basak , Frederik Denorme , Jesse W Rowley , James Alsobrooks , Krishna Parsawar , Marvin T Nieman , Christian Con Yost , Justin R Hamilton , Paul F Bray , Robert A Campbell

Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake.

Journal of thrombosis and haemostasis : JTH

Avec: Frederik Denorme , Irina Portier , Yasuhiro Kosaka , Robert A Campbell

COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Emma G Bouck , Frederik Denorme , Lori A Holle , Elizabeth A Middelton , Antoinette M Blair , Bas de Laat , Joshua D Schiffman , Christian Con Yost , Matthew T Rondina , Alisa S Wolberg , Robert A Campbell

Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia-reperfusion injury in a mouse model of temporary middle cerebral artery occlusion-implications for neurovascular procedures.

Acta neurochirurgica

Avec: Frederik Denorme , Juhana Frösen , Annukka Jouppila , Antti Lindgren , Julio C Resendiz-Nieves , Hannu Manninen , Simon F De Meyer , Riitta Lassila

Platelet MHC class I mediates CD8+ T-cell suppression during sepsis.

Blood

Avec: Li Guo , Sikui Shen , Jesse W Rowley , Neal D Tolley , Wenwen Jia , Bhanu Kanth Manne , Kyra N McComas , Ben Bolingbroke , Yasuhiro Kosaka , Krystin Krauel , Frederik Denorme , Shancy P Jacob , Alicia S Eustes , Robert A Campbell , Elizabeth A Middleton , Xiao He , Samuel M Brown , Craig N Morrell , Andrew S Weyrich , Matthew T Rondina

Comparison of the coagulopathies associated with COVID-19 and sepsis.

Research and practice in thrombosis and haemostasis

Avec: Robert A Campbell , Yohei Hisada , Frederik Denorme , Steven P Grover , Emma G Bouck , Elizabeth A Middleton , Alisa S Wolberg , Matthew T Rondina , Nigel Mackman

Brothers in arms: platelets and neutrophils in ischemic stroke.

Current opinion in hematology

Avec: Frederik Denorme , John L Rustad , Robert A Campbell

Mechanisms of immunothrombosis in COVID-19.

Current opinion in hematology

Avec: Irina Portier , Robert A Campbell , Frederik Denorme

IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.

The Journal of clinical investigation

Avec: Robert A Campbell , Bhanu Kanth Manne , Meenakshi Banerjee , Elizabeth A Middleton , Abigail Ajanel , Hansjorg Schwertz , Frederik Denorme , Chris Stubben , Emilie Montenont , Samantha Saperstein , Lauren Page , Neal D Tolley , Diana L Lim , Samuel M Brown , Colin K Grissom , Douglas W Sborov , Anandi Krishnan , Matthew T Rondina

Investigation of Neutrophil Extracellular Traps as Potential Mediators in the Pathogenesis of Non-Acute Subdural Hematomas: A Pilot Study.

Diagnostics (Basel, Switzerland)

Avec: Michael T Bounajem , Frederik Denorme , John L Rustad , Robert A Campbell , Ramesh Grandhi

Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps.

Frontiers in immunology

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.

The Journal of clinical investigation

Avec: Frederik Denorme , Nicole D Armstrong , Michelle L Stoller , Irina Portier , Emilia A Tugolukova , Rikki M Tanner , Emilie Montenont , Seema Bhatlekar , Mark Cody , John L Rustad , Abigail Ajanel , Neal D Tolley , Darian C Murray , Julie L Boyle , Marvin T Nieman , Steven E McKenzie , Christian Con Yost , Leslie A Lange , Mary Cushman , Marguerite R Irvin , Paul F Bray , Robert A Campbell

Platelet mitochondria: the mighty few.

Current opinion in hematology

Avec: Abigail Ajanel , Robert A Campbell , Frederik Denorme

Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi.

Journal of thrombosis and haemostasis : JTH

Avec: Kimberly Martinod , Frederik Denorme , Severien Meyers , Marilena Crescente , Stijn Van Bruggen , Mathias Stroobants , Patrick M Siegel , Ramesh Grandhi , Katharina Glatz , Thilo Witsch

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance.

Haematologica

Avec: Senna Staessens , Frederik Denorme , Olivier Francois , Linda Desender , Tom Dewaele , Peter Vanacker , Hans Deckmyn , Karen Vanhoorelbeke , Tommy Andersson , Simon F De Meyer

COVID-19 patients exhibit reduced procoagulant platelet responses.

Journal of thrombosis and haemostasis : JTH

Avec: Frederik Denorme , Bhanu Kanth Manne , Irina Portier , Aaron C Petrey , Elizabeth A Middleton , Benjamin T Kile , Matthew T Rondina , Robert A Campbell

Placental HTRA1 cleaves α1-antitrypsin to generate a NET-inhibitory peptide.

Blood

Avec: Robert A Campbell , Heather D Campbell , J Samuel Bircher , Claudia Valeria de Araujo , Frederik Denorme , Jacob L Crandell , John L Rustad , Josh Monts , Mark J Cody , Yasuhiro Kosaka , Christian C Yost

COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction.

JCI insight

Avec: Kimberly A Queisser , Rebecca A Mellema , Elizabeth A Middleton , Irina Portier , Bhanu Kanth Manne , Frederik Denorme , Ellen J Beswick , Matthew T Rondina , Robert A Campbell , Aaron C Petrey

Neutrophil extracellular traps regulate ischemic stroke brain injury.

The Journal of clinical investigation

Avec: Frederik Denorme , Irina Portier , John L Rustad , Mark J Cody , Claudia V de Araujo , Chieko Hoki , Matthew D Alexander , Ramesh Grandhi , Mitchell R Dyer , Matthew D Neal , Jennifer J Majersik , Christian C Yost , Robert A Campbell

Immunothrombosis in neurovascular disease.

Research and practice in thrombosis and haemostasis

Avec: Frederik Denorme , Abigail Ajanel , Robert A Campbell

Mitofusin-2 Regulates Platelet Mitochondria and Function.

Circulation research

Avec: Shancy Jacob , Yasuhiro Kosaka , Seema Bhatlekar , Frederik Denorme , Haley Benzon , Alexandra Moody , Victoria Moody , Emilia Tugolukova , Grayson Hull , Nina Kishimoto , Bhanu K Manne , Li Guo , Rhonda Souvenir , Brayden J Seliger , Alicia S Eustes , Kelly Hoerger , Neal D Tolley , Amir N Fatahian , Sihem Boudina , David C Christiani , Yongyue Wei , Can Ju , Robert A Campbell , Matthew T Rondina , E Dale Abel , Paul F Bray , Andrew S Weyrich , Jesse W Rowley

Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis.

Pediatric research

Avec: Frederik Denorme , John L Rustad , Irina Portier , Jacob L Crandell , Claudia V de Araujo , Mark J Cody , Robert A Campbell , Christian C Yost

Procoagulant platelets: novel players in thromboinflammation.

American journal of physiology. Cell physiology

Avec: Frederik Denorme , Robert A Campbell

Aging-related Alterations in mTOR Signaling Promote Platelet Hyperreactivity and Thrombosis.

Journal of thrombosis and haemostasis : JTH

Avec: Irina Portier , Bhanu Kanth Manne , Yasuhiro Kosaka , Neal D Tolley , Frederik Denorme , Özgün Babur , Ashok P Reddy , Phillip A Wilmarth , Joseph E Aslan , Andrew S Weyrich , Matthew T Rondina , Robert A Campbell

Alterations in visible light exposure modulate platelet function and regulate thrombus formation.

Journal of thrombosis and haemostasis : JTH

Avec: Elizabeth A Andraska , Frederik Denorme , Christof Kaltenmeier , Aishwarrya Arivudainabi , Emily P Mihalko , Mitchell Dyer , Gowtham K Annarapu , Mohammadreza Zarisfi , Patricia Loughran , Mehves Ozel , Kelly Williamson , Roberto Mota-Alvidrez , Kimberly Thomas , Sruti Shiva , Susan Shea , Richard A Steinman , Robert A Campbell , Matthew R Rosengart , Matthew D Neal

Réseau de co-auteurs

Frederik Denorme 37 collaborations

Robert A Campbell 30 collaborations

Irina Portier 12 collaborations

Matthew T Rondina 12 collaborations

Bhanu Kanth Manne 9 collaborations

Yasuhiro Kosaka 8 collaborations

John L Rustad 8 collaborations

Elizabeth A Middleton 8 collaborations

Mark J Cody 7 collaborations

Neal D Tolley 7 collaborations

Jesse W Rowley 6 collaborations

Aaron C Petrey 6 collaborations

Christian C Yost 6 collaborations

Andrew S Weyrich 6 collaborations

Li Guo 5 collaborations

Paul F Bray 5 collaborations

Ramesh Grandhi 5 collaborations

Abigail Ajanel 5 collaborations

Simon F De Meyer 4 collaborations

Seema Bhatlekar 4 collaborations

Claudia V de Araujo 4 collaborations

Jacob L Crandell 4 collaborations

Joshua D Schiffman 4 collaborations

Christian Con Yost 4 collaborations

Karen Vanhoorelbeke 3 collaborations

Shancy Jacob 3 collaborations

Kimberly A Queisser 3 collaborations

Emilie Montenont 3 collaborations

Alicia S Eustes 3 collaborations

Bhanu K Manne 2 collaborations

Emilia A Tugolukova 2 collaborations

W Zac Stephens 2 collaborations

Qing Li 2 collaborations

James M Fulcher 2 collaborations

Judah L Evangelista 2 collaborations

Michael S Kay 2 collaborations

Chris Stubben 2 collaborations

Mark Cody 2 collaborations

Michael T Bounajem 2 collaborations

Matthew D Alexander 2 collaborations

Ellen J Beswick 2 collaborations

Kimberly Martinod 2 collaborations

Hans Deckmyn 2 collaborations

Benjamin T Kile 2 collaborations

Michelle L Stoller 2 collaborations

Marvin T Nieman 2 collaborations

Emma G Bouck 2 collaborations

Alisa S Wolberg 2 collaborations

Samuel M Brown 2 collaborations

Matthew D Neal 2 collaborations

Isidore Rigoutsos 1 collaboration

Ryan M O'Connell 1 collaboration

Izabella Andrianova 1 collaboration

Mia Kowalczyk 1 collaboration

Maha Othman 1 collaboration

Matthew Cormier 1 collaboration

Geoffrey D Barnes 1 collaboration

Shane P Comer 1 collaboration

Jean M Connors 1 collaboration

Alok A Khorana 1 collaboration

Pedro Henrique Las Casas 1 collaboration

Shravan Morla 1 collaboration

Joshua Muia 1 collaboration

Fionnuala Ní Áinle 1 collaboration

Kirk A Taylor 1 collaboration

Dianne E van der Wal 1 collaboration

Angela C Weyand 1 collaboration

Michelle Lavin 1 collaboration

None None 1 collaboration

S Staessens 1 collaboration

S Fitzgerald 1 collaboration

T Andersson 1 collaboration

F Clarençon 1 collaboration

M J Gounis 1 collaboration

W Hacke 1 collaboration

D S Liebeskind 1 collaboration

I Szikora 1 collaboration

Acgm van Es 1 collaboration

W Brinjikji 1 collaboration

K M Doyle 1 collaboration

S F De Meyer 1 collaboration

Vijay M Ravindra 1 collaboration

Rikiro Fukanaga 1 collaboration

Christopher Proud 1 collaboration

Xue-Yan He 1 collaboration

David Ng 1 collaboration

Steven P Salvatore 1 collaboration

Maria Mostyka 1 collaboration

Amelia Baxter-Stoltzfus 1 collaboration

Alain C Borczuk 1 collaboration

Massimo Loda 1 collaboration

Estelle S Harris 1 collaboration

Aleah F Caulin 1 collaboration

Anthony Iovino 1 collaboration

Lisa M Abegglen 1 collaboration

Mikala Egeblad 1 collaboration

Aline Vandenbulcke 1 collaboration

Cécile V Denis 1 collaboration

Peter J Lenting 1 collaboration

Indranil Basak 1 collaboration

James Alsobrooks 1 collaboration

Krishna Parsawar 1 collaboration

Justin R Hamilton 1 collaboration

Lori A Holle 1 collaboration

Elizabeth A Middelton 1 collaboration

Antoinette M Blair 1 collaboration

Bas de Laat 1 collaboration

Juhana Frösen 1 collaboration

Annukka Jouppila 1 collaboration

Antti Lindgren 1 collaboration

Julio C Resendiz-Nieves 1 collaboration

Hannu Manninen 1 collaboration

Riitta Lassila 1 collaboration

Sikui Shen 1 collaboration

Wenwen Jia 1 collaboration

Kyra N McComas 1 collaboration

Ben Bolingbroke 1 collaboration

Krystin Krauel 1 collaboration

Shancy P Jacob 1 collaboration

Xiao He 1 collaboration

Craig N Morrell 1 collaboration

Yohei Hisada 1 collaboration

Steven P Grover 1 collaboration

Nigel Mackman 1 collaboration

Meenakshi Banerjee 1 collaboration

Hansjorg Schwertz 1 collaboration

Samantha Saperstein 1 collaboration

Lauren Page 1 collaboration

Diana L Lim 1 collaboration

Colin K Grissom 1 collaboration

Douglas W Sborov 1 collaboration

Anandi Krishnan 1 collaboration

Nicole D Armstrong 1 collaboration

Rikki M Tanner 1 collaboration

Darian C Murray 1 collaboration

Julie L Boyle 1 collaboration

Steven E McKenzie 1 collaboration

Leslie A Lange 1 collaboration

Mary Cushman 1 collaboration

Marguerite R Irvin 1 collaboration

Severien Meyers 1 collaboration

Marilena Crescente 1 collaboration

Stijn Van Bruggen 1 collaboration

Mathias Stroobants 1 collaboration

Patrick M Siegel 1 collaboration

Katharina Glatz 1 collaboration

Thilo Witsch 1 collaboration

Senna Staessens 1 collaboration

Olivier Francois 1 collaboration

Linda Desender 1 collaboration

Tom Dewaele 1 collaboration

Peter Vanacker 1 collaboration

Tommy Andersson 1 collaboration

Heather D Campbell 1 collaboration

J Samuel Bircher 1 collaboration

Claudia Valeria de Araujo 1 collaboration

Josh Monts 1 collaboration

Rebecca A Mellema 1 collaboration

Chieko Hoki 1 collaboration

Mitchell R Dyer 1 collaboration

Jennifer J Majersik 1 collaboration

Haley Benzon 1 collaboration

Alexandra Moody 1 collaboration

Victoria Moody 1 collaboration

Emilia Tugolukova 1 collaboration

Grayson Hull 1 collaboration

Nina Kishimoto 1 collaboration

Rhonda Souvenir 1 collaboration

Brayden J Seliger 1 collaboration

Kelly Hoerger 1 collaboration

Amir N Fatahian 1 collaboration

Sihem Boudina 1 collaboration

David C Christiani 1 collaboration

Yongyue Wei 1 collaboration

Can Ju 1 collaboration

E Dale Abel 1 collaboration

Özgün Babur 1 collaboration

Ashok P Reddy 1 collaboration

Phillip A Wilmarth 1 collaboration

Joseph E Aslan 1 collaboration

Elizabeth A Andraska 1 collaboration

Christof Kaltenmeier 1 collaboration

Aishwarrya Arivudainabi 1 collaboration

Emily P Mihalko 1 collaboration

Mitchell Dyer 1 collaboration

Gowtham K Annarapu 1 collaboration

Mohammadreza Zarisfi 1 collaboration

Patricia Loughran 1 collaboration

Mehves Ozel 1 collaboration

Kelly Williamson 1 collaboration

Roberto Mota-Alvidrez 1 collaboration

Kimberly Thomas 1 collaboration

Sruti Shiva 1 collaboration

Susan Shea 1 collaboration

Richard A Steinman 1 collaboration

Matthew R Rosengart 1 collaboration