Giulio Draetta

Affiliations

Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.

Publications (9)

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

Journal of medicinal chemistry

Avec: Michael J Soth , Kang Le , Maria Emilia Di Francesco , Matthew M Hamilton , Gang Liu , Jason P Burke , Chris L Carroll , Jeffrey J Kovacs , Jennifer P Bardenhagen , Christopher A Bristow , Mario Cardozo , Barbara Czako , Elisa de Stanchina , Ningping Feng , Jill R Garvey , Jason P Gay , Mary K Geck Do , Jennifer Greer , Michelle Han , Angela Harris , Zachary Herrera , Sha Huang , Virginia Giuliani , Yongying Jiang , Sarah B Johnson , Troy A Johnson , Zhijun Kang , Paul G Leonard , Zhen Liu , Timothy McAfoos , Meredith Miller , Pietro Morlacchi , Robert A Mullinax , Wylie S Palmer , Jihai Pang , Norma Rogers , Charles M Rudin , Hannah E Shepard , Nakia D Spencer , Jay Theroff , Qi Wu , Alan Xu , Ju Anne Yau , Giulio Draetta , Carlo Toniatti , Timothy P Heffernan , Philip Jones

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.

Nature communications

Avec: Virginia Giuliani , Meredith A Miller , Chiu-Yi Liu , Stella R Hartono , Caleb A Class , Christopher A Bristow , Erika Suzuki , Lionel A Sanz , Guang Gao , Jason P Gay , Ningping Feng , Johnathon L Rose , Hideo Tomihara , Joseph R Daniele , Michael D Peoples , Jennifer P Bardenhagen , Mary K Geck Do , Qing E Chang , Bhavatarini Vangamudi , Christopher Vellano , Haoqiang Ying , Angela K Deem , Kim-Anh Do , Giannicola Genovese , Joseph R Marszalek , Jeffrey J Kovacs , Michael Kim , Jason B Fleming , Ernesto Guccione , Andrea Viale , Anirban Maitra , M Emilia Di Francesco , Timothy A Yap , Philip Jones , Giulio Draetta , Alessandro Carugo , Frederic Chedin , Timothy P Heffernan

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells.

The Journal of experimental medicine

Avec: Teresa Manzo , Boone M Prentice , Kristin G Anderson , Ayush Raman , Aislyn Schalck , Gabriela S Codreanu , Carina B Nava Lauson , Silvia Tiberti , Andrea Raimondi , Marissa A Jones , Michelle Reyzer , Breanna M Bates , Jeffrey M Spraggins , Nathan H Patterson , John A McLean , Kunal Rai , Carlo Tacchetti , Sara Tucci , Jennifer A Wargo , Simona Rodighiero , Karen Clise-Dwyer , Stacy D Sherrod , Michael Kim , Nicholas E Navin , Richard M Caprioli , Philip D Greenberg , Giulio Draetta , Luigi Nezi

Discovery of 6-[(3

Journal of medicinal chemistry

Avec: Barbara Czako , Yuting Sun , Timothy McAfoos , Jason B Cross , Paul G Leonard , Jason P Burke , Christopher L Carroll , Ningping Feng , Angela L Harris , Yongying Jiang , Zhijun Kang , Jeffrey J Kovacs , Pijus Mandal , Brooke A Meyers , Faika Mseeh , Connor A Parker , Simon S Yu , Christopher C Williams , Qi Wu , Maria Emilia Di Francesco , Giulio Draetta , Timothy Heffernan , Joseph R Marszalek , Nancy E Kohl , Philip Jones

Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells.

The Journal of clinical investigation

Avec: Hila Shaim , Mayra Shanley , Rafet Basar , May Daher , Joy Gumin , Daniel B Zamler , Nadima Uprety , Fang Wang , Yuefan Huang , Konrad Gabrusiewicz , Qi Miao , Jinzhuang Dou , Abdullah Alsuliman , Lucila N Kerbauy , Sunil Acharya , Vakul Mohanty , Mayela Mendt , Sufang Li , JunJun Lu , Jun Wei , Natalie W Fowlkes , Elif Gokdemir , Emily L Ensley , Mecit Kaplan , Cynthia Kassab , Li Li , Gonca Ozcan , Pinaki P Banerjee , Yifei Shen , April L Gilbert , Corry M Jones , Mustafa Bdiwi , Ana K Nunez-Cortes , Enli Liu , Jun Yu , Nobuhiko Imahashi , Luis Muniz-Feliciano , Ye Li , Jian Hu , Giulio Draetta , David Marin , Dihua Yu , Stephan Mielke , Matthias Eyrich , Richard E Champlin , Ken Chen , Frederick F Lang , Elizabeth J Shpall , Amy B Heimberger , Katayoun Rezvani

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.

Science translational medicine

Avec: Liang Zhang , Yixin Yao , Shaojun Zhang , Yang Liu , Hui Guo , Makhdum Ahmed , Taylor Bell , Hui Zhang , Guangchun Han , Elizabeth Lorence , Maria Badillo , Shouhao Zhou , Yuting Sun , M Emilia Di Francesco , Ningping Feng , Randy Haun , Renny Lan , Samuel G Mackintosh , Xizeng Mao , Xingzhi Song , Jianhua Zhang , Lan V Pham , Philip L Lorenzi , Joseph Marszalek , Tim Heffernan , Giulio Draetta , Philip Jones , Andrew Futreal , Krystle Nomie , Linghua Wang , Michael Wang

Clonal dominance defines metastatic dissemination in pancreatic cancer.

Science advances

Avec: I-Lin Ho , Chieh-Yuan Li , Fuchenchu Wang , Li Zhao , Jingjing Liu , Er-Yen Yen , Charles A Dyke , Rutvi Shah , Zhaoliang Liu , Ali Osman Çetin , Yanshuo Chu , Francesca Citron , Sergio Attanasio , Denise Corti , Faezeh Darbaniyan , Edoardo Del Poggetto , Sara Loponte , Jintan Liu , Melinda Soeung , Ziheng Chen , Shan Jiang , Hong Jiang , Akira Inoue , Sisi Gao , Angela Deem , Ningping Feng , Haoqiang Ying , Michael Kim , Virginia Giuliani , Giannicola Genovese , Jianhua Zhang , Andrew Futreal , Anirban Maitra , Timothy Heffernan , Linghua Wang , Kim-Anh Do , Gaetano Gargiulo , Giulio Draetta , Alessandro Carugo , Ruitao Lin , Andrea Viale

Pooled library screening with multiplexed Cpf1 library.

Nature communications

Avec: Jintan Liu , Sanjana Srinivasan , Chieh-Yuan Li , I-Lin Ho , Johnathon Rose , MennatAllah Shaheen , Gang Wang , Wantong Yao , Angela Deem , Chris Bristow , Traver Hart , Giulio Draetta

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer.

Cancer research

Avec: Carmen Ghilardi , Catarina Moreira-Barbosa , Laura Brunelli , Paola Ostano , Nicolò Panini , Monica Lupi , Alessia Anastasia , Fabio Fiordaliso , Monica Salio , Laura Formenti , Massimo Russo , Edoardo Arrigoni , Ferdinando Chiaradonna , Giovanna Chiorino , Giulio Draetta , Joseph R Marszalek , Christopher P Vellano , Roberta Pastorelli , MariaRosa Bani , Alessandra Decio , Raffaella Giavazzi

Réseau de co-auteurs

Ningping Feng 5 collaborations

Philip Jones 4 collaborations

Jeffrey J Kovacs 3 collaborations

Virginia Giuliani 3 collaborations

Joseph R Marszalek 3 collaborations

Michael Kim 3 collaborations

Maria Emilia Di Francesco 2 collaborations

Jason P Burke 2 collaborations

Jennifer P Bardenhagen 2 collaborations

Christopher A Bristow 2 collaborations

Barbara Czako 2 collaborations

Jason P Gay 2 collaborations

Mary K Geck Do 2 collaborations

Yongying Jiang 2 collaborations

Zhijun Kang 2 collaborations

Paul G Leonard 2 collaborations

Timothy McAfoos 2 collaborations

Qi Wu 2 collaborations

Timothy P Heffernan 2 collaborations

Haoqiang Ying 2 collaborations

Kim-Anh Do 2 collaborations

Giannicola Genovese 2 collaborations

Andrea Viale 2 collaborations

Anirban Maitra 2 collaborations

M Emilia Di Francesco 2 collaborations

Alessandro Carugo 2 collaborations

Yuting Sun 2 collaborations

Timothy Heffernan 2 collaborations

Jianhua Zhang 2 collaborations

Andrew Futreal 2 collaborations

Linghua Wang 2 collaborations

I-Lin Ho 2 collaborations

Chieh-Yuan Li 2 collaborations

Jintan Liu 2 collaborations

Angela Deem 2 collaborations

Michael J Soth 1 collaboration

Kang Le 1 collaboration

Matthew M Hamilton 1 collaboration

Gang Liu 1 collaboration

Chris L Carroll 1 collaboration

Mario Cardozo 1 collaboration

Elisa de Stanchina 1 collaboration

Jill R Garvey 1 collaboration

Jennifer Greer 1 collaboration

Michelle Han 1 collaboration

Angela Harris 1 collaboration

Zachary Herrera 1 collaboration

Sha Huang 1 collaboration

Sarah B Johnson 1 collaboration

Troy A Johnson 1 collaboration

Zhen Liu 1 collaboration

Meredith Miller 1 collaboration

Pietro Morlacchi 1 collaboration

Robert A Mullinax 1 collaboration

Wylie S Palmer 1 collaboration

Jihai Pang 1 collaboration

Norma Rogers 1 collaboration

Charles M Rudin 1 collaboration

Hannah E Shepard 1 collaboration

Nakia D Spencer 1 collaboration

Jay Theroff 1 collaboration

Alan Xu 1 collaboration

Ju Anne Yau 1 collaboration

Carlo Toniatti 1 collaboration

Meredith A Miller 1 collaboration

Chiu-Yi Liu 1 collaboration

Stella R Hartono 1 collaboration

Caleb A Class 1 collaboration

Erika Suzuki 1 collaboration

Lionel A Sanz 1 collaboration

Guang Gao 1 collaboration

Johnathon L Rose 1 collaboration

Hideo Tomihara 1 collaboration

Joseph R Daniele 1 collaboration

Michael D Peoples 1 collaboration

Qing E Chang 1 collaboration

Bhavatarini Vangamudi 1 collaboration

Christopher Vellano 1 collaboration

Angela K Deem 1 collaboration

Jason B Fleming 1 collaboration

Ernesto Guccione 1 collaboration

Timothy A Yap 1 collaboration

Frederic Chedin 1 collaboration

Teresa Manzo 1 collaboration

Boone M Prentice 1 collaboration

Kristin G Anderson 1 collaboration

Ayush Raman 1 collaboration

Aislyn Schalck 1 collaboration

Gabriela S Codreanu 1 collaboration

Carina B Nava Lauson 1 collaboration

Silvia Tiberti 1 collaboration

Andrea Raimondi 1 collaboration

Marissa A Jones 1 collaboration

Michelle Reyzer 1 collaboration

Breanna M Bates 1 collaboration

Jeffrey M Spraggins 1 collaboration

Nathan H Patterson 1 collaboration

John A McLean 1 collaboration

Kunal Rai 1 collaboration

Carlo Tacchetti 1 collaboration

Sara Tucci 1 collaboration

Jennifer A Wargo 1 collaboration

Simona Rodighiero 1 collaboration

Karen Clise-Dwyer 1 collaboration

Stacy D Sherrod 1 collaboration

Nicholas E Navin 1 collaboration

Richard M Caprioli 1 collaboration

Philip D Greenberg 1 collaboration

Luigi Nezi 1 collaboration

Jason B Cross 1 collaboration

Christopher L Carroll 1 collaboration

Angela L Harris 1 collaboration

Pijus Mandal 1 collaboration

Brooke A Meyers 1 collaboration

Faika Mseeh 1 collaboration

Connor A Parker 1 collaboration

Simon S Yu 1 collaboration

Christopher C Williams 1 collaboration

Nancy E Kohl 1 collaboration

Hila Shaim 1 collaboration

Mayra Shanley 1 collaboration

Rafet Basar 1 collaboration

May Daher 1 collaboration

Joy Gumin 1 collaboration

Daniel B Zamler 1 collaboration

Nadima Uprety 1 collaboration

Fang Wang 1 collaboration

Yuefan Huang 1 collaboration

Konrad Gabrusiewicz 1 collaboration

Qi Miao 1 collaboration

Jinzhuang Dou 1 collaboration

Abdullah Alsuliman 1 collaboration

Lucila N Kerbauy 1 collaboration

Sunil Acharya 1 collaboration

Vakul Mohanty 1 collaboration

Mayela Mendt 1 collaboration

Sufang Li 1 collaboration

JunJun Lu 1 collaboration

Jun Wei 1 collaboration

Natalie W Fowlkes 1 collaboration

Elif Gokdemir 1 collaboration

Emily L Ensley 1 collaboration

Mecit Kaplan 1 collaboration

Cynthia Kassab 1 collaboration

Li Li 1 collaboration

Gonca Ozcan 1 collaboration

Pinaki P Banerjee 1 collaboration

Yifei Shen 1 collaboration

April L Gilbert 1 collaboration

Corry M Jones 1 collaboration

Mustafa Bdiwi 1 collaboration

Ana K Nunez-Cortes 1 collaboration

Enli Liu 1 collaboration

Jun Yu 1 collaboration

Nobuhiko Imahashi 1 collaboration

Luis Muniz-Feliciano 1 collaboration

Ye Li 1 collaboration

Jian Hu 1 collaboration

David Marin 1 collaboration

Dihua Yu 1 collaboration

Stephan Mielke 1 collaboration

Matthias Eyrich 1 collaboration

Richard E Champlin 1 collaboration

Ken Chen 1 collaboration

Frederick F Lang 1 collaboration

Elizabeth J Shpall 1 collaboration

Amy B Heimberger 1 collaboration

Katayoun Rezvani 1 collaboration

Liang Zhang 1 collaboration

Yixin Yao 1 collaboration

Shaojun Zhang 1 collaboration

Yang Liu 1 collaboration

Hui Guo 1 collaboration

Makhdum Ahmed 1 collaboration

Taylor Bell 1 collaboration

Hui Zhang 1 collaboration

Guangchun Han 1 collaboration

Elizabeth Lorence 1 collaboration

Maria Badillo 1 collaboration

Shouhao Zhou 1 collaboration

Randy Haun 1 collaboration

Renny Lan 1 collaboration

Samuel G Mackintosh 1 collaboration

Xizeng Mao 1 collaboration

Xingzhi Song 1 collaboration

Lan V Pham 1 collaboration

Philip L Lorenzi 1 collaboration

Joseph Marszalek 1 collaboration

Tim Heffernan 1 collaboration

Krystle Nomie 1 collaboration

Michael Wang 1 collaboration

Fuchenchu Wang 1 collaboration

Li Zhao 1 collaboration

Jingjing Liu 1 collaboration

Er-Yen Yen 1 collaboration

Charles A Dyke 1 collaboration

Rutvi Shah 1 collaboration

Zhaoliang Liu 1 collaboration

Ali Osman Çetin 1 collaboration

Yanshuo Chu 1 collaboration

Francesca Citron 1 collaboration

Sergio Attanasio 1 collaboration

Denise Corti 1 collaboration

Faezeh Darbaniyan 1 collaboration

Edoardo Del Poggetto 1 collaboration

Sara Loponte 1 collaboration

Melinda Soeung 1 collaboration

Ziheng Chen 1 collaboration

Shan Jiang 1 collaboration

Hong Jiang 1 collaboration

Akira Inoue 1 collaboration

Sisi Gao 1 collaboration

Gaetano Gargiulo 1 collaboration

Ruitao Lin 1 collaboration

Sanjana Srinivasan 1 collaboration

Johnathon Rose 1 collaboration

MennatAllah Shaheen 1 collaboration

Gang Wang 1 collaboration

Wantong Yao 1 collaboration

Chris Bristow 1 collaboration

Traver Hart 1 collaboration

Carmen Ghilardi 1 collaboration

Catarina Moreira-Barbosa 1 collaboration

Laura Brunelli 1 collaboration

Paola Ostano 1 collaboration

Nicolò Panini 1 collaboration

Monica Lupi 1 collaboration

Alessia Anastasia 1 collaboration

Fabio Fiordaliso 1 collaboration

Monica Salio 1 collaboration

Laura Formenti 1 collaboration

Massimo Russo 1 collaboration

Edoardo Arrigoni 1 collaboration

Ferdinando Chiaradonna 1 collaboration

Giovanna Chiorino 1 collaboration

Christopher P Vellano 1 collaboration

Roberta Pastorelli 1 collaboration

MariaRosa Bani 1 collaboration

Alessandra Decio 1 collaboration

Raffaella Giavazzi 1 collaboration