Igor Odintsov

Affiliations

Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague 150 06, Czech Republic.

Publications (27)

Expression of molecules of the Wnt pathway and of E-cadherin in the etiopathogenesis of human thymomas.

Oncology letters

Avec: Prokop Vodicka , Lenka Krskova , Igor Odintsov , Ludmila Krizova , Eva Sedlackova , Jan Schutzner , Josef Zamecnik

Prevalence and Therapeutic Targeting of High Level ERBB2 Amplification in Non-Small Cell Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Igor Odintsov , Maisam Makarem , Mizuki Nishino , Sara Emily Bachert , Tom Zhang , Jaclyn LoPiccolo , Cloud P Paweletz , Prafulla C Gokhale , Elena Ivanova , Aisha Saldanha , Charles M Rudin , William W Lockwood , Marc Ladanyi , Romel Somwar , Pasi A Jänne , Lynette M Sholl

Clear Cell Stromal Tumor of Lung: A Clinicopathologic, Immunohistochemical, and Molecular Characterization of 8 Cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Avec: Igor Odintsov , Alexandra Isaacson , Karen J Fritchie , Yin P Hung , Pooria Khoshnoodi , Lynette M Sholl , Christopher D M Fletcher , William J Anderson

The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Igor Odintsov , Allan J W Lui , Whitney J Sisso , Eric Gladstone , Zebing Liu , Lukas Delasos , Renate I Kurth , Exequiel M Sisso , Morana Vojnic , Inna Khodos , Marissa S Mattar , Elisa de Stanchina , Shawn M Leland , Marc Ladanyi , Romel Somwar

Prognostic and predictive biomarkers in non-small cell lung carcinoma.

Pathology

Avec: Igor Odintsov , Lynette M Sholl

Integrating Molecular Sequencing Into the Pathological Diagnosis of Clinically Suspected Non-Small Cell Lung Carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Avec: Ying-Chun Lo , Anna H Bauer , Igor Odintsov , Stephanie E Siegmund , Lynette M Sholl , Fei Dong

Myxoid Inflammatory Myofibroblastic Sarcoma: Clinicopathologic Analysis of 25 Cases of a Distinctive Sarcoma With Deceptively Bland Morphology and Aggressive Clinical Behavior.

The American journal of surgical pathology

Avec: David J Papke , Igor Odintsov , Brendan C Dickson , Marisa R Nucci , Abbas Agaimy , Christopher D M Fletcher

HER2 antibody-drug conjugates are active against desmoplastic small round cell tumor.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Tom Zhang , Christopher A Febres-Aldana , Zebing Liu , Jenna-Marie Dix , Ryan Cheng , Raymond G Dematteo , Allan J W Lui , Inna Khodos , Leo Gili , Marissa S Mattar , Jeanine Lisanti , Charlene Kwong , Irina Linkov , Murray J Tipping , Elisa de Stanchina , Igor Odintsov , Marc Ladanyi , Romel Somwar

RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation.

Disease models & mechanisms

Avec: Takuo Hayashi , Igor Odintsov , Roger S Smith , Kota Ishizawa , Allan J W Liu , Lukas Delasos , Christopher Kurzatkowski , Huichun Tai , Eric Gladstone , Morana Vojnic , Shinji Kohsaka , Ken Suzawa , Zebing Liu , Siddharth Kunte , Marissa S Mattar , Inna Khodos , Monika A Davare , Alexander Drilon , Emily Cheng , Elisa de Stanchina , Marc Ladanyi , Romel Somwar

Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.

Nature cancer

Avec: Isao Miyazaki , Igor Odintsov , Keiji Ishida , Allan J W Lui , Masanori Kato , Tatsuya Suzuki , Tom Zhang , Kentaro Wakayama , Renate I Kurth , Ryan Cheng , Hidenori Fujita , Lukas Delasos , Morana Vojnic , Inna Khodos , Yukari Yamada , Kota Ishizawa , Marissa S Mattar , Kaoru Funabashi , Qing Chang , Shuichi Ohkubo , Wakako Yano , Ryuichiro Terada , Claudio Giuliano , Yue Christine Lu , Annalisa Bonifacio , Siddharth Kunte , Monika A Davare , Emily H Cheng , Elisa de Stanchina , Emanuela Lovati , Yoshikazu Iwasawa , Marc Ladanyi , Romel Somwar

HER4 and EGFR Activate Cell Signaling in NRG1 Fusion-Driven Cancers: Implications for HER2-HER3-specific Versus Pan-HER Targeting Strategies.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Hibiki Udagawa , Monique B Nilsson , Jacqulyne P Robichaux , Junqin He , Alissa Poteete , Hong Jiang , Simon Heeke , Yasir Y Elamin , Yuji Shibata , Shingo Matsumoto , Kiyotaka Yoh , Shogo Okazaki , Takashi Masuko , Igor Odintsov , Romel Somwar , Marc Ladanyi , Koichi Goto , John V Heymach

Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Koichi Ogura , Romel Somwar , Julija Hmeljak , Heather Magnan , Ryma Benayed , Amir Momeni Boroujeni , Anita S Bowman , Marissa S Mattar , Inna Khodos , Elisa de Stanchina , Achim Jungbluth , Marina Asher , Igor Odintsov , Alifiani B Hartono , Michael P LaQuaglia , Emily Slotkin , Christine A Pratilas , Sean Bong Lee , Lee Spraggon , Marc Ladanyi

Novel Preclinical Patient-Derived Lung Cancer Models Reveal Inhibition of HER3 and MTOR Signaling as Therapeutic Strategies for NRG1 Fusion-Positive Cancers.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Igor Odintsov , Marissa S Mattar , Allan J W Lui , Michael Offin , Christopher Kurzatkowski , Lukas Delasos , Inna Khodos , Marina Asher , Robert M Daly , Natasha Rekhtman , Elisa de Stanchina , Gopinath Ganji , Marc Ladanyi , Romel Somwar

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors.

Communications biology

Avec: Romel Somwar , Nicolle E Hofmann , Bryan Smith , Igor Odintsov , Morana Vojnic , Irina Linkov , Ashley Tam , Inna Khodos , Marissa S Mattar , Elisa de Stanchina , Daniel Flynn , Marc Ladanyi , Alexander Drilon , Ujwal Shinde , Monika A Davare

Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs.

Neoplasma

Avec: Lenka Krsková , Igor Odintsov , Ondřej Fabián , Petra Hroudová , Marcela Mrhalová

Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements.

Cancer discovery

Avec: Alison M Schram , Igor Odintsov , Madelyn Espinosa-Cotton , Inna Khodos , Whitney J Sisso , Marissa S Mattar , Allan J W Lui , Morana Vojnic , Sara H Shameem , Thrusha Chauhan , Jean Torrisi , Jim Ford , Marie N O'Connor , Cecile A W Geuijen , Ron C J Schackmann , Jeroen J Lammerts van Bueren , Ernesto Wasserman , Elisa de Stanchina , Eileen M O'Reilly , Marc Ladanyi , Alexander Drilon , Romel Somwar

CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.

Cancer research

Avec: Igor Odintsov , Michael V Ortiz , Inna Khodos , Marissa S Mattar , Allan J W Lui , Shinji Kohsaka , Elisa de Stanchina , Julia L Glade Bender , Marc Ladanyi , Romel Somwar

MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer.

Molecular cancer research : MCR

Avec: Sudarshan R Iyer , Igor Odintsov , Adam J Schoenfeld , Evan Siau , Marissa S Mattar , Elisa de Stanchina , Inna Khodos , Alexander Drilon , Gregory J Riely , Marc Ladanyi , Romel Somwar , Monika A Davare

Functional impact and targetability of

Cold Spring Harbor molecular case studies

Avec: Florence Choo , Igor Odintsov , Kevin Nusser , Katelyn S Nicholson , Lara Davis , Christopher L Corless , Linda Stork , Romel Somwar , Marc Ladanyi , Jessica L Davis , Monika A Davare

Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling.

Disease models & mechanisms

Avec: Roger S Smith , Igor Odintsov , Zebing Liu , Allan Jo-Weng Lui , Takuo Hayashi , Morana Vojnic , Yoshiyuki Suehara , Lukas Delasos , Marissa S Mattar , Julija Hmeljak , Hillary A Ramirez , Melissa Shaw , Gabrielle Bui , Alifiani B Hartono , Eric Gladstone , Siddharth Kunte , Heather Magnan , Inna Khodos , Elisa De Stanchina , Michael P La Quaglia , Jinjuan Yao , Marick Laé , Sean B Lee , Lee Spraggon , Christine A Pratilas , Marc Ladanyi , Romel Somwar

Infantile Sinonasal Myxoma Is Clinically and Genetically Distinct From Other Myxomas of the Craniofacial Bones and From Desmoid Fibromatosis.

The American journal of surgical pathology

Avec: Igor Odintsov , Fei Dong , Jeffrey P Guenette , Karen J Fritchie , Vickie Y Jo , Christopher D M Fletcher , David J Papke

Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Arielle Elkrief , Igor Odintsov , Vladimir Markov , Rebecca Caeser , Pawel Sobczuk , Sam E Tischfield , Umesh Bhanot , Chad M Vanderbilt , Emily H Cheng , Alexander Drilon , Gregory J Riely , William W Lockwood , Elisa de Stanchina , Vijaya G Tirunagaru , Robert C Doebele , Álvaro Quintanal-Villalonga , Charles M Rudin , Romel Somwar , Marc Ladanyi

Primary Clear Cell Sarcoma of Bone: Clinicopathologic Study of a Rare Presentation.

The American journal of surgical pathology

Avec: Igor Odintsov , Jyothi P Jagannathan , Alyaa Al-Ibraheemi , Martin K Selig , Erik T Newman , Christopher D M Fletcher , Gunnlaugur P Nielsen , Jason L Hornick

A visual-language foundation model for computational pathology.

Nature medicine

Avec: Ming Y Lu , Bowen Chen , Drew F K Williamson , Richard J Chen , Ivy Liang , Tong Ding , Guillaume Jaume , Igor Odintsov , Long Phi Le , Georg Gerber , Anil V Parwani , Andrew Zhang , Faisal Mahmood

Combination of MDM2 and Targeted Kinase Inhibitors Results in Prolonged Tumor Control in Lung Adenocarcinomas With Oncogenic Tyrosine Kinase Drivers and

JCO precision oncology

Avec: Arielle Elkrief , Igor Odintsov , Roger S Smith , Morana Vojnic , Takuo Hayashi , Inna Khodos , Vladimir Markov , Zebing Liu , Allan J W Lui , Jamie L Bloom , Michael D Offin , Charles M Rudin , Elisa de Stanchina , Gregory J Riely , Romel Somwar , Marc Ladanyi

Preclinical evaluation of targeted therapies for central nervous system metastases.

Disease models & mechanisms

Avec: Alexander J Pfeil , Joshua D Hale , Tiger S Zhang , Kentaro Wakayama , Isao Miyazaki , Igor Odintsov , Romel Somwar

Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK-rearranged Myxoid Spindle Cell Neoplasm: A Clinicopathologic Series of 35 Cases Including Alternate RET and NTRK3 Fusions.

The American journal of surgical pathology

Avec: Mia S DeSimone , Igor Odintsov , Harrison K Tsai , Brendan C Dickson , Ahmed K Alomari , Jason L Hornick , Christopher D M Fletcher , David J Papke

Réseau de co-auteurs

Romel Somwar 17 collaborations

Marc Ladanyi 16 collaborations

Inna Khodos 12 collaborations

Elisa de Stanchina 12 collaborations

Marissa S Mattar 11 collaborations

Allan J W Lui 7 collaborations

Morana Vojnic 7 collaborations

Christopher D M Fletcher 5 collaborations

Zebing Liu 5 collaborations

Lukas Delasos 5 collaborations

Monika A Davare 5 collaborations

Alexander Drilon 5 collaborations

Lynette M Sholl 4 collaborations

Tom Zhang 3 collaborations

Charles M Rudin 3 collaborations

Eric Gladstone 3 collaborations

David J Papke 3 collaborations

Takuo Hayashi 3 collaborations

Roger S Smith 3 collaborations

Siddharth Kunte 3 collaborations

Gregory J Riely 3 collaborations

William W Lockwood 2 collaborations

Karen J Fritchie 2 collaborations

Whitney J Sisso 2 collaborations

Renate I Kurth 2 collaborations

Fei Dong 2 collaborations

Brendan C Dickson 2 collaborations

Ryan Cheng 2 collaborations

Irina Linkov 2 collaborations

Kota Ishizawa 2 collaborations

Christopher Kurzatkowski 2 collaborations

Shinji Kohsaka 2 collaborations

Isao Miyazaki 2 collaborations

Kentaro Wakayama 2 collaborations

Emily H Cheng 2 collaborations

Julija Hmeljak 2 collaborations

Heather Magnan 2 collaborations

Marina Asher 2 collaborations

Alifiani B Hartono 2 collaborations

Christine A Pratilas 2 collaborations

Lee Spraggon 2 collaborations

Arielle Elkrief 2 collaborations

Vladimir Markov 2 collaborations

Jason L Hornick 2 collaborations

Prokop Vodicka 1 collaboration

Lenka Krskova 1 collaboration

Ludmila Krizova 1 collaboration

Eva Sedlackova 1 collaboration

Jan Schutzner 1 collaboration

Josef Zamecnik 1 collaboration

Maisam Makarem 1 collaboration

Mizuki Nishino 1 collaboration

Sara Emily Bachert 1 collaboration

Jaclyn LoPiccolo 1 collaboration

Cloud P Paweletz 1 collaboration

Prafulla C Gokhale 1 collaboration

Elena Ivanova 1 collaboration

Aisha Saldanha 1 collaboration

Pasi A Jänne 1 collaboration

Alexandra Isaacson 1 collaboration

Yin P Hung 1 collaboration

Pooria Khoshnoodi 1 collaboration

William J Anderson 1 collaboration

Exequiel M Sisso 1 collaboration

Shawn M Leland 1 collaboration

Ying-Chun Lo 1 collaboration

Anna H Bauer 1 collaboration

Stephanie E Siegmund 1 collaboration

Marisa R Nucci 1 collaboration

Abbas Agaimy 1 collaboration

Christopher A Febres-Aldana 1 collaboration

Jenna-Marie Dix 1 collaboration

Raymond G Dematteo 1 collaboration

Leo Gili 1 collaboration

Jeanine Lisanti 1 collaboration

Charlene Kwong 1 collaboration

Murray J Tipping 1 collaboration

Allan J W Liu 1 collaboration

Huichun Tai 1 collaboration

Ken Suzawa 1 collaboration

Emily Cheng 1 collaboration

Keiji Ishida 1 collaboration

Masanori Kato 1 collaboration

Tatsuya Suzuki 1 collaboration

Hidenori Fujita 1 collaboration

Yukari Yamada 1 collaboration

Kaoru Funabashi 1 collaboration

Qing Chang 1 collaboration

Shuichi Ohkubo 1 collaboration

Wakako Yano 1 collaboration

Ryuichiro Terada 1 collaboration

Claudio Giuliano 1 collaboration

Yue Christine Lu 1 collaboration

Annalisa Bonifacio 1 collaboration

Emanuela Lovati 1 collaboration

Yoshikazu Iwasawa 1 collaboration

Hibiki Udagawa 1 collaboration

Monique B Nilsson 1 collaboration

Jacqulyne P Robichaux 1 collaboration

Junqin He 1 collaboration

Alissa Poteete 1 collaboration

Hong Jiang 1 collaboration

Simon Heeke 1 collaboration

Yasir Y Elamin 1 collaboration

Yuji Shibata 1 collaboration

Shingo Matsumoto 1 collaboration

Kiyotaka Yoh 1 collaboration

Shogo Okazaki 1 collaboration

Takashi Masuko 1 collaboration

Koichi Goto 1 collaboration

John V Heymach 1 collaboration

Koichi Ogura 1 collaboration

Ryma Benayed 1 collaboration

Amir Momeni Boroujeni 1 collaboration

Anita S Bowman 1 collaboration

Achim Jungbluth 1 collaboration

Michael P LaQuaglia 1 collaboration

Emily Slotkin 1 collaboration

Sean Bong Lee 1 collaboration

Michael Offin 1 collaboration

Robert M Daly 1 collaboration

Natasha Rekhtman 1 collaboration

Gopinath Ganji 1 collaboration

Nicolle E Hofmann 1 collaboration

Bryan Smith 1 collaboration

Ashley Tam 1 collaboration

Daniel Flynn 1 collaboration

Ujwal Shinde 1 collaboration

Lenka Krsková 1 collaboration

Ondřej Fabián 1 collaboration

Petra Hroudová 1 collaboration

Marcela Mrhalová 1 collaboration

Alison M Schram 1 collaboration

Madelyn Espinosa-Cotton 1 collaboration

Sara H Shameem 1 collaboration

Thrusha Chauhan 1 collaboration

Jean Torrisi 1 collaboration

Jim Ford 1 collaboration

Marie N O'Connor 1 collaboration

Cecile A W Geuijen 1 collaboration

Ron C J Schackmann 1 collaboration

Jeroen J Lammerts van Bueren 1 collaboration

Ernesto Wasserman 1 collaboration

Eileen M O'Reilly 1 collaboration

Michael V Ortiz 1 collaboration

Julia L Glade Bender 1 collaboration

Sudarshan R Iyer 1 collaboration

Adam J Schoenfeld 1 collaboration

Evan Siau 1 collaboration

Florence Choo 1 collaboration

Kevin Nusser 1 collaboration

Katelyn S Nicholson 1 collaboration

Lara Davis 1 collaboration

Christopher L Corless 1 collaboration

Linda Stork 1 collaboration

Jessica L Davis 1 collaboration

Allan Jo-Weng Lui 1 collaboration

Yoshiyuki Suehara 1 collaboration

Hillary A Ramirez 1 collaboration

Melissa Shaw 1 collaboration

Gabrielle Bui 1 collaboration

Elisa De Stanchina 1 collaboration

Michael P La Quaglia 1 collaboration

Jinjuan Yao 1 collaboration

Marick Laé 1 collaboration

Sean B Lee 1 collaboration

Jeffrey P Guenette 1 collaboration

Vickie Y Jo 1 collaboration

Rebecca Caeser 1 collaboration

Pawel Sobczuk 1 collaboration

Sam E Tischfield 1 collaboration

Umesh Bhanot 1 collaboration

Chad M Vanderbilt 1 collaboration

Vijaya G Tirunagaru 1 collaboration

Robert C Doebele 1 collaboration

Álvaro Quintanal-Villalonga 1 collaboration

Jyothi P Jagannathan 1 collaboration

Alyaa Al-Ibraheemi 1 collaboration

Martin K Selig 1 collaboration

Erik T Newman 1 collaboration

Gunnlaugur P Nielsen 1 collaboration

Ming Y Lu 1 collaboration

Bowen Chen 1 collaboration

Drew F K Williamson 1 collaboration

Richard J Chen 1 collaboration

Ivy Liang 1 collaboration

Tong Ding 1 collaboration

Guillaume Jaume 1 collaboration

Long Phi Le 1 collaboration

Georg Gerber 1 collaboration

Anil V Parwani 1 collaboration

Andrew Zhang 1 collaboration

Faisal Mahmood 1 collaboration

Jamie L Bloom 1 collaboration

Michael D Offin 1 collaboration

Alexander J Pfeil 1 collaboration

Joshua D Hale 1 collaboration

Tiger S Zhang 1 collaboration

Mia S DeSimone 1 collaboration

Harrison K Tsai 1 collaboration

Ahmed K Alomari 1 collaboration