Jan Chmielecki

Affiliations

Department of General, Endocrinological and Gastroenterological Surgery, Poznań University of Medical Sciences, Poland.

ORCID: https://orcid.org/0000-0002-5730-6129

Publications (17)

Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Kathleen N Moore , Setsuko K Chambers , Erika P Hamilton , Lee-May Chen , Amit M Oza , Sharad A Ghamande , Gottfried E Konecny , Steven C Plaxe , Daniel L Spitz , Jill J J Geenen , Tiffany A Troso-Sandoval , Janiel M Cragun , Esteban Rodrigo Imedio , Sanjeev Kumar , Ganesh M Mugundu , Zhongwu Lai , Juliann Chmielecki , Suzanne F Jones , David R Spigel , Karen A Cadoo

Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer.

Clinical pharmacology and therapeutics

Avec: Martin Johnson , Carlos Serra Traynor , Karthick Vishwanathan , Philip Overend , Ryan Hartmaier , Aleksandra Markovets , Juliann Chmielecki , Ganesh M Mugundu , J Carl Barrett , Helen Tomkinson , Suresh S Ramalingam

A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.

Investigational new drugs

Avec: Gerald S Falchook , Jasgit Sachdev , Esteban Rodrigo Imedio , Sanjeev Kumar , Ganesh M Mugundu , Suzanne Jenkins , Juliann Chmielecki , Suzanne Jones , David R Spigel , Melissa Johnson

A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.

Targeted oncology

Avec: Todd M Bauer , Kathleen N Moore , Janet S Rader , Fiona Simpkins , Alain C Mita , J Thaddeus Beck , Lowell Hart , Quincy Chu , Amit Oza , Anna V Tinker , Esteban Rodrigo Imedio , Sanjeev Kumar , Ganesh Mugundu , Suzanne Jenkins , Juliann Chmielecki , Suzanne Jones , David Spigel , Siqing Fu

Biomarker-Directed Phase II Platform Study in Patients With EGFR Sensitizing Mutation-Positive Advanced/Metastatic Non-Small Cell Lung Cancer Whose Disease Has Progressed on First-Line Osimertinib Therapy (ORCHARD).

Clinical lung cancer

Avec: Helena A Yu , Sarah B Goldberg , Xiuning Le , Zofia Piotrowska , Jonathan W Goldman , Adrianus J De Langen , Isamu Okamoto , Byoung Chul Cho , Paul Smith , Ilhem Mensi , Helen Ambrose , Silvija Kraljevic , Julie Maidment , Juliann Chmielecki , Xiaocheng Li-Sucholeiki , Gail Doughton , Gargi Patel , Phil Jewsbury , Phil Szekeres , Jonathan W Riess

Pan-tumor analytical validation and osimertinib clinical validation in EGFR mutant non-small cell lung cancer, supporting the first next generation sequencing liquid biopsy in vitro diagnostic.

The Journal of molecular diagnostics : JMD

Avec: Jhanelle E Gray , Ji-Youn Han , Aino Telaranta-Keerie , Xiangning Huang , Alexander Kohlmann , Rachel Hodge , Yuri Rukazenkov , Juliann Chmielecki , Carin R Espenschied , Martina Lefterova , Yi-Long Wu , Suresh S Ramalingam , J Carl Barrett , Justin I Odegaard

Programmed Cell Death Ligand 1 Expression in Untreated EGFR Mutated Advanced NSCLC and Response to Osimertinib Versus Comparator in FLAURA.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Helen Brown , Johan Vansteenkiste , Kazuhiko Nakagawa , Manuel Cobo , Thomas John , Craig Barker , Alexander Kohlmann , Alexander Todd , Matilde Saggese , Juliann Chmielecki , Aleksandra Markovets , Marietta Scott , Suresh S Ramalingam

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers.

Nature communications

Avec: Tereza Vaclova , Ursula Grazini , Lewis Ward , Daniel O'Neill , Aleksandra Markovets , Xiangning Huang , Juliann Chmielecki , Ryan Hartmaier , Kenneth S Thress , Paul D Smith , J Carl Barrett , Julian Downward , Elza C de Bruin

Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.

Nature communications

Avec: Juliann Chmielecki , Tony Mok , Yi-Long Wu , Ji-Youn Han , Myung-Ju Ahn , Suresh S Ramalingam , Thomas John , Isamu Okamoto , James Chih-Hsin Yang , Frances A Shepherd , Krishna C Bulusu , Gianluca Laus , Barbara Collins , J Carl Barrett , Ryan J Hartmaier , Vassiliki Papadimitrakopoulou

Pancreaticopleural Fistula as a Rare Cause of Both-Sided Pleural Effusion.

Case reports in surgery

Avec: Jan Chmielecki , Tomasz Kościński , Tomasz Banasiewicz

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Philip Jonsson , Andrew L Lin , Robert J Young , Natalie M DiStefano , David M Hyman , Bob T Li , Michael F Berger , Ahmet Zehir , Marc Ladanyi , David B Solit , Angela G Arnold , Zsofia K Stadler , Diana Mandelker , Michael E Goldberg , Juliann Chmielecki , Maryam Pourmaleki , Shahiba Q Ogilvie , Shweta S Chavan , Andrew T McKeown , Malbora Manne , Allison Hyde , Kathryn Beal , T Jonathan Yang , Craig P Nolan , Elena Pentsova , Antonio Omuro , Igor T Gavrilovic , Thomas J Kaley , Eli L Diamond , Jacqueline B Stone , Christian Grommes , Adrienne Boire , Mariza Daras , Anna F Piotrowski , Alexandra M Miller , Philip H Gutin , Timothy A Chan , Viviane S Tabar , Cameron W Brennan , Marc Rosenblum , Lisa M DeAngelis , Ingo K Mellinghoff , Barry S Taylor

Longitudinal Analyses of Circulating-Tumor DNA for Detection of EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer Progression During Treatment: Data From FLAURA and AURA3.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Jhanelle E Gray , Aleksandra Markovets , Thanyanan Reungwetwattana , Margarita Majem , Naoyuki Nogami , Nir Peled , Jong-Seok Lee , Byoung Chul Cho , Busayamas Chewaskulyong , Tom John , Ji-Youn Han , Martin Sebastian , Alexander Todd , Yuri Rukazenkov , Carl Barrett , Juliann Chmielecki , Siow Ming Lee , Suresh S Ramalingam , Ryan Hartmaier

Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non-Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Jhanelle E Gray , Myung-Ju Ahn , Geoffrey R Oxnard , Frances A Shepherd , Fumio Imamura , Ying Cheng , Isamu Okamoto , Byoung Chul Cho , Meng-Chih Lin , Yi-Long Wu , Margarita Majem , Oliver Gautschi , Michael Boyer , Krishna C Bulusu , Aleksandra Markovets , J Carl Barrett , Rachel Hodge , Astrid McKeown , Ryan J Hartmaier , Juliann Chmielecki , Vassiliki A Papadimitrakopoulou , Suresh S Ramalingam

An ErbB2 splice variant lacking exon 16 drives lung carcinoma.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Harvey W Smith , Lei Yang , Chen Ling , Arlan Walsh , Victor D Martinez , Jonathan Boucher , Dongmei Zuo , Ethan S Sokol , Dean C Pavlick , Garrett M Frampton , Juliann Chmielecki , Laura M Jones , Philippe P Roux , William W Lockwood , William J Muller

Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: James C H Yang , Sang-We Kim , Dong-Wan Kim , Jong-Seok Lee , Byoung Chul Cho , Jin-Seok Ahn , Dae H Lee , Tae Min Kim , Jonathan W Goldman , Ronald B Natale , Andrew P Brown , Barbara Collins , Juliann Chmielecki , Karthick Vishwanathan , Ariadna Mendoza-Naranjo , Myung-Ju Ahn

Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature communications

Avec: Juliann Chmielecki , Jhanelle E Gray , Ying Cheng , Yuichiro Ohe , Fumio Imamura , Byoung Chul Cho , Meng-Chih Lin , Margarita Majem , Riyaz Shah , Yuri Rukazenkov , Alexander Todd , Aleksandra Markovets , J Carl Barrett , Ryan J Hartmaier , Suresh S Ramalingam

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.

Nature communications

Avec: Sebastijan Hobor , Maise Al Bakir , Crispin T Hiley , Marcin Skrzypski , Alexander M Frankell , Bjorn Bakker , Thomas B K Watkins , Aleksandra Markovets , Jonathan R Dry , Andrew P Brown , Jasper van der Aart , Hilda van den Bos , Diana Spierings , Dahmane Oukrif , Marco Novelli , Turja Chakrabarti , Adam H Rabinowitz , Laila Ait Hassou , Saskia Litière , D Lucas Kerr , Lisa Tan , Gavin Kelly , David A Moore , Matthew J Renshaw , Subramanian Venkatesan , William Hill , Ariana Huebner , Carlos Martínez-Ruiz , James R M Black , Wei Wu , Mihaela Angelova , Nicholas McGranahan , Julian Downward , Juliann Chmielecki , Carl Barrett , Kevin Litchfield , Su Kit Chew , Collin M Blakely , Elza C de Bruin , Floris Foijer , Karen H Vousden , Trever G Bivona , Auteur inconnu , Robert E Hynds , Nnennaya Kanu , Simone Zaccaria , Eva Grönroos , Charles Swanton

Réseau de co-auteurs

Juliann Chmielecki 16 collaborations

Aleksandra Markovets 7 collaborations

Suresh S Ramalingam 7 collaborations

J Carl Barrett 6 collaborations

Byoung Chul Cho 5 collaborations

Jhanelle E Gray 4 collaborations

Esteban Rodrigo Imedio 3 collaborations

Sanjeev Kumar 3 collaborations

Ganesh M Mugundu 3 collaborations

Ryan Hartmaier 3 collaborations

Isamu Okamoto 3 collaborations

Ji-Youn Han 3 collaborations

Yuri Rukazenkov 3 collaborations

Yi-Long Wu 3 collaborations

Alexander Todd 3 collaborations

Myung-Ju Ahn 3 collaborations

Ryan J Hartmaier 3 collaborations

Margarita Majem 3 collaborations

Kathleen N Moore 2 collaborations

David R Spigel 2 collaborations

Karthick Vishwanathan 2 collaborations

Suzanne Jenkins 2 collaborations

Suzanne Jones 2 collaborations

Jonathan W Goldman 2 collaborations

Xiangning Huang 2 collaborations

Alexander Kohlmann 2 collaborations

Rachel Hodge 2 collaborations

Thomas John 2 collaborations

Julian Downward 2 collaborations

Elza C de Bruin 2 collaborations

Frances A Shepherd 2 collaborations

Krishna C Bulusu 2 collaborations

Barbara Collins 2 collaborations

Jong-Seok Lee 2 collaborations

Carl Barrett 2 collaborations

Fumio Imamura 2 collaborations

Ying Cheng 2 collaborations

Meng-Chih Lin 2 collaborations

Andrew P Brown 2 collaborations

Setsuko K Chambers 1 collaboration

Erika P Hamilton 1 collaboration

Lee-May Chen 1 collaboration

Amit M Oza 1 collaboration

Sharad A Ghamande 1 collaboration

Gottfried E Konecny 1 collaboration

Steven C Plaxe 1 collaboration

Daniel L Spitz 1 collaboration

Jill J J Geenen 1 collaboration

Tiffany A Troso-Sandoval 1 collaboration

Janiel M Cragun 1 collaboration

Zhongwu Lai 1 collaboration

Suzanne F Jones 1 collaboration

Karen A Cadoo 1 collaboration

Martin Johnson 1 collaboration

Carlos Serra Traynor 1 collaboration

Philip Overend 1 collaboration

Helen Tomkinson 1 collaboration

Gerald S Falchook 1 collaboration

Jasgit Sachdev 1 collaboration

Melissa Johnson 1 collaboration

Todd M Bauer 1 collaboration

Janet S Rader 1 collaboration

Fiona Simpkins 1 collaboration

Alain C Mita 1 collaboration

J Thaddeus Beck 1 collaboration

Lowell Hart 1 collaboration

Quincy Chu 1 collaboration

Amit Oza 1 collaboration

Anna V Tinker 1 collaboration

Ganesh Mugundu 1 collaboration

David Spigel 1 collaboration

Siqing Fu 1 collaboration

Helena A Yu 1 collaboration

Sarah B Goldberg 1 collaboration

Xiuning Le 1 collaboration

Zofia Piotrowska 1 collaboration

Adrianus J De Langen 1 collaboration

Paul Smith 1 collaboration

Ilhem Mensi 1 collaboration

Helen Ambrose 1 collaboration

Silvija Kraljevic 1 collaboration

Julie Maidment 1 collaboration

Xiaocheng Li-Sucholeiki 1 collaboration

Gail Doughton 1 collaboration

Gargi Patel 1 collaboration

Phil Jewsbury 1 collaboration

Phil Szekeres 1 collaboration

Jonathan W Riess 1 collaboration

Aino Telaranta-Keerie 1 collaboration

Carin R Espenschied 1 collaboration

Martina Lefterova 1 collaboration

Justin I Odegaard 1 collaboration

Helen Brown 1 collaboration

Johan Vansteenkiste 1 collaboration

Kazuhiko Nakagawa 1 collaboration

Manuel Cobo 1 collaboration

Craig Barker 1 collaboration

Matilde Saggese 1 collaboration

Marietta Scott 1 collaboration

Tereza Vaclova 1 collaboration

Ursula Grazini 1 collaboration

Lewis Ward 1 collaboration

Daniel O'Neill 1 collaboration

Kenneth S Thress 1 collaboration

Paul D Smith 1 collaboration

Tony Mok 1 collaboration

James Chih-Hsin Yang 1 collaboration

Gianluca Laus 1 collaboration

Vassiliki Papadimitrakopoulou 1 collaboration

Tomasz Kościński 1 collaboration

Tomasz Banasiewicz 1 collaboration

Philip Jonsson 1 collaboration

Andrew L Lin 1 collaboration

Robert J Young 1 collaboration

Natalie M DiStefano 1 collaboration

David M Hyman 1 collaboration

Bob T Li 1 collaboration

Michael F Berger 1 collaboration

Ahmet Zehir 1 collaboration

Marc Ladanyi 1 collaboration

David B Solit 1 collaboration

Angela G Arnold 1 collaboration

Zsofia K Stadler 1 collaboration

Diana Mandelker 1 collaboration

Michael E Goldberg 1 collaboration

Maryam Pourmaleki 1 collaboration

Shahiba Q Ogilvie 1 collaboration

Shweta S Chavan 1 collaboration

Andrew T McKeown 1 collaboration

Malbora Manne 1 collaboration

Allison Hyde 1 collaboration

Kathryn Beal 1 collaboration

T Jonathan Yang 1 collaboration

Craig P Nolan 1 collaboration

Elena Pentsova 1 collaboration

Antonio Omuro 1 collaboration

Igor T Gavrilovic 1 collaboration

Thomas J Kaley 1 collaboration

Eli L Diamond 1 collaboration

Jacqueline B Stone 1 collaboration

Christian Grommes 1 collaboration

Adrienne Boire 1 collaboration

Mariza Daras 1 collaboration

Anna F Piotrowski 1 collaboration

Alexandra M Miller 1 collaboration

Philip H Gutin 1 collaboration

Timothy A Chan 1 collaboration

Viviane S Tabar 1 collaboration

Cameron W Brennan 1 collaboration

Marc Rosenblum 1 collaboration

Lisa M DeAngelis 1 collaboration

Ingo K Mellinghoff 1 collaboration

Barry S Taylor 1 collaboration

Thanyanan Reungwetwattana 1 collaboration

Naoyuki Nogami 1 collaboration

Nir Peled 1 collaboration

Busayamas Chewaskulyong 1 collaboration

Tom John 1 collaboration

Martin Sebastian 1 collaboration

Siow Ming Lee 1 collaboration

Geoffrey R Oxnard 1 collaboration

Oliver Gautschi 1 collaboration

Michael Boyer 1 collaboration

Astrid McKeown 1 collaboration

Vassiliki A Papadimitrakopoulou 1 collaboration

Harvey W Smith 1 collaboration

Lei Yang 1 collaboration

Chen Ling 1 collaboration

Arlan Walsh 1 collaboration

Victor D Martinez 1 collaboration

Jonathan Boucher 1 collaboration

Dongmei Zuo 1 collaboration

Ethan S Sokol 1 collaboration

Dean C Pavlick 1 collaboration

Garrett M Frampton 1 collaboration

Laura M Jones 1 collaboration

Philippe P Roux 1 collaboration

William W Lockwood 1 collaboration

William J Muller 1 collaboration

James C H Yang 1 collaboration

Sang-We Kim 1 collaboration

Dong-Wan Kim 1 collaboration

Jin-Seok Ahn 1 collaboration

Dae H Lee 1 collaboration

Tae Min Kim 1 collaboration

Ronald B Natale 1 collaboration

Ariadna Mendoza-Naranjo 1 collaboration

Yuichiro Ohe 1 collaboration

Riyaz Shah 1 collaboration

Sebastijan Hobor 1 collaboration

Maise Al Bakir 1 collaboration

Crispin T Hiley 1 collaboration

Marcin Skrzypski 1 collaboration

Alexander M Frankell 1 collaboration

Bjorn Bakker 1 collaboration

Thomas B K Watkins 1 collaboration

Jonathan R Dry 1 collaboration

Jasper van der Aart 1 collaboration

Hilda van den Bos 1 collaboration

Diana Spierings 1 collaboration

Dahmane Oukrif 1 collaboration

Marco Novelli 1 collaboration

Turja Chakrabarti 1 collaboration

Adam H Rabinowitz 1 collaboration

Laila Ait Hassou 1 collaboration

Saskia Litière 1 collaboration

D Lucas Kerr 1 collaboration

Lisa Tan 1 collaboration

Gavin Kelly 1 collaboration

David A Moore 1 collaboration

Matthew J Renshaw 1 collaboration

Subramanian Venkatesan 1 collaboration

William Hill 1 collaboration

Ariana Huebner 1 collaboration

Carlos Martínez-Ruiz 1 collaboration

James R M Black 1 collaboration

Wei Wu 1 collaboration

Mihaela Angelova 1 collaboration

Nicholas McGranahan 1 collaboration

Kevin Litchfield 1 collaboration

Su Kit Chew 1 collaboration

Collin M Blakely 1 collaboration

Floris Foijer 1 collaboration

Karen H Vousden 1 collaboration

Trever G Bivona 1 collaboration

None None 1 collaboration

Robert E Hynds 1 collaboration

Nnennaya Kanu 1 collaboration

Simone Zaccaria 1 collaboration

Eva Grönroos 1 collaboration

Charles Swanton 1 collaboration