Jonathan Strecker

Affiliations

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

ORCID: 0000-0001-8953-5615

Publications (16)

RNA-guided DNA insertion with CRISPR-associated transposases.

Science (New York, N.Y.)

Avec: Jonathan Strecker , Alim Ladha , Zachary Gardner , Jonathan L Schmid-Burgk , Kira S Makarova , Eugene V Koonin , Feng Zhang

Highly Parallel Profiling of Cas9 Variant Specificity.

Molecular cell

Avec: Jonathan L Schmid-Burgk , Linyi Gao , David Li , Zachary Gardner , Jonathan Strecker , Blake Lash , Feng Zhang

Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma.

STAR protocols

Avec: Isabella Del Priore , Sai Ma , Jonathan Strecker , Tyler Jacks , Lindsay M LaFave , Jason D Buenrostro

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

Nature biotechnology

Avec: Kerstin U Ludwig , Ricarda M Schmithausen , David Li , Max L Jacobs , Ronja Hollstein , Katja Blumenstock , Jana Liebing , Mikołaj Słabicki , Amir Ben-Shmuel , Ofir Israeli , Shay Weiss , Thomas S Ebert , Nir Paran , Wibke Rüdiger , Gero Wilbring , David Feldman , Bärbel Lippke , Nina Ishorst , Lara M Hochfeld , Eva C Beins , Ines H Kaltheuner , Maximilian Schmitz , Aliona Wöhler , Manuel Döhla , Esther Sib , Marius Jentzsch , Eva-Maria C Moench , Jacob D Borrajo , Jonathan Strecker , Julia Reinhardt , Brian Cleary , Matthias Geyer , Michael Hölzel , Rhiannon Macrae , Markus M Nöthen , Per Hoffmann , Martin Exner , Aviv Regev , Feng Zhang , Jonathan L Schmid-Burgk

Anti-LINGO-1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke.

Brain pathology (Zurich, Switzerland)

Avec: Jan-Kolja Strecker , Antje Schmidt-Pogoda , Kai Diederich , Dario Zaremba , Frederique Wieters , Carolin Beuker , Mailin Hannah Marie Koecke , Frederike Anne Straeten , Heinz Wiendl , Jens Minnerup

Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1.

Circulation research

Avec: Tobias Petzold , Manuela Thienel , Lisa Dannenberg , Philipp Mourikis , Carolin Helten , Aysel Ayhan , René M'Pembele , Alina Achilles , Kajetan Trojovky , Daniel Konsek , Zhe Zhang , Ron Regenauer , Joachim Pircher , Andreas Ehrlich , Enzo Lüsebrink , Leo Nicolai , Thomas J Stocker , Richard Brandl , Franz Röschenthaler , Jan Strecker , Inas Saleh , Michael Spannagl , Christoph H Mayr , Herbert B Schiller , Christian Jung , Norbert Gerdes , Till Hoffmann , Bodo Levkau , Thomas Hohlfeld , Tobias Zeus , Christian Schulz , Malte Kelm , Amin Polzin

Dual modes of CRISPR-associated transposon homing.

Cell

Avec: Makoto Saito , Alim Ladha , Jonathan Strecker , Guilhem Faure , Edwin Neumann , Han Altae-Tran , Rhiannon K Macrae , Feng Zhang

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.

Nature neuroscience

Avec: David Schafflick , Jolien Wolbert , Michael Heming , Christian Thomas , Maike Hartlehnert , Anna-Lena Börsch , Alessio Ricci , Sandra Martín-Salamanca , Xiaolin Li , I-Na Lu , Mathias Pawlak , Jens Minnerup , Jan-Kolja Strecker , Thomas Seidenbecher , Sven G Meuth , Andres Hidalgo , Arthur Liesz , Heinz Wiendl , Gerd Meyer Zu Horste

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.

Cell reports

Avec: Ian M Slaymaker , Pablo Mesa , Max J Kellner , Soumya Kannan , Edward Brignole , Jeremy Koob , Patricia R Feliciano , Stefano Stella , Omar O Abudayyeh , Jonathan S Gootenberg , Jonathan Strecker , Guillermo Montoya , Feng Zhang

Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents.

Annals of neurology

Avec: Antje Schmidt-Pogoda , Nadine Bonberg , Mailin Hannah Marie Koecke , Jan-Kolja Strecker , Jürgen Wellmann , Nils-Martin Bruckmann , Carolin Beuker , Wolf-Rüdiger Schäbitz , Sven G Meuth , Heinz Wiendl , Heike Minnerup , Jens Minnerup

Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Maike Hartlehnert , Anna-Lena Börsch , Xiaolin Li , Miriam Burmeister , Hanna Gerwien , David Schafflick , Michael Heming , I-Na Lu , Venu Narayanan , Jan-Kolja Strecker , Anna Kolz , Anneli Peters , Gregory F Wu , Heinz Wiendl , Lydia Sorokin , Gerd Meyer Zu Horste

Natural Killer Cells Are Present in Rag1

Translational stroke research

Avec: Leoni Rolfes , Tobias Ruck , Christina David , Stine Mencl , Stefanie Bock , Mariella Schmidt , Jan-Kolja Strecker , Steffen Pfeuffer , Andreas-Schulte Mecklenbeck , Catharina Gross , Michael Gliem , Jens Minnerup , Michael K Schuhmann , Christoph Kleinschnitz , Sven G Meuth

Inhibition of leukocyte migration after ischemic stroke by VE-cadherin mutation in a mouse model leads to reduced infarct volumes and improved motor skills.

Brain and behavior

Avec: Mailin Hannah Marie Koecke , Jan-Kolja Strecker , Frederike Anne Straeten , Carolin Beuker , Jens Minnerup , Antje Schmidt-Pogoda

RNA-activated protein cleavage with a CRISPR-associated endopeptidase.

Science (New York, N.Y.)

Avec: Jonathan Strecker , F Esra Demircioglu , David Li , Guilhem Faure , Max E Wilkinson , Jonathan S Gootenberg , Omar O Abudayyeh , Hiroshi Nishimasu , Rhiannon K Macrae , Feng Zhang

Prokaryotic innate immunity through pattern recognition of conserved viral proteins.

Science (New York, N.Y.)

Avec: Linyi Alex Gao , Max E Wilkinson , Jonathan Strecker , Kira S Makarova , Rhiannon K Macrae , Eugene V Koonin , Feng Zhang

Modularity and diversity of target selectors in Tn7 transposons.

Molecular cell

Avec: Guilhem Faure , Makoto Saito , Sean Benler , Iris Peng , Yuri I Wolf , Jonathan Strecker , Han Altae-Tran , Edwin Neumann , David Li , Kira S Makarova , Rhiannon K Macrae , Eugene V Koonin , Feng Zhang

Réseau de co-auteurs

Feng Zhang 8 collaborations

Jan-Kolja Strecker 6 collaborations

Jens Minnerup 5 collaborations

David Li 4 collaborations

Heinz Wiendl 4 collaborations

Rhiannon K Macrae 4 collaborations

Jonathan L Schmid-Burgk 3 collaborations

Kira S Makarova 3 collaborations

Eugene V Koonin 3 collaborations

Antje Schmidt-Pogoda 3 collaborations

Carolin Beuker 3 collaborations

Mailin Hannah Marie Koecke 3 collaborations

Guilhem Faure 3 collaborations

Sven G Meuth 3 collaborations

Alim Ladha 2 collaborations

Zachary Gardner 2 collaborations

Frederike Anne Straeten 2 collaborations

Makoto Saito 2 collaborations

Edwin Neumann 2 collaborations

Han Altae-Tran 2 collaborations

David Schafflick 2 collaborations

Michael Heming 2 collaborations

Maike Hartlehnert 2 collaborations

Anna-Lena Börsch 2 collaborations

Xiaolin Li 2 collaborations

I-Na Lu 2 collaborations

Gerd Meyer Zu Horste 2 collaborations

Omar O Abudayyeh 2 collaborations

Jonathan S Gootenberg 2 collaborations

Max E Wilkinson 2 collaborations

Linyi Gao 1 collaboration

Blake Lash 1 collaboration

Isabella Del Priore 1 collaboration

Sai Ma 1 collaboration

Tyler Jacks 1 collaboration

Lindsay M LaFave 1 collaboration

Jason D Buenrostro 1 collaboration

Kerstin U Ludwig 1 collaboration

Ricarda M Schmithausen 1 collaboration

Max L Jacobs 1 collaboration

Ronja Hollstein 1 collaboration

Katja Blumenstock 1 collaboration

Jana Liebing 1 collaboration

Mikołaj Słabicki 1 collaboration

Amir Ben-Shmuel 1 collaboration

Ofir Israeli 1 collaboration

Shay Weiss 1 collaboration

Thomas S Ebert 1 collaboration

Nir Paran 1 collaboration

Wibke Rüdiger 1 collaboration

Gero Wilbring 1 collaboration

David Feldman 1 collaboration

Bärbel Lippke 1 collaboration

Nina Ishorst 1 collaboration

Lara M Hochfeld 1 collaboration

Eva C Beins 1 collaboration

Ines H Kaltheuner 1 collaboration

Maximilian Schmitz 1 collaboration

Aliona Wöhler 1 collaboration

Manuel Döhla 1 collaboration

Esther Sib 1 collaboration

Marius Jentzsch 1 collaboration

Eva-Maria C Moench 1 collaboration

Jacob D Borrajo 1 collaboration

Julia Reinhardt 1 collaboration

Brian Cleary 1 collaboration

Matthias Geyer 1 collaboration

Michael Hölzel 1 collaboration

Rhiannon Macrae 1 collaboration

Markus M Nöthen 1 collaboration

Per Hoffmann 1 collaboration

Martin Exner 1 collaboration

Aviv Regev 1 collaboration

Kai Diederich 1 collaboration

Dario Zaremba 1 collaboration

Frederique Wieters 1 collaboration

Tobias Petzold 1 collaboration

Manuela Thienel 1 collaboration

Lisa Dannenberg 1 collaboration

Philipp Mourikis 1 collaboration

Carolin Helten 1 collaboration

Aysel Ayhan 1 collaboration

René M'Pembele 1 collaboration

Alina Achilles 1 collaboration

Kajetan Trojovky 1 collaboration

Daniel Konsek 1 collaboration

Zhe Zhang 1 collaboration

Ron Regenauer 1 collaboration

Joachim Pircher 1 collaboration

Andreas Ehrlich 1 collaboration

Enzo Lüsebrink 1 collaboration

Leo Nicolai 1 collaboration

Thomas J Stocker 1 collaboration

Richard Brandl 1 collaboration

Franz Röschenthaler 1 collaboration

Jan Strecker 1 collaboration

Inas Saleh 1 collaboration

Michael Spannagl 1 collaboration

Christoph H Mayr 1 collaboration

Herbert B Schiller 1 collaboration

Christian Jung 1 collaboration

Norbert Gerdes 1 collaboration

Till Hoffmann 1 collaboration

Bodo Levkau 1 collaboration

Thomas Hohlfeld 1 collaboration

Tobias Zeus 1 collaboration

Christian Schulz 1 collaboration

Malte Kelm 1 collaboration

Amin Polzin 1 collaboration

Jolien Wolbert 1 collaboration

Christian Thomas 1 collaboration

Alessio Ricci 1 collaboration

Sandra Martín-Salamanca 1 collaboration

Mathias Pawlak 1 collaboration

Thomas Seidenbecher 1 collaboration

Andres Hidalgo 1 collaboration

Arthur Liesz 1 collaboration

Ian M Slaymaker 1 collaboration

Pablo Mesa 1 collaboration

Max J Kellner 1 collaboration

Soumya Kannan 1 collaboration

Edward Brignole 1 collaboration

Jeremy Koob 1 collaboration

Patricia R Feliciano 1 collaboration

Stefano Stella 1 collaboration

Guillermo Montoya 1 collaboration

Nadine Bonberg 1 collaboration

Jürgen Wellmann 1 collaboration

Nils-Martin Bruckmann 1 collaboration

Wolf-Rüdiger Schäbitz 1 collaboration

Heike Minnerup 1 collaboration

Miriam Burmeister 1 collaboration

Hanna Gerwien 1 collaboration

Venu Narayanan 1 collaboration

Anna Kolz 1 collaboration

Anneli Peters 1 collaboration

Gregory F Wu 1 collaboration

Lydia Sorokin 1 collaboration

Leoni Rolfes 1 collaboration

Tobias Ruck 1 collaboration

Christina David 1 collaboration

Stine Mencl 1 collaboration

Stefanie Bock 1 collaboration

Mariella Schmidt 1 collaboration

Steffen Pfeuffer 1 collaboration

Andreas-Schulte Mecklenbeck 1 collaboration

Catharina Gross 1 collaboration

Michael Gliem 1 collaboration

Michael K Schuhmann 1 collaboration

Christoph Kleinschnitz 1 collaboration

F Esra Demircioglu 1 collaboration

Hiroshi Nishimasu 1 collaboration

Linyi Alex Gao 1 collaboration

Sean Benler 1 collaboration

Iris Peng 1 collaboration

Yuri I Wolf 1 collaboration