L Serghides

Affiliations

Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Department of Immunology and Institutes of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.

Publications (36)

Perinatal outcomes in women living with HIV-1 and receiving antiretroviral therapy-a systematic review and meta-analysis.

Acta obstetricia et gynecologica Scandinavica

Avec: Shiri Shinar , Swati Agrawal , Michelle Ryu , Sharon Walmsley , Lena Serghides , Mark H Yudin , Kellie E Murphy

Impact of in-utero antiretroviral drug exposure on expression of membrane-associated transporters in mouse placenta and fetal brain.

AIDS (London, England)

Avec: Julian C Gilmore , Guijun Zhang , D William Cameron , Lena Serghides , Reina Bendayan

Doppler Ultrasound of the Fetal Descending Aorta: An Objective Tool to Assess Placental Blood Flow Resistance in Pregnancies With Discordant Umbilical Arteries.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Avec: Lindsay S Cahill , Grace V Mercer , Dakshita Jagota , Anjana Ravi Chandran , Natasha Milligan , Shiri Shinar , Clare L Whitehead , Sebastian R Hobson , Lena Serghides , W Tony Parks , Christopher K Macgowan , John C Kingdom , John G Sled , Ahmet A Baschat

Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States.

The Journal of infectious diseases

Avec: Stephanie Shiau , Denise L Jacobson , Yanling Huo , Deborah Kacanek , Lynn M Yee , David B Williams , Lisa B Haddad , Lena Serghides , Kathleen Powis , Rhoda S Sperling , Paige L Williams , Jennifer Jao , Auteur inconnu

Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies.

Human reproduction (Oxford, England)

Avec: Smriti Kala , Caroline Dunk , Sebastian Acosta , Lena Serghides

Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua.

The lancet. HIV

Avec: Caroline E Dunk , Lena Serghides

ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection.

The Journal of infectious diseases

Avec: Smriti Kala , Ksenia Meteleva , Lena Serghides

Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology.

EBioMedicine

Avec: Lindsay S Cahill , Greg Stortz , Anjana Ravi Chandran , Natasha Milligan , Shiri Shinar , Clare L Whitehead , Sebastian R Hobson , Viji Ayyathurai , Anum Rahman , Rojan Saghian , Karl J Jobst , Cyrethia McShane , Dana Block-Abraham , Viola Seravalli , Melissa Laurie , Sarah Millard , Cassandra Delp , Denise Wolfson , Ahmet A Baschat , Kellie E Murphy , Lena Serghides , Eric Morgen , Christopher K Macgowan , W Tony Parks , John C Kingdom , John G Sled

Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta.

EBioMedicine

Avec: Julian C Gilmore , Md Tozammel Hoque , Wanying Dai , Haneesha Mohan , Caroline Dunk , Lena Serghides , Reina Bendayan

Adjunctive rosiglitazone treatment for severe paediatric malaria: a randomized placebo-controlled trial in Mozambican children.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Avec: Rosauro Varo , Valerie M Crowley , Humberto Mucasse , Antonio Sitoe , Justina Bramugy , Lena Serghides , Andrea M Weckman , Clara Erice , Rubao Bila , Pio Vitorino , Campos Mucasse , Marta Valente , Sara Ajanovic , Núria Balanza , Kathleen Zhong , Yiovanna Derpsch , Melissa Gladstone , Alfredo Mayor , Quique Bassat , Kevin C Kain

Wharton's jelly area and its association with placental morphometry and pathology.

Placenta

Avec: Sarah K Debebe , Lindsay S Cahill , John C Kingdom , Clare L Whitehead , Anjana Ravi Chandran , W Tony Parks , Lena Serghides , Ahmet Baschat , Christopher K Macgowan , John G Sled

Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries.

American journal of physiology. Heart and circulatory physiology

Avec: John G Sled , Greg Stortz , Lindsay S Cahill , Natasha Milligan , Viji Ayyathurai , Lena Serghides , Eric Morgen , Viola Seravalli , Cassandra Delp , Cyrethia McShane , Ahmet Baschat , John Kingdom , Christopher K Macgowan

Sex differences in fetal Doppler parameters during gestation.

Biology of sex differences

Avec: Dakshita Jagota , Hannah George , Melissa Walker , Anjana Ravi Chandran , Natasha Milligan , Shiri Shinar , Clare L Whitehead , Sebastian R Hobson , Lena Serghides , W Tony Parks , Ahmet A Baschat , Christopher K Macgowan , John G Sled , John C Kingdom , Lindsay S Cahill

In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice.

PloS one

Avec: Ambalika Sarkar , Kayode Balogun , Monica S Guzman Lenis , Sebastian Acosta , Howard T Mount , Lena Serghides

Differential effects of antiretroviral drug toxicity in male versus female children who are HIV-exposed but uninfected.

AIDS (London, England)

Avec: Julian C Gilmore , Lena Serghides , Reina Bendayan

Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels.

EBioMedicine

Avec: Haneesha Mohan , Monica Guzman Lenis , Evelyn Y Laurette , Oscar Tejada , Tanvi Sanghvi , Kit-Yi Leung , Lindsay S Cahill , John G Sled , Paul Delgado-Olguín , Nicholas D E Greene , Andrew J Copp , Lena Serghides

Sex differences in uterine artery Doppler during gestation in pregnancies complicated by placental dysfunction.

Biology of sex differences

Avec: Leah Paranavitana , Melissa Walker , Anjana Ravi Chandran , Natasha Milligan , Shiri Shinar , Clare L Whitehead , Sebastian R Hobson , Lena Serghides , W Tony Parks , Ahmet A Baschat , Christopher K Macgowan , John G Sled , John C Kingdom , Lindsay S Cahill

A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.

American journal of obstetrics and gynecology

Avec: Drucilla J Roberts , Andrea G Edlow , Roberto J Romero , Carolyn B Coyne , David T Ting , Jason L Hornick , Sherif R Zaki , Upasana Das Adhikari , Lena Serghides , Stephanie L Gaw , Torri D Metz , Auteur inconnu

HIV care cascade for women living with HIV in the Greater Toronto Area versus the rest of Ontario and Canada.

International journal of STD & AIDS

Avec: Priscilla Medeiros , Laura Warren , Mina Kazemi , Notisha Massaquoi , Stephanie Smith , Wangari Tharao , Lena Serghides , Carmen H Logie , Abigail Kroch , Ann N Burchell , Alexandra de Pokomandy , Angela Kaida , Mona Loutfy , Auteur inconnu

Allometric scaling relationships in mouse placenta.

Journal of the Royal Society, Interface

Avec: Rojan Saghian , Lindsay S Cahill , Sarah K Debebe , Anum Rahman , Lena Serghides , Chloe R McDonald , Andrea M Weckman , Kevin C Kain , John G Sled

Peripheral cord insertion is associated with adverse pregnancy outcome only when accompanied by clinically significant placental pathology.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Avec: D Stapleton , A Darmonkow , A Ravi Chandran , N Milligan , R Saghian , S Shinar , C L Whitehead , S R Hobson , L Serghides , C K Macgowan , J G Sled , J C Kingdom , A A Baschat , W T Parks , L S Cahill

Metabolic implications and safety of dolutegravir use in pregnancy.

The lancet. HIV

Avec: Valeriya Dontsova , Haneesha Mohan , Camille Blanco , Jennifer Jao , Nicholas D E Greene , Andrew J Copp , Rebecca Zash , Lena Serghides

Association of Fatty Acid Signatures with HIV Viremia in Pregnancy.

AIDS research and human retroviruses

Avec: Stephanie A Fisher , Jennifer K Jao , Lynn M Yee , Lena Serghides , Ellen G Chadwick , Denise L Jacobson

Role of HIV and Antiretroviral Therapy on the Expression of Placental Transporters in Women with HIV.

The AAPS journal

Avec: Dea Kojovic , Ragia H Ghoneim , Lena Serghides , Micheline Piquette-Miller

Sex differences in modulation of fetoplacental vascular resistance in growth-restricted mouse fetuses following betamethasone administration: comparisons with human fetuses.

American journal of obstetrics & gynecology MFM

Avec: Lindsay S Cahill , Shiri Shinar , Clare L Whitehead , Sebastian R Hobson , Greg Stortz , Viji Ayyathurai , Anjana Ravi Chandran , Anum Rahman , John C Kingdom , Ahmet Baschat , Kellie E Murphy , Lena Serghides , Christopher K Macgowan , John G Sled

Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology.

Placenta

Avec: Michael Yampolsky , Oleksandr Shlakhter , Dianna Deng , Smriti Kala , Sharon L Walmsley , Kellie E Murphy , Mark H Yudin , Jay MacGillivray , Mona Loutfy , Caroline Dunk , Lena Serghides

Effect of maternal betamethasone administration on feto-placental vascular resistance in the mouse†.

Biology of reproduction

Avec: Lindsay S Cahill , Clare L Whitehead , Sebastian R Hobson , Greg Stortz , John C Kingdom , Ahmet Baschat , Kellie E Murphy , Lena Serghides , Christopher K Macgowan , John G Sled

In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes.

Journal of the International AIDS Society

Avec: Megan S McHenry , Kayode A Balogun , Brenna C McDonald , Rachel C Vreeman , Elizabeth C Whipple , Lena Serghides

Placental vascular abnormalities in the mouse alter umbilical artery wave reflections.

American journal of physiology. Heart and circulatory physiology

Avec: Lindsay S Cahill , Yu-Qing Zhou , Johnathan Hoggarth , Lisa X Yu , Anum Rahman , Greg Stortz , Clare L Whitehead , Ahmet Baschat , John C Kingdom , Christopher K Macgowan , Lena Serghides , John G Sled

Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants.

The Journal of infectious diseases

Avec: Denise L Jacobson , Krista S Crider , Patricia DeMarrais , Sean Brummel , Mindy Zhang , Christine M Pfeiffer , Cynthia A Moore , Katie McCarthy , Benjamin Johnston , Terence Mohammed , Tichaona Vhembo , Enid Kabugho , Gerald Agaba Muzorah , Haseena Cassim , Lee Fairlie , Elizabeth S Machado , James S Ngocho , Roger L Shapiro , Lena Serghides , Nahida Chakhtoura , Lameck Chinula , Shahin Lockman

Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone.

Frontiers in molecular neuroscience

Avec: Shreya H Dhume , Kayode Balogun , Ambalika Sarkar , Sebastian Acosta , Howard T J Mount , Lindsay S Cahill , John G Sled , Lena Serghides

Second-Generation Human Immunodeficiency Virus Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models.

The Journal of infectious diseases

Avec: Marie-Soleil R Smith , Haneesha Mohan , Abhinav Ajaykumar , Anthony Y Y Hsieh , Lou Martineau , Ronil Patel , Izabella Gadawska , Christopher Sherwood , Lena Serghides , James M Piret , Hélène C F Côté

A Pharmacokinetic Dose-Optimization Study of Cabotegravir and Bictegravir in a Mouse Pregnancy Model.

Pharmaceutics

Avec: Haneesha Mohan , Kieran Atkinson , Birgit Watson , Chanson J Brumme , Lena Serghides

The impact of a stress management intervention including cultural components on stress biomarker levels and mental health indicators among indigenous women.

Journal of behavioral medicine

Avec: Amira Aker , Lena Serghides , Jasmine Cotnam , Randy Jackson , Margaret Robinson , Holly Gauvin , Christopher Mushquash , Dionne Gesink , Marni Amirault , Anita C Benoit

Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model.

Pharmaceutics

Avec: Kayode Balogun , Lena Serghides

Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model.

EBioMedicine

Avec: Haneesha Mohan , Jessica Nguyen , Ben MacKenzie , Audrey Yee , Evelyn Yukino Laurette , Tanvi Sanghvi , Oscar Tejada , Valeriya Dontsova , Kit-Yi Leung , Cameron Goddard , Taylor De Young , John G Sled , Nicholas D E Greene , Andrew J Copp , Lena Serghides

Réseau de co-auteurs

Lena Serghides 35 collaborations

John G Sled 13 collaborations

Lindsay S Cahill 12 collaborations

Christopher K Macgowan 9 collaborations

Clare L Whitehead 8 collaborations

John C Kingdom 8 collaborations

Shiri Shinar 6 collaborations

Anjana Ravi Chandran 6 collaborations

Sebastian R Hobson 6 collaborations

Haneesha Mohan 6 collaborations

Kellie E Murphy 5 collaborations

Natasha Milligan 5 collaborations

W Tony Parks 5 collaborations

Greg Stortz 5 collaborations

Ahmet Baschat 5 collaborations

Ahmet A Baschat 4 collaborations

Anum Rahman 4 collaborations

Julian C Gilmore 3 collaborations

Reina Bendayan 3 collaborations

Denise L Jacobson 3 collaborations

None None 3 collaborations

Smriti Kala 3 collaborations

Caroline Dunk 3 collaborations

Sebastian Acosta 3 collaborations

Viji Ayyathurai 3 collaborations

Kayode Balogun 3 collaborations

Nicholas D E Greene 3 collaborations

Andrew J Copp 3 collaborations

Mark H Yudin 2 collaborations

Dakshita Jagota 2 collaborations

Lynn M Yee 2 collaborations

Jennifer Jao 2 collaborations

Rojan Saghian 2 collaborations

Cyrethia McShane 2 collaborations

Viola Seravalli 2 collaborations

Cassandra Delp 2 collaborations

Eric Morgen 2 collaborations

Andrea M Weckman 2 collaborations

Kevin C Kain 2 collaborations

Sarah K Debebe 2 collaborations

Melissa Walker 2 collaborations

Ambalika Sarkar 2 collaborations

Oscar Tejada 2 collaborations

Tanvi Sanghvi 2 collaborations

Kit-Yi Leung 2 collaborations

Mona Loutfy 2 collaborations

Valeriya Dontsova 2 collaborations

Swati Agrawal 1 collaboration

Michelle Ryu 1 collaboration

Sharon Walmsley 1 collaboration

Guijun Zhang 1 collaboration

D William Cameron 1 collaboration

Grace V Mercer 1 collaboration

Stephanie Shiau 1 collaboration

Yanling Huo 1 collaboration

Deborah Kacanek 1 collaboration

David B Williams 1 collaboration

Lisa B Haddad 1 collaboration

Kathleen Powis 1 collaboration

Rhoda S Sperling 1 collaboration

Paige L Williams 1 collaboration

Caroline E Dunk 1 collaboration

Ksenia Meteleva 1 collaboration

Karl J Jobst 1 collaboration

Dana Block-Abraham 1 collaboration

Melissa Laurie 1 collaboration

Sarah Millard 1 collaboration

Denise Wolfson 1 collaboration

Md Tozammel Hoque 1 collaboration

Wanying Dai 1 collaboration

Rosauro Varo 1 collaboration

Valerie M Crowley 1 collaboration

Humberto Mucasse 1 collaboration

Antonio Sitoe 1 collaboration

Justina Bramugy 1 collaboration

Clara Erice 1 collaboration

Rubao Bila 1 collaboration

Pio Vitorino 1 collaboration

Campos Mucasse 1 collaboration

Marta Valente 1 collaboration

Sara Ajanovic 1 collaboration

Núria Balanza 1 collaboration

Kathleen Zhong 1 collaboration

Yiovanna Derpsch 1 collaboration

Melissa Gladstone 1 collaboration

Alfredo Mayor 1 collaboration

Quique Bassat 1 collaboration

John Kingdom 1 collaboration

Hannah George 1 collaboration

Monica S Guzman Lenis 1 collaboration

Howard T Mount 1 collaboration

Monica Guzman Lenis 1 collaboration

Evelyn Y Laurette 1 collaboration

Paul Delgado-Olguín 1 collaboration

Leah Paranavitana 1 collaboration

Drucilla J Roberts 1 collaboration

Andrea G Edlow 1 collaboration

Roberto J Romero 1 collaboration

Carolyn B Coyne 1 collaboration

David T Ting 1 collaboration

Jason L Hornick 1 collaboration

Sherif R Zaki 1 collaboration

Upasana Das Adhikari 1 collaboration

Stephanie L Gaw 1 collaboration

Torri D Metz 1 collaboration

Priscilla Medeiros 1 collaboration

Laura Warren 1 collaboration

Mina Kazemi 1 collaboration

Notisha Massaquoi 1 collaboration

Stephanie Smith 1 collaboration

Wangari Tharao 1 collaboration

Carmen H Logie 1 collaboration

Abigail Kroch 1 collaboration

Ann N Burchell 1 collaboration

Alexandra de Pokomandy 1 collaboration

Angela Kaida 1 collaboration

Chloe R McDonald 1 collaboration

D Stapleton 1 collaboration

A Darmonkow 1 collaboration

A Ravi Chandran 1 collaboration

N Milligan 1 collaboration

R Saghian 1 collaboration

S Shinar 1 collaboration

C L Whitehead 1 collaboration

S R Hobson 1 collaboration

C K Macgowan 1 collaboration

J G Sled 1 collaboration

J C Kingdom 1 collaboration

A A Baschat 1 collaboration

W T Parks 1 collaboration

L S Cahill 1 collaboration

Camille Blanco 1 collaboration

Rebecca Zash 1 collaboration

Stephanie A Fisher 1 collaboration

Jennifer K Jao 1 collaboration

Ellen G Chadwick 1 collaboration

Dea Kojovic 1 collaboration

Ragia H Ghoneim 1 collaboration

Micheline Piquette-Miller 1 collaboration

Michael Yampolsky 1 collaboration

Oleksandr Shlakhter 1 collaboration

Dianna Deng 1 collaboration

Sharon L Walmsley 1 collaboration

Jay MacGillivray 1 collaboration

Megan S McHenry 1 collaboration

Kayode A Balogun 1 collaboration

Brenna C McDonald 1 collaboration

Rachel C Vreeman 1 collaboration

Elizabeth C Whipple 1 collaboration

Yu-Qing Zhou 1 collaboration

Johnathan Hoggarth 1 collaboration

Lisa X Yu 1 collaboration

Krista S Crider 1 collaboration

Patricia DeMarrais 1 collaboration

Sean Brummel 1 collaboration

Mindy Zhang 1 collaboration

Christine M Pfeiffer 1 collaboration

Cynthia A Moore 1 collaboration

Katie McCarthy 1 collaboration

Benjamin Johnston 1 collaboration

Terence Mohammed 1 collaboration

Tichaona Vhembo 1 collaboration

Enid Kabugho 1 collaboration

Gerald Agaba Muzorah 1 collaboration

Haseena Cassim 1 collaboration

Lee Fairlie 1 collaboration

Elizabeth S Machado 1 collaboration

James S Ngocho 1 collaboration

Roger L Shapiro 1 collaboration

Nahida Chakhtoura 1 collaboration

Lameck Chinula 1 collaboration

Shahin Lockman 1 collaboration

Shreya H Dhume 1 collaboration

Howard T J Mount 1 collaboration

Marie-Soleil R Smith 1 collaboration

Abhinav Ajaykumar 1 collaboration

Anthony Y Y Hsieh 1 collaboration

Lou Martineau 1 collaboration

Ronil Patel 1 collaboration

Izabella Gadawska 1 collaboration

Christopher Sherwood 1 collaboration

James M Piret 1 collaboration

Hélène C F Côté 1 collaboration

Kieran Atkinson 1 collaboration

Birgit Watson 1 collaboration

Chanson J Brumme 1 collaboration

Amira Aker 1 collaboration

Jasmine Cotnam 1 collaboration

Randy Jackson 1 collaboration

Margaret Robinson 1 collaboration

Holly Gauvin 1 collaboration

Christopher Mushquash 1 collaboration

Dionne Gesink 1 collaboration

Marni Amirault 1 collaboration

Anita C Benoit 1 collaboration

Jessica Nguyen 1 collaboration

Ben MacKenzie 1 collaboration

Audrey Yee 1 collaboration

Evelyn Yukino Laurette 1 collaboration

Cameron Goddard 1 collaboration

Taylor De Young 1 collaboration