Lydia Cassard

Affiliations

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Publications (23)

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment.

Journal for immunotherapy of cancer

Avec: Mélanie Desbois , Coralie Béal , Mélinda Charrier , Benjamin Besse , Guillaume Meurice , Nicolas Cagnard , Yannick Jacques , David Béchard , Lydie Cassard , Nathalie Chaput

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8

Science advances

Avec: Marie Naigeon , Matthieu Roulleaux Dugage , François-Xavier Danlos , Lisa Boselli , Jean-Mehdi Jouniaux , Caroline de Oliveira , Roberto Ferrara , Boris Duchemann , Caroline Berthot , Lou Girard , Ronan Flippot , Laurence Albiges , Siham Farhane , Patrick Saulnier , Ludovic Lacroix , Frank Griscelli , Gabriel Roman , Tyler Hulett , Aurélien Marabelle , Lydie Cassard , Benjamin Besse , Nathalie Chaput

Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers.

Journal for immunotherapy of cancer

Avec: Laetitia Nebot-Bral , Antoine Hollebecque , Andrey A Yurchenko , Louise de Forceville , Mathieu Danjou , Jean-Mehdi Jouniaux , Reginaldo C A Rosa , Caroline Pouvelle , Said Aoufouchi , Perrine Vuagnat , Cristina Smolenschi , Emeline Colomba , Alexandra Leary , Aurelien Marabelle , Jean-Yves Scoazec , Lydie Cassard , Sergey Nikolaev , Nathalie Chaput , Patricia Kannouche

Primary care physician referral practices regarding BRCA1/2 genetic counseling in a major health system.

Breast cancer research and treatment

Avec: Debra T Linfield , Michael B Rothberg , Elizabeth R Pfoh , Ryan Noss , Lydia Cassard , Joseph C Powers , Laura Lipold , Kathryn A Martinez

Circulating T-cell Immunosenescence in Patients with Advanced Non-small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Roberto Ferrara , Marie Naigeon , Edouard Auclin , Boris Duchemann , Lydie Cassard , Jean-Mehdi Jouniaux , Lisa Boselli , Jonathan Grivel , Aude Desnoyer , Laura Mezquita , Matthieu Texier , Caroline Caramella , Lizza Hendriks , David Planchard , Jordi Remon , Sabina Sangaletti , Claudia Proto , Marina C Garassino , Jean-Charles Soria , Aurelien Marabelle , Anne-Laure Voisin , Siham Farhane , Benjamin Besse , Nathalie Chaput

Phase II and biomarker study of programmed cell death protein 1 inhibitor nivolumab and metronomic cyclophosphamide in paediatric relapsed/refractory solid tumours: Arm G of AcSé-ESMART, a trial of the European Innovative Therapies for Children With Cancer Consortium.

European journal of cancer (Oxford, England : 1990)

Avec: Claudia Pasqualini , Jonathan Rubino , Caroline Brard , Lydie Cassard , Nicolas André , Windy Rondof , Jean-Yves Scoazec , Antonin Marchais , Souad Nebchi , Lisa Boselli , Jonathan Grivel , Isabelle Aerts , Estelle Thebaud , Xavier Paoletti , Véronique Minard-Colin , Gilles Vassal , Birgit Geoerger

Current and future biomarkers for outcomes with immunotherapy in non-small cell lung cancer.

Translational lung cancer research

Avec: Boris Duchemann , Jordi Remon , Marie Naigeon , Lydie Cassard , Jean Mehdi Jouniaux , Lisa Boselli , Jonathan Grivel , Edouard Auclin , Aude Desnoyer , Benjamin Besse , Nathalie Chaput

CD8

Journal for immunotherapy of cancer

Avec: Boris Duchemann , Marie Naigeon , Edouard Auclin , Roberto Ferrara , Lydie Cassard , Jean-Mehdi Jouniaux , Lisa Boselli , Jonathan Grivel , Aude Desnoyer , François-Xavier Danlos , Laura Mezquita , Caroline Caramella , Aurelien Marabelle , Benjamin Besse , Nathalie Chaput

Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers.

Journal of experimental & clinical cancer research : CR

Avec: Capucine Baldini , Francois-Xavier Danlos , Andreea Varga , Matthieu Texier , Heloise Halse , Severine Mouraud , Lydie Cassard , Stéphane Champiat , Nicolas Signolle , Perrine Vuagnat , Patricia Martin-Romano , Jean-Marie Michot , Rastislav Bahleda , Anas Gazzah , Lisa Boselli , Delphine Bredel , Jonathan Grivel , Chifaou Mohamed-Djalim , Guillaume Escriou , Laetitia Grynszpan , Amelie Bigorgne , Saloomeh Rafie , Alae Abbassi , Vincent Ribrag , Sophie Postel-Vinay , Antoine Hollebecque , Sandrine Susini , Siham Farhane , Ludovic Lacroix , Aurelien Parpaleix , Salim Laghouati , Laurence Zitvogel , Julien Adam , Nathalie Chaput , Jean-Charles Soria , Christophe Massard , Aurelien Marabelle

The Skin and Lewy Body Disease.

Journal of Alzheimer's disease : JAD

Avec: Lydia Cassard , Golara Honari , Babak Tousi

Dose escalation phase 1 study of radiotherapy in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 monoclonal antibody ipilimumab in patients with metastatic melanoma.

Journal for immunotherapy of cancer

Avec: Celine Boutros , Nathalie Chaput-Gras , Emilie Lanoy , Alicia Larive , Christine Mateus , Emilie Routier , Roger Sun , Yun Gan Tao , Christophe Massard , Rastilav Bahleda , Dominique Schwob , Nathalie Ibrahim , Rita Maria Khoury Abboud , Caroline Caramella , Andrea Lancia , Lydie Cassard , Severine Roy , J-C Soria , Caroline Robert , Eric Deutsch

Circulating innate immune markers and outcomes in treatment-naïve advanced non-small cell lung cancer patients.

European journal of cancer (Oxford, England : 1990)

Avec: M Charrier , L Mezquita , B Lueza , L Dupraz , D Planchard , J Remon , C Caramella , L Cassard , L Boselli , K S Reiners , E Pogge von Strandmann , S Rusakiewicz , R Ferrara , B Duchemann , M Naigeon , J P Pignon , B Besse , N Chaput

Integrating Circulating Biomarkers in the Immune Checkpoint Inhibitor Treatment in Lung Cancer.

Cancers

Avec: Boris Duchemann , Jordi Remon , Marie Naigeon , Laura Mezquita , Roberto Ferrara , Lydie Cassard , Jean Mehdi Jouniaux , Lisa Boselli , Jonathan Grivel , Edouard Auclin , Aude Desnoyer , Benjamin Besse , Nathalie Chaput

Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren's Syndrome.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly , Audrey Paoletti , Raphaèle Seror , Nicolas Tchitchek , Michael Mingueneau , Nikaïa Smith , Darragh Duffy , Lydie Cassard , Nathalie Chaput , Sabrina Pengam , Vanessa Gauttier , Nicolas Poirier , Xavier Mariette , Gaetane Nocturne

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer.

Nature communications

Avec: Clélia Coutzac , Jean-Mehdi Jouniaux , Angelo Paci , Julien Schmidt , Domenico Mallardo , Atmane Seck , Vahe Asvatourian , Lydie Cassard , Patrick Saulnier , Ludovic Lacroix , Paul-Louis Woerther , Aurore Vozy , Marie Naigeon , Laetitia Nebot-Bral , Mélanie Desbois , Ester Simeone , Christine Mateus , Lisa Boselli , Jonathan Grivel , Emilie Soularue , Patricia Lepage , Franck Carbonnel , Paolo Antonio Ascierto , Caroline Robert , Nathalie Chaput

Baseline circulating unswitched memory B cells and B-cell related soluble factors are associated with overall survival in patients with clear cell renal cell carcinoma treated with nivolumab within the NIVOREN GETUG-AFU 26 study.

Journal for immunotherapy of cancer

Avec: Lucia Carril-Ajuria , Aude Desnoyer , Maxime Meylan , Cécile Dalban , Marie Naigeon , Lydie Cassard , Yann Vano , Nathalie Rioux-Leclercq , Salem Chouaib , Benoit Beuselinck , Sylvie Chabaud , Janice Barros-Monteiro , Antoine Bougoüin , Guillaume Lacroix , Irelka Colina-Moreno , Florence Tantot , Lisa Boselli , Caroline De Oliveira , Wolf Herve Fridman , Bernard Escudier , Catherine Sautes-Fridman , Laurence Albiges , Nathalie Chaput-Gras

Gefitinib plus tremelimumab combination in refractory non-small cell lung cancer patients harbouring EGFR mutations: The GEFTREM phase I trial.

Lung cancer (Amsterdam, Netherlands)

Avec: Mariona Riudavets , Marie Naigeon , Matthieu Texier , Miriam Dorta , Fabrice Barlesi , Julien Mazieres , Andrea Varga , Lydie Cassard , Lisa Boselli , Jonathan Grivel , Maud NgoCamus , Ludovic Lacroix , Laura Mezquita , Benjamin Besse , Nathalie Chaput , David Planchard

Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation.

Cancers

Avec: Mélissa Prat , Marie Salon , Thibault Allain , Olivier Dubreuil , Grégory Noël , Laurence Preisser , Bérangère Jean , Lydie Cassard , Fanny Lemée , Isabelle Tabah-Fish , Bernard Pipy , Pascale Jeannin , Jean-François Prost , Jean-Marc Barret , Agnès Coste

A 39,600-year-old leather punch board from Canyars, Gavà, Spain.

Science advances

Avec: Luc Doyon , Thomas Faure , Montserrat Sanz , Joan Daura , Laura Cassard , Francesco d'Errico

Predicting immunotherapy outcomes under therapy in patients with advanced NSCLC using dNLR and its early dynamics.

European journal of cancer (Oxford, England : 1990)

Avec: Laura Mezquita , Isabel Preeshagul , Edouard Auclin , Diana Saravia , Lizza Hendriks , Hira Rizvi , Wungki Park , Ernest Nadal , Patricia Martin-Romano , Jose C Ruffinelli , Santiago Ponce , Clarisse Audigier-Valette , Simona Carnio , Felix Blanc-Durand , Paolo Bironzo , Fabrizio Tabbò , Maria Lucia Reale , Silvia Novello , Matthew D Hellmann , Peter Sawan , Jeffrey Girshman , Andrew J Plodkowski , Gerard Zalcman , Margarita Majem , Melinda Charrier , Marie Naigeon , Caroline Rossoni , AnnaPaola Mariniello , Luis Paz-Ares , Anne Marie Dingemans , David Planchard , Nathalie Cozic , Lydie Cassard , Gilberto Lopes , Nathalie Chaput , Kathryn Arbour , Benjamin Besse

Dermatomyositis: Practical Guidance and Unmet Needs.

ImmunoTargets and therapy

Avec: Lydia Cassard , Noelle Seraly , Maureen Riegert , Aditi Patel , Anthony P Fernandez

Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti-PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma.

Cancer discovery

Avec: François-Xavier Danlos , Matthieu Texier , Bastien Job , Severine Mouraud , Lydie Cassard , Capucine Baldini , Andrea Varga , Andrey A Yurchenko , Audrey Rabeau , Stéphane Champiat , Diane Letourneur , Delphine Bredel , Sandrine Susini , Yuna Blum , Aurelien Parpaleix , Cedric Parlavecchio , Lambros Tselikas , Jean-Eudes Fahrner , Anne-Gaelle Goubet , Mathieu Rouanne , Saloomeh Rafie , Alae Abbassi , Ines Kasraoui , Marie Breckler , Siham Farhane , Samy Ammari , Salim Laghouati , Anas Gazzah , Ludovic Lacroix , Benjamin Besse , Nathalie Droin , Marc Deloger , Sophie Cotteret , Julien Adam , Laurence Zitvogel , Sergey I Nikolaev , Nathalie Chaput , Christophe Massard , Jean-Charles Soria , Carlos Gomez-Roca , Gerard Zalcman , David Planchard , Aurelien Marabelle

B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors.

Journal for immunotherapy of cancer

Avec: Ronan Flippot , Marcus Teixeira , Macarena Rey-Cardenas , Lucia Carril-Ajuria , Larissa Rainho , Natacha Naoun , Jean-Mehdi Jouniaux , Lisa Boselli , Marie Naigeon , Francois-Xavier Danlos , Bernard Escudier , Jean-Yves Scoazec , Lydie Cassard , Laurence Albiges , Nathalie Chaput

Réseau de co-auteurs

Lydie Cassard 18 collaborations

Nathalie Chaput 14 collaborations

Lisa Boselli 11 collaborations

Marie Naigeon 10 collaborations

Benjamin Besse 9 collaborations

Jonathan Grivel 8 collaborations

Jean-Mehdi Jouniaux 6 collaborations

Boris Duchemann 5 collaborations

Ludovic Lacroix 5 collaborations

Aurelien Marabelle 5 collaborations

Edouard Auclin 5 collaborations

Aude Desnoyer 5 collaborations

Laura Mezquita 5 collaborations

Roberto Ferrara 4 collaborations

Siham Farhane 4 collaborations

Matthieu Texier 4 collaborations

David Planchard 4 collaborations

François-Xavier Danlos 3 collaborations

Laurence Albiges 3 collaborations

Jean-Yves Scoazec 3 collaborations

Caroline Caramella 3 collaborations

Jordi Remon 3 collaborations

Jean-Charles Soria 3 collaborations

Christophe Massard 3 collaborations

Mélanie Desbois 2 collaborations

Ronan Flippot 2 collaborations

Patrick Saulnier 2 collaborations

Laetitia Nebot-Bral 2 collaborations

Antoine Hollebecque 2 collaborations

Andrey A Yurchenko 2 collaborations

Perrine Vuagnat 2 collaborations

Lizza Hendriks 2 collaborations

Jean Mehdi Jouniaux 2 collaborations

Capucine Baldini 2 collaborations

Francois-Xavier Danlos 2 collaborations

Severine Mouraud 2 collaborations

Stéphane Champiat 2 collaborations

Patricia Martin-Romano 2 collaborations

Anas Gazzah 2 collaborations

Delphine Bredel 2 collaborations

Saloomeh Rafie 2 collaborations

Alae Abbassi 2 collaborations

Sandrine Susini 2 collaborations

Aurelien Parpaleix 2 collaborations

Salim Laghouati 2 collaborations

Laurence Zitvogel 2 collaborations

Julien Adam 2 collaborations

Nathalie Chaput-Gras 2 collaborations

Christine Mateus 2 collaborations

Caroline Robert 2 collaborations

Lucia Carril-Ajuria 2 collaborations

Bernard Escudier 2 collaborations

Andrea Varga 2 collaborations

Gerard Zalcman 2 collaborations

Coralie Béal 1 collaboration

Mélinda Charrier 1 collaboration

Guillaume Meurice 1 collaboration

Nicolas Cagnard 1 collaboration

Yannick Jacques 1 collaboration

David Béchard 1 collaboration

Matthieu Roulleaux Dugage 1 collaboration

Caroline de Oliveira 1 collaboration

Caroline Berthot 1 collaboration

Lou Girard 1 collaboration

Frank Griscelli 1 collaboration

Gabriel Roman 1 collaboration

Tyler Hulett 1 collaboration

Aurélien Marabelle 1 collaboration

Louise de Forceville 1 collaboration

Mathieu Danjou 1 collaboration

Reginaldo C A Rosa 1 collaboration

Caroline Pouvelle 1 collaboration

Said Aoufouchi 1 collaboration

Cristina Smolenschi 1 collaboration

Emeline Colomba 1 collaboration

Alexandra Leary 1 collaboration

Sergey Nikolaev 1 collaboration

Patricia Kannouche 1 collaboration

Debra T Linfield 1 collaboration

Michael B Rothberg 1 collaboration

Elizabeth R Pfoh 1 collaboration

Ryan Noss 1 collaboration

Joseph C Powers 1 collaboration

Laura Lipold 1 collaboration

Kathryn A Martinez 1 collaboration

Sabina Sangaletti 1 collaboration

Claudia Proto 1 collaboration

Marina C Garassino 1 collaboration

Anne-Laure Voisin 1 collaboration

Claudia Pasqualini 1 collaboration

Jonathan Rubino 1 collaboration

Caroline Brard 1 collaboration

Nicolas André 1 collaboration

Windy Rondof 1 collaboration

Antonin Marchais 1 collaboration

Souad Nebchi 1 collaboration

Isabelle Aerts 1 collaboration

Estelle Thebaud 1 collaboration

Xavier Paoletti 1 collaboration

Véronique Minard-Colin 1 collaboration

Gilles Vassal 1 collaboration

Birgit Geoerger 1 collaboration

Andreea Varga 1 collaboration

Heloise Halse 1 collaboration

Nicolas Signolle 1 collaboration

Jean-Marie Michot 1 collaboration

Rastislav Bahleda 1 collaboration

Chifaou Mohamed-Djalim 1 collaboration

Guillaume Escriou 1 collaboration

Laetitia Grynszpan 1 collaboration

Amelie Bigorgne 1 collaboration

Vincent Ribrag 1 collaboration

Sophie Postel-Vinay 1 collaboration

Golara Honari 1 collaboration

Babak Tousi 1 collaboration

Celine Boutros 1 collaboration

Emilie Lanoy 1 collaboration

Alicia Larive 1 collaboration

Emilie Routier 1 collaboration

Roger Sun 1 collaboration

Yun Gan Tao 1 collaboration

Rastilav Bahleda 1 collaboration

Dominique Schwob 1 collaboration

Nathalie Ibrahim 1 collaboration

Rita Maria Khoury Abboud 1 collaboration

Andrea Lancia 1 collaboration

Severine Roy 1 collaboration

J-C Soria 1 collaboration

Eric Deutsch 1 collaboration

M Charrier 1 collaboration

L Mezquita 1 collaboration

B Lueza 1 collaboration

L Dupraz 1 collaboration

D Planchard 1 collaboration

J Remon 1 collaboration

C Caramella 1 collaboration

L Cassard 1 collaboration

L Boselli 1 collaboration

K S Reiners 1 collaboration

E Pogge von Strandmann 1 collaboration

S Rusakiewicz 1 collaboration

R Ferrara 1 collaboration

B Duchemann 1 collaboration

M Naigeon 1 collaboration

J P Pignon 1 collaboration

B Besse 1 collaboration

N Chaput 1 collaboration

Elodie Rivière 1 collaboration

Juliette Pascaud 1 collaboration

Alexandre Virone 1 collaboration

Anastasia Dupré 1 collaboration

Bineta Ly 1 collaboration

Audrey Paoletti 1 collaboration

Raphaèle Seror 1 collaboration

Nicolas Tchitchek 1 collaboration

Michael Mingueneau 1 collaboration

Nikaïa Smith 1 collaboration

Darragh Duffy 1 collaboration

Sabrina Pengam 1 collaboration

Vanessa Gauttier 1 collaboration

Nicolas Poirier 1 collaboration

Xavier Mariette 1 collaboration

Gaetane Nocturne 1 collaboration

Clélia Coutzac 1 collaboration

Angelo Paci 1 collaboration

Julien Schmidt 1 collaboration

Domenico Mallardo 1 collaboration

Atmane Seck 1 collaboration

Vahe Asvatourian 1 collaboration

Paul-Louis Woerther 1 collaboration

Aurore Vozy 1 collaboration

Ester Simeone 1 collaboration

Emilie Soularue 1 collaboration

Patricia Lepage 1 collaboration

Franck Carbonnel 1 collaboration

Paolo Antonio Ascierto 1 collaboration

Maxime Meylan 1 collaboration

Cécile Dalban 1 collaboration

Yann Vano 1 collaboration

Nathalie Rioux-Leclercq 1 collaboration

Salem Chouaib 1 collaboration

Benoit Beuselinck 1 collaboration

Sylvie Chabaud 1 collaboration

Janice Barros-Monteiro 1 collaboration

Antoine Bougoüin 1 collaboration

Guillaume Lacroix 1 collaboration

Irelka Colina-Moreno 1 collaboration

Florence Tantot 1 collaboration

Caroline De Oliveira 1 collaboration

Wolf Herve Fridman 1 collaboration

Catherine Sautes-Fridman 1 collaboration

Mariona Riudavets 1 collaboration

Miriam Dorta 1 collaboration

Fabrice Barlesi 1 collaboration

Julien Mazieres 1 collaboration

Maud NgoCamus 1 collaboration

Mélissa Prat 1 collaboration

Marie Salon 1 collaboration

Thibault Allain 1 collaboration

Olivier Dubreuil 1 collaboration

Grégory Noël 1 collaboration

Laurence Preisser 1 collaboration

Bérangère Jean 1 collaboration

Fanny Lemée 1 collaboration

Isabelle Tabah-Fish 1 collaboration

Bernard Pipy 1 collaboration

Pascale Jeannin 1 collaboration

Jean-François Prost 1 collaboration

Jean-Marc Barret 1 collaboration

Agnès Coste 1 collaboration

Luc Doyon 1 collaboration

Thomas Faure 1 collaboration

Montserrat Sanz 1 collaboration

Joan Daura 1 collaboration

Laura Cassard 1 collaboration

Francesco d'Errico 1 collaboration

Isabel Preeshagul 1 collaboration

Diana Saravia 1 collaboration

Hira Rizvi 1 collaboration

Wungki Park 1 collaboration

Ernest Nadal 1 collaboration

Jose C Ruffinelli 1 collaboration

Santiago Ponce 1 collaboration

Clarisse Audigier-Valette 1 collaboration

Simona Carnio 1 collaboration

Felix Blanc-Durand 1 collaboration

Paolo Bironzo 1 collaboration

Fabrizio Tabbò 1 collaboration

Maria Lucia Reale 1 collaboration

Silvia Novello 1 collaboration

Matthew D Hellmann 1 collaboration

Peter Sawan 1 collaboration

Jeffrey Girshman 1 collaboration

Andrew J Plodkowski 1 collaboration

Margarita Majem 1 collaboration

Melinda Charrier 1 collaboration

Caroline Rossoni 1 collaboration

AnnaPaola Mariniello 1 collaboration

Luis Paz-Ares 1 collaboration

Anne Marie Dingemans 1 collaboration

Nathalie Cozic 1 collaboration

Gilberto Lopes 1 collaboration

Kathryn Arbour 1 collaboration

Noelle Seraly 1 collaboration

Maureen Riegert 1 collaboration

Aditi Patel 1 collaboration

Anthony P Fernandez 1 collaboration

Bastien Job 1 collaboration

Audrey Rabeau 1 collaboration

Diane Letourneur 1 collaboration

Yuna Blum 1 collaboration

Cedric Parlavecchio 1 collaboration

Lambros Tselikas 1 collaboration

Jean-Eudes Fahrner 1 collaboration

Anne-Gaelle Goubet 1 collaboration

Mathieu Rouanne 1 collaboration

Ines Kasraoui 1 collaboration

Marie Breckler 1 collaboration

Samy Ammari 1 collaboration

Nathalie Droin 1 collaboration

Marc Deloger 1 collaboration

Sophie Cotteret 1 collaboration

Sergey I Nikolaev 1 collaboration

Carlos Gomez-Roca 1 collaboration

Marcus Teixeira 1 collaboration

Macarena Rey-Cardenas 1 collaboration

Larissa Rainho 1 collaboration

Natacha Naoun 1 collaboration