M P Lolkema

Affiliations
  • Department of Medical Oncology, Erasmus MC Cancer Center, Rotterdam, the Netherlands.

Publications (65)

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Neuroendocrine Tumors: Results From the Phase II KEYNOTE-158 Study.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Jonathan Strosberg , Nobumasa Mizuno , Toshihiko Doi , Enrique Grande , Jean-Pierre Delord , Ronnie Shapira-Frommer , Emily Bergsland , Manisha Shah , Marwan Fakih , Shunji Takahashi , Sarina A Piha-Paul , Bert O'Neil , Sajeve Thomas , Martijn P Lolkema , Menghui Chen , Nageatte Ibrahim , Kevin Norwood , Julien Hadoux

ESMO Clinical Research Observatory (ECRO): improving the efficiency of clinical research through rationalisation of bureaucracy.

ESMO open
Avec: Jose Luis Perez-Gracia , Ahmad Awada , Emiliano Calvo , Teresa Amaral , Hendrik-Tobias Arkenau , Viktor Gruenwald , Gyorgy Bodoky , Martijn P Lolkema , Massimo Di Nicola , Nicolas Penel , Ruth Vera , Miguel F Sanmamed , Jean-Yves Douillard

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.

Annals of oncology : official journal of the European Society for Medical Oncology
Avec: F Mosele , J Remon , J Mateo , C B Westphalen , F Barlesi , M P Lolkema , N Normanno , A Scarpa , M Robson , F Meric-Bernstam , N Wagle , A Stenzinger , J Bonastre , A Bayle , S Michiels , I Bièche , E Rouleau , S Jezdic , J-Y Douillard , J S Reis-Filho , R Dienstmann , F André

A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Florence Atrafi , Oliver Boix , Vivek Subbiah , Jennifer R Diamond , Sant P Chawla , Anthony W Tolcher , Patricia M LoRusso , Joseph P Eder , Martin Gutierrez , Kumar Sankhala , Prabhu Rajagopalan , Isabelle Genvresse , Simon Langer , Ron H J Mathijssen , Jaap Verweij , Ingmar Bruns , Martijn P Lolkema

Generating human prostate cancer organoids from leukapheresis enriched circulating tumour cells.

European journal of cancer (Oxford, England : 1990)
Avec: Lisanne Mout , Lisanne F van Dessel , Jaco Kraan , Anouk C de Jong , Rui P L Neves , Sigrun Erkens-Schulze , Corine M Beaufort , Anieta M Sieuwerts , Job van Riet , Thomas L C Woo , Ronald de Wit , Stefan Sleijfer , Paul Hamberg , Yorick Sandberg , Peter A W Te Boekhorst , Harmen J G van de Werken , John W M Martens , Nikolas H Stoecklein , Wytske M van Weerden , Martijn P Lolkema

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer.

Nature genetics
Avec: Emre Kocakavuk , Kevin J Anderson , Frederick S Varn , Kevin C Johnson , Samirkumar B Amin , Erik P Sulman , Martijn P Lolkema , Floris P Barthel , Roel G W Verhaak

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets.

Nature communications
Avec: Job van Riet , Harmen J G van de Werken , Edwin Cuppen , Ferry A L M Eskens , Margot Tesselaar , Linde M van Veenendaal , Heinz-Josef Klümpen , Marcus W Dercksen , Gerlof D Valk , Martijn P Lolkema , Stefan Sleijfer , Bianca Mostert

A Phase I Trial of the Dual MET Kinase/OCT-2 Inhibitor OMO-1 in Metastatic Solid Malignancies Including MET Exon 14 Mutated Lung Cancer.

The oncologist
Avec: Melinda A Pruis , Matthew G Krebs , Ruth Plummer , Filip De Vos , Eric Angevin , Hans Prenen , Martin D Forster , Glen Clack , Annegret Van der Aa , Marc Tjwa , Ellen Jansen , Timothy Perera , Martijn P Lolkema

Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning.

Nature communications
Avec: Anouk C de Jong , Alexandra Danyi , Job van Riet , Ronald de Wit , Martin Sjöström , Felix Feng , Jeroen de Ridder , Martijn P Lolkema

Realizing better doctor-patient dialogue about choices in palliative care and early phase clinical trial participation: towards an online value clarification tool (OnVaCT).

BMC palliative care
Avec: Liza G G van Lent , Nicole K Stoel , Julia C M van Weert , Jelle van Gurp , Maja J A de Jonge , Martijn P Lolkema , Eelke H Gort , Saskia M Pulleman , Esther Oomen-de Hoop , Jeroen Hasselaar , Carin C D van der Rijt

Fundamentals of liquid biopsies in metastatic prostate cancer: from characterization to stratification.

Current opinion in oncology
Avec: Lisanne F van Dessel , John W M Martens , Martijn P Lolkema

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).

Investigational new drugs
Avec: Ruud van der Noll , Agnes Jager , Joo Ern Ang , Serena Marchetti , Marja W J Mergui-Roelvink , Martijn P Lolkema , Maja J A de Jonge , Diane A van der Biessen , Andre T Brunetto , Hendrik-Tobias Arkenau , Ilian Tchakov , Jos H Beijnen , Johann S de Bono , Jan H M Schellens

[Genetic testing in patients with cancer; new developments].

Nederlands tijdschrift voor geneeskunde
Avec: Margreet G E M Ausems , Jan C Oosterwijk , Maartje Nielsen , Martijn P Lolkema , Nicoline Hoogerbrugge , Marjolijn J L Ligtenberg

Optimizing Nanopore sequencing-based detection of structural variants enables individualized circulating tumor DNA-based disease monitoring in cancer patients.

Genome medicine
Avec: Jose Espejo Valle-Inclan , Christina Stangl , Anouk C de Jong , Lisanne F van Dessel , Markus J van Roosmalen , Jean C A Helmijr , Ivo Renkens , Roel Janssen , Sam de Blank , Chris J de Witte , John W M Martens , Maurice P H M Jansen , Martijn P Lolkema , Wigard P Kloosterman

Circulating

Therapeutic advances in medical oncology
Avec: Fleur van der Sijde , Zakia Azmani , Marc G Besselink , Bert A Bonsing , Jan Willem B de Groot , Bas Groot Koerkamp , Brigitte C M Haberkorn , Marjolein Y V Homs , Wilfred F J van IJcken , Quisette P Janssen , Martijn P Lolkema , Saskia A C Luelmo , Leonie J M Mekenkamp , Dana A M Mustafa , Ron H N van Schaik , Johanna W Wilmink , Eveline E Vietsch , Casper H J van Eijck

A blood-based immune marker for resistance to pembrolizumab in patients with metastatic urothelial cancer.

Cancer immunology, immunotherapy : CII
Avec: Maud Rijnders , Debbie G J Robbrecht , Astrid A M Oostvogels , Mandy van Brakel , Joost L Boormans , Maureen J B Aarts , Hayri E Balcioglu , Paul Hamberg , Jens Voortman , Hans M Westgeest , Martijn P Lolkema , Ronald de Wit , Astrid A M van der Veldt , Reno Debets

Characterizing Circulating Tumor Cells and Tumor-Derived Extracellular Vesicles in Metastatic Castration-Naive and Castration-Resistant Prostate Cancer Patients.

Cancers
Avec: Khrystany T Isebia , Eshwari Dathathri , Noortje Verschoor , Afroditi Nanou , Anouk C De Jong , Frank A W Coumans , Leon W M M Terstappen , Jaco Kraan , John W M Martens , Ruchi Bansal , Martijn P Lolkema

A Compendium of AR Splice Variants in Metastatic Castration-Resistant Prostate Cancer.

International journal of molecular sciences
Avec: Khrystany T Isebia , Martijn P Lolkema , Guido Jenster , Ronald de Wit , John W M Martens , Job van Riet

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

Nature communications
Avec: Lisanne F van Dessel , Job van Riet , Minke Smits , Yanyun Zhu , Paul Hamberg , Michiel S van der Heijden , Andries M Bergman , Inge M van Oort , Ronald de Wit , Emile E Voest , Neeltje Steeghs , Takafumi N Yamaguchi , Julie Livingstone , Paul C Boutros , John W M Martens , Stefan Sleijfer , Edwin Cuppen , Wilbert Zwart , Harmen J G van de Werken , Niven Mehra , Martijn P Lolkema

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).

Investigational new drugs
Avec: Ruud van der Noll , Agnes Jager , Joo Ern Ang , Serena Marchetti , Marja W J Mergui-Roelvink , Johann S de Bono , Martijn P Lolkema , Maja J A de Jonge , Diane A van der Biessen , Andre T Brunetto , Hendrik-Tobias Arkenau , Ilian Tchakov , Jos H Beijnen , Jacques De Grève , Jan H M Schellens

Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations.

The oncologist
Avec: Aditya Bardia , Mrinal Gounder , Jordi Rodon , Filip Janku , Martijn P Lolkema , Joe J Stephenson , Philippe L Bedard , Martin Schuler , Cristiana Sessa , Patricia LoRusso , Michael Thomas , Heiko Maacke , Helen Evans , Yongjian Sun , Daniel S W Tan

Continued androgen signalling inhibition improves cabazitaxel efficacy in prostate cancer.

EBioMedicine
Avec: Lisanne Mout , Martin E van Royen , Corrina de Ridder , Debra Stuurman , Wesley S van de Geer , Rute Marques , Stefan A J Buck , Pim J French , Harmen J G van de Werken , Ron H J Mathijssen , Ronald de Wit , Martijn P Lolkema , Wytske M van Weerden

Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.

British journal of cancer
Avec: Lisanne Mout , Jan M Moll , Mingqing Chen , Eleonora S de Morrée , Corrina M A de Ridder , Alice Gibson , Debra Stuurman , Ashraf Aghai , Sigrun Erkens-Schulze , Ron H J Mathijssen , Alex Sparreboom , Ronald de Wit , Martijn P Lolkema , Wytske M van Weerden

Decisional Conflict after Deciding on Potential Participation in Early Phase Clinical Cancer Trials: Dependent on Global Health Status, Satisfaction with Communication, and Timing.

Cancers
Avec: Liza G G van Lent , Maja J A de Jonge , Mirte van der Ham , Marjolein van Mil , Eelke H Gort , Jeroen Hasselaar , Esther Oomen-de Hoop , Carin C D van der Rijt , Julia C M van Weert , Martijn P Lolkema

Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing.

British journal of cancer
Avec: Melinda A Pruis , Floris H Groenendijk , K Sangeeta Badloe , Andrea van Puffelen , Debbie Robbrecht , Winand N M Dinjens , Stefan Sleijfer , Anne-Marie C Dingemans , Jan H von der Thüsen , Paul Roepman , Martijn P Lolkema

A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.

The oncologist
Avec: Hui K Gan , Michael Millward , Mathilde Jalving , Ignacio Garrido-Laguna , Jason D Lickliter , Jan H M Schellens , Martijn P Lolkema , Carla L M Van Herpen , Bruce Hug , Lihua Tang , Robin O'Connor-Semmes , Robert Gagnon , Catherine Ellis , Gopinath Ganji , Christopher Matheny , Alexander Drilon

CABA-V7: a prospective biomarker selected trial of cabazitaxel treatment in AR-V7 positive prostate cancer patients.

European journal of cancer (Oxford, England : 1990)
Avec: Khrystany T Isebia , Bianca Mostert , Bodine P S Belderbos , Stefan A J Buck , Jean C A Helmijr , Jaco Kraan , Corine M Beaufort , Mai N Van , Esther Oomen-de Hoop , Anieta M Sieuwerts , Wilfred F J van IJcken , Mirjam C G N van den Hout-van Vroonhoven , Rutger W W Brouwer , Edwin Oole , Paul Hamberg , Brigitte C M Haberkorn , Helgi H Helgason , Ronald de Wit , Stefan Sleijfer , Ron H J Mathijssen , John W M Martens , Maurice P H M Jansen , Job van Riet , Martijn P Lolkema

Streamlining clinical research: an ESMO awareness call to improve sponsoring and monitoring of clinical trials.

Annals of oncology : official journal of the European Society for Medical Oncology
Avec: J L Perez-Gracia , N Penel , E Calvo , A Awada , H T Arkenau , T Amaral , V Grünwald , M F Sanmamed , L Castelo-Branco , G Bodoky , M P Lolkema , M Di Nicola , P Casali , R Giuliani , G Pentheroudakis

Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer: protocol for a phase I, open-label, single-arm, dose-escalation study (REACtiVe-2 trial).

BMJ open
Avec: Sai Ping Lau , Freek R van 't Land , Sjoerd H van der Burg , Marjolein Y V Homs , Martijn P Lolkema , Joachim G J V Aerts , Casper H J van Eijck

A phase I study of ATR inhibitor gartisertib (M4344) as a single agent and in combination with carboplatin in patients with advanced solid tumours.

British journal of cancer
Avec: Howard A Burris , Jordan Berlin , Tobias Arkenau , Gregory M Cote , Martijn P Lolkema , Jordi Ferrer-Playan , Anup Kalapur , Jayaprakasam Bolleddula , Giuseppe Locatelli , Thomas Goddemeier , Ioannis Gounaris , Johann de Bono

Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.

Frontiers in immunology
Avec: Mark A Kroenke , Marta Starcevic Manning , Christina L Zuch de Zafra , Xinwen Zhang , Kevin D Cook , Michael Archer , Martijn P Lolkema , Jin Wang , Sarah Hoofring , Gurleen Saini , Famke Aeffner , Elizabeth Ahern , Elena Garralda Cabanas , Ramaswamy Govindan , Mun Hui , Shalini Gupta , Daniel T Mytych

Validation of circulating steroid hormone measurements across different matrices by liquid chromatography-tandem mass spectrometry.

Steroids
Avec: Gido Snaterse , Lisanne F van Dessel , Angela E Taylor , Jenny A Visser , Wiebke Arlt , Martijn P Lolkema , Johannes Hofland

Ceritinib plus Nivolumab in Patients with Advanced ALK-Rearranged Non-Small Cell Lung Cancer: Results of an Open-Label, Multicenter, Phase 1B Study.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Avec: Enriqueta Felip , Filippo G de Braud , Michela Maur , Herbert H Loong , Alice Tsang Shaw , Johan F Vansteenkiste , Thomas John , Geoffrey Liu , Martijn P Lolkema , Giovanni Selvaggi , Vanessa Giannone , Pilar Cazorla , Jason Baum , O Alejandro Balbin , Luojun Victor Wang , Yvonne Y Lau , Jeffrey W Scott , Daniel Shao-Weng Tan

Oligometastatic Prostate Cancer: Results of a Dutch Multidisciplinary Consensus Meeting.

European urology oncology
Avec: Shafak S Aluwini , Niven Mehra , Martijn P Lolkema , Daniela E Oprea-Lager , Derya Yakar , Herman Stoevelaar , Henk van der Poel , Auteur inconnu , Martijn Busstra , Igle-Jan de Jong , Theo de Reijke , Kim de Vries , Stijn Heijmink , Guido Jenster , Sjoerd Klaver , Jeroen Kneppers , Jules Lavalaye , Gisèle Leyten , Luc Moonen , James Nagaraj , Walter Noordzij , Susanne Osanto , Irma Oving , Eva Schaake , Tom Scheenen , Ivo Schoots , Michiel Sedelaar , Diederik Somford , Franchette van den Berkmortel , Tom van der Hulle , Jochem van der Voort van Zyp , Pim van Leeuwen , Jeroen van Moorselaar , Inge van Oort , Wouter Vogel , Hans Westgeest

Associations between AR-V7 status in circulating tumour cells, circulating tumour cell count and survival in men with metastatic castration-resistant prostate cancer.

European journal of cancer (Oxford, England : 1990)
Avec: Bodine P S Belderbos , Anieta M Sieuwerts , Esther Oomen-de Hoop , Bianca Mostert , Jaco Kraan , Paul Hamberg , Mai N Van , Corine M Beaufort , Wendy Onstenk , Robert J van Soest , John Martens , Stefan Sleijfer , Ronald de Wit , Ron H J Mathijssen , Martijn P Lolkema

Circulating Tumor Cell Enumeration and Characterization in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Cabazitaxel.

Cancers
Avec: Ingeborg E de Kruijff , Anieta M Sieuwerts , Wendy Onstenk , Jaco Kraan , Marcel Smid , Mai N Van , Michelle van der Vlugt-Daane , Esther Oomen-de Hoop , Ron H J Mathijssen , Martijn P Lolkema , Ronald de Wit , Paul Hamberg , Hielke J Meulenbeld , Aart Beeker , Geert-Jan Creemers , John W M Martens , Stefan Sleijfer

Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520.

Targeted oncology
Avec: Remy B Verheijen , Diane A J van der Biessen , Sebastien J Hotte , Lillian L Siu , Anna Spreafico , Maja J A de Jonge , Linda C Pronk , Filip Y F L De Vos , David Schnell , Hal W Hirte , Neeltje Steeghs , Martijn P Lolkema

High-throughput isolation of circulating tumor DNA: a comparison of automated platforms.

Molecular oncology
Avec: Lisanne F van Dessel , Silvia R Vitale , Jean C A Helmijr , Saskia M Wilting , Michelle van der Vlugt-Daane , Esther Oomen-de Hoop , Stefan Sleijfer , John W M Martens , Maurice P H M Jansen , Martijn P Lolkema

Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.

Lung cancer (Amsterdam, Netherlands)
Avec: M A Pruis , W R R Geurts-Giele , Thüsen J H von der , I C Meijssen , W N M Dinjens , J G J V Aerts , A M C Dingemans , M P Lolkema , M S Paats , H J Dubbink

Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Florence Atrafi , Ruben A G van Eerden , Marte A M van Hylckama Vlieg , Esther Oomen-de Hoop , Peter de Bruijn , Martijn P Lolkema , Adriaan Moelker , Cristianne J Rijcken , Rob Hanssen , Alex Sparreboom , Ferry A L M Eskens , Ron H J Mathijssen , Stijn L W Koolen

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Avec: Anouk C de Jong , Minke Smits , Job van Riet , Jurgen J Fütterer , Tessa Brabander , Paul Hamberg , Inge M van Oort , Ronald de Wit , Martijn P Lolkema , Niven Mehra , Marcel Segbers , Astrid A M van der Veldt

Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634.

Cancers
Avec: Florence Atrafi , Ruben A G van Eerden , Stijn L W Koolen , Peter de Bruijn , Cristianne J F Rijcken , Rob Hanssen , Ferry A L M Eskens , Martijn P Lolkema , Esther Oomen-de Hoop , Jeffrey Damman , Ron H J Mathijssen

Identifying patient values impacting the decision whether to participate in early phase clinical cancer trials: A systematic review.

Cancer treatment reviews
Avec: Liza G G van Lent , Lea J Jabbarian , Jelle van Gurp , Jeroen Hasselaar , Martijn P Lolkema , Julia C M van Weert , Carin C D van der Rijt , Maja J A de Jonge

Liquid Biopsy Based Circulating Biomarkers in Metastatic Prostate Cancer.

Frontiers in oncology
Avec: Eshwari Dathathri , Khrystany T Isebia , Fikri Abali , Martijn P Lolkema , John W M Martens , Leon W M M Terstappen , Ruchi Bansal

Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling.

Cancers
Avec: Lindsay Angus , Marcel Smid , Saskia M Wilting , Manouk K Bos , Neeltje Steeghs , Inge R H M Konings , Vivianne C G Tjan-Heijnen , Johanna M G H van Riel , Agnes J van de Wouw , Cpct Consortium , Edwin Cuppen , Martijn P Lolkema , Agnes Jager , Stefan Sleijfer , John W M Martens

Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer.

Nature communications
Avec: Maud Rijnders , J Alberto Nakauma-González , Debbie G J Robbrecht , Alberto Gil-Jimenez , Hayri E Balcioglu , Astrid A M Oostvogels , Maureen J B Aarts , Joost L Boormans , Paul Hamberg , Michiel S van der Heijden , Bernadett E Szabados , Geert J L H van Leenders , Niven Mehra , Jens Voortman , Hans M Westgeest , Ronald de Wit , Astrid A M van der Veldt , Reno Debets , Martijn P Lolkema

Preferences to receive unsolicited findings of germline genome sequencing in a large population of patients with cancer.

ESMO open
Avec: Rhode Bijlsma , Roel Wouters , Hester Wessels , Stefan Sleijfer , Laurens Beerepoot , Daan Ten Bokkel Huinink , Hester Cruijsen , Joan Heijns , Martijn P Lolkema , Neeltje Steeghs , Theo van Voorthuizen , Annelie Vulink , Els Witteveen , Margreet Ausems , Annelien Bredenoord , Anne M May , Emile Voest

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.

Nature communications
Avec: Wei Jiao , Gurnit Atwal , Paz Polak , Rosa Karlic , Edwin Cuppen , Auteur inconnu , Alexandra Danyi , Jeroen de Ridder , Carla van Herpen , Martijn P Lolkema , Neeltje Steeghs , Gad Getz , Quaid D Morris , Lincoln D Stein , Auteur inconnu

The mutational footprints of cancer therapies.

Nature genetics
Avec: Oriol Pich , Ferran Muiños , Martijn Paul Lolkema , Neeltje Steeghs , Abel Gonzalez-Perez , Nuria Lopez-Bigas

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

Nature genetics
Avec: Lindsay Angus , Marcel Smid , Saskia M Wilting , Job van Riet , Arne Van Hoeck , Luan Nguyen , Serena Nik-Zainal , Tessa G Steenbruggen , Vivianne C G Tjan-Heijnen , Mariette Labots , Johanna M G H van Riel , Haiko J Bloemendal , Neeltje Steeghs , Martijn P Lolkema , Emile E Voest , Harmen J G van de Werken , Agnes Jager , Edwin Cuppen , Stefan Sleijfer , John W M Martens

Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature
Avec: Peter Priestley , Jonathan Baber , Martijn P Lolkema , Neeltje Steeghs , Ewart de Bruijn , Charles Shale , Korneel Duyvesteyn , Susan Haidari , Arne van Hoeck , Wendy Onstenk , Paul Roepman , Mircea Voda , Haiko J Bloemendal , Vivianne C G Tjan-Heijnen , Carla M L van Herpen , Mariette Labots , Petronella O Witteveen , Egbert F Smit , Stefan Sleijfer , Emile E Voest , Edwin Cuppen

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies.

Targeted oncology
Avec: Maja J A de Jonge , Neeltje Steeghs , Martijn P Lolkema , Sebastien J Hotte , Hal W Hirte , Diane A J van der Biessen , Albiruni R Abdul Razak , Filip Y F L De Vos , Remy B Verheijen , David Schnell , Linda C Pronk , Monique Jansen , Lillian L Siu

Effects of prednisone on docetaxel pharmacokinetics in men with metastatic prostate cancer: A randomized drug-drug interaction study.

British journal of clinical pharmacology
Avec: Bodine P S Belderbos , Koen G A M Hussaarts , Leonie J van Harten , Esther Oomen-de Hoop , Peter de Bruijn , Paul Hamberg , Robbert J van Alphen , Brigitte C M Haberkorn , Martijn P Lolkema , Ronald de Wit , Robert J van Soest , Ron H J Mathijssen

A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Florence Atrafi , Harry J M Groen , Lauren A Byers , Elena Garralda , Martijn P Lolkema , Randeep S Sangha , Santiago Viteri , Young Kwang Chae , D Ross Camidge , Nashat Y Gabrail , Beibei Hu , Tian Tian , Silpa Nuthalapati , Elizabeth Hoening , Lei He , Philip Komarnitsky , Antonio Calles

Effects of Protein and Calorie Restriction on the Metabolism and Toxicity Profile of Irinotecan in Cancer Patients.

Clinical pharmacology and therapeutics
Avec: Femke M de Man , Ruben A G van Eerden , Gerdien M van Doorn , Esther Oomen-de Hoop , Stijn L W Koolen , Joanne F Olieman , Peter de Bruijn , Joris N Veraart , Henk K van Halteren , Yorick Sandberg , Adriaan Moelker , Jan N M IJzermans , Martijn P Lolkema , Teun van Gelder , Martijn E T Dollé , Ron W F de Bruin , Ron H J Mathijssen

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features.

Nature communications
Avec: Pauline A J Mendelaar , Marcel Smid , Job van Riet , Lindsay Angus , Mariette Labots , Neeltje Steeghs , Mathijs P Hendriks , Geert A Cirkel , Johan M van Rooijen , Albert J Ten Tije , Martijn P Lolkema , Edwin Cuppen , Stefan Sleijfer , John W M Martens , Saskia M Wilting

Anti-PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Maud Rijnders , Hayri E Balcioglu , Debbie G J Robbrecht , Astrid A M Oostvogels , Rebecca Wijers , Maureen J B Aarts , Paul Hamberg , Geert J L H van Leenders , J Alberto Nakauma-González , Jens Voortman , Hans M Westgeest , Joost L Boormans , Ronald de Wit , Martijn P Lolkema , Astrid A M van der Veldt , Reno Debets

11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration.

JCI insight
Avec: Gido Snaterse , Lisanne F van Dessel , Job van Riet , Angela E Taylor , Michelle van der Vlugt-Daane , Paul Hamberg , Ronald de Wit , Jenny A Visser , Wiebke Arlt , Martijn P Lolkema , Johannes Hofland

Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

Nature medicine
Avec: Joris van de Haar , Louisa R Hoes , Paul Roepman , Martijn P Lolkema , Henk M W Verheul , Hans Gelderblom , Adrianus J de Langen , Egbert F Smit , Edwin Cuppen , Lodewyk F A Wessels , Emile E Voest

Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Louisa R Hoes , Jade M van Berge Henegouwen , Hanneke van der Wijngaart , Laurien J Zeverijn , Daphne L van der Velden , Joris van de Haar , Paul Roepman , Wendy J de Leng , Anne M L Jansen , Erik van Werkhoven , Vincent van der Noort , Alwin D R Huitema , Eelke H Gort , Jan Willem B de Groot , Emile D Kerver , Derk Jan de Groot , Frans Erdkamp , Laurens V Beerepoot , Mathijs P Hendriks , Egbert F Smit , Winette T A van der Graaf , Carla M L van Herpen , Mariette Labots , Ann Hoeben , Hans Morreau , Martijn P Lolkema , Edwin Cuppen , Hans Gelderblom , Henk M W Verheul , Emile E Voest

mFast-SeqS-based aneuploidy score in circulating cell-free DNA is a prognostic biomarker in prostate cancer.

Molecular oncology
Avec: Khrystany T Isebia , Bianca Mostert , Teoman Deger , Jaco Kraan , Vanja de Weerd , Esther Oomen-de Hoop , Paul Hamberg , Brigitte C M Haberkorn , Helgi H Helgason , Ronald de Wit , Ron H J Mathijssen , Martijn P Lolkema , Saskia M Wilting , Job van Riet , John W M Martens

The genomic and transcriptomic landscape of advanced renal cell cancer for individualized treatment strategies.

Scientific reports
Avec: K de Joode , W S van de Geer , G J L H van Leenders , P Hamberg , H M Westgeest , A Beeker , S F Oosting , J M van Rooijen , L V Beerepoot , M Labots , R H J Mathijssen , M P Lolkema , E Cuppen , S Sleijfer , H J G van de Werken , A A M van der Veldt

Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.

Frontiers in immunology
Avec: Mark A Kroenke , Marta Starcevic Manning , Christina L Zuch de Zafra , Xinwen Zhang , Kevin D Cook , Michael Archer , Martijn P Lolkema , Jin Wang , Sarah Hoofring , Gurleen Saini , Famke Aeffner , Elizabeth Ahern , Elena Garralda Cabanas , Ramaswamy Govindan , Mun Hui , Shalini Gupta , Daniel T Mytych

Liquid Biopsies for Early Response Evaluation of Radium-223 in Metastatic Prostate Cancer.

JCO precision oncology
Avec: Anouk C de Jong , Khrystany T Isebia , Sui Wai Ling , Vanja de Weerd , Ngoc M Van , Jaco Kraan , John W M Martens , Niven Mehra , Paul Hamberg , Martijn P Lolkema , Ronald de Wit , Astrid A M van der Veldt , Saskia M Wilting

A phase 1 study of acapatamab, a half-life extended, PSMA-targeting bispecific T-cell engager for metastatic castration-resistant prostate cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Tanya Dorff , Lisa G Horvath , Karen Autio , Alice Bernard-Tessier , Matthew B Rettig , Jean-Pascal Machiels , Mehmet A Bilen , Martijn P Lolkema , Nabil Adra , Sylvie Rottey , Richard Greil , Nobuaki Matsubara , Daniel S W Tan , Alvin Wong , Hiroji Uemura , Charlotte Lemech , Johannes Meran , Youfei Yu , Mukul Minocha , Mason McComb , Hweixian Leong Penny , Vinita Gupta , Xuguang Hu , Gabor Jurida , Hosein Kouros-Mehr , Margit M Janát-Amsbury , Tobias Eggert , Ben Tran

Réseau de co-auteurs

Martijn P Lolkema 60 collaborations
Ronald de Wit 17 collaborations
John W M Martens 15 collaborations
Stefan Sleijfer 13 collaborations
Paul Hamberg 13 collaborations
Ron H J Mathijssen 11 collaborations
Job van Riet 11 collaborations
Esther Oomen-de Hoop 11 collaborations
Neeltje Steeghs 10 collaborations
Edwin Cuppen 9 collaborations
Lisanne F van Dessel 7 collaborations
Jaco Kraan 7 collaborations
Maja J A de Jonge 7 collaborations
Khrystany T Isebia 6 collaborations
Saskia M Wilting 6 collaborations
Anouk C de Jong 5 collaborations
Harmen J G van de Werken 5 collaborations
Astrid A M van der Veldt 5 collaborations
Emile E Voest 5 collaborations
Niven Mehra 5 collaborations
Florence Atrafi 4 collaborations
Anieta M Sieuwerts 4 collaborations
Bianca Mostert 4 collaborations
Agnes Jager 4 collaborations
Brigitte C M Haberkorn 4 collaborations
Paul Roepman 4 collaborations
Marcel Smid 4 collaborations
Peter de Bruijn 4 collaborations
Mariette Labots 4 collaborations
Hendrik-Tobias Arkenau 3 collaborations
Lisanne Mout 3 collaborations
Corine M Beaufort 3 collaborations
Wytske M van Weerden 3 collaborations
Ferry A L M Eskens 3 collaborations
Liza G G van Lent 3 collaborations
Julia C M van Weert 3 collaborations
Eelke H Gort 3 collaborations
Jeroen Hasselaar 3 collaborations
Carin C D van der Rijt 3 collaborations
Jan H M Schellens 3 collaborations
Jean C A Helmijr 3 collaborations
Maurice P H M Jansen 3 collaborations
Maud Rijnders 3 collaborations
Debbie G J Robbrecht 3 collaborations
Astrid A M Oostvogels 3 collaborations
Joost L Boormans 3 collaborations
Maureen J B Aarts 3 collaborations
Hayri E Balcioglu 3 collaborations
Jens Voortman 3 collaborations
Hans M Westgeest 3 collaborations
Reno Debets 3 collaborations
Bodine P S Belderbos 3 collaborations
Mai N Van 3 collaborations
None None 3 collaborations
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Michelle van der Vlugt-Daane 3 collaborations
Ruben A G van Eerden 3 collaborations
Stijn L W Koolen 3 collaborations
Lindsay Angus 3 collaborations
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Yorick Sandberg 2 collaborations
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Ruud van der Noll 2 collaborations
Joo Ern Ang 2 collaborations
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Marja W J Mergui-Roelvink 2 collaborations
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Ilian Tchakov 2 collaborations
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Leon W M M Terstappen 2 collaborations
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Daniel S W Tan 2 collaborations
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Alex Sparreboom 2 collaborations
Helgi H Helgason 2 collaborations
Mark A Kroenke 2 collaborations
Marta Starcevic Manning 2 collaborations
Christina L Zuch de Zafra 2 collaborations
Xinwen Zhang 2 collaborations
Kevin D Cook 2 collaborations
Michael Archer 2 collaborations
Jin Wang 2 collaborations
Sarah Hoofring 2 collaborations
Gurleen Saini 2 collaborations
Famke Aeffner 2 collaborations
Elizabeth Ahern 2 collaborations
Elena Garralda Cabanas 2 collaborations
Ramaswamy Govindan 2 collaborations
Mun Hui 2 collaborations
Shalini Gupta 2 collaborations
Daniel T Mytych 2 collaborations
Gido Snaterse 2 collaborations
Angela E Taylor 2 collaborations
Jenny A Visser 2 collaborations
Wiebke Arlt 2 collaborations
Johannes Hofland 2 collaborations
Robert J van Soest 2 collaborations
Remy B Verheijen 2 collaborations
Diane A J van der Biessen 2 collaborations
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Lillian L Siu 2 collaborations
Linda C Pronk 2 collaborations
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Rob Hanssen 2 collaborations
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Geert J L H van Leenders 2 collaborations
Haiko J Bloemendal 2 collaborations
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