Mark R Cookson

Affiliations

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

Publications (24)

Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.

Glia

Avec: Alice Filippini , Veronica Mutti , Gaia Faustini , Francesca Longhena , Ileana Ramazzina , Federica Rizzi , Alice Kaganovich , Dorien A Roosen , Natalie Landeck , Megan Duffy , Isabella Tessari , Federica Bono , Chiara Fiorentini , Elisa Greggio , Luigi Bubacco , Arianna Bellucci , Mariacristina Missale , Mark R Cookson , Massimo Gennarelli , Isabella Russo

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.

Neuron

Avec: Daniel M Ramos , William C Skarnes , Andrew B Singleton , Mark R Cookson , Michael E Ward

Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.

Molecular neurodegeneration

Avec: Jillian H Kluss , Melissa Conti Mazza , Yan Li , Claudia Manzoni , Patrick A Lewis , Mark R Cookson , Adamantios Mamais

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.

Cell reports

Avec: Alexandra Beilina , Luis Bonet-Ponce , Ravindran Kumaran , Jennifer J Kordich , Morié Ishida , Adamantios Mamais , Alice Kaganovich , Sara Saez-Atienzar , David C Gershlick , Dorien A Roosen , Laura Pellegrini , Vlad Malkov , Matthew J Fell , Kirsten Harvey , Juan S Bonifacino , Darren J Moore , Mark R Cookson

Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation.

Stem cell research

Avec: Melissa Conti Mazza , Alexandra Beilina , Dorien A Roosen , David Hauser , Mark R Cookson

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.

Movement disorders : official journal of the Movement Disorder Society

Avec: Julie Lake , Xylena Reed , Rebekah G Langston , Mike A Nalls , Ziv Gan-Or , Mark R Cookson , Andrew B Singleton , Cornelis Blauwendraat , Hampton L Leonard , Auteur inconnu

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.

Journal of Parkinson's disease

Avec: Belén Fernández , Vinita G Chittoor-Vinod , Jillian H Kluss , Kaela Kelly , Nicole Bryant , An Phu Tran Nguyen , Syed A Bukhari , Nathan Smith , Antonio Jesús Lara Ordóñez , Elena Fdez , Marie-Christine Chartier-Harlin , Thomas J Montine , Mark A Wilson , Darren J Moore , Andrew B West , Mark R Cookson , R Jeremy Nichols , Sabine Hilfiker

LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease.

NPJ Parkinson's disease

Avec: Maria Kedariti , Emanuele Frattini , Pascale Baden , Susanna Cogo , Laura Civiero , Elena Ziviani , Gianluca Zilio , Federico Bertoli , Massimo Aureli , Alice Kaganovich , Mark R Cookson , Leonidas Stefanis , Matthew Surface , Michela Deleidi , Alessio Di Fonzo , Roy N Alcalay , Hardy Rideout , Elisa Greggio , Nicoletta Plotegher

Association of a common genetic variant with Parkinson's disease is mediated by microglia.

Science translational medicine

Avec: Rebekah G Langston , Alexandra Beilina , Xylena Reed , Alice Kaganovich , Andrew B Singleton , Cornelis Blauwendraat , J Raphael Gibbs , Mark R Cookson

How Parkinson's Disease-Linked LRRK2 Mutations Affect Different CNS Cell Types.

Journal of Parkinson's disease

Avec: Hannah M Bailey , Mark R Cookson

Brain responses to intermittent fasting and the healthy living diet in older adults.

Cell metabolism

Avec: Dimitrios Kapogiannis , Apostolos Manolopoulos , Roger Mullins , Konstantinos Avgerinos , Francheska Delgado-Peraza , Maja Mustapic , Carlos Nogueras-Ortiz , Pamela J Yao , Krishna A Pucha , Janet Brooks , Qinghua Chen , Shalaila S Haas , Ruiyang Ge , Lisa M Hartnell , Mark R Cookson , Josephine M Egan , Sophia Frangou , Mark P Mattson

Hallmarks of neurodegenerative diseases.

Cell

Avec: David M Wilson , Mark R Cookson , Ludo Van Den Bosch , Henrik Zetterberg , David M Holtzman , Ilse Dewachter

RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease.

Nature aging

Avec: David W Craig , Elizabeth Hutchins , Ivo Violich , Eric Alsop , J Raphael Gibbs , Shawn Levy , Madison Robison , Nripesh Prasad , Tatiana Foroud , Karen L Crawford , Arthur W Toga , Timothy G Whitsett , Seungchan Kim , Bradford Casey , Alyssa Reimer , Samantha J Hutten , Mark Frasier , Fabian Kern , Tobias Fehlman , Andreas Keller , Mark R Cookson , Kendall Van Keuren-Jensen , Auteur inconnu

Application of Aligned-UMAP to longitudinal biomedical studies.

Patterns (New York, N.Y.)

Avec: Anant Dadu , Vipul K Satone , Rachneet Kaur , Mathew J Koretsky , Hirotaka Iwaki , Yue A Qi , Daniel M Ramos , Brian Avants , Jacob Hesterman , Roger Gunn , Mark R Cookson , Michael E Ward , Andrew B Singleton , Roy H Campbell , Mike A Nalls , Faraz Faghri

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2.

Cells

Avec: Iqra Nazish , Adamantios Mamais , Anna Mallach , Conceicao Bettencourt , Alice Kaganovich , Thomas Warner , John Hardy , Patrick A Lewis , Jennifer Pocock , Mark R Cookson , Rina Bandopadhyay

Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling.

bioRxiv : the preprint server for biology

Avec: Mallory Ryan , Justin A McDonough , Michael E Ward , Mark R Cookson , William C Skarnes , Florian T Merkle

ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics.

bioRxiv : the preprint server for biology

Avec: Ziyi Li , Cory A Weller , Syed Shah , Nicholas Johnson , Ying Hao , Jessica Roberts , Colleen Bereda , Sydney Klaisner , Pedro Machado , Pietro Fratta , Leonard Petrucelli , Mercedes Prudencio , Björn Oskarsson , Nathan P Staff , Dennis W Dickson , Mark R Cookson , Michael E Ward , Andrew B Singleton , Mike A Nalls , Yue A Qi

Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease.

bioRxiv : the preprint server for biology

Avec: Liam Horan-Portelance , Michiyo Iba , Dominic J Acri , J Raphael Gibbs , Eliezer Masliah , Mark R Cookson

DNAJC proteins and pathways to parkinsonism.

The FEBS journal

Avec: Dorien A Roosen , Cornelis Blauwendraat , Mark R Cookson , Patrick A Lewis

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Cellular and molecular life sciences : CMLS

Avec: Amandine Rovini , Philip A Gurnev , Alexandra Beilina , María Queralt-Martín , William Rosencrans , Mark R Cookson , Sergey M Bezrukov , Tatiana K Rostovtseva

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.

Scientific reports

Avec: Scott C Vermilyea , Alexander Babinski , Nina Tran , Samantha To , Scott Guthrie , Jillian H Kluss , Jenna Kropp Schmidt , Gregory J Wiepz , Michael G Meyer , Megan E Murphy , Mark R Cookson , Marina E Emborg , Thaddeus G Golos

LRRK2 mediates tubulation and vesicle sorting from lysosomes.

Science advances

Avec: Luis Bonet-Ponce , Alexandra Beilina , Chad D Williamson , Eric Lindberg , Jillian H Kluss , Sara Saez-Atienzar , Natalie Landeck , Ravindran Kumaran , Adamantios Mamais , Christopher K E Bleck , Yan Li , Mark R Cookson

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.

Science advances

Avec: Sara Saez-Atienzar , Sara Bandres-Ciga , Rebekah G Langston , Jonggeol J Kim , Shing Wan Choi , Regina H Reynolds , Auteur inconnu , Auteur inconnu , Yevgeniya Abramzon , Ramita Dewan , Sarah Ahmed , John E Landers , Ruth Chia , Mina Ryten , Mark R Cookson , Michael A Nalls , Adriano Chiò , Bryan J Traynor

LRRK2 recruitment, activity, and function in organelles.

The FEBS journal

Avec: Luis Bonet-Ponce , Mark R Cookson

Réseau de co-auteurs

Alice Kaganovich 5 collaborations

Andrew B Singleton 5 collaborations

Alexandra Beilina 5 collaborations

Dorien A Roosen 4 collaborations

Michael E Ward 4 collaborations

Jillian H Kluss 4 collaborations

Adamantios Mamais 4 collaborations

None None 4 collaborations

Patrick A Lewis 3 collaborations

Luis Bonet-Ponce 3 collaborations

Sara Saez-Atienzar 3 collaborations

Rebekah G Langston 3 collaborations

Mike A Nalls 3 collaborations

Cornelis Blauwendraat 3 collaborations

J Raphael Gibbs 3 collaborations

Natalie Landeck 2 collaborations

Elisa Greggio 2 collaborations

Daniel M Ramos 2 collaborations

William C Skarnes 2 collaborations

Melissa Conti Mazza 2 collaborations

Yan Li 2 collaborations

Ravindran Kumaran 2 collaborations

Darren J Moore 2 collaborations

Xylena Reed 2 collaborations

Yue A Qi 2 collaborations

Alice Filippini 1 collaboration

Veronica Mutti 1 collaboration

Gaia Faustini 1 collaboration

Francesca Longhena 1 collaboration

Ileana Ramazzina 1 collaboration

Federica Rizzi 1 collaboration

Megan Duffy 1 collaboration

Isabella Tessari 1 collaboration

Federica Bono 1 collaboration

Chiara Fiorentini 1 collaboration

Luigi Bubacco 1 collaboration

Arianna Bellucci 1 collaboration

Mariacristina Missale 1 collaboration

Massimo Gennarelli 1 collaboration

Isabella Russo 1 collaboration

Claudia Manzoni 1 collaboration

Jennifer J Kordich 1 collaboration

Morié Ishida 1 collaboration

David C Gershlick 1 collaboration

Laura Pellegrini 1 collaboration

Vlad Malkov 1 collaboration

Matthew J Fell 1 collaboration

Kirsten Harvey 1 collaboration

Juan S Bonifacino 1 collaboration

David Hauser 1 collaboration

Julie Lake 1 collaboration

Ziv Gan-Or 1 collaboration

Hampton L Leonard 1 collaboration

Belén Fernández 1 collaboration

Vinita G Chittoor-Vinod 1 collaboration

Kaela Kelly 1 collaboration

Nicole Bryant 1 collaboration

An Phu Tran Nguyen 1 collaboration

Syed A Bukhari 1 collaboration

Nathan Smith 1 collaboration

Antonio Jesús Lara Ordóñez 1 collaboration

Elena Fdez 1 collaboration

Marie-Christine Chartier-Harlin 1 collaboration

Thomas J Montine 1 collaboration

Mark A Wilson 1 collaboration

Andrew B West 1 collaboration

R Jeremy Nichols 1 collaboration

Sabine Hilfiker 1 collaboration

Maria Kedariti 1 collaboration

Emanuele Frattini 1 collaboration

Pascale Baden 1 collaboration

Susanna Cogo 1 collaboration

Laura Civiero 1 collaboration

Elena Ziviani 1 collaboration

Gianluca Zilio 1 collaboration

Federico Bertoli 1 collaboration

Massimo Aureli 1 collaboration

Leonidas Stefanis 1 collaboration

Matthew Surface 1 collaboration

Michela Deleidi 1 collaboration

Alessio Di Fonzo 1 collaboration

Roy N Alcalay 1 collaboration

Hardy Rideout 1 collaboration

Nicoletta Plotegher 1 collaboration

Hannah M Bailey 1 collaboration

Dimitrios Kapogiannis 1 collaboration

Apostolos Manolopoulos 1 collaboration

Roger Mullins 1 collaboration

Konstantinos Avgerinos 1 collaboration

Francheska Delgado-Peraza 1 collaboration

Maja Mustapic 1 collaboration

Carlos Nogueras-Ortiz 1 collaboration

Pamela J Yao 1 collaboration

Krishna A Pucha 1 collaboration

Janet Brooks 1 collaboration

Qinghua Chen 1 collaboration

Shalaila S Haas 1 collaboration

Ruiyang Ge 1 collaboration

Lisa M Hartnell 1 collaboration

Josephine M Egan 1 collaboration

Sophia Frangou 1 collaboration

Mark P Mattson 1 collaboration

David M Wilson 1 collaboration

Ludo Van Den Bosch 1 collaboration

Henrik Zetterberg 1 collaboration

David M Holtzman 1 collaboration

Ilse Dewachter 1 collaboration

David W Craig 1 collaboration

Elizabeth Hutchins 1 collaboration

Ivo Violich 1 collaboration

Eric Alsop 1 collaboration

Shawn Levy 1 collaboration

Madison Robison 1 collaboration

Nripesh Prasad 1 collaboration

Tatiana Foroud 1 collaboration

Karen L Crawford 1 collaboration

Arthur W Toga 1 collaboration

Timothy G Whitsett 1 collaboration

Seungchan Kim 1 collaboration

Bradford Casey 1 collaboration

Alyssa Reimer 1 collaboration

Samantha J Hutten 1 collaboration

Mark Frasier 1 collaboration

Fabian Kern 1 collaboration

Tobias Fehlman 1 collaboration

Andreas Keller 1 collaboration

Kendall Van Keuren-Jensen 1 collaboration

Anant Dadu 1 collaboration

Vipul K Satone 1 collaboration

Rachneet Kaur 1 collaboration

Mathew J Koretsky 1 collaboration

Hirotaka Iwaki 1 collaboration

Brian Avants 1 collaboration

Jacob Hesterman 1 collaboration

Roger Gunn 1 collaboration

Roy H Campbell 1 collaboration

Faraz Faghri 1 collaboration

Iqra Nazish 1 collaboration

Anna Mallach 1 collaboration

Conceicao Bettencourt 1 collaboration

Thomas Warner 1 collaboration

John Hardy 1 collaboration

Jennifer Pocock 1 collaboration

Rina Bandopadhyay 1 collaboration

Mallory Ryan 1 collaboration

Justin A McDonough 1 collaboration

Florian T Merkle 1 collaboration

Ziyi Li 1 collaboration

Cory A Weller 1 collaboration

Syed Shah 1 collaboration

Nicholas Johnson 1 collaboration

Ying Hao 1 collaboration

Jessica Roberts 1 collaboration

Colleen Bereda 1 collaboration

Sydney Klaisner 1 collaboration

Pedro Machado 1 collaboration

Pietro Fratta 1 collaboration

Leonard Petrucelli 1 collaboration

Mercedes Prudencio 1 collaboration

Björn Oskarsson 1 collaboration

Nathan P Staff 1 collaboration

Dennis W Dickson 1 collaboration

Liam Horan-Portelance 1 collaboration

Michiyo Iba 1 collaboration

Dominic J Acri 1 collaboration

Eliezer Masliah 1 collaboration

Amandine Rovini 1 collaboration

Philip A Gurnev 1 collaboration

María Queralt-Martín 1 collaboration

William Rosencrans 1 collaboration

Sergey M Bezrukov 1 collaboration

Tatiana K Rostovtseva 1 collaboration

Scott C Vermilyea 1 collaboration

Alexander Babinski 1 collaboration

Nina Tran 1 collaboration

Samantha To 1 collaboration

Scott Guthrie 1 collaboration

Jenna Kropp Schmidt 1 collaboration

Gregory J Wiepz 1 collaboration

Michael G Meyer 1 collaboration

Megan E Murphy 1 collaboration

Marina E Emborg 1 collaboration

Thaddeus G Golos 1 collaboration

Chad D Williamson 1 collaboration

Eric Lindberg 1 collaboration

Christopher K E Bleck 1 collaboration

Sara Bandres-Ciga 1 collaboration

Jonggeol J Kim 1 collaboration

Shing Wan Choi 1 collaboration

Regina H Reynolds 1 collaboration

Yevgeniya Abramzon 1 collaboration

Ramita Dewan 1 collaboration

Sarah Ahmed 1 collaboration

John E Landers 1 collaboration

Ruth Chia 1 collaboration

Mina Ryten 1 collaboration

Michael A Nalls 1 collaboration

Adriano Chiò 1 collaboration

Bryan J Traynor 1 collaboration