Matthias Lesche

Affiliations

Center for Regenerative Therapies Dresden (CRTD), CMCB, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany.
DRESDEN-concept Genome Center, c/o Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany.

Publications (25)

Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.

Stem cells (Dayton, Ohio)

Avec: Ioannis Giannios , Ioannis Serafimidis , Vivian Anastasiou , Daniela Pezzolla , Mathias Lesche , Cordula Andree , Marc Bickle , Anthony Gavalas

SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.

Gut

Avec: Lea Južnić , Kenneth Peuker , Anne Strigli , Mario Brosch , Alexander Herrmann , Robert Häsler , Michael Koch , Liz Matthiesen , Yvonne Zeissig , Britt-Sabina Löscher , Alexander Nuber , Gunnar Schotta , Volker Neumeister , Triantafyllos Chavakis , Thomas Kurth , Mathias Lesche , Andreas Dahl , Anne von Mässenhausen , Andreas Linkermann , Stefan Schreiber , Konrad Aden , Philip C Rosenstiel , Andre Franke , Jochen Hampe , Sebastian Zeissig

MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis.

Development (Cambridge, England)

Avec: Martina Dori , Daniel Cavalli , Mathias Lesche , Simone Massalini , Leila Haj Abdullah Alieh , Beatriz Cardoso de Toledo , Sharof Khudayberdiev , Gerhard Schratt , Andreas Dahl , Federico Calegari

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus.

Nature communications

Avec: Sara Zocher , Rupert W Overall , Mathias Lesche , Andreas Dahl , Gerd Kempermann

A gene expression map of host immune response in human brucellosis.

Frontiers in immunology

Avec: Ioannis Mitroulis , Akrivi Chrysanthopoulou , Georgios Divolis , Charalampos Ioannidis , Maria Ntinopoulou , Athanasios Tasis , Theocharis Konstantinidis , Christina Antoniadou , Natalia Soteriou , George Lallas , Stella Mitka , Mathias Lesche , Andreas Dahl , Stephanie Gembardt , Maria Panopoulou , Paschalis Sideras , Ben Wielockx , Ünal Coskun , Konstantinos Ritis , Panagiotis Skendros

Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions.

eLife

Avec: Luka Jarc , Manuj Bandral , Elisa Zanfrini , Mathias Lesche , Vida Kufrin , Raquel Sendra , Daniela Pezzolla , Ioannis Giannios , Shahryar Khattak , Katrin Neumann , Barbara Ludwig , Anthony Gavalas

Lifelong persistence of nuclear RNAs in the mouse brain.

Science (New York, N.Y.)

Avec: Sara Zocher , Asako McCloskey , Anne Karasinsky , Roberta Schulte , Ulrike Friedrich , Mathias Lesche , Nicole Rund , Fred H Gage , Martin W Hetzer , Tomohisa Toda

Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Steven W Poser , Oliver Otto , Carina Arps-Forker , Yan Ge , Maik Herbig , Cordula Andree , Konrad Gruetzmann , Melissa F Adasme , Szymon Stodolak , Polyxeni Nikolakopoulou , Deric M Park , Alan Mcintyre , Mathias Lesche , Andreas Dahl , Petra Lennig , Stefan R Bornstein , Evelin Schroeck , Barbara Klink , Ronen R Leker , Marc Bickle , George P Chrousos , Michael Schroeder , Carlo Vittorio Cannistraci , Jochen Guck , Andreas Androutsellis-Theotokis

A switch in pdgfrb

Developmental cell

Avec: Vasiliki Tsata , Stephanie Möllmert , Christine Schweitzer , Julia Kolb , Conrad Möckel , Benjamin Böhm , Gonzalo Rosso , Christian Lange , Mathias Lesche , Juliane Hammer , Gokul Kesavan , Dimitris Beis , Jochen Guck , Michael Brand , Daniel Wehner

Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis.

Cancer research

Avec: Nicole Dressel , Loreen Natusch , Clara M Munz , Santiago Costas Ramon , Mina N F Morcos , Anja Loff , Björn Hiller , Christa Haase , Livia Schulze , Patrick Müller , Mathias Lesche , Andreas Dahl , Hella Luksch , Angela Rösen-Wolff , Axel Roers , Rayk Behrendt , Alexander Gerbaulet

BRAF and MEK inhibitor combinations induce potent molecular and immunological effects in NRAS-mutant melanoma cells: Insights into mode of action and resistance mechanisms.

International journal of cancer

Avec: Lisa Dinter , Paula C Karitzky , Alexander Schulz , Alexander A Wurm , Marie-Christin Mehnert , Mildred Sergon , Antje Tunger , Mathias Lesche , Rebekka Wehner , Anja Müller , Theresa Käubler , Heike Niessner , Andreas Dahl , Stefan Beissert , Marc Schmitz , Friedegund Meier , Barbara Seliger , Dana Westphal

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.

Cell

Avec: Lydia Kalafati , Ioannis Kourtzelis , Jonas Schulte-Schrepping , Xiaofei Li , Aikaterini Hatzioannou , Tatyana Grinenko , Eman Hagag , Anupam Sinha , Canan Has , Sevina Dietz , Antonio Miguel de Jesus Domingues , Marina Nati , Sundary Sormendi , Ales Neuwirth , Antonios Chatzigeorgiou , Athanasios Ziogas , Mathias Lesche , Andreas Dahl , Ian Henry , Pallavi Subramanian , Ben Wielockx , Peter Murray , Peter Mirtschink , Kyoung-Jin Chung , Joachim L Schultze , Mihai G Netea , George Hajishengallis , Panayotis Verginis , Ioannis Mitroulis , Triantafyllos Chavakis

Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis.

Life science alliance

Avec: Martina Dori , Leila Haj Abdullah Alieh , Daniel Cavalli , Simone Massalini , Mathias Lesche , Andreas Dahl , Federico Calegari

A smart polymer for sequence-selective binding, pulldown, and release of DNA targets.

Communications biology

Avec: Elisha Krieg , Krishna Gupta , Andreas Dahl , Mathias Lesche , Susanne Boye , Albena Lederer , William M Shih

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Nature metabolism

Avec: Leonore Wigger , Marko Barovic , Andreas-David Brunner , Flavia Marzetta , Eyke Schöniger , Florence Mehl , Nicole Kipke , Daniela Friedland , Frederic Burdet , Camille Kessler , Mathias Lesche , Bernard Thorens , Ezio Bonifacio , Cristina Legido-Quigley , Pierre Barbier Saint Hilaire , Philippe Delerive , Andreas Dahl , Christian Klose , Mathias J Gerl , Kai Simons , Daniela Aust , Jürgen Weitz , Marius Distler , Anke M Schulte , Matthias Mann , Mark Ibberson , Michele Solimena

Hoxb1 Regulates Distinct Signaling Pathways in Neuromesodermal and Hindbrain Progenitors to Promote Cell Survival and Specification.

Stem cells (Dayton, Ohio)

Avec: Kristijan Pazur , Ioannis Giannios , Mathias Lesche , Eva Rodriguez-Aznar , Anthony Gavalas

Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.

Biology open

Avec: Diana Ezhkova , Simone Schwarzer , Sandra Spieß , Michaela Geffarth , Anja Machate , Daniela Zöller , Johanna Stucke , Dimitra Alexopoulou , Mathias Lesche , Andreas Dahl , Stefan Hans

Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin.

iScience

Avec: Nicole Cudak , Alejandra Cristina López-Delgado , Fabian Rost , Thomas Kurth , Mathias Lesche , Susanne Reinhardt , Andreas Dahl , Steffen Rulands , Franziska Knopf

Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain.

Development (Cambridge, England)

Avec: Christian Lange , Fabian Rost , Anja Machate , Susanne Reinhardt , Matthias Lesche , Anke Weber , Veronika Kuscha , Andreas Dahl , Steffen Rulands , Michael Brand

Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Ekaterina Mameishvili , Ioannis Serafimidis , Sara Iwaszkiewicz , Mathias Lesche , Susanne Reinhardt , Nora Bölicke , Maren Büttner , Dimitris Stellas , Adriana Papadimitropoulou , Matthias Szabolcs , Konstantinos Anastassiadis , Andreas Dahl , Fabian Theis , Argiris Efstratiadis , Anthony Gavalas

Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage.

Pflugers Archiv : European journal of physiology

Avec: Anne Steglich , Friederike Kessel , Linda Hickmann , Michael Gerlach , Peter Lachmann , Florian Gembardt , Mathias Lesche , Andreas Dahl , Anna Federlein , Frank Schweda , Christian P M Hugo , Vladimir T Todorov

The RNA binding protein human antigen R is a gatekeeper of liver homeostasis.

Hepatology (Baltimore, Md.)

Avec: Pallavi Subramanian , Sofia Gargani , Alessandra Palladini , Margarita Chatzimike , Michal Grzybek , Mirko Peitzsch , Anastasios D Papanastasiou , Iryna Pyrina , Vasileios Ntafis , Bettina Gercken , Mathias Lesche , Andreas Petzold , Anupam Sinha , Marina Nati , Veera Raghavan Thangapandi , Ioannis Kourtzelis , Margarita Andreadou , Anke Witt , Andreas Dahl , Ralph Burkhardt , Robert Haase , António Miguel de Jesus Domingues , Ian Henry , Nicola Zamboni , Peter Mirtschink , Kyoung-Jin Chung , Jochen Hampe , Ünal Coskun , Dimitris L Kontoyiannis , Triantafyllos Chavakis

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.

Immunology

Avec: Julia Reinhardt , Virag Sharma , Antigoni Stavridou , Annett Lindner , Susanne Reinhardt , Andreas Petzold , Mathias Lesche , Fabian Rost , Ezio Bonifacio , Anne Eugster

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

Nature communications

Avec: Erik Klapproth , Anke Witt , Pauline Klose , Johanna Wiedemann , Nikitha Vavilthota , Stephan R Künzel , Susanne Kämmerer , Mario Günscht , David Sprott , Mathias Lesche , Fabian Rost , Andreas Dahl , Erik Rauch , Lars Kattner , Silvio Weber , Peter Mirtschink , Irakli Kopaliani , Kaomei Guan , Kristina Lorenz , Paul Saftig , Michael Wagner , Ali El-Armouche

Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeres.

Life science alliance

Avec: Uddipta Biswas , Tanaya Deb Mallik , Johannes Pschirer , Matthias Lesche , Katrin Sameith , Rolf Jessberger

Réseau de co-auteurs

Mathias Lesche 23 collaborations

Andreas Dahl 18 collaborations

Anthony Gavalas 4 collaborations

Fabian Rost 4 collaborations

Susanne Reinhardt 4 collaborations

Ioannis Giannios 3 collaborations

Triantafyllos Chavakis 3 collaborations

Peter Mirtschink 3 collaborations

Ioannis Serafimidis 2 collaborations

Daniela Pezzolla 2 collaborations

Cordula Andree 2 collaborations

Marc Bickle 2 collaborations

Thomas Kurth 2 collaborations

Jochen Hampe 2 collaborations

Martina Dori 2 collaborations

Daniel Cavalli 2 collaborations

Simone Massalini 2 collaborations

Leila Haj Abdullah Alieh 2 collaborations

Federico Calegari 2 collaborations

Sara Zocher 2 collaborations

Ioannis Mitroulis 2 collaborations

Ben Wielockx 2 collaborations

Ünal Coskun 2 collaborations

Jochen Guck 2 collaborations

Christian Lange 2 collaborations

Michael Brand 2 collaborations

Ioannis Kourtzelis 2 collaborations

Anupam Sinha 2 collaborations

Marina Nati 2 collaborations

Ian Henry 2 collaborations

Pallavi Subramanian 2 collaborations

Kyoung-Jin Chung 2 collaborations

Ezio Bonifacio 2 collaborations

Anja Machate 2 collaborations

Steffen Rulands 2 collaborations

Andreas Petzold 2 collaborations

Anke Witt 2 collaborations

Vivian Anastasiou 1 collaboration

Lea Južnić 1 collaboration

Kenneth Peuker 1 collaboration

Anne Strigli 1 collaboration

Mario Brosch 1 collaboration

Alexander Herrmann 1 collaboration

Robert Häsler 1 collaboration

Michael Koch 1 collaboration

Liz Matthiesen 1 collaboration

Yvonne Zeissig 1 collaboration

Britt-Sabina Löscher 1 collaboration

Alexander Nuber 1 collaboration

Gunnar Schotta 1 collaboration

Volker Neumeister 1 collaboration

Anne von Mässenhausen 1 collaboration

Andreas Linkermann 1 collaboration

Stefan Schreiber 1 collaboration

Konrad Aden 1 collaboration

Philip C Rosenstiel 1 collaboration

Andre Franke 1 collaboration

Sebastian Zeissig 1 collaboration

Beatriz Cardoso de Toledo 1 collaboration

Sharof Khudayberdiev 1 collaboration

Gerhard Schratt 1 collaboration

Rupert W Overall 1 collaboration

Gerd Kempermann 1 collaboration

Akrivi Chrysanthopoulou 1 collaboration

Georgios Divolis 1 collaboration

Charalampos Ioannidis 1 collaboration

Maria Ntinopoulou 1 collaboration

Athanasios Tasis 1 collaboration

Theocharis Konstantinidis 1 collaboration

Christina Antoniadou 1 collaboration

Natalia Soteriou 1 collaboration

George Lallas 1 collaboration

Stella Mitka 1 collaboration

Stephanie Gembardt 1 collaboration

Maria Panopoulou 1 collaboration

Paschalis Sideras 1 collaboration

Konstantinos Ritis 1 collaboration

Panagiotis Skendros 1 collaboration

Luka Jarc 1 collaboration

Manuj Bandral 1 collaboration

Elisa Zanfrini 1 collaboration

Vida Kufrin 1 collaboration

Raquel Sendra 1 collaboration

Shahryar Khattak 1 collaboration

Katrin Neumann 1 collaboration

Barbara Ludwig 1 collaboration

Asako McCloskey 1 collaboration

Anne Karasinsky 1 collaboration

Roberta Schulte 1 collaboration

Ulrike Friedrich 1 collaboration

Nicole Rund 1 collaboration

Fred H Gage 1 collaboration

Martin W Hetzer 1 collaboration

Tomohisa Toda 1 collaboration

Steven W Poser 1 collaboration

Oliver Otto 1 collaboration

Carina Arps-Forker 1 collaboration

Yan Ge 1 collaboration

Maik Herbig 1 collaboration

Konrad Gruetzmann 1 collaboration

Melissa F Adasme 1 collaboration

Szymon Stodolak 1 collaboration

Polyxeni Nikolakopoulou 1 collaboration

Deric M Park 1 collaboration

Alan Mcintyre 1 collaboration

Petra Lennig 1 collaboration

Stefan R Bornstein 1 collaboration

Evelin Schroeck 1 collaboration

Barbara Klink 1 collaboration

Ronen R Leker 1 collaboration

George P Chrousos 1 collaboration

Michael Schroeder 1 collaboration

Carlo Vittorio Cannistraci 1 collaboration

Andreas Androutsellis-Theotokis 1 collaboration

Vasiliki Tsata 1 collaboration

Stephanie Möllmert 1 collaboration

Christine Schweitzer 1 collaboration

Julia Kolb 1 collaboration

Conrad Möckel 1 collaboration

Benjamin Böhm 1 collaboration

Gonzalo Rosso 1 collaboration

Juliane Hammer 1 collaboration

Gokul Kesavan 1 collaboration

Dimitris Beis 1 collaboration

Daniel Wehner 1 collaboration

Nicole Dressel 1 collaboration

Loreen Natusch 1 collaboration

Clara M Munz 1 collaboration

Santiago Costas Ramon 1 collaboration

Mina N F Morcos 1 collaboration

Anja Loff 1 collaboration

Björn Hiller 1 collaboration

Christa Haase 1 collaboration

Livia Schulze 1 collaboration

Patrick Müller 1 collaboration

Hella Luksch 1 collaboration

Angela Rösen-Wolff 1 collaboration

Axel Roers 1 collaboration

Rayk Behrendt 1 collaboration

Alexander Gerbaulet 1 collaboration

Lisa Dinter 1 collaboration

Paula C Karitzky 1 collaboration

Alexander Schulz 1 collaboration

Alexander A Wurm 1 collaboration

Marie-Christin Mehnert 1 collaboration

Mildred Sergon 1 collaboration

Antje Tunger 1 collaboration

Rebekka Wehner 1 collaboration

Anja Müller 1 collaboration

Theresa Käubler 1 collaboration

Heike Niessner 1 collaboration

Stefan Beissert 1 collaboration

Marc Schmitz 1 collaboration

Friedegund Meier 1 collaboration

Barbara Seliger 1 collaboration

Dana Westphal 1 collaboration

Lydia Kalafati 1 collaboration

Jonas Schulte-Schrepping 1 collaboration

Xiaofei Li 1 collaboration

Aikaterini Hatzioannou 1 collaboration

Tatyana Grinenko 1 collaboration

Eman Hagag 1 collaboration

Canan Has 1 collaboration

Sevina Dietz 1 collaboration

Antonio Miguel de Jesus Domingues 1 collaboration

Sundary Sormendi 1 collaboration

Ales Neuwirth 1 collaboration

Antonios Chatzigeorgiou 1 collaboration

Athanasios Ziogas 1 collaboration

Peter Murray 1 collaboration

Joachim L Schultze 1 collaboration

Mihai G Netea 1 collaboration

George Hajishengallis 1 collaboration

Panayotis Verginis 1 collaboration

Elisha Krieg 1 collaboration

Krishna Gupta 1 collaboration

Susanne Boye 1 collaboration

Albena Lederer 1 collaboration

William M Shih 1 collaboration

Leonore Wigger 1 collaboration

Marko Barovic 1 collaboration

Andreas-David Brunner 1 collaboration

Flavia Marzetta 1 collaboration

Eyke Schöniger 1 collaboration

Florence Mehl 1 collaboration

Nicole Kipke 1 collaboration

Daniela Friedland 1 collaboration

Frederic Burdet 1 collaboration

Camille Kessler 1 collaboration

Bernard Thorens 1 collaboration

Cristina Legido-Quigley 1 collaboration

Pierre Barbier Saint Hilaire 1 collaboration

Philippe Delerive 1 collaboration

Christian Klose 1 collaboration

Mathias J Gerl 1 collaboration

Kai Simons 1 collaboration

Daniela Aust 1 collaboration

Jürgen Weitz 1 collaboration

Marius Distler 1 collaboration

Anke M Schulte 1 collaboration

Matthias Mann 1 collaboration

Mark Ibberson 1 collaboration

Michele Solimena 1 collaboration

Kristijan Pazur 1 collaboration

Eva Rodriguez-Aznar 1 collaboration

Diana Ezhkova 1 collaboration

Simone Schwarzer 1 collaboration

Sandra Spieß 1 collaboration

Michaela Geffarth 1 collaboration

Daniela Zöller 1 collaboration

Johanna Stucke 1 collaboration

Dimitra Alexopoulou 1 collaboration

Stefan Hans 1 collaboration

Nicole Cudak 1 collaboration

Alejandra Cristina López-Delgado 1 collaboration

Franziska Knopf 1 collaboration

Anke Weber 1 collaboration

Veronika Kuscha 1 collaboration

Ekaterina Mameishvili 1 collaboration

Sara Iwaszkiewicz 1 collaboration

Nora Bölicke 1 collaboration

Maren Büttner 1 collaboration

Dimitris Stellas 1 collaboration

Adriana Papadimitropoulou 1 collaboration

Matthias Szabolcs 1 collaboration

Konstantinos Anastassiadis 1 collaboration

Fabian Theis 1 collaboration

Argiris Efstratiadis 1 collaboration

Anne Steglich 1 collaboration

Friederike Kessel 1 collaboration

Linda Hickmann 1 collaboration

Michael Gerlach 1 collaboration

Peter Lachmann 1 collaboration

Florian Gembardt 1 collaboration

Anna Federlein 1 collaboration

Frank Schweda 1 collaboration

Christian P M Hugo 1 collaboration

Vladimir T Todorov 1 collaboration

Sofia Gargani 1 collaboration

Alessandra Palladini 1 collaboration

Margarita Chatzimike 1 collaboration

Michal Grzybek 1 collaboration

Mirko Peitzsch 1 collaboration

Anastasios D Papanastasiou 1 collaboration

Iryna Pyrina 1 collaboration

Vasileios Ntafis 1 collaboration

Bettina Gercken 1 collaboration

Veera Raghavan Thangapandi 1 collaboration

Margarita Andreadou 1 collaboration

Ralph Burkhardt 1 collaboration

Robert Haase 1 collaboration

António Miguel de Jesus Domingues 1 collaboration

Nicola Zamboni 1 collaboration

Dimitris L Kontoyiannis 1 collaboration

Julia Reinhardt 1 collaboration

Virag Sharma 1 collaboration

Antigoni Stavridou 1 collaboration

Annett Lindner 1 collaboration

Anne Eugster 1 collaboration

Erik Klapproth 1 collaboration

Pauline Klose 1 collaboration

Johanna Wiedemann 1 collaboration

Nikitha Vavilthota 1 collaboration

Stephan R Künzel 1 collaboration

Susanne Kämmerer 1 collaboration

Mario Günscht 1 collaboration

David Sprott 1 collaboration

Erik Rauch 1 collaboration

Lars Kattner 1 collaboration

Silvio Weber 1 collaboration

Irakli Kopaliani 1 collaboration

Kaomei Guan 1 collaboration

Kristina Lorenz 1 collaboration

Paul Saftig 1 collaboration

Michael Wagner 1 collaboration

Ali El-Armouche 1 collaboration

Uddipta Biswas 1 collaboration

Tanaya Deb Mallik 1 collaboration

Johannes Pschirer 1 collaboration

Katrin Sameith 1 collaboration

Rolf Jessberger 1 collaboration