Pascal Brouillard

Affiliations

Human Molecular Genetics, de Duve Institute, UCLouvain, 1200 Brussels, Belgium.

Publications (30)

Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis.

Biomolecules

Avec: Hélène Pollet , Anne-Sophie Cloos , Amaury Stommen , Juliette Vanderroost , Louise Conrard , Adrien Paquot , Marine Ghodsi , Mélanie Carquin , Catherine Léonard , Manuel Guthmann , Maxime Lingurski , Christiane Vermylen , Theodore Killian , Laurent Gatto , Mark Rider , Sébastien Pyr Dit Ruys , Didier Vertommen , Miikka Vikkula , Pascal Brouillard , Patrick Van Der Smissen , Giulio G Muccioli , Donatienne Tyteca

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.

Structure (London, England : 1993)

Avec: Patrick Hansmann , Anne Brückner , Stephan Kiontke , Bianca Berkenfeld , Guiscard Seebohm , Pascal Brouillard , Miikka Vikkula , Floor E Jansen , Mark Nellist , Andrea Oeckinghaus , Daniel Kümmel

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

Nature communications

Avec: Ines Martinez-Corral , Yan Zhang , Milena Petkova , Henrik Ortsäter , Sofie Sjöberg , Sandra D Castillo , Pascal Brouillard , Louis Libbrecht , Dieter Saur , Mariona Graupera , Kari Alitalo , Laurence Boon , Miikka Vikkula , Taija Mäkinen

Pathogenic variants in

Science translational medicine

Avec: Alicia B Byrne , Pascal Brouillard , Drew L Sutton , Jan Kazenwadel , Saba Montazaribarforoushi , Genevieve A Secker , Anna Oszmiana , Milena Babic , Kelly L Betterman , Peter J Brautigan , Melissa White , Sandra G Piltz , Paul Q Thomas , Christopher N Hahn , Matthias Rath , Ute Felbor , G Christoph Korenke , Christopher L Smith , Kathleen H Wood , Sarah E Sheppard , Denise M Adams , Ariana Kariminejad , Raphael Helaers , Laurence M Boon , Nicole Revencu , Lynette Moore , Christopher Barnett , Eric Haan , Peer Arts , Miikka Vikkula , Hamish S Scott , Natasha L Harvey

Human chromosome map of lymphedema-lymphangiogenesis genes: Template for current and future discovery.

Lymphology

Avec: M H Witte , R P Erickson , L Luy , P Brouillard , M Vikkula

Somatic loss-of-function PIK3R1 and activating non-hotspot PIK3CA mutations associated with Capillary Malformation with Dilated Veins (CMDV).

The Journal of investigative dermatology

Avec: Martina De Bortoli , Angela Queisser , Van Cuong Pham , Anne Dompmartin , Raphaël Helaers , Simon Boutry , Cathy Claus , An-Katrien De Roo , Frank Hammer , Pascal Brouillard , Salim Abdelilah-Seyfried , Laurence M Boon , Miikka Vikkula

Association of PDGFRB Mutations With Pediatric Myofibroma and Myofibromatosis.

JAMA dermatology

Avec: Guillaume Dachy , Ronald R de Krijger , Sylvie Fraitag , Ivan Théate , Bénédicte Brichard , Suma B Hoffman , Louis Libbrecht , Florence A Arts , Pascal Brouillard , Miikka Vikkula , Nisha Limaye , Jean-Baptiste Demoulin

Inter-individual predictors of pain inhibition during performance of a competing cognitive task.

Scientific reports

Avec: V Tabry , T A Vogel , M Lussier , P Brouillard , J Buhle , P Rainville , L Bherer , M Roy

Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations.

Orphanet journal of rare diseases

Avec: Pascal Brouillard , Matthieu J Schlögel , Nassim Homayun Sepehr , Raphaël Helaers , Angela Queisser , Elodie Fastré , Simon Boutry , Sandra Schmitz , Philippe Clapuyt , Frank Hammer , Anne Dompmartin , Annamaria Weitz-Tuoretmaa , Jussi Laranne , Louise Pasquesoone , Catheline Vilain , Laurence M Boon , Miikka Vikkula

EPHB4 mutation causes adult and adolescent-onset primary lymphedema.

American journal of medical genetics. Part A

Avec: Arin K Greene , Pascal Brouillard , Christopher L Sudduth , Patrick J Smits , Dennis J Konczyk , Miikka Vikkula

Two types of human TCR differentially regulate reactivity to self and non-self antigens.

iScience

Avec: Assya Trofimov , Philippe Brouillard , Jean-David Larouche , Jonathan Séguin , Jean-Philippe Laverdure , Ann Brasey , Gregory Ehx , Denis-Claude Roy , Lambert Busque , Silvy Lachance , Sébastien Lemieux , Claude Perreault

Ureteropelvic junction obstruction with primary lymphoedema associated with

Journal of medical genetics

Avec: Murat Alpaslan , Sandrine Mestré-Godin , Aurélie Lay , Guido Giacalone , Raphaël Helaers , Salma Adham , Hélène Kovacsik , Sophie Guillemard , Erick Mercier , Laurence Boon , Nicole Revencu , Pascal Brouillard , Isabelle Quere , Miikka Vikkula

Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema.

The Journal of clinical investigation

Avec: Pascal Brouillard , Aino Murtomäki , Veli-Matti Leppänen , Marko Hyytiäinen , Sandrine Mestre , Lucas Potier , Laurence M Boon , Nicole Revencu , Arin K Greene , Andrey Anisimov , Miia H Salo , Reetta Hinttala , Lauri Eklund , Isabelle Quéré , Kari Alitalo , Miikka Vikkula

Journal of medical genetics

Avec: Nicole Revencu , Elodie Fastre , Marie Ravoet , Raphaël Helaers , Pascal Brouillard , Annouk Bisdorff-Bresson , Clara W T Chung , Marion Gerard , Veronika Dvorakova , Alan D Irvine , Laurence M Boon , Miikka Vikkula

Co-construction of health technology assessment recommendations with patients: An example with cardiac defibrillator replacement.

Health expectations : an international journal of public participation in health care and health policy

Avec: Marie-Pascale Pomey , Philippe Brouillard , Isabelle Ganache , Laurie Lambert , Lucy Boothroyd , Caroline Collette , Sylvain Bédard , Alexandre Grégoire , Sandra Pelaez , Olivier Demers-Payette , Mireille Goetghebeur , Michèle de Guise , Denis Roy

Biallelic

Journal of medical genetics

Avec: Marie F Smeland , Pascal Brouillard , Trine Prescott , Laurence M Boon , Bodil Hvingel , Cecilie V Nordbakken , Mona Nystad , Øystein L Holla , Miikka Vikkula

KRAS-driven model of Gorham-Stout disease effectively treated with trametinib.

JCI insight

Avec: Nassim Homayun-Sepehr , Anna L McCarter , Raphaël Helaers , Christine Galant , Laurence M Boon , Pascal Brouillard , Miikka Vikkula , Michael T Dellinger

Monkeypox associated myocarditis: A case report.

IDCases

Avec: Philippe Brouillard , Anthony Valin-Thorburn , Yves Provost , Arpita Chakravarti , George Honos , François Tournoux , Cécile Tremblay

Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations.

JCI insight

Avec: Emmanuel Seront , An Van Damme , Catherine Legrand , Annouk Bisdorff-Bresson , Philippe Orcel , Thomas Funck-Brentano , Marie-Antoinette Sevestre , Anne Dompmartin , Isabelle Quere , Pascal Brouillard , Nicole Revencu , Martina De Bortoli , Frank Hammer , Philippe Clapuyt , Dana Dumitriu , Miikka Vikkula , Laurence M Boon

Real-world management strategies of anticoagulated atrial fibrillation patients following a clinically significant bleeding episode: Afib patients bleeding on anticoagulants.

The Canadian journal of cardiology

Avec: Philippe Brouillard , El Hadji Diallo , Jean-Bernard Masson , Jean-Marc Raymond , Mounir Riahi , Brian Potter , Rémi Kouz , Jeannot Potvin

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma.

bioRxiv : the preprint server for biology

Avec: Annegret Holm , Matthew S Graus , Jill Wylie-Sears , Luke Borgelt , Jerry Wei Heng Tan , Sana Nasim , Long Chung , Ashish Jain , Mingwei Sun , Liang Sun , Pascal Brouillard , Ramrada Lekwuttikarn , Harry Kozakewich , Jacob Yanfei Qi , Joyce C Teng , John B Mulliken , Miikka Vikkula , Mathias Francois , Joyce Bischoff

Hypotrichosis-lymphedema-telangiectasia syndrome: Report of ileal atresia associated with a SOX18 de novo pathogenic variant and review of the phenotypic spectrum.

American journal of medical genetics. Part A

Avec: Richard Coulie , Dmitriy M Niyazov , Michael J Gambello , Elodie Fastré , Pascal Brouillard , Miikka Vikkula

First Draft Genome of the Trypanosomatid

Tropical medicine and infectious disease

Avec: Claudia M d'Avila-Levy , Bertrand Bearzatto , Jérôme Ambroise , Raphaël Helaers , Anzhelika Butenko , Vyacheslav Yurchenko , Karina A Morelli , Helena L C Santos , Pascal Brouillard , Philippe Grellier , Jean-Luc Gala , Miikka Vikkula

Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families.

Breast cancer research : BCR

Avec: Cédric Van Marcke , Raphaël Helaers , Anne De Leener , Ahmad Merhi , Céline A Schoonjans , Jérôme Ambroise , Christine Galant , Paul Delrée , Françoise Rothé , Isabelle Bar , Elsa Khoury , Pascal Brouillard , Jean-Luc Canon , Peter Vuylsteke , Jean-Pascal Machiels , Martine Berlière , Nisha Limaye , Miikka Vikkula , François P Duhoux

Characterization of

Science translational medicine

Avec: Veli-Matti Leppänen , Pascal Brouillard , Emilia A Korhonen , Tuomas Sipilä , Sawan Kumar Jha , Nicole Revencu , Veerle Labarque , Elodie Fastré , Matthieu Schlögel , Marie Ravoet , Amihood Singer , Claudia Luzzatto , Donatella Angelone , Giovanni Crichiutti , Angela D'Elia , Jaakko Kuurne , Harri Elamaa , Gou Young Koh , Pipsa Saharinen , Miikka Vikkula , Kari Alitalo

Primary lymphoedema.

Nature reviews. Disease primers

Avec: Pascal Brouillard , Marlys H Witte , Robert P Erickson , Robert J Damstra , Corinne Becker , Isabelle Quéré , Miikka Vikkula

Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function.

Human molecular genetics

Avec: Murat Alpaslan , Elodie Fastré , Sandrine Mestre , Arie van Haeringen , Gabriela M Repetto , Kathelijn Keymolen , Laurence M Boon , Florence Belva , Guido Giacalone , Nicole Revencu , Yves Sznajer , Katie Riches , Vaughan Keeley , Sahar Mansour , Kristiana Gordon , Silvia Martin-Almedina , Sara Dobbins , Pia Ostergaard , Isabelle Quere , Pascal Brouillard , Miikka Vikkula

Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects.

Blood advances

Avec: Anne-Sophie Cloos , Hélène Pollet , Amaury Stommen , Mauriane Maja , Maxime Lingurski , Bénédicte Brichard , Catherine Lambert , Patrick Henriet , Christophe Pierreux , Sébastien Pyr Dit Ruys , Patrick Van Der Smissen , Miikka Vikkula , Laurent Gatto , Manon Martin , Pascal Brouillard , Didier Vertommen , Donatienne Tyteca

Predictors and impact of postoperative atrial fibrillation following thoracic surgery: a state-of-the-art review.

Anaesthesia

Avec: E-H Diallo , P Brouillard , J-M Raymond , M Liberman , E Duceppe , B J Potter

A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms.

Diabetes & metabolism journal

Avec: Sophie Welsch , Antoine Harvengta , Paola Gallo , Manon Martin , Dominique Beckers , Thierry Mouraux , Nicole Seret , Marie-Christine Lebrethon , Raphael Helear , Pascal Brouillard , Miikka Vikkula , Philippe A Lysy

Réseau de co-auteurs

Miikka Vikkula 23 collaborations

Laurence M Boon 9 collaborations

Nicole Revencu 7 collaborations

Raphaël Helaers 7 collaborations

Elodie Fastré 4 collaborations

Philippe Brouillard 4 collaborations

Kari Alitalo 3 collaborations

P Brouillard 3 collaborations

Anne Dompmartin 3 collaborations

Frank Hammer 3 collaborations

Isabelle Quere 3 collaborations

Hélène Pollet 2 collaborations

Anne-Sophie Cloos 2 collaborations

Amaury Stommen 2 collaborations

Maxime Lingurski 2 collaborations

Laurent Gatto 2 collaborations

Sébastien Pyr Dit Ruys 2 collaborations

Didier Vertommen 2 collaborations

Patrick Van Der Smissen 2 collaborations

Donatienne Tyteca 2 collaborations

Louis Libbrecht 2 collaborations

Laurence Boon 2 collaborations

Martina De Bortoli 2 collaborations

Angela Queisser 2 collaborations

Simon Boutry 2 collaborations

Bénédicte Brichard 2 collaborations

Nisha Limaye 2 collaborations

Philippe Clapuyt 2 collaborations

Arin K Greene 2 collaborations

Murat Alpaslan 2 collaborations

Guido Giacalone 2 collaborations

Veli-Matti Leppänen 2 collaborations

Sandrine Mestre 2 collaborations

Isabelle Quéré 2 collaborations

Marie Ravoet 2 collaborations

Annouk Bisdorff-Bresson 2 collaborations

Christine Galant 2 collaborations

Jérôme Ambroise 2 collaborations

Manon Martin 2 collaborations

Juliette Vanderroost 1 collaboration

Louise Conrard 1 collaboration

Adrien Paquot 1 collaboration

Marine Ghodsi 1 collaboration

Mélanie Carquin 1 collaboration

Catherine Léonard 1 collaboration

Manuel Guthmann 1 collaboration

Christiane Vermylen 1 collaboration

Theodore Killian 1 collaboration

Mark Rider 1 collaboration

Giulio G Muccioli 1 collaboration

Patrick Hansmann 1 collaboration

Anne Brückner 1 collaboration

Stephan Kiontke 1 collaboration

Bianca Berkenfeld 1 collaboration

Guiscard Seebohm 1 collaboration

Floor E Jansen 1 collaboration

Mark Nellist 1 collaboration

Andrea Oeckinghaus 1 collaboration

Daniel Kümmel 1 collaboration

Ines Martinez-Corral 1 collaboration

Yan Zhang 1 collaboration

Milena Petkova 1 collaboration

Henrik Ortsäter 1 collaboration

Sofie Sjöberg 1 collaboration

Sandra D Castillo 1 collaboration

Dieter Saur 1 collaboration

Mariona Graupera 1 collaboration

Taija Mäkinen 1 collaboration

Alicia B Byrne 1 collaboration

Drew L Sutton 1 collaboration

Jan Kazenwadel 1 collaboration

Saba Montazaribarforoushi 1 collaboration

Genevieve A Secker 1 collaboration

Anna Oszmiana 1 collaboration

Milena Babic 1 collaboration

Kelly L Betterman 1 collaboration

Peter J Brautigan 1 collaboration

Melissa White 1 collaboration

Sandra G Piltz 1 collaboration

Paul Q Thomas 1 collaboration

Christopher N Hahn 1 collaboration

Matthias Rath 1 collaboration

Ute Felbor 1 collaboration

G Christoph Korenke 1 collaboration

Christopher L Smith 1 collaboration

Kathleen H Wood 1 collaboration

Sarah E Sheppard 1 collaboration

Denise M Adams 1 collaboration

Ariana Kariminejad 1 collaboration

Raphael Helaers 1 collaboration

Lynette Moore 1 collaboration

Christopher Barnett 1 collaboration

Eric Haan 1 collaboration

Peer Arts 1 collaboration

Hamish S Scott 1 collaboration

Natasha L Harvey 1 collaboration

M H Witte 1 collaboration

R P Erickson 1 collaboration

L Luy 1 collaboration

M Vikkula 1 collaboration

Van Cuong Pham 1 collaboration

Cathy Claus 1 collaboration

An-Katrien De Roo 1 collaboration

Salim Abdelilah-Seyfried 1 collaboration

Guillaume Dachy 1 collaboration

Ronald R de Krijger 1 collaboration

Sylvie Fraitag 1 collaboration

Ivan Théate 1 collaboration

Suma B Hoffman 1 collaboration

Florence A Arts 1 collaboration

Jean-Baptiste Demoulin 1 collaboration

V Tabry 1 collaboration

T A Vogel 1 collaboration

M Lussier 1 collaboration

J Buhle 1 collaboration

P Rainville 1 collaboration

L Bherer 1 collaboration

M Roy 1 collaboration

Matthieu J Schlögel 1 collaboration

Nassim Homayun Sepehr 1 collaboration

Sandra Schmitz 1 collaboration

Annamaria Weitz-Tuoretmaa 1 collaboration

Jussi Laranne 1 collaboration

Louise Pasquesoone 1 collaboration

Catheline Vilain 1 collaboration

Christopher L Sudduth 1 collaboration

Patrick J Smits 1 collaboration

Dennis J Konczyk 1 collaboration

Assya Trofimov 1 collaboration

Jean-David Larouche 1 collaboration

Jonathan Séguin 1 collaboration

Jean-Philippe Laverdure 1 collaboration

Ann Brasey 1 collaboration

Gregory Ehx 1 collaboration

Denis-Claude Roy 1 collaboration

Lambert Busque 1 collaboration

Silvy Lachance 1 collaboration

Sébastien Lemieux 1 collaboration

Claude Perreault 1 collaboration

Sandrine Mestré-Godin 1 collaboration

Aurélie Lay 1 collaboration

Salma Adham 1 collaboration

Hélène Kovacsik 1 collaboration

Sophie Guillemard 1 collaboration

Erick Mercier 1 collaboration

Aino Murtomäki 1 collaboration

Marko Hyytiäinen 1 collaboration

Lucas Potier 1 collaboration

Andrey Anisimov 1 collaboration

Miia H Salo 1 collaboration

Reetta Hinttala 1 collaboration

Lauri Eklund 1 collaboration

Elodie Fastre 1 collaboration

Clara W T Chung 1 collaboration

Marion Gerard 1 collaboration

Veronika Dvorakova 1 collaboration

Alan D Irvine 1 collaboration

Marie-Pascale Pomey 1 collaboration

Isabelle Ganache 1 collaboration

Laurie Lambert 1 collaboration

Lucy Boothroyd 1 collaboration

Caroline Collette 1 collaboration

Sylvain Bédard 1 collaboration

Alexandre Grégoire 1 collaboration

Sandra Pelaez 1 collaboration

Olivier Demers-Payette 1 collaboration

Mireille Goetghebeur 1 collaboration

Michèle de Guise 1 collaboration

Denis Roy 1 collaboration

Marie F Smeland 1 collaboration

Trine Prescott 1 collaboration

Bodil Hvingel 1 collaboration

Cecilie V Nordbakken 1 collaboration

Mona Nystad 1 collaboration

Øystein L Holla 1 collaboration

Nassim Homayun-Sepehr 1 collaboration

Anna L McCarter 1 collaboration

Michael T Dellinger 1 collaboration

Anthony Valin-Thorburn 1 collaboration

Yves Provost 1 collaboration

Arpita Chakravarti 1 collaboration

George Honos 1 collaboration

François Tournoux 1 collaboration

Cécile Tremblay 1 collaboration

Emmanuel Seront 1 collaboration

An Van Damme 1 collaboration

Catherine Legrand 1 collaboration

Philippe Orcel 1 collaboration

Thomas Funck-Brentano 1 collaboration

Marie-Antoinette Sevestre 1 collaboration

Dana Dumitriu 1 collaboration

El Hadji Diallo 1 collaboration

Jean-Bernard Masson 1 collaboration

Jean-Marc Raymond 1 collaboration

Mounir Riahi 1 collaboration

Brian Potter 1 collaboration

Rémi Kouz 1 collaboration

Jeannot Potvin 1 collaboration

Annegret Holm 1 collaboration

Matthew S Graus 1 collaboration

Jill Wylie-Sears 1 collaboration

Luke Borgelt 1 collaboration

Jerry Wei Heng Tan 1 collaboration

Sana Nasim 1 collaboration

Long Chung 1 collaboration

Ashish Jain 1 collaboration

Mingwei Sun 1 collaboration

Liang Sun 1 collaboration

Ramrada Lekwuttikarn 1 collaboration

Harry Kozakewich 1 collaboration

Jacob Yanfei Qi 1 collaboration

Joyce C Teng 1 collaboration

John B Mulliken 1 collaboration

Mathias Francois 1 collaboration

Joyce Bischoff 1 collaboration

Richard Coulie 1 collaboration

Dmitriy M Niyazov 1 collaboration

Michael J Gambello 1 collaboration

Claudia M d'Avila-Levy 1 collaboration

Bertrand Bearzatto 1 collaboration

Anzhelika Butenko 1 collaboration

Vyacheslav Yurchenko 1 collaboration

Karina A Morelli 1 collaboration

Helena L C Santos 1 collaboration

Philippe Grellier 1 collaboration

Jean-Luc Gala 1 collaboration

Cédric Van Marcke 1 collaboration

Anne De Leener 1 collaboration

Ahmad Merhi 1 collaboration

Céline A Schoonjans 1 collaboration

Paul Delrée 1 collaboration

Françoise Rothé 1 collaboration

Isabelle Bar 1 collaboration

Elsa Khoury 1 collaboration

Jean-Luc Canon 1 collaboration

Peter Vuylsteke 1 collaboration

Jean-Pascal Machiels 1 collaboration

Martine Berlière 1 collaboration

François P Duhoux 1 collaboration

Emilia A Korhonen 1 collaboration

Tuomas Sipilä 1 collaboration

Sawan Kumar Jha 1 collaboration

Veerle Labarque 1 collaboration

Matthieu Schlögel 1 collaboration

Amihood Singer 1 collaboration

Claudia Luzzatto 1 collaboration

Donatella Angelone 1 collaboration

Giovanni Crichiutti 1 collaboration

Angela D'Elia 1 collaboration

Jaakko Kuurne 1 collaboration

Harri Elamaa 1 collaboration

Gou Young Koh 1 collaboration

Pipsa Saharinen 1 collaboration

Marlys H Witte 1 collaboration

Robert P Erickson 1 collaboration

Robert J Damstra 1 collaboration

Corinne Becker 1 collaboration

Arie van Haeringen 1 collaboration

Gabriela M Repetto 1 collaboration

Kathelijn Keymolen 1 collaboration

Florence Belva 1 collaboration

Yves Sznajer 1 collaboration

Katie Riches 1 collaboration

Vaughan Keeley 1 collaboration

Sahar Mansour 1 collaboration

Kristiana Gordon 1 collaboration

Silvia Martin-Almedina 1 collaboration

Sara Dobbins 1 collaboration

Pia Ostergaard 1 collaboration

Mauriane Maja 1 collaboration

Catherine Lambert 1 collaboration

Patrick Henriet 1 collaboration

Christophe Pierreux 1 collaboration

E-H Diallo 1 collaboration

J-M Raymond 1 collaboration

M Liberman 1 collaboration

E Duceppe 1 collaboration

B J Potter 1 collaboration

Sophie Welsch 1 collaboration

Antoine Harvengta 1 collaboration

Paola Gallo 1 collaboration

Dominique Beckers 1 collaboration

Thierry Mouraux 1 collaboration

Nicole Seret 1 collaboration

Marie-Christine Lebrethon 1 collaboration

Raphael Helear 1 collaboration

Philippe A Lysy 1 collaboration