Therese Stachyra

Affiliations

Disease area Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Publications (5)

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.

RSC chemical biology

Avec: Anselm F L Schneider , Joerg Kallen , Johannes Ottl , Patrick C Reid , Sebastien Ripoche , Stephan Ruetz , Therese-Marie Stachyra , Samuel Hintermann , Christoph E Dumelin , Christian P R Hackenberger , Andreas L Marzinzik

Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.

ChemMedChem

Avec: Joerg Kallen , Aude Izaac , Suzanne Chau , Emmanuelle Wirth , Joseph Schoepfer , Robert Mah , Achim Schlapbach , Stefan Stutz , Andrea Vaupel , Vito Guagnano , Keiichi Masuya , Therese-Marie Stachyra , Bahaa Salem , Patrick Chene , Francois Gessier , Philipp Holzer , Pascal Furet

PAX8 and MECOM are interaction partners driving ovarian cancer.

Nature communications

Avec: Melusine Bleu , Fanny Mermet-Meillon , Verena Apfel , Louise Barys , Laura Holzer , Marianne Bachmann Salvy , Rui Lopes , Inês Amorim Monteiro Barbosa , Cecile Delmas , Alexandra Hinniger , Suzanne Chau , Markus Kaufmann , Simon Haenni , Karolin Berneiser , Maria Wahle , Ivana Moravec , Alexandra Vissières , Tania Poetsch , Erik Ahrné , Nathalie Carte , Johannes Voshol , Elisabeth Bechter , Jacques Hamon , Marco Meyerhofer , Dirk Erdmann , Matteo Fischer , Therese Stachyra , Felix Freuler , Sascha Gutmann , César Fernández , Tobias Schmelzle , Ulrike Naumann , Guglielmo Roma , Kate Lawrenson , Cristina Nieto-Oberhuber , Amanda Cobos-Correa , Stephane Ferretti , Dirk Schübeler , Giorgio Giacomo Galli

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.

Nature communications

Avec: Martin Schröder , Martin Renatus , Xiaoyou Liang , Fabian Meili , Thomas Zoller , Sandrine Ferrand , Francois Gauter , Xiaoyan Li , Frederic Sigoillot , Scott Gleim , Therese-Marie Stachyra , Jason R Thomas , Damien Begue , Maryam Khoshouei , Peggy Lefeuvre , Rita Andraos-Rey , BoYee Chung , Renate Ma , Benika Pinch , Andreas Hofmann , Markus Schirle , Niko Schmiedeberg , Patricia Imbach , Delphine Gorses , Keith Calkins , Beatrice Bauer-Probst , Magdalena Maschlej , Matt Niederst , Rob Maher , Martin Henault , John Alford , Erik Ahrne , Luca Tordella , Greg Hollingworth , Nicolas H Thomä , Anna Vulpetti , Thomas Radimerski , Philipp Holzer , Seth Carbonneau , Claudio R Thoma

Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.

ACS medicinal chemistry letters

Avec: Anna Vulpetti , Philipp Holzer , Niko Schmiedeberg , Patricia Imbach-Weese , Carole Pissot-Soldermann , Gregory J Hollingworth , Thomas Radimerski , Claudio R Thoma , Therese-Marie Stachyra , Matthias Wojtynek , Magdalena Maschlej , Suzanne Chau , Ansgar Schuffenhauer , César Fernández , Martin Schröder , Martin Renatus

Réseau de co-auteurs

Therese-Marie Stachyra 4 collaborations

Suzanne Chau 3 collaborations

Philipp Holzer 3 collaborations

Joerg Kallen 2 collaborations

César Fernández 2 collaborations

Martin Schröder 2 collaborations

Martin Renatus 2 collaborations

Niko Schmiedeberg 2 collaborations

Magdalena Maschlej 2 collaborations

Anna Vulpetti 2 collaborations

Thomas Radimerski 2 collaborations

Claudio R Thoma 2 collaborations

Anselm F L Schneider 1 collaboration

Johannes Ottl 1 collaboration

Patrick C Reid 1 collaboration

Sebastien Ripoche 1 collaboration

Stephan Ruetz 1 collaboration

Samuel Hintermann 1 collaboration

Christoph E Dumelin 1 collaboration

Christian P R Hackenberger 1 collaboration

Andreas L Marzinzik 1 collaboration

Aude Izaac 1 collaboration

Emmanuelle Wirth 1 collaboration

Joseph Schoepfer 1 collaboration

Robert Mah 1 collaboration

Achim Schlapbach 1 collaboration

Stefan Stutz 1 collaboration

Andrea Vaupel 1 collaboration

Vito Guagnano 1 collaboration

Keiichi Masuya 1 collaboration

Bahaa Salem 1 collaboration

Patrick Chene 1 collaboration

Francois Gessier 1 collaboration

Pascal Furet 1 collaboration

Melusine Bleu 1 collaboration

Fanny Mermet-Meillon 1 collaboration

Verena Apfel 1 collaboration

Louise Barys 1 collaboration

Laura Holzer 1 collaboration

Marianne Bachmann Salvy 1 collaboration

Rui Lopes 1 collaboration

Inês Amorim Monteiro Barbosa 1 collaboration

Cecile Delmas 1 collaboration

Alexandra Hinniger 1 collaboration

Markus Kaufmann 1 collaboration

Simon Haenni 1 collaboration

Karolin Berneiser 1 collaboration

Maria Wahle 1 collaboration

Ivana Moravec 1 collaboration

Alexandra Vissières 1 collaboration

Tania Poetsch 1 collaboration

Erik Ahrné 1 collaboration

Nathalie Carte 1 collaboration

Johannes Voshol 1 collaboration

Elisabeth Bechter 1 collaboration

Jacques Hamon 1 collaboration

Marco Meyerhofer 1 collaboration

Dirk Erdmann 1 collaboration

Matteo Fischer 1 collaboration

Felix Freuler 1 collaboration

Sascha Gutmann 1 collaboration

Tobias Schmelzle 1 collaboration

Ulrike Naumann 1 collaboration

Guglielmo Roma 1 collaboration

Kate Lawrenson 1 collaboration

Cristina Nieto-Oberhuber 1 collaboration

Amanda Cobos-Correa 1 collaboration

Stephane Ferretti 1 collaboration

Dirk Schübeler 1 collaboration

Giorgio Giacomo Galli 1 collaboration

Xiaoyou Liang 1 collaboration

Fabian Meili 1 collaboration

Thomas Zoller 1 collaboration

Sandrine Ferrand 1 collaboration

Francois Gauter 1 collaboration

Xiaoyan Li 1 collaboration

Frederic Sigoillot 1 collaboration

Scott Gleim 1 collaboration

Jason R Thomas 1 collaboration

Damien Begue 1 collaboration

Maryam Khoshouei 1 collaboration

Peggy Lefeuvre 1 collaboration

Rita Andraos-Rey 1 collaboration

BoYee Chung 1 collaboration

Renate Ma 1 collaboration

Benika Pinch 1 collaboration

Andreas Hofmann 1 collaboration

Markus Schirle 1 collaboration

Patricia Imbach 1 collaboration

Delphine Gorses 1 collaboration

Keith Calkins 1 collaboration

Beatrice Bauer-Probst 1 collaboration

Matt Niederst 1 collaboration

Rob Maher 1 collaboration

Martin Henault 1 collaboration

John Alford 1 collaboration

Erik Ahrne 1 collaboration

Luca Tordella 1 collaboration

Greg Hollingworth 1 collaboration

Nicolas H Thomä 1 collaboration

Seth Carbonneau 1 collaboration

Patricia Imbach-Weese 1 collaboration

Carole Pissot-Soldermann 1 collaboration

Gregory J Hollingworth 1 collaboration

Matthias Wojtynek 1 collaboration

Ansgar Schuffenhauer 1 collaboration