Thomas A Reh

Affiliations

Department of Biological Structure, University of Washington, Box 357420, Seattle, WA, 98195, USA.
Institute for Stem Cells and Regenerative Medicine, University of Washington, Box 358056, Seattle, WA, 98109, USA.

Publications (32)

Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.

Scientific reports

Avec: Brent A Wilkerson , Alex D Chitsazan , Leah S VandenBosch , Matthew S Wilken , Thomas A Reh , Olivia Bermingham-McDonogh

Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice.

Cell reports

Avec: Levi Todd , Connor Finkbeiner , Claire K Wong , Marcus J Hooper , Thomas A Reh

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.

Molecular neurodegeneration

Avec: Jonathan R Soucy , Erika A Aguzzi , Julie Cho , Michael James Gilhooley , Casey Keuthan , Ziming Luo , Aboozar Monavarfeshani , Meher A Saleem , Xue-Wei Wang , Juilette Wohlschlegel , Auteur inconnu , Petr Baranov , Adriana Di Polo , Brad Fortune , Kimberly K Gokoffski , Jeffrey L Goldberg , William Guido , Alex L Kolodkin , Carol A Mason , Yvonne Ou , Thomas A Reh , Ahmara G Ross , Brian C Samuels , Derek Welsbie , Donald J Zack , Thomas V Johnson

STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina.

Cell reports

Avec: Nikolas L Jorstad , Matthew S Wilken , Levi Todd , Connor Finkbeiner , Paul Nakamura , Nicholas Radulovich , Marcus J Hooper , Alex Chitsazan , Brent A Wilkerson , Fred Rieke , Thomas A Reh

Microglial depletion abolishes ischemic preconditioning in white matter.

Glia

Avec: Margaret A Hamner , Ashley McDonough , Davin C Gong , Levi J Todd , German Rojas , Sibylle Hodecker , Christopher B Ransom , Thomas A Reh , Bruce R Ransom , Jonathan R Weinstein

The importance of unambiguous cell origin determination in neuronal repopulation studies.

iScience

Avec: Thomas V Johnson , David J Calkins , Brad Fortune , Jeffrey L Goldberg , Anna La Torre , Deepak A Lamba , Jason S Meyer , Thomas A Reh , Valerie A Wallace , Donald J Zack , Petr Baranov

The impact of timing and injury mode on induced neurogenesis in the adult mammalian retina.

Stem cell reports

Avec: Marina Pavlou , Marlene Probst , Nicolai Blasdel , Aric R Prieve , Thomas A Reh

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jonathan R Soucy , Levi Todd , Emil Kriukov , Monichan Phay , Volha V Malechka , John Dayron Rivera , Thomas A Reh , Petr Baranov

Synchronized long-read genome, methylome, epigenome, and transcriptome for resolving a Mendelian condition.

bioRxiv : the preprint server for biology

Avec: Mitchell R Vollger , Jonas Korlach , Kiara C Eldred , Elliott Swanson , Jason G Underwood , Yong-Han H Cheng , Jane Ranchalis , Yizi Mao , Elizabeth E Blue , Ulrike Schwarze , Katherine M Munson , Christopher T Saunders , Aaron M Wenger , Aimee Allworth , Sirisak Chanprasert , Brittney L Duerden , Ian Glass , Martha Horike-Pyne , Michelle Kim , Kathleen A Leppig , Ian J McLaughlin , Jessica Ogawa , Elisabeth A Rosenthal , Sam Sheppeard , Stephanie M Sherman , Samuel Strohbehn , Amy L Yuen , Auteur inconnu , Thomas A Reh , Peter H Byers , Michael J Bamshad , Fuki M Hisama , Gail P Jarvik , Yasemin Sancak , Katrina M Dipple , Andrew B Stergachis

Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential.

Scientific reports

Avec: Leah S VandenBosch , Stefanie G Wohl , Matthew S Wilken , Marcus Hooper , Connor Finkbeiner , Kristen Cox , Laura Chipman , Thomas A Reh

MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice.

Development (Cambridge, England)

Avec: Stefanie G Wohl , Marcus J Hooper , Thomas A Reh

Epigenetics in neuronal regeneration.

Seminars in cell & developmental biology

Avec: Leah S VandenBosch , Thomas A Reh

Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition.

Cell reports

Avec: Connor Finkbeiner , Isabel Ortuño-Lizarán , Akshayalakshmi Sridhar , Marcus Hooper , Sidnee Petter , Thomas A Reh

Single cell dual-omic atlas of the human developing retina.

Nature communications

Avec: Zhen Zuo , Xuesen Cheng , Salma Ferdous , Jianming Shao , Jin Li , Yourong Bao , Jean Li , Jiaxiong Lu , Antonio Jacobo Lopez , Juliette Wohlschlegel , Aric Prieve , Mervyn G Thomas , Thomas A Reh , Yumei Li , Ala Moshiri , Rui Chen

Monocyte invasion into the retina restricts the regeneration of neurons from M

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Nicolai Blasdel , Sucheta Bhattacharya , Phoebe C Donaldson , Thomas A Reh , Levi Todd

Synchrony and asynchrony between an epigenetic clock and developmental timing.

Scientific reports

Avec: Akina Hoshino , Steve Horvath , Akshayalakshmi Sridhar , Alex Chitsazan , Thomas A Reh

Human retinal model systems: Strengths, weaknesses, and future directions.

Developmental biology

Avec: Kiara C Eldred , Thomas A Reh

NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina.

Glia

Avec: Isabella Palazzo , Levi J Todd , Thanh V Hoang , Thomas A Reh , Seth Blackshaw , Andy J Fischer

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia.

bioRxiv : the preprint server for biology

Avec: Amy Tresenrider , Marcus Hooper , Levi Todd , Faith Kierney , Nicolai Blasdel , Cole Trapnell , Thomas A Reh

The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium.

Ophthalmology science

Avec: Thomas V Johnson , Petr Baranov , Adriana Di Polo , Brad Fortune , Kimberly K Gokoffski , Jeffrey L Goldberg , William Guido , Alex L Kolodkin , Carol A Mason , Yvonne Ou , Thomas A Reh , Ahmara G Ross , Brian C Samuels , Donald J Zack

ASCL1 induces neurogenesis in human Müller glia.

Stem cell reports

Avec: Juliette Wohlschlegel , Connor Finkbeiner , Dawn Hoffer , Faith Kierney , Aric Prieve , Alexandria D Murry , Alexandra K Haugan , Isabel Ortuño-Lizarán , Fred Rieke , Sam A Golden , Thomas A Reh

Development of ON and OFF cholinergic amacrine cells in the human fetal retina.

The Journal of comparative neurology

Avec: Chi Zhang , Wan-Qing Yu , Akina Hoshino , Jing Huang , Fred Rieke , Thomas A Reh , Rachel O L Wong

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures.

Cell reports

Avec: Akshayalakshmi Sridhar , Akina Hoshino , Connor R Finkbeiner , Alex Chitsazan , Li Dai , Alexandra K Haugan , Kayla M Eschenbacher , Dana L Jackson , Cole Trapnell , Olivia Bermingham-McDonogh , Ian Glass , Thomas A Reh

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.

Translational vision science & technology

Avec: Debra A Thompson , Alessandro Iannaccone , Robin R Ali , Vadim Y Arshavsky , Isabelle Audo , James W B Bainbridge , Cagri G Besirli , David G Birch , Kari E Branham , Artur V Cideciyan , Steven P Daiger , Deniz Dalkara , Jacque L Duncan , Abigail T Fahim , John G Flannery , Roberto Gattegna , John R Heckenlively , Elise Heon , K Thiran Jayasundera , Naheed W Khan , Henry Klassen , Bart P Leroy , Robert S Molday , David C Musch , Mark E Pennesi , Simon M Petersen-Jones , Eric A Pierce , Rajesh C Rao , Thomas A Reh , Jose A Sahel , Dror Sharon , Paul A Sieving , Enrica Strettoi , Paul Yang , David N Zacks , Auteur inconnu

Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming.

Cold Spring Harbor perspectives in biology

Avec: Levi Todd , Thomas A Reh

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.

Cell reports

Avec: Levi Todd , Marcus J Hooper , Alexandra K Haugan , Connor Finkbeiner , Nikolas Jorstad , Nicholas Radulovich , Claire K Wong , Phoebe C Donaldson , Wesley Jenkins , Qiang Chen , Fred Rieke , Thomas A Reh

A Comparative Analysis of Reactive Müller Glia Gene Expression After Light Damage and microRNA-Depleted Müller Glia-Focus on microRNAs.

Frontiers in cell and developmental biology

Avec: Seoyoung Kang , Daniel Larbi , Monica Andrade , Sara Reardon , Thomas A Reh , Stefanie G Wohl

Circuit Reorganization Shapes the Developing Human Foveal Midget Connectome toward Single-Cone Resolution.

Neuron

Avec: Chi Zhang , Yeon Jin Kim , Ana R Silverstein , Akina Hoshino , Thomas A Reh , Dennis M Dacey , Rachel O Wong

Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors.

Science advances

Avec: Levi Todd , Wesley Jenkins , Connor Finkbeiner , Marcus J Hooper , Phoebe C Donaldson , Marina Pavlou , Juliette Wohlschlegel , Norianne Ingram , Fred Rieke , Thomas A Reh , Xiuqian Mu

Cell-Based Therapies: Strategies for Regeneration.

Cold Spring Harbor perspectives in medicine

Avec: Marina Pavlou , Thomas A Reh

Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity.

bioRxiv : the preprint server for biology

Avec: Amy Tresenrider , Akshayalakshmi Sridhar , Kiara C Eldred , Sophia Cuschieri , Dawn Hoffer , Cole Trapnell , Thomas A Reh

Single-cell sequencing of individual retinal organoids reveals determinants of cell-fate heterogeneity.

Cell reports methods

Avec: Amy Tresenrider , Akshayalakshmi Sridhar , Kiara C Eldred , Sophia Cuschieri , Dawn Hoffer , Cole Trapnell , Thomas A Reh

Réseau de co-auteurs

Levi Todd 8 collaborations

Connor Finkbeiner 7 collaborations

Marcus J Hooper 5 collaborations

Fred Rieke 5 collaborations

Akshayalakshmi Sridhar 5 collaborations

Petr Baranov 4 collaborations

Kiara C Eldred 4 collaborations

Akina Hoshino 4 collaborations

Cole Trapnell 4 collaborations

Leah S VandenBosch 3 collaborations

Matthew S Wilken 3 collaborations

None None 3 collaborations

Brad Fortune 3 collaborations

Jeffrey L Goldberg 3 collaborations

Donald J Zack 3 collaborations

Thomas V Johnson 3 collaborations

Alex Chitsazan 3 collaborations

Marina Pavlou 3 collaborations

Nicolai Blasdel 3 collaborations

Stefanie G Wohl 3 collaborations

Marcus Hooper 3 collaborations

Juliette Wohlschlegel 3 collaborations

Phoebe C Donaldson 3 collaborations

Amy Tresenrider 3 collaborations

Dawn Hoffer 3 collaborations

Alexandra K Haugan 3 collaborations

Brent A Wilkerson 2 collaborations

Olivia Bermingham-McDonogh 2 collaborations

Claire K Wong 2 collaborations

Jonathan R Soucy 2 collaborations

Adriana Di Polo 2 collaborations

Kimberly K Gokoffski 2 collaborations

William Guido 2 collaborations

Alex L Kolodkin 2 collaborations

Carol A Mason 2 collaborations

Yvonne Ou 2 collaborations

Ahmara G Ross 2 collaborations

Brian C Samuels 2 collaborations

Nicholas Radulovich 2 collaborations

Levi J Todd 2 collaborations

Ian Glass 2 collaborations

Isabel Ortuño-Lizarán 2 collaborations

Aric Prieve 2 collaborations

Faith Kierney 2 collaborations

Chi Zhang 2 collaborations

Wesley Jenkins 2 collaborations

Sophia Cuschieri 2 collaborations

Alex D Chitsazan 1 collaboration

Erika A Aguzzi 1 collaboration

Julie Cho 1 collaboration

Michael James Gilhooley 1 collaboration

Casey Keuthan 1 collaboration

Ziming Luo 1 collaboration

Aboozar Monavarfeshani 1 collaboration

Meher A Saleem 1 collaboration

Xue-Wei Wang 1 collaboration

Juilette Wohlschlegel 1 collaboration

Derek Welsbie 1 collaboration

Nikolas L Jorstad 1 collaboration

Paul Nakamura 1 collaboration

Margaret A Hamner 1 collaboration

Ashley McDonough 1 collaboration

Davin C Gong 1 collaboration

German Rojas 1 collaboration

Sibylle Hodecker 1 collaboration

Christopher B Ransom 1 collaboration

Bruce R Ransom 1 collaboration

Jonathan R Weinstein 1 collaboration

David J Calkins 1 collaboration

Anna La Torre 1 collaboration

Deepak A Lamba 1 collaboration

Jason S Meyer 1 collaboration

Valerie A Wallace 1 collaboration

Marlene Probst 1 collaboration

Aric R Prieve 1 collaboration

Emil Kriukov 1 collaboration

Monichan Phay 1 collaboration

Volha V Malechka 1 collaboration

John Dayron Rivera 1 collaboration

Mitchell R Vollger 1 collaboration

Jonas Korlach 1 collaboration

Elliott Swanson 1 collaboration

Jason G Underwood 1 collaboration

Yong-Han H Cheng 1 collaboration

Jane Ranchalis 1 collaboration

Yizi Mao 1 collaboration

Elizabeth E Blue 1 collaboration

Ulrike Schwarze 1 collaboration

Katherine M Munson 1 collaboration

Christopher T Saunders 1 collaboration

Aaron M Wenger 1 collaboration

Aimee Allworth 1 collaboration

Sirisak Chanprasert 1 collaboration

Brittney L Duerden 1 collaboration

Martha Horike-Pyne 1 collaboration

Michelle Kim 1 collaboration

Kathleen A Leppig 1 collaboration

Ian J McLaughlin 1 collaboration

Jessica Ogawa 1 collaboration

Elisabeth A Rosenthal 1 collaboration

Sam Sheppeard 1 collaboration

Stephanie M Sherman 1 collaboration

Samuel Strohbehn 1 collaboration

Amy L Yuen 1 collaboration

Peter H Byers 1 collaboration

Michael J Bamshad 1 collaboration

Fuki M Hisama 1 collaboration

Gail P Jarvik 1 collaboration

Yasemin Sancak 1 collaboration

Katrina M Dipple 1 collaboration

Andrew B Stergachis 1 collaboration

Kristen Cox 1 collaboration

Laura Chipman 1 collaboration

Sidnee Petter 1 collaboration

Zhen Zuo 1 collaboration

Xuesen Cheng 1 collaboration

Salma Ferdous 1 collaboration

Jianming Shao 1 collaboration

Jin Li 1 collaboration

Yourong Bao 1 collaboration

Jean Li 1 collaboration

Jiaxiong Lu 1 collaboration

Antonio Jacobo Lopez 1 collaboration

Mervyn G Thomas 1 collaboration

Yumei Li 1 collaboration

Ala Moshiri 1 collaboration

Rui Chen 1 collaboration

Sucheta Bhattacharya 1 collaboration

Steve Horvath 1 collaboration

Isabella Palazzo 1 collaboration

Thanh V Hoang 1 collaboration

Seth Blackshaw 1 collaboration

Andy J Fischer 1 collaboration

Alexandria D Murry 1 collaboration

Sam A Golden 1 collaboration

Wan-Qing Yu 1 collaboration

Jing Huang 1 collaboration

Rachel O L Wong 1 collaboration

Connor R Finkbeiner 1 collaboration

Li Dai 1 collaboration

Kayla M Eschenbacher 1 collaboration

Dana L Jackson 1 collaboration

Debra A Thompson 1 collaboration

Alessandro Iannaccone 1 collaboration

Robin R Ali 1 collaboration

Vadim Y Arshavsky 1 collaboration

Isabelle Audo 1 collaboration

James W B Bainbridge 1 collaboration

Cagri G Besirli 1 collaboration

David G Birch 1 collaboration

Kari E Branham 1 collaboration

Artur V Cideciyan 1 collaboration

Steven P Daiger 1 collaboration

Deniz Dalkara 1 collaboration

Jacque L Duncan 1 collaboration

Abigail T Fahim 1 collaboration

John G Flannery 1 collaboration

Roberto Gattegna 1 collaboration

John R Heckenlively 1 collaboration

Elise Heon 1 collaboration

K Thiran Jayasundera 1 collaboration

Naheed W Khan 1 collaboration

Henry Klassen 1 collaboration

Bart P Leroy 1 collaboration

Robert S Molday 1 collaboration

David C Musch 1 collaboration

Mark E Pennesi 1 collaboration

Simon M Petersen-Jones 1 collaboration

Eric A Pierce 1 collaboration

Rajesh C Rao 1 collaboration

Jose A Sahel 1 collaboration

Dror Sharon 1 collaboration

Paul A Sieving 1 collaboration

Enrica Strettoi 1 collaboration

Paul Yang 1 collaboration

David N Zacks 1 collaboration

Nikolas Jorstad 1 collaboration

Qiang Chen 1 collaboration

Seoyoung Kang 1 collaboration

Daniel Larbi 1 collaboration

Monica Andrade 1 collaboration

Sara Reardon 1 collaboration

Yeon Jin Kim 1 collaboration

Ana R Silverstein 1 collaboration

Dennis M Dacey 1 collaboration

Rachel O Wong 1 collaboration

Norianne Ingram 1 collaboration

Xiuqian Mu 1 collaboration