questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxygénases
Dioxygenases
AlkB enzymes
AlkB enzymes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Borderline Personality Disorder
Diagnostic
5
Déficience enzymatique
Tests génétiques
Tests enzymatiques
Métabolites
Réparation de l'ADN
Cancer
Marqueurs biologiques
Activité enzymatique
Symptômes
5
Déficience enzymatique
Troubles neurologiques
Types d'enzymes
Fonction enzymatique
Gestion des symptômes
Gravité
Prévention
5
Prévention
Agents alkylants
Régime alimentaire
Antioxydants
Tests génétiques
Surveillance
Éducation
Sensibilisation
Traitements
5
Thérapie génique
Médicaments ciblés
Supplémentation
Antioxydants
Médecine personnalisée
Déficience enzymatique
Essais cliniques
Thérapies
Efficacité
Résultats à long terme
Complications
5
Gestion des complications
Permanence
Effets secondaires
Traitements
Facteurs de risque
5
Facteurs de risque
Prédispositions génétiques
Environnement
Produits chimiques
Antécédents familiaux
Cancers
Groupes à risque
Agents chimiques
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en enzymes AlkB ?",
"position": 1,
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"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?",
"position": 2,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
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"text": "Pas toujours, mais elles peuvent être utiles pour évaluer des tissus spécifiques."
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les enzymes AlkB ?",
"position": 4,
"acceptedAnswer": {
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"@type": "Question",
"name": "Y a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
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"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en AlkB ?",
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"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'AlkB ?",
"position": 7,
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"text": "Oui, différents types d'AlkB peuvent entraîner des symptômes variés selon leur fonction."
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"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec l'âge ?",
"position": 8,
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"@type": "Answer",
"text": "Les symptômes peuvent s'aggraver avec l'âge, surtout en cas d'exposition à des agents alkylants."
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"name": "Y a-t-il des symptômes spécifiques liés au cancer ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la fatigue, la perte de poids et des douleurs peuvent survenir."
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"@type": "Question",
"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
"acceptedAnswer": {
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"text": "Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents selon la gravité."
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"@type": "Question",
"name": "Peut-on prévenir les déficiences en AlkB ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais éviter les agents alkylants peut réduire les risques."
}
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"@type": "Question",
"name": "Y a-t-il des recommandations diététiques ?",
"position": 12,
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"@type": "Answer",
"text": "Une alimentation riche en antioxydants peut aider à protéger l'ADN contre les dommages."
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"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 13,
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"name": "L'éducation sur les risques est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sensibiliser aux risques liés aux agents alkylants est crucial pour la prévention."
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"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 15,
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"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les déficiences en AlkB."
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"@type": "Question",
"name": "Quels traitements existent pour les déficiences en AlkB ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie génique et des médicaments ciblés pour améliorer la réparation de l'ADN."
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"@type": "Question",
"name": "La supplémentation en nutriments aide-t-elle ?",
"position": 17,
"acceptedAnswer": {
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"text": "Certaines études suggèrent que des antioxydants peuvent aider à réduire les dommages à l'ADN."
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"name": "Les traitements sont-ils personnalisés ?",
"position": 18,
"acceptedAnswer": {
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"text": "Oui, les traitements peuvent être adaptés en fonction du type de déficience et des symptômes."
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"name": "Y a-t-il des essais cliniques en cours ?",
"position": 19,
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"text": "Oui, plusieurs essais cliniques explorent de nouvelles thérapies pour les déficiences en AlkB."
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"name": "Les traitements sont-ils efficaces à long terme ?",
"position": 20,
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"text": "L'efficacité varie, mais certains traitements montrent des résultats prometteurs sur le long terme."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec une déficience en AlkB ?",
"position": 21,
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"text": "Les complications incluent un risque accru de cancers et des troubles neurologiques graves."
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"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
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"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
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"@type": "Question",
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"position": 23,
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"@type": "Question",
"name": "Les complications varient-elles selon l'âge ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou immunodéprimées."
}
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"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests de dépistage peuvent aider à surveiller les complications."
}
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"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?",
"position": 26,
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"text": "Les facteurs incluent des prédispositions génétiques et l'exposition à des agents alkylants."
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"@type": "Question",
"name": "L'environnement joue-t-il un rôle ?",
"position": 27,
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"@type": "Answer",
"text": "Oui, l'exposition à des produits chimiques et à des radiations peut augmenter le risque."
}
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"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
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"name": "Y a-t-il des groupes à risque particulier ?",
"position": 30,
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/05/2025
Contenu vérifié selon les dernières recommandations médicales
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AlkB Homolog 1, histone H2a dioxygenase
AlkB Homolog 1, Histone H2a Dioxygenase
D000071498
-
D08.811.682.690.416.139.500
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AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071499
-
D08.811.682.690.416.139.750
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AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071500
-
D08.811.682.690.416.139.875
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AlkB Homolog 4, lysine demethylase
AlkB Homolog 4, Lysine Demethylase
D000071501
-
D08.811.682.690.416.139.937
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AlkB Homolog 5, RNA demethylase
AlkB Homolog 5, RNA Demethylase
D000071502
-
D08.811.682.690.416.139.968
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Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
D000071516
-
D08.811.682.690.416.139.992
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA. raustin@barnard.edu.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA, 91125, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA. liangf@stanford.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Sauvage Center for Molecular Sciences , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA. Electronic address: raustin@barnard.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Departamento de Biocatálisis, ICP-CSIC, Campus UAM-CSIC, Madrid, Spain; Center of Excellence in Bionanoscience Research, External Scientific Advisory Academic, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: rfl@icp.csic.es.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
R&D Center, BTC Corporation, Ansan 15588, Republic of Korea.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, University of Southern California, Los Angeles, CA, 90007, USA.
Publications dans "AlkB enzymes" :
Individuals with borderline personality disorder (BPD) or antisocial personality disorder (ASPD) are overrepresented in forensic settings. Yet, despite the burden these disorders place on healthcare a...
Borderline personality disorder (BPD) is a complex condition marked by heterogeneity. People with BPD have a profusion of symptoms spread across various levels of lived experience, such as identity, a...
Low personal agency is the concept of attributing successes and failures to external factors rather than personal characteristics. Previous research supported links between low personal agency and sym...
Patients (N = 57, age 18-72, 91.5% female) were assessed at intake, after three months of DBT treatment, and 12 months follow up on measures of symptoms and personal agency. Three separate measures we...
Mixed model analyses found BPD symptoms significantly reduced as a result of DBT treatment and were maintained at follow-up. However, 47% of participants continued to meet BPD criteria 12 months later...
Despite the reductions in BPD symptomology, personal agency did not significantly change over time. Those with lower agency at intake continued to do more poorly at follow up. We speculate that poor o...
The goal of this study was to evaluate specific characteristics associated with hopelessness, potentially correlated with coping strategies, sensory profile, and alexithymia in patients with borderlin...
Two hundred twenty-four (N=224) inpatients completed a clinical interview with administration of the Beck Hopelessness Scale (BHS), the Adolescent/Adult Sensory Profile (AASP), the Coping Orientation ...
Hopelessness was significantly associated with female gender, more hospitalizations, current suicidal ideation, number of suicide attempts, current and lifetime medication abuse, and alcohol misuse. F...
Hopelessness in BPD was associated with higher severity of illness, alternative process sensory input from the environment, reduced ability to cope with stressful events, and alexithymia. Therefore, a...
Among people with a diagnosis of borderline personality disorder (BPD) who are engaged in clinical care, prescription rates of psychotropic medications are high, despite the fact that medication use i...
To assess the effects of pharmacological treatment for people with BPD....
For this update, we searched CENTRAL, MEDLINE, Embase, 14 other databases and four trials registers up to February 2022. We contacted researchers working in the field to ask for additional data from p...
Randomised controlled trials comparing pharmacological treatment to placebo, other pharmacologic treatments or a combination of pharmacologic treatments in people of all ages with a formal diagnosis o...
At least two review authors independently selected trials, extracted data, assessed risk of bias using Cochrane's risk of bias tool and assessed the certainty of the evidence using the GRADE approach....
We included 46 randomised controlled trials (2769 participants) in this review, 45 of which were eligible for quantitative analysis and comprised 2752 participants with BPD in total. This is 18 more t...
This review included 18 more trials than the 2010 version, so larger meta-analyses with more statistical power were feasible. We found mostly very low-certainty evidence that medication may result in ...
People diagnosed with borderline personality disorder (BPD) frequently present to healthcare services in crisis, often with suicidal thoughts or actions. Despite this, little is known about what const...
To assess the effects of crisis interventions in adults diagnosed with BPD in any setting....
We searched CENTRAL, MEDLINE, Embase, nine other databases and three trials registers up to January 2022. We also checked reference lists, handsearched relevant journal archives and contacted experts ...
Randomised controlled trials (RCTs) comparing crisis interventions with usual care, no intervention or waiting list, in adults of any age diagnosed with BPD....
We used standard methodological procedures expected by Cochrane....
We included two studies with 213 participants. One study (88 participants) was a feasibility RCT conducted in the UK that examined the effects of joint crisis plans (JCPs) plus treatment as usual (TAU...
A comprehensive search of the literature revealed very little RCT-based evidence to inform the management of acute crises in people diagnosed with BPD. We included two studies of two very different ty...
The progressively improving understanding of the borderline personality disorder (BPD) has led to an increased interest in the better clarification of the integrated role of biological and psychosocia...
A growing body of research has shown that people with a wide range of psychiatric disorders, including depression, present with alterations of the gut microbiota, although it is unclear if differences...
Twenty-four unmedicated patients and twenty-one age- and sex-matched healthy controls were recruited. Stool samples were frozen at -80 °C within ten minutes after defecation. The V4 region of bacteria...
There was no significant difference in alpha- and beta-diversity between patients and controls. However, the Bacteroidetes/Firmicutes-ratio was higher in patients, approaching significance (p = 0.06, ...
Differences in the taxonomic composition may indicate a potential dysbiosis among SCFA-producing bacteria in BPD. Future research is warranted to replicate these findings in independent and larger sam...
Previous research has emphasized the importance of therapists giving Routine Outcome Monitoring (ROM) feedback to their patients. It has been shown that several factors influence therapists' tendency ...
In this qualitative study, using a semi-structured interview followed by thematic analysis using Atlas.ti, we focused on experiences of therapists and patients with a disorder specific ROM instrument:...
Qualitative analysis revealed that patients experienced benefits of ROM using the BPDSI-IV. Patients gained more insight in and recognition of their borderline personality disorder symptoms. They also...
Experiences of both patients and therapists with the BPDSI-IV were positive. It seems to be valuable and promising for healthcare institutions to evaluate treatment with a disorder specific ROM instru...
It has been suggested that the diagnosis of borderline personality disorder (BPD) is associated with particularly stigmatizing connotations, particularly among mental health professionals. The goal of...
A systematic search was carried out using MEDLINE Complete, CINAHL Complete, PsychoINFO, PsychARTICLES, Scopus, Social Sciences Citation Index, and Academic Search Complete. Study quality was rated us...
This review included 37 papers involving an estimated 8196 participants: 21 cross-sectional survey studies, 5 studies assessing training workshops, 5 studies assessing countertransference, and 6 exper...
Negative attitudes toward BPD continue to be a problem to differing degrees among clinical staff. Although this issue is most prominent among psychiatric nurses, the results of this review highlight e...