questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxygénases
Dioxygenases
AlkB enzymes
AlkB enzymes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Cost-Effectiveness Analysis
Diagnostic
5
Déficience enzymatique
Tests génétiques
Tests enzymatiques
Métabolites
Réparation de l'ADN
Cancer
Marqueurs biologiques
Activité enzymatique
Symptômes
5
Déficience enzymatique
Troubles neurologiques
Types d'enzymes
Fonction enzymatique
Gestion des symptômes
Gravité
Prévention
5
Prévention
Agents alkylants
Régime alimentaire
Antioxydants
Tests génétiques
Surveillance
Éducation
Sensibilisation
Traitements
5
Thérapie génique
Médicaments ciblés
Supplémentation
Antioxydants
Médecine personnalisée
Déficience enzymatique
Essais cliniques
Thérapies
Efficacité
Résultats à long terme
Complications
5
Gestion des complications
Permanence
Effets secondaires
Traitements
Facteurs de risque
5
Facteurs de risque
Prédispositions génétiques
Environnement
Produits chimiques
Antécédents familiaux
Cancers
Groupes à risque
Agents chimiques
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"name": "Quels sont les symptômes d'une déficience en AlkB ?",
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"position": 8,
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"name": "Y a-t-il des symptômes spécifiques liés au cancer ?",
"position": 9,
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"text": "Oui, des symptômes comme la fatigue, la perte de poids et des douleurs peuvent survenir."
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"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
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"text": "Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents selon la gravité."
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"@type": "Question",
"name": "Peut-on prévenir les déficiences en AlkB ?",
"position": 11,
"acceptedAnswer": {
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"text": "La prévention est difficile, mais éviter les agents alkylants peut réduire les risques."
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"position": 12,
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"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 13,
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"text": "Oui, les tests génétiques peuvent identifier les personnes à risque et permettre une surveillance précoce."
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"name": "L'éducation sur les risques est-elle importante ?",
"position": 14,
"acceptedAnswer": {
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"text": "Oui, sensibiliser aux risques liés aux agents alkylants est crucial pour la prévention."
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"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 15,
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"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les déficiences en AlkB."
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"name": "Quels traitements existent pour les déficiences en AlkB ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie génique et des médicaments ciblés pour améliorer la réparation de l'ADN."
}
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"@type": "Question",
"name": "La supplémentation en nutriments aide-t-elle ?",
"position": 17,
"acceptedAnswer": {
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"text": "Certaines études suggèrent que des antioxydants peuvent aider à réduire les dommages à l'ADN."
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"name": "Les traitements sont-ils personnalisés ?",
"position": 18,
"acceptedAnswer": {
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"text": "Oui, les traitements peuvent être adaptés en fonction du type de déficience et des symptômes."
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"name": "Y a-t-il des essais cliniques en cours ?",
"position": 19,
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"text": "Oui, plusieurs essais cliniques explorent de nouvelles thérapies pour les déficiences en AlkB."
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"name": "Quelles complications peuvent survenir avec une déficience en AlkB ?",
"position": 21,
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"text": "Les complications incluent un risque accru de cancers et des troubles neurologiques graves."
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"position": 22,
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"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
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"name": "Y a-t-il des complications liées à des traitements ?",
"position": 23,
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"name": "Les complications varient-elles selon l'âge ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou immunodéprimées."
}
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"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests de dépistage peuvent aider à surveiller les complications."
}
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"name": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?",
"position": 26,
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"text": "Les facteurs incluent des prédispositions génétiques et l'exposition à des agents alkylants."
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"name": "L'environnement joue-t-il un rôle ?",
"position": 27,
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"text": "Oui, l'exposition à des produits chimiques et à des radiations peut augmenter le risque."
}
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"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/05/2025
Contenu vérifié selon les dernières recommandations médicales
└─
AlkB Homolog 1, histone H2a dioxygenase
AlkB Homolog 1, Histone H2a Dioxygenase
D000071498
-
D08.811.682.690.416.139.500
└─
AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071499
-
D08.811.682.690.416.139.750
└─
AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071500
-
D08.811.682.690.416.139.875
└─
AlkB Homolog 4, lysine demethylase
AlkB Homolog 4, Lysine Demethylase
D000071501
-
D08.811.682.690.416.139.937
└─
AlkB Homolog 5, RNA demethylase
AlkB Homolog 5, RNA Demethylase
D000071502
-
D08.811.682.690.416.139.968
└─
Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
D000071516
-
D08.811.682.690.416.139.992
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA. raustin@barnard.edu.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA, 91125, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA. liangf@stanford.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Sauvage Center for Molecular Sciences , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA. Electronic address: raustin@barnard.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Departamento de Biocatálisis, ICP-CSIC, Campus UAM-CSIC, Madrid, Spain; Center of Excellence in Bionanoscience Research, External Scientific Advisory Academic, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: rfl@icp.csic.es.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
R&D Center, BTC Corporation, Ansan 15588, Republic of Korea.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, University of Southern California, Los Angeles, CA, 90007, USA.
Publications dans "AlkB enzymes" :
While contrast-enhanced MR imaging is the criterion standard in meningioma diagnosis and treatment response assessment, gallium...
We developed a decision-analytical model based on both recommended guidelines on meningioma management and our institutional experience. Markov models were implemented to estimate quality-adjusted lif...
The cost-effectiveness results demonstrated that...
Gene expression profiling tests can predict the risk of disease recurrence and select patients who are expected to benefit from therapy, while allowing other patients to forgo therapy. For breast canc...
We constructed a Markov decision model to calculate the lifetime costs (in 2020 Euros) and effects (survival and quality-adjusted life-years) of MammaPrint...
Adjuvant endocrine therapy guided by MammaPrint...
Standard MammaPrint...
The traditional cost-effectiveness analysis framework usually takes a healthcare system perspective, where the aim is to maximise population health from a fixed budget allocated to healthcare. Extensi...
This paper aims to develop a comprehensive framework that incorporates into the cost-effectiveness analysis framework some of its most advocated extensions and provides a means of arriving at a unidim...
Building on previous work, I proposed a framework that explicitly incorporates the full extent of the opportunity costs that arise when new dimensions and distributional concerns are included in cost-...
Operationalising the proposed framework requires system-wide representative values and/or robust estimates concerning: (i) selecting dimensions; (ii) measuring opportunity costs associated with each d...
Extending the cost-effectiveness analysis framework entails extending the measurement of the opportunity costs of funding decisions. This implies populating an ambitious puzzle that in some cases pose...
Cost-effectiveness analysis (CEA) is the main way that economic evaluations are carried out in the health care field. However, CEA has limited validity in deciding whether any health care evaluation i...
Cost effectiveness analysis (CEA) has been increasingly used to inform cancer treatment coverage policy making worldwide. The primary objective of this study was to assess the association between indu...
All CEAs in oncology used incremental cost per quality-adjusted life year (QALY) as health effect identified from the Tufts CEA Registry since 1976 was analyzed. Descriptive analyses were performed to...
A total of 1537 CEAs in oncology published from 1976 to 2021 were included. There were 387 (25.2%) with the industry sponsorship. CEAs sponsored by the industry were more likely to report ICERs below ...
Our study suggests that there has been a significant sponsorship bias in CEAs in oncology. This bias could have a profound implication on drug pricing and coverage policy making....
Several interventions exist for treating myopia progression in children. While these interventions' efficacy has been studied, their cost-effectiveness remains unknown and has not been compared....
To determine cost-effective options for controlling myopia progression in children....
In this cost-effectiveness analysis, a Markov model was designed to compare the cost-effectiveness of interventions for controlling myopia progression over 5 years from a societal perspective in a sim...
The mean costs (in US dollars) per child included the cost of hospital visits, medications, and optical lenses. The outcomes of effectiveness were the annual spherical equivalent refraction (SER) and ...
Outdoor activity, atropine (0.05%), red light therapy, HALs, and orthokeratology were cost-effective. The ICER of atropine, 0.05%, was US $220/SER reduction; red light therapy, US $846/SER reduction; ...
These findings suggest that atropine eye drops, 0.05%, and outdoor activity are cost-effective for controlling myopia progression in children. Though more expensive, red light therapy, HALs, and ortho...
The rising prevalence of myopia is a major global public health concern. Economic evaluation of myopia interventions is critical for maximizing the benefits of treatment and the healthcare system. Thi...
Probability based criteria are proposed for the assessment of cost-effectiveness of a new treatment compared to a standard treatment when there are multiple effectiveness measures. Depending on the pr...
Identification the optimal management intervention of sarcopenia is a concern of health systems. We aimed to analyze the cost-effectiveness of sarcopenia management strategies in Iran....
We constructed a lifetime Markov model based on natural history. The strategies comparedincluded exercise training, nutritional supplements, whole body vibration (WBV), and various exercise interventi...
All seven strategies increased lifetime effectiveness (QALYs). The protein and Vitamin D...
Study results, as the first economic evaluation of sarcopenia management interventions, showed that despite the higher effectiveness of D + P, the D strategy was the most cost-effective. Completing cl...
Typhoid vaccination has been shown to be an effective intervention to prevent enteric fever and is under consideration for inclusion in the national immunization program in Lao PDR....
A cost-utility analysis was performed using an age-structured static decision tree model to estimate the costs and health outcomes of introducing TCV. Vaccination strategies combined with five deliver...
In the model, we estimated 172.2 cases of enteric fever, with 1.3 deaths and a total treatment cost of USD 7,244, based on a birth cohort of 164,662 births without TCV vaccination that was followed ov...
Inclusion of TCV in the national vaccination program in Lao PDR would only be cost-effective if the true typhoid incidence is 25-times higher than our current estimate....