questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxygénases
Dioxygenases
AlkB enzymes
AlkB enzymes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Neoplasm Recurrence, Local
Diagnostic
5
Déficience enzymatique
Tests génétiques
Tests enzymatiques
Métabolites
Réparation de l'ADN
Cancer
Marqueurs biologiques
Activité enzymatique
Symptômes
5
Déficience enzymatique
Troubles neurologiques
Types d'enzymes
Fonction enzymatique
Gestion des symptômes
Gravité
Prévention
5
Prévention
Agents alkylants
Régime alimentaire
Antioxydants
Tests génétiques
Surveillance
Éducation
Sensibilisation
Traitements
5
Thérapie génique
Médicaments ciblés
Supplémentation
Antioxydants
Médecine personnalisée
Déficience enzymatique
Essais cliniques
Thérapies
Efficacité
Résultats à long terme
Complications
5
Gestion des complications
Permanence
Effets secondaires
Traitements
Facteurs de risque
5
Facteurs de risque
Prédispositions génétiques
Environnement
Produits chimiques
Antécédents familiaux
Cancers
Groupes à risque
Agents chimiques
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"description": "Comment diagnostiquer une déficience en enzymes AlkB ?\nQuels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec les enzymes AlkB ?\nY a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en enzymes AlkB ?",
"position": 1,
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"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer."
}
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des tests enzymatiques spécifiques et des analyses de métabolites peuvent être réalisés."
}
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{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
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"text": "Pas toujours, mais elles peuvent être utiles pour évaluer des tissus spécifiques."
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les enzymes AlkB ?",
"position": 4,
"acceptedAnswer": {
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"text": "Des anomalies dans la réparation de l'ADN, pouvant mener à des cancers ou des maladies génétiques."
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"@type": "Question",
"name": "Y a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
"position": 5,
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}
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"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en AlkB ?",
"position": 6,
"acceptedAnswer": {
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"text": "Les symptômes incluent des anomalies de croissance, des troubles neurologiques et un risque accru de cancer."
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"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'AlkB ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, différents types d'AlkB peuvent entraîner des symptômes variés selon leur fonction."
}
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"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec l'âge ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent s'aggraver avec l'âge, surtout en cas d'exposition à des agents alkylants."
}
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"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques liés au cancer ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la fatigue, la perte de poids et des douleurs peuvent survenir."
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"@type": "Question",
"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents selon la gravité."
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{
"@type": "Question",
"name": "Peut-on prévenir les déficiences en AlkB ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais éviter les agents alkylants peut réduire les risques."
}
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"@type": "Question",
"name": "Y a-t-il des recommandations diététiques ?",
"position": 12,
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"@type": "Answer",
"text": "Une alimentation riche en antioxydants peut aider à protéger l'ADN contre les dommages."
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"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 13,
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"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les personnes à risque et permettre une surveillance précoce."
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"@type": "Question",
"name": "L'éducation sur les risques est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sensibiliser aux risques liés aux agents alkylants est crucial pour la prévention."
}
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"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 15,
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"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les déficiences en AlkB."
}
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"@type": "Question",
"name": "Quels traitements existent pour les déficiences en AlkB ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie génique et des médicaments ciblés pour améliorer la réparation de l'ADN."
}
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"@type": "Question",
"name": "La supplémentation en nutriments aide-t-elle ?",
"position": 17,
"acceptedAnswer": {
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"text": "Certaines études suggèrent que des antioxydants peuvent aider à réduire les dommages à l'ADN."
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 18,
"acceptedAnswer": {
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"text": "Oui, les traitements peuvent être adaptés en fonction du type de déficience et des symptômes."
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"@type": "Question",
"name": "Y a-t-il des essais cliniques en cours ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques explorent de nouvelles thérapies pour les déficiences en AlkB."
}
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"@type": "Question",
"name": "Les traitements sont-ils efficaces à long terme ?",
"position": 20,
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"text": "L'efficacité varie, mais certains traitements montrent des résultats prometteurs sur le long terme."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec une déficience en AlkB ?",
"position": 21,
"acceptedAnswer": {
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"text": "Les complications incluent un risque accru de cancers et des troubles neurologiques graves."
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"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
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"@type": "Question",
"name": "Y a-t-il des complications liées à des traitements ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des effets secondaires et des complications."
}
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"@type": "Question",
"name": "Les complications varient-elles selon l'âge ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou immunodéprimées."
}
},
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"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests de dépistage peuvent aider à surveiller les complications."
}
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"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques et l'exposition à des agents alkylants."
}
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"@type": "Question",
"name": "L'environnement joue-t-il un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des produits chimiques et à des radiations peut augmenter le risque."
}
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"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
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"text": "Oui, des antécédents familiaux de cancers ou de maladies génétiques augmentent le risque."
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"name": "Le mode de vie influence-t-il le risque ?",
"position": 29,
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"text": "Oui, des habitudes comme le tabagisme et une mauvaise alimentation peuvent augmenter le risque."
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"@type": "Question",
"name": "Y a-t-il des groupes à risque particulier ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes exposées à des agents chimiques au travail sont à risque accru."
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/05/2025
Contenu vérifié selon les dernières recommandations médicales
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AlkB Homolog 1, histone H2a dioxygenase
AlkB Homolog 1, Histone H2a Dioxygenase
D000071498
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D08.811.682.690.416.139.500
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AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071499
-
D08.811.682.690.416.139.750
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AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071500
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D08.811.682.690.416.139.875
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AlkB Homolog 4, lysine demethylase
AlkB Homolog 4, Lysine Demethylase
D000071501
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D08.811.682.690.416.139.937
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AlkB Homolog 5, RNA demethylase
AlkB Homolog 5, RNA Demethylase
D000071502
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D08.811.682.690.416.139.968
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Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
D000071516
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D08.811.682.690.416.139.992
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA. raustin@barnard.edu.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA, 91125, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA. liangf@stanford.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Sauvage Center for Molecular Sciences , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA. Electronic address: raustin@barnard.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Departamento de Biocatálisis, ICP-CSIC, Campus UAM-CSIC, Madrid, Spain; Center of Excellence in Bionanoscience Research, External Scientific Advisory Academic, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: rfl@icp.csic.es.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
R&D Center, BTC Corporation, Ansan 15588, Republic of Korea.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, University of Southern California, Los Angeles, CA, 90007, USA.
Publications dans "AlkB enzymes" :
Little information is available about the clinical and pathologic characteristics of local recurrence (LR) after nipple-sparing mastectomy according to the locations of LR....
This study classified 99 patients into the following two groups according to the location of LR after nipple-sparing mastectomy: nipple-areolar recurrence (NAR) group and other locations of LR (oLR) g...
For about half of the patients (44.4 %) with NAR, the primary cancer was estrogen receptor (ER)-negative and human epidermal growth factor receptor 2 (HER2)-positive. Conversely, in most of the patien...
This multi-institutional retrospective study demonstrated that the features of NAR, such as the characteristics of the primary and recurrent tumors and the prognostic factors after LR resection, were ...
Despite advances in perioperative management, recurrence after curative pancreatectomy is a critical issue in the treatment of pancreatic ductal adenocarcinoma (PDAC). The significance of local therap...
We reviewed the medical records of patients with PDAC who underwent curative resection at our institution between January 2009 and December 2019. We examined the patterns of relapse and assessed the c...
A total of 246 patients with PDAC who underwent R0 or R1 resection were included in this study. The 3-year overall survival (OS) rate was 39.8%, and the 1-year recurrence-free survival rate was 51.2% ...
Our results suggest that a multimodal approach may improve the clinical outcomes of patients with recurrent PDAC....
Skin cancer may recur at or around the surgical site despite wide excisions. Prompt clinical and sonographic detection of local recurrence is important since subjects with relapsing melanomas or nonme...
Pathological factors that influence and predict survival following pelvic exenteration (PE) for locally advanced (LARC) or locally recurrent rectal cancer (LRRC), especially LRRC, remain poorly unders...
A retrospective cohort study was performed for all patients undergoing a curative PE for LARC or LRRC between 2008 and 2021 at a tertiary referral UK specialist colorectal hospital. Cox regression ana...
388 patients were included in the analysis with 256 resections for LARC and 132 for LRRC. 62.4% of patients were male with a median age of 59 years (IQR 49-67). 247 (64%) partial pelvic exenterations ...
A positive resection margin and poorly differentiated tumours are significant negative prognostic markers for survival and recurrence in LARC. The results of this study support the need to look for al...
Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal h...
The initial approach to the treatment of desmoid tumors has changed from surgical resection to watchful waiting. However, surgery is still sometimes considered for some patients, and it is likely that...
We sought to explore whether a combined molecular and clinical prognostic model for relapse in patients with desmoid tumors treated with surgery would allow us to identify patients who might do well w...
This was a retrospective, single-center study of 107 patients with desmoid tumors who were surgically treated between January 1980 and December 2015, with a median follow-up of 106 months (range 7 to ...
The multivariable analysis showed that S45F mutations (hazard ratio 5.25 [95% confidence interval 2.27 to 12.15]; p < 0.001) and tumor in the extremities (HR 3.15 [95% CI 1.35 to 7.33]; p = 0.008) wer...
CTNNB1 S45F mutations combined with other clinical variables are a potential prognostic biomarker associated with the risk of relapse in patients with desmoid tumors. The developed nomogram is simple ...
Level III, therapeutic study....
A first local recurrence is common after resection or radiotherapy for brain metastasis (BM). However, patients with BMs can develop multiple local recurrences over time. Published data on second loca...
Patients were identified from a database at Brigham and Women's Hospital in Boston. Hazard ratios and 95% confidence intervals for predictors of a second local recurrence were computed using a Cox pro...
Of 170 identified surgically treated first locally recurrent lesions, 74 (43.5%) progressed to second locally recurrent lesions at a median of 7 months after craniotomy. Subtotal resection of the firs...
A second local recurrence occurred after 43.5% of craniotomies for first recurrent lesions. Subtotal resection and infratentorial location were the strongest risk factors for worse second local recurr...
The current study was undertaken to provide more detailed prognostic models for early prediction of local recurrences and local recurrence free survival (RFS) using different radiologic and pathologic...
One hundred patients with locally advanced rectal carcinomas decided to receive neoadjuvant CRT were retrospectively recruited, Hazard ratios (HR) were determined in the two cox regression models and ...
HR of 1st group of models: T+N, T+N+G, T+N+G+S, T+N+G+S+PNI, and T+N+G+S+PNI+R were summated and categorized into scores, these scores were significantly correlated with the risk of recurrence (Somer'...
We propose that the addition of biologic factors to staging of rectal cancer provide precise stratification and association with local recurrences in patients received preoperative CRT....
This study aims to identify prognostic factors and define the best extent of surgery for optimizing treatment of local recurrence (LR) following colorectal cancer (CRC)....
An institutional database of consecutive patients who underwent radical resection (R0/R1) of LR following CRC was analyzed prospectively from 2010 to 2021 at one tertiary cancer center....
In this study, 75 patients were included with LR following CRC and analyzed. Patients were categorized as compartmental resections (CompRe) (n = 47) if all adjacent organs were systematically removed,...
Complete compartmental surgery is safe and improves local control. Optimal LR resection needs to remove all contiguous organs, with or without tumor involvement....
RET-fused mesenchymal neoplasms mostly affect the soft tissue of paediatric patients. Given their responsiveness to selective RET inhibitors, it remains critical to identify those extraordinary cases ...
Clinicopathological features were assessed and partner agnostic targeted next-generation sequencing on clinically validated platforms were performed. The patients were 18, 53, and 55 years old and inc...
Our study expands the clinicopathological and genetic spectrum of mesenchymal neoplasms associated with RET fusions....