questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxygénases
Dioxygenases
AlkB enzymes
AlkB enzymes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Randomized Controlled Trials as Topic
Diagnostic
5
Déficience enzymatique
Tests génétiques
Tests enzymatiques
Métabolites
Réparation de l'ADN
Cancer
Marqueurs biologiques
Activité enzymatique
Symptômes
5
Déficience enzymatique
Troubles neurologiques
Types d'enzymes
Fonction enzymatique
Gestion des symptômes
Gravité
Prévention
5
Prévention
Agents alkylants
Régime alimentaire
Antioxydants
Tests génétiques
Surveillance
Éducation
Sensibilisation
Traitements
5
Thérapie génique
Médicaments ciblés
Supplémentation
Antioxydants
Médecine personnalisée
Déficience enzymatique
Essais cliniques
Thérapies
Efficacité
Résultats à long terme
Complications
5
Gestion des complications
Permanence
Effets secondaires
Traitements
Facteurs de risque
5
Facteurs de risque
Prédispositions génétiques
Environnement
Produits chimiques
Antécédents familiaux
Cancers
Groupes à risque
Agents chimiques
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "AlkB enzymes : Questions médicales les plus fréquentes",
"headline": "AlkB enzymes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les AlkB enzymes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-02-07",
"dateModified": "2025-05-02",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "AlkB enzymes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Dioxygenases",
"url": "https://questionsmedicales.fr/mesh/D049308",
"about": {
"@type": "MedicalCondition",
"name": "Dioxygenases",
"code": {
"@type": "MedicalCode",
"code": "D049308",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "AlkB Homolog 1, histone H2a dioxygenase",
"alternateName": "AlkB Homolog 1, Histone H2a Dioxygenase",
"url": "https://questionsmedicales.fr/mesh/D000071498",
"about": {
"@type": "MedicalCondition",
"name": "AlkB Homolog 1, histone H2a dioxygenase",
"code": {
"@type": "MedicalCode",
"code": "D000071498",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.500"
}
}
},
{
"@type": "MedicalWebPage",
"name": "AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase",
"alternateName": "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase",
"url": "https://questionsmedicales.fr/mesh/D000071499",
"about": {
"@type": "MedicalCondition",
"name": "AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase",
"code": {
"@type": "MedicalCode",
"code": "D000071499",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.750"
}
}
},
{
"@type": "MedicalWebPage",
"name": "AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase",
"alternateName": "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase",
"url": "https://questionsmedicales.fr/mesh/D000071500",
"about": {
"@type": "MedicalCondition",
"name": "AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase",
"code": {
"@type": "MedicalCode",
"code": "D000071500",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.875"
}
}
},
{
"@type": "MedicalWebPage",
"name": "AlkB Homolog 4, lysine demethylase",
"alternateName": "AlkB Homolog 4, Lysine Demethylase",
"url": "https://questionsmedicales.fr/mesh/D000071501",
"about": {
"@type": "MedicalCondition",
"name": "AlkB Homolog 4, lysine demethylase",
"code": {
"@type": "MedicalCode",
"code": "D000071501",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.937"
}
}
},
{
"@type": "MedicalWebPage",
"name": "AlkB Homolog 5, RNA demethylase",
"alternateName": "AlkB Homolog 5, RNA Demethylase",
"url": "https://questionsmedicales.fr/mesh/D000071502",
"about": {
"@type": "MedicalCondition",
"name": "AlkB Homolog 5, RNA demethylase",
"code": {
"@type": "MedicalCode",
"code": "D000071502",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.968"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Alpha-ketoglutarate-dependent dioxygenase FTO",
"alternateName": "Alpha-Ketoglutarate-Dependent Dioxygenase FTO",
"url": "https://questionsmedicales.fr/mesh/D000071516",
"about": {
"@type": "MedicalCondition",
"name": "Alpha-ketoglutarate-dependent dioxygenase FTO",
"code": {
"@type": "MedicalCode",
"code": "D000071516",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416.139.992"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "AlkB enzymes",
"alternateName": "AlkB Enzymes",
"code": {
"@type": "MedicalCode",
"code": "D000071496",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Shoshana C Williams",
"url": "https://questionsmedicales.fr/author/Shoshana%20C%20Williams",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA."
}
},
{
"@type": "Person",
"name": "Rachel Narehood Austin",
"url": "https://questionsmedicales.fr/author/Rachel%20Narehood%20Austin",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA. raustin@barnard.edu."
}
},
{
"@type": "Person",
"name": "Deyu Li",
"url": "https://questionsmedicales.fr/author/Deyu%20Li",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA."
}
},
{
"@type": "Person",
"name": "Zhijie Xu",
"url": "https://questionsmedicales.fr/author/Zhijie%20Xu",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China."
}
},
{
"@type": "Person",
"name": "Juliet Lee",
"url": "https://questionsmedicales.fr/author/Juliet%20Lee",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Topical diquafosol versus hyaluronic acid for the treatment of dry eye disease: a meta-analysis of randomized controlled trials.",
"datePublished": "2023-05-10",
"url": "https://questionsmedicales.fr/article/37162564",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00417-023-06083-4"
}
},
{
"@type": "ScholarlyArticle",
"name": "The UPDATE trial (UVB Phototherapy in Dermatology for ATopic Eczema): study protocol for a randomized controlled trial of narrowband UVB with optimal topical therapy versus optimal topical therapy in patients with atopic eczema.",
"datePublished": "2024-07-16",
"url": "https://questionsmedicales.fr/article/39014498",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13063-024-08334-z"
}
},
{
"@type": "ScholarlyArticle",
"name": "Design and Methodological Issues of Within-Person (Split-Body) Randomized Controlled Trials Evaluating a Topical Treatment: A Systematic Review.",
"datePublished": "2023-03-29",
"url": "https://questionsmedicales.fr/article/36990057",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1159/000530149"
}
},
{
"@type": "ScholarlyArticle",
"name": "Laser and light therapy combined with topical minoxidil for alopecia areata: a systematic review and meta-analysis of randomized controlled trials.",
"datePublished": "2023-02-17",
"url": "https://questionsmedicales.fr/article/36800063",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s10103-023-03734-0"
}
},
{
"@type": "ScholarlyArticle",
"name": "Nd:YAG/Er:YAG dual laser vs. topical steroid to treat vulvar lichen sclerosus: study protocol of a randomized controlled trial.",
"datePublished": "2023-05-05",
"url": "https://questionsmedicales.fr/article/37145134",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00404-023-07055-z"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Enzymes et coenzymes",
"item": "https://questionsmedicales.fr/mesh/D045762"
},
{
"@type": "ListItem",
"position": 3,
"name": "Enzymes",
"item": "https://questionsmedicales.fr/mesh/D004798"
},
{
"@type": "ListItem",
"position": 4,
"name": "Oxidoreductases",
"item": "https://questionsmedicales.fr/mesh/D010088"
},
{
"@type": "ListItem",
"position": 5,
"name": "Oxygénases",
"item": "https://questionsmedicales.fr/mesh/D010105"
},
{
"@type": "ListItem",
"position": 6,
"name": "Dioxygenases",
"item": "https://questionsmedicales.fr/mesh/D049308"
},
{
"@type": "ListItem",
"position": 7,
"name": "AlkB enzymes",
"item": "https://questionsmedicales.fr/mesh/D000071496"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : AlkB enzymes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur AlkB enzymes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-08",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur AlkB enzymes",
"description": "Comment diagnostiquer une déficience en enzymes AlkB ?\nQuels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec les enzymes AlkB ?\nY a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur AlkB enzymes",
"description": "Quels sont les symptômes d'une déficience en AlkB ?\nLes symptômes varient-ils selon le type d'AlkB ?\nComment les symptômes évoluent-ils avec l'âge ?\nY a-t-il des symptômes spécifiques liés au cancer ?\nLes symptômes sont-ils réversibles ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur AlkB enzymes",
"description": "Peut-on prévenir les déficiences en AlkB ?\nY a-t-il des recommandations diététiques ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nL'éducation sur les risques est-elle importante ?\nLes vaccinations peuvent-elles jouer un rôle ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur AlkB enzymes",
"description": "Quels traitements existent pour les déficiences en AlkB ?\nLa supplémentation en nutriments aide-t-elle ?\nLes traitements sont-ils personnalisés ?\nY a-t-il des essais cliniques en cours ?\nLes traitements sont-ils efficaces à long terme ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur AlkB enzymes",
"description": "Quelles complications peuvent survenir avec une déficience en AlkB ?\nLes complications sont-elles réversibles ?\nY a-t-il des complications liées à des traitements ?\nLes complications varient-elles selon l'âge ?\nComment surveiller les complications ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur AlkB enzymes",
"description": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?\nL'environnement joue-t-il un rôle ?\nLes antécédents familiaux sont-ils un facteur de risque ?\nLe mode de vie influence-t-il le risque ?\nY a-t-il des groupes à risque particulier ?",
"url": "https://questionsmedicales.fr/mesh/D000071496?mesh_terms=Randomized+Controlled+Trials+as+Topic#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une déficience en enzymes AlkB ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques spécifiques et des analyses de métabolites peuvent être réalisés."
}
},
{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pas toujours, mais elles peuvent être utiles pour évaluer des tissus spécifiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les enzymes AlkB ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réparation de l'ADN, pouvant mener à des cancers ou des maladies génétiques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains marqueurs peuvent indiquer l'activité ou la déficience des enzymes."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en AlkB ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des anomalies de croissance, des troubles neurologiques et un risque accru de cancer."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'AlkB ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, différents types d'AlkB peuvent entraîner des symptômes variés selon leur fonction."
}
},
{
"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec l'âge ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent s'aggraver avec l'âge, surtout en cas d'exposition à des agents alkylants."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques liés au cancer ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la fatigue, la perte de poids et des douleurs peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents selon la gravité."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les déficiences en AlkB ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais éviter les agents alkylants peut réduire les risques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en antioxydants peut aider à protéger l'ADN contre les dommages."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les personnes à risque et permettre une surveillance précoce."
}
},
{
"@type": "Question",
"name": "L'éducation sur les risques est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sensibiliser aux risques liés aux agents alkylants est crucial pour la prévention."
}
},
{
"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les déficiences en AlkB."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour les déficiences en AlkB ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie génique et des médicaments ciblés pour améliorer la réparation de l'ADN."
}
},
{
"@type": "Question",
"name": "La supplémentation en nutriments aide-t-elle ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent que des antioxydants peuvent aider à réduire les dommages à l'ADN."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du type de déficience et des symptômes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des essais cliniques en cours ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques explorent de nouvelles thérapies pour les déficiences en AlkB."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils efficaces à long terme ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité varie, mais certains traitements montrent des résultats prometteurs sur le long terme."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une déficience en AlkB ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent un risque accru de cancers et des troubles neurologiques graves."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications liées à des traitements ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des effets secondaires et des complications."
}
},
{
"@type": "Question",
"name": "Les complications varient-elles selon l'âge ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou immunodéprimées."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests de dépistage peuvent aider à surveiller les complications."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques et l'exposition à des agents alkylants."
}
},
{
"@type": "Question",
"name": "L'environnement joue-t-il un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des produits chimiques et à des radiations peut augmenter le risque."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers ou de maladies génétiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme et une mauvaise alimentation peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Y a-t-il des groupes à risque particulier ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes exposées à des agents chimiques au travail sont à risque accru."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
└─
AlkB Homolog 1, histone H2a dioxygenase
AlkB Homolog 1, Histone H2a Dioxygenase
D000071498 -
D08.811.682.690.416.139.500
└─
AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071499 -
D08.811.682.690.416.139.750
└─
AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071500 -
D08.811.682.690.416.139.875
└─
AlkB Homolog 4, lysine demethylase
AlkB Homolog 4, Lysine Demethylase
D000071501 -
D08.811.682.690.416.139.937
└─
AlkB Homolog 5, RNA demethylase
AlkB Homolog 5, RNA Demethylase
D000071502 -
D08.811.682.690.416.139.968
└─
Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
D000071516 -
D08.811.682.690.416.139.992
4 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Publications dans "AlkB enzymes" :
Diquafosol enhances fluid transfer and mucin secretion on ocular surface, which has been suggested as an effective treatment for dry eye disease (DED). The aim of the systematic review and meta-analys...
Relevant randomized controlled trials were obtained via search of electronic including PubMed, Embase, Cochrane Library, and Web of Science. A random-effects model was used to pool the results after i...
A total of nine RCTs involving 1295 patients with DED were included in the meta-analysis. Compared to treatment with 0.1% HA, topical treatment with 3% diquafosol significantly improved the Ocular Sur...
Topical treatment with 3% diquafosol may be more effective than 0.1% HA for patients with DED. However, the long-term efficacy and tolerability of diquafosol still need to be determined....
Narrowband ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, a...
A pragmatic, multicenter, PROBE trial will be performed with 1:1 randomization of 316 adult patients with moderate-to-severe AE who have inadequate disease control with topical therapy and who are eli...
The UPDATE trial aims to provide high-quality evidence regarding the (cost-)effectiveness and safety of NB-UVB phototherapy in moderate-to-severe AE patients. Challenges that are addressed in the prot...
ClinicalTrials.gov NCT05704205. Registered on December 8, 2022....
Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions/body sites rather than patients,...
The aim of this review was to provide a methodological overview of within-person randomized trials (WP-RCTs) in dermatology....
We searched for eligible trials published between 2017 and 2021 in MEDLINE, Embase, and Central in dermatology journals and the 6 highest-impact-factor general medical journals. Two authors selected p...
From 1,034 articles identified, we included 54 WP-RCTs, mainly for acne vulgaris, psoriasis, actinic keratosis, and atopic dermatitis. In most of the trials, patients had only 2 lesions/body sites. In...
Our systematic review highlights that despite the publication of the CONSORT checklist extension for WP-RCTs in 2017, this design is rarely used, and when it is, there are methodological and reporting...
We aim to evaluate the clinical efficacy and safety of using laser and light combined with topical minoxidil for alopecia areata. We searched PubMed, Embase, Web of Science, the Cochrane Library, Chin...
Vulvar lichen sclerosus (LS) is a chronic debilitating inflammatory skin disease. Today, the gold standard is a life-long topical steroid treatment. Alternative options are highly desired. We present ...
We recruited 66 patients, 44 in the laser arm and 22 in the steroid arm. Patients with a physician-administered clinical LS score ≥ 4 were included. Participants received either four laser treatments ...
The findings of this trial have the potential to offer a novel treatment option for LS. The standardized Nd:YAG/Er:YAG laser settings and the treatment regime are presented in this paper....
NCT03926299....
Alopecia areata (AA) is a common autoimmune skin disease. Our study aimed to systematically evaluate the efficacy and safety of compound glycyrrhizin (CG) combined with topical minoxidil therapy in tr...
We searched the PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases. Randomized controlled trials (RCTs) on CG combined with topical minoxidil therapy compared with topi...
11 RCTs and 1189 patients were included. Compared with topical minoxidil therapy alone, CG combined with topical minoxidil therapy was more effective at improving the clinical efficacy (RR = 1.36, 95%...
The current evidence indicates that CG combined with topical minoxidil therapy is effective and safe for AA. However, owing to the suboptimal quality of the included studies, more high-quality and lar...
The purpose was to identify and summarize the existing evidence on the efficacy and safety of the topical application of olive oil for preventing pressure ulcers (PUs). We included only randomized con...
To investigate the clinical efficacy and safety of topical difamilast in mild-to-moderate atopic dermatitis (AD)....
Only randomized controlled trials (RCTs) that compared topical difamilast with vehicle treatment for patients with AD were included. PubMed, Web of Science, Ovid Medline, Cochrane Library, ClinicalTri...
Five studies enrolling a total of 1009 patients with mild-to-moderate AD were identified. Compared with the topical vehicle, topical difamilast was associated with a significantly higher success rate ...
This meta-analysis suggests that topical difamilast is an effective and safe treatment for mild-to-moderate AD....
Melasma is a chronic relapsing skin condition. Laser therapy is a new advancement in treatment. Whether the topical application of tranexamic acid (TXA) increases the efficacy of laser therapy in mela...
Randomized controlled trials are used to estimate the causal effect of a treatment on a health outcome of interest in a patient population. Often the specified treatment in a randomized controlled tri...
We use causal reasoning to explain why randomized controlled trials of biomarker targets can arrive at conflicting or misleading conclusions. We describe four key threats to the validity of trials of ...
We illustrate these findings using evidence from 15 randomized controlled trials of blood pressure targets for management of hypertension. Randomized trials of blood pressure targets exhibit substanti...
Researchers should critically assess meta-analyses of trials of targets for variation in the types, distributions, and off-target effects of therapies studied. Trial investigators should release detai...
