questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxygénases
Dioxygenases
AlkB enzymes
AlkB enzymes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déficience enzymatique
Tests génétiques
Tests enzymatiques
Métabolites
Réparation de l'ADN
Cancer
Marqueurs biologiques
Activité enzymatique
Symptômes
5
Déficience enzymatique
Troubles neurologiques
Types d'enzymes
Fonction enzymatique
Gestion des symptômes
Gravité
Prévention
5
Prévention
Agents alkylants
Régime alimentaire
Antioxydants
Tests génétiques
Surveillance
Éducation
Sensibilisation
Traitements
5
Thérapie génique
Médicaments ciblés
Supplémentation
Antioxydants
Médecine personnalisée
Déficience enzymatique
Essais cliniques
Thérapies
Efficacité
Résultats à long terme
Complications
5
Gestion des complications
Permanence
Effets secondaires
Traitements
Facteurs de risque
5
Facteurs de risque
Prédispositions génétiques
Environnement
Produits chimiques
Antécédents familiaux
Cancers
Groupes à risque
Agents chimiques
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"description": "Comment diagnostiquer une déficience en enzymes AlkB ?\nQuels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec les enzymes AlkB ?\nY a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en enzymes AlkB ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer."
}
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des enzymes AlkB ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des tests enzymatiques spécifiques et des analyses de métabolites peuvent être réalisés."
}
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"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
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"text": "Pas toujours, mais elles peuvent être utiles pour évaluer des tissus spécifiques."
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les enzymes AlkB ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réparation de l'ADN, pouvant mener à des cancers ou des maladies génétiques."
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{
"@type": "Question",
"name": "Y a-t-il des marqueurs biologiques pour les enzymes AlkB ?",
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"text": "Oui, certains marqueurs peuvent indiquer l'activité ou la déficience des enzymes."
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"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en AlkB ?",
"position": 6,
"acceptedAnswer": {
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"text": "Les symptômes incluent des anomalies de croissance, des troubles neurologiques et un risque accru de cancer."
}
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{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'AlkB ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, différents types d'AlkB peuvent entraîner des symptômes variés selon leur fonction."
}
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{
"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec l'âge ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent s'aggraver avec l'âge, surtout en cas d'exposition à des agents alkylants."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques liés au cancer ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la fatigue, la perte de poids et des douleurs peuvent survenir."
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{
"@type": "Question",
"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents selon la gravité."
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{
"@type": "Question",
"name": "Peut-on prévenir les déficiences en AlkB ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais éviter les agents alkylants peut réduire les risques."
}
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"@type": "Question",
"name": "Y a-t-il des recommandations diététiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en antioxydants peut aider à protéger l'ADN contre les dommages."
}
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"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les personnes à risque et permettre une surveillance précoce."
}
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"@type": "Question",
"name": "L'éducation sur les risques est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sensibiliser aux risques liés aux agents alkylants est crucial pour la prévention."
}
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{
"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les déficiences en AlkB."
}
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"@type": "Question",
"name": "Quels traitements existent pour les déficiences en AlkB ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie génique et des médicaments ciblés pour améliorer la réparation de l'ADN."
}
},
{
"@type": "Question",
"name": "La supplémentation en nutriments aide-t-elle ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent que des antioxydants peuvent aider à réduire les dommages à l'ADN."
}
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du type de déficience et des symptômes."
}
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"@type": "Question",
"name": "Y a-t-il des essais cliniques en cours ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques explorent de nouvelles thérapies pour les déficiences en AlkB."
}
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"@type": "Question",
"name": "Les traitements sont-ils efficaces à long terme ?",
"position": 20,
"acceptedAnswer": {
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"text": "L'efficacité varie, mais certains traitements montrent des résultats prometteurs sur le long terme."
}
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec une déficience en AlkB ?",
"position": 21,
"acceptedAnswer": {
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"text": "Les complications incluent un risque accru de cancers et des troubles neurologiques graves."
}
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"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
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"@type": "Question",
"name": "Y a-t-il des complications liées à des traitements ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des effets secondaires et des complications."
}
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{
"@type": "Question",
"name": "Les complications varient-elles selon l'âge ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou immunodéprimées."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers et des tests de dépistage peuvent aider à surveiller les complications."
}
},
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"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les déficiences en AlkB ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques et l'exposition à des agents alkylants."
}
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{
"@type": "Question",
"name": "L'environnement joue-t-il un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des produits chimiques et à des radiations peut augmenter le risque."
}
},
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"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
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"text": "Oui, des antécédents familiaux de cancers ou de maladies génétiques augmentent le risque."
}
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"name": "Le mode de vie influence-t-il le risque ?",
"position": 29,
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"text": "Oui, des habitudes comme le tabagisme et une mauvaise alimentation peuvent augmenter le risque."
}
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"@type": "Question",
"name": "Y a-t-il des groupes à risque particulier ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes exposées à des agents chimiques au travail sont à risque accru."
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/05/2025
Contenu vérifié selon les dernières recommandations médicales
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AlkB Homolog 1, histone H2a dioxygenase
AlkB Homolog 1, Histone H2a Dioxygenase
D000071498
-
D08.811.682.690.416.139.500
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AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071499
-
D08.811.682.690.416.139.750
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AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
D000071500
-
D08.811.682.690.416.139.875
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AlkB Homolog 4, lysine demethylase
AlkB Homolog 4, Lysine Demethylase
D000071501
-
D08.811.682.690.416.139.937
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AlkB Homolog 5, RNA demethylase
AlkB Homolog 5, RNA Demethylase
D000071502
-
D08.811.682.690.416.139.968
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Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
D000071516
-
D08.811.682.690.416.139.992
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA. raustin@barnard.edu.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Publications dans "AlkB enzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA, 91125, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA. liangf@stanford.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Sauvage Center for Molecular Sciences , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry , Wuhan University , Wuhan 430072 , P.R. China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY 10027, USA. Electronic address: raustin@barnard.edu.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
Departamento de Biocatálisis, ICP-CSIC, Campus UAM-CSIC, Madrid, Spain; Center of Excellence in Bionanoscience Research, External Scientific Advisory Academic, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: rfl@icp.csic.es.
Publications dans "AlkB enzymes" :
2 publications dans cette catégorie
Affiliations :
R&D Center, BTC Corporation, Ansan 15588, Republic of Korea.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Publications dans "AlkB enzymes" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Barnard College, 3009 Broadway, New York, NY, 10027, USA.
Department of Chemistry, University of Southern California, Los Angeles, CA, 90007, USA.
Publications dans "AlkB enzymes" :
Vision screening during childhood is vital for the early detection and treatment of visual impairment that may significantly impact a child's development and quality of life. This nationwide cross-sec...
For a good vision screening battery to quickly and accurately reflect the status of the human visual system it should be relevant, reliable, and streamlined. Because the early visual system has limite...
The World Health Organization (WHO) estimates that 1.5 billion and 2.2 billion people have hearing and vision impairment, respectively. The burden of these non-communicable diseases is highest in low-...
A keyword search of three electronic databases, namely Scopus, MEDLINE (PubMed), and Web of Science, was conducted, resulting in 219 results. After removing duplicates and screening based on eligibili...
Most studies (63.2%) were from high-income countries, with 31.6% from middle-income and 5.2% from low-income countries. The majority of studies (78.9%) involved children and the four studies reporting...
There is limited research evidence for combined hearing and vision screening programs. Although potential benefits are demonstrated, especially for mHealth-supported programs in communities, more feas...
The aim was to investigate universality of access, screening rate, and outcomes from the New South Wales (NSW) Statewide Eyesight Preschooler Screening (StEPS) over the period of 2009 to 2016....
Cross-sectional, observational study....
The StEPS program provides vision screening to 4-year-old children residing in NSW and is administered within Local Health Districts (LHDs). Visual acuity (VA) was examined by trained lay and nurse sc...
A total of 719,686 (96.4%) NSW 4-year-old children were offered StEPS vision screening between 2009 and 2016, 84% accepted and 564,825 children (75.6%) were screened. The screening rate increased from...
StEPS is an ideal service model for preschool vision screening providing coverage that is comparable to school-based screening programs and at an age likely to facilitate optimal treatment outcomes....
To investigate the relationship between neighbourhood disadvantage and vision screening failure rates....
This analysis uses aggregate data from pre-kindergarten to eighth grade schools participating in a school-based vision programme in Baltimore, Maryland, from 2016 to 2019. Data on number of students s...
Nine hundred seventy-two grades across 117 schools were included in this analysis. Median national ADI percentile across the sample was 71 [interquartile range (IQR): 48-85] (100 = most deprived). The...
In this study, there was no association between vision screening failure rates and school ADI. With one in three students failing screening in a high poverty public school district, these findings sug...
Myopia prevalence has increased in the UK at age 10-16y, but little is known about younger children. We hypothesise that if the 'myopia epidemic' is affecting young children, then there will be increa...
Retrospective anonymised data from computerised vision screening at age 4-5 years were analysed from serial cross-sectional data. Refractive error is not assessed in UK vision screening, so vision was...
Anonymised raw data were obtained for 359,634 screening episodes from 2075 schools. Once schools were excluded where data were not available for every year and data were cleaned, the final database co...
For children 4-5 years of age, there were signs of reduced vision over the last 7 years in England. Consideration of the most likely causes support the hypothesis of increasing myopia. The increase in...
Effective vision screening programs for children require follow-up with eye care providers, but studies demonstrate poor follow-up rates after failed screenings. Programs have attempted to address thi...
Between 2018 and 2021, a nonprofit organization provided in-school instrument-based screening and noncycloplegic examinations and refractions in elementary, middle, and high schools. Deidentified scre...
In the 2019-2020 school year, 14,006 students from 58 schools were screened, and 4,238 (30.3%) were referred. The percentage of economically disadvantaged students was positively correlated to referra...
A combined screening program and mobile clinic traveling directly to schools can provide a pipeline for delivering eye care to vulnerable populations....
Children in socioeconomically disadvantaged communities often do not access follow-up eye care services when referred from vision screenings; whether this is due to lack of availability is not known. ...
Vision impairments develop from a young age and may inhibit learning experiences and impact life outcomes. Vision screening to detect and refer vision abnormalities supports children in their educatio...
The programme involved all prep children from participating schools in Queensland. Vision screening was conducted with the Parr 4 m Visual Acuity Test and Welch Allyn Spot Vision Screener. A cross-sec...
Of 71,003 prep students screened, 4,855 (6.8%) received a referral recommendation. A higher proportion of children who received a referral recommendation was from more disadvantaged locations (?2 = 10...
It is important that vision screening programmes target disadvantaged populations and support families of children who require further health assessment to access health services....
Nationwide in Japan, a community-based vision-screening program in 3.5-year-old children is conducted in three steps: questionnaires and home visual acuity testing as the primary screening; visual acu...
For cost-effectiveness comparison of child vision and hearing screening programmes, methods and data should be available. We assessed the current state of data collection and its availability in Europ...
The EUSCREEN Questionnaire, conducted in 2017-2018, assessed paediatric vision and hearing screening programmes in 45 countries in Europe. For the current study, its items on data collection, monitori...
The practice of data collection in vision screening was reported in 36% (N = 42) of countries and in hearing screening in 81% (N = 43); collected data were published in 12% and 35%, respectively. Proc...
Data collection is insufficient in hearing screening and even more so in vision screening: data essential for cost-effectiveness comparison could not be reported from most countries. When collection t...