questionsmedicales.fr
Métabolisme
Désalkylation
Déméthylation
Déméthylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déméthylation
Analyse de l'ADN
Marqueurs épigénétiques
5-méthylcytosine
Tests sanguins
ADN circulant
Biopsie
Analyse tissulaire
Troubles neurologiques
Cancers
Symptômes
5
Troubles cognitifs
Anomalies de croissance
Maladies génétiques
Cancer
Changements de comportement
Anomalies physiques
Système immunitaire
Infections
Prévention
5
Alimentation équilibrée
Mode de vie sain
Suppléments
Acide folique
Exercice physique
Santé épigénétique
Toxines environnementales
Perturbation épigénétique
Traitements
5
Thérapie génique
Médicaments ciblés
Thérapies épigénétiques
Cancer
Médecine personnalisée
Profil génétique
Complications
5
Cancers
Maladies auto-immunes
Réversibilité
Modifications épigénétiques
Maladies chroniques
Troubles de développement
Fertilité
Fonction reproductive
Effets à long terme
Prédispositions
Facteurs de risque
5
Facteurs de risque
Toxines
Hérédité
Facteurs génétiques
Maladies chroniques
Risque
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{
"@type": "Question",
"name": "Quels marqueurs sont utilisés pour la déméthylation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
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{
"@type": "Question",
"name": "Quels tests sanguins peuvent indiquer une déméthylation ?",
"position": 3,
"acceptedAnswer": {
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},
{
"@type": "Question",
"name": "La biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?",
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"acceptedAnswer": {
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{
"@type": "Question",
"name": "Quels symptômes peuvent alerter sur une déméthylation ?",
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"@type": "Question",
"name": "Quels symptômes sont associés à la déméthylation ?",
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"@type": "Question",
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"@type": "Question",
"name": "Y a-t-il des signes cliniques de déméthylation ?",
"position": 8,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le développement."
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{
"@type": "Question",
"name": "La déméthylation affecte-t-elle le système immunitaire ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut altérer la réponse immunitaire, augmentant le risque d'infections."
}
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{
"@type": "Question",
"name": "Comment prévenir la déméthylation ?",
"position": 11,
"acceptedAnswer": {
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"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les suppléments peuvent-ils aider ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme l'acide folique peuvent soutenir la méthylation."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la déméthylation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régulier peut améliorer la santé épigénétique et la méthylation."
}
},
{
"@type": "Question",
"name": "Les toxines environnementales jouent-elles un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour la déméthylation ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies géniques et des médicaments ciblés."
}
},
{
"@type": "Question",
"name": "La nutrition peut-elle influencer la déméthylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains nutriments comme l'acide folique peuvent moduler la méthylation."
}
},
{
"@type": "Question",
"name": "Les thérapies épigénétiques sont-elles efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles montrent un potentiel prometteur dans le traitement de certains cancers."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la déméthylation par des médicaments ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques peuvent être utilisés pour prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles neurologiques et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "La déméthylation est-elle réversible ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines modifications peuvent être réversibles, mais pas toutes."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à la déméthylation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent des maladies chroniques et des troubles de développement."
}
},
{
"@type": "Question",
"name": "La déméthylation peut-elle affecter la fertilité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut influencer la fertilité en altérant la fonction reproductive."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets à long terme peuvent inclure des prédispositions à diverses maladies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de déméthylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'alimentation, le stress, et l'exposition à des toxines."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs génétiques peuvent influencer la déméthylation."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies chroniques peuvent augmenter le risque de déméthylation."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il la déméthylation ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie malsain peut favoriser la déméthylation."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles affecter la déméthylation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections peuvent perturber les mécanismes de méthylation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 19/04/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran. Electronic address: s_farivar@sbu.ac.ir.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China. liujihua@cpu.edu.cn.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China. liujihua@cpu.edu.cn.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea huhjh@snu.ac.kr.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
Exogenous endophthalmitis (ExE) results from microbial infection as a complication of ocular surgery, penetrating ocular trauma, and intraocular foreign bodies. We herein review the classification of ...
Narrative Literature Review....
Identification of the causative agent through ocular fluid analysis is central in the diagnostic work-up of ExE. Prompt intravitreal antimicrobial therapy is key to successful management of ExE and vi...
Strict adherence to treatment guidelines may improve outcomes of ExE, however the ultimate prognosis, especially in severe cases, may depend more on the virulence of the causative organism and associa...
Endophthalmitis is one of the most severe ophthalmic emergencies. Most patients experience a permanent decrease in visual acuity after the event, but the eye can be preserved in most cases. However, w...
Endogenous endophthalmitis (EE) is an uncommon but potentially devastating ocular infection involving the inner layers of the eye. The global incidence of EE is on the rise. Common ocular signs and sy...
We report an atypical presentation of endophthalmitis in a 2-month-old infant due to a rare infection by Pasteurella canis, small Gram-negative coccobacilli that inhabit the oral cavity and the gastro...
Coronavirus disease 2019 (COVID-19) is associated with immune system dysfunction and makes patients vulnerable to opportunistic infections. This report presents a patient with a history of COVID-19, s...
We reported a 64-year-old man complaining of progressive visual loss in his left eye, who had previously been hospitalized for three weeks due to COVID-19. In the ophthalmologic assessment, large foci...
In patients with severe COVID-19, long-term ICU admission and immunosuppressive drugs lead to immune system dysfunction and make the patient more susceptible to opportunistic infections. Consequently,...
Corynespora cassiicola is an environmental phytopathogen implicated in various human infections and has been isolated from one case of keratitis. We report here the first case of endophthalmitis cause...
The aim of this study is to report the clinical characteristics, causative organisms, and treatment outcomes in patients presenting with endophthalmitis related to XEN stent implants....
Retrospective, noncomparative consecutive case series....
Clinical and microbiologic review was performed for 8 patients presenting to the Bascom Palmer Eye Institute Emergency Room between 2021 and 2022 with XEN stent-related endophthalmitis. Data collected...
The current study included 8 eyes from 8 patients. All cases of endophthalmitis occurred >30 days after implantation of the XEN stent. At the time of presentation, there were external exposures of the...
Endophthalmitis in the setting of XEN stents results in poor visual outcomes. The most common causative organisms are staphylococcus or streptococcus species. At time of diagnosis, prompt treatment wi...
To identify clinical risk factors for enucleation or evisceration in patients with endophthalmitis at an academic institution....
A retrospective review of patients diagnosed with endophthalmitis at Wilmer Eye Institute from 2010 to 2019 was conducted. Clinical characteristics, including demographics, cause for endophthalmitis, ...
Two hundred and fifty three patients treated for endophthalmitis over the study period were identified, of which 25 (9.88%) underwent enucleation or evisceration. Risk factors for enucleation or evisc...
Patients with endophthalmitis who underwent enucleation or evisceration had more severe disease on presentation compared to those treated with eye sparing therapy. Presenting clinical characteristics ...
Endophthalmitis is a serious, vision-threatening condition that carries with it a high rate of morbidity....
This review highlights the pearls and pitfalls of endophthalmitis, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence....
Endophthalmitis is a vision-threatening emergency associated with infection and inflammation of vitreous and aqueous humor. Risk factors include ocular trauma or surgery, immunocompromised state, diab...
An understanding of endophthalmitis can assist emergency clinicians in diagnosing and managing this serious disease....
To analyze intravitreal antifungal injections performed at a tertiary center to determine (1) risk factors increasing fungal endophthalmitis likelihood at the time of patient presentation, (2) prognos...
Single-center, retrospective clinical case-control study....
Clinical course, visual outcome, and final diagnosis were analyzed for 75 patients (81 eyes) receiving intravitreal antifungal injections between 2014 and 2021. Features were compared between fungal e...
Fungal endophthalmitis was more likely than masquerade based on injection in emergency department or inpatient setting (P = .0002) vs outpatient, greater visual acuity (P = .049), artificial indwellin...
Many conditions can mimic fungal endophthalmitis, but certain risk factors should raise its suspicion. Regardless of diagnosis, presenting vision correlates with final vision. Lastly, no patients with...