Titre : Acides aminés

Acides aminés : Questions médicales fréquentes

Termes MeSH sélectionnés :

Early Detection of Cancer
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"Fatigue, faiblesse musculaire et troubles de l'humeur peuvent indiquer un déséquilibre." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils utiles pour les acides aminés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent identifier des troubles métaboliques liés aux acides aminés." } }, { "@type": "Question", "name": "Comment évaluer l'absorption des acides aminés ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'évaluation se fait par des tests de fonction intestinale et des analyses de sang." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une carence en acides aminés ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, perte de muscle, et troubles immunitaires." } }, { "@type": "Question", "name": "Comment reconnaître un excès d'acides aminés ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Un excès peut provoquer des troubles digestifs et des déséquilibres métaboliques." } }, { "@type": "Question", "name": "Les troubles de l'humeur sont-ils liés aux acides aminés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains acides aminés influencent la production de neurotransmetteurs." } }, { "@type": "Question", "name": "Quels signes indiquent un déséquilibre en acides aminés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des signes incluent irritabilité, troubles de la concentration et fatigue chronique." } }, { "@type": "Question", "name": "Les douleurs musculaires peuvent-elles être liées aux acides aminés ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un manque d'acides aminés essentiels peut entraîner des douleurs musculaires." } }, { "@type": "Question", "name": "Comment prévenir une carence en acides aminés ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation variée et équilibrée riche en protéines aide à prévenir les carences." } }, { "@type": "Question", "name": "Quels aliments sont riches en acides aminés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Les viandes, poissons, œufs, produits laitiers et légumineuses sont de bonnes sources." } }, { "@type": "Question", "name": "Les végétariens peuvent-ils obtenir assez d'acides aminés ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en combinant différentes sources végétales, ils peuvent couvrir leurs besoins." } }, { "@type": "Question", "name": "Les régimes spéciaux affectent-ils l'apport en acides aminés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les régimes restrictifs peuvent entraîner des carences si mal planifiés." } }, { "@type": "Question", "name": "Les suppléments préventifs d'acides aminés sont-ils nécessaires ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Généralement, une alimentation équilibrée suffit, mais des suppléments peuvent aider." } }, { "@type": "Question", "name": "Comment traiter une carence en acides aminés ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement inclut des suppléments d'acides aminés et une alimentation équilibrée." } }, { "@type": "Question", "name": "Les acides aminés peuvent-ils être pris en supplément ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les suppléments d'acides aminés sont disponibles pour soutenir la santé." } }, { "@type": "Question", "name": "Quel rôle jouent les acides aminés dans la récupération musculaire ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Ils aident à réparer les tissus musculaires et à réduire la fatigue après l'exercice." } }, { "@type": "Question", "name": "Les acides aminés sont-ils utiles pour les sportifs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils améliorent la performance et favorisent la récupération après l'effort." } }, { "@type": "Question", "name": "Comment les acides aminés aident-ils à la gestion du stress ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Certains acides aminés peuvent réguler les neurotransmetteurs liés à l'humeur." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec une carence prolongée ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des troubles immunitaires, des problèmes de croissance et de développement." } }, { "@type": "Question", "name": "Un excès d'acides aminés peut-il être dangereux ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un excès peut entraîner des troubles métaboliques et des problèmes rénaux." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils être liés aux acides aminés ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un déséquilibre peut affecter la neurotransmission et provoquer des troubles neurologiques." } }, { "@type": "Question", "name": "Comment une carence affecte-t-elle la santé mentale ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut entraîner des troubles de l'humeur, de l'anxiété et des problèmes cognitifs." } }, { "@type": "Question", "name": "Les maladies métaboliques sont-elles liées aux acides aminés ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines maladies métaboliques sont causées par des anomalies dans le métabolisme des acides aminés." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de carence en acides aminés ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les régimes restrictifs, les maladies chroniques et les troubles de l'absorption augmentent le risque." } }, { "@type": "Question", "name": "Les personnes âgées sont-elles à risque de carence ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut affecter l'absorption et les besoins en acides aminés." } }, { "@type": "Question", "name": "Les sportifs ont-ils des besoins accrus en acides aminés ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils ont des besoins plus élevés pour la récupération et la performance." } }, { "@type": "Question", "name": "Les maladies digestives influencent-elles l'apport en acides aminés ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les maladies comme la maladie cœliaque peuvent réduire l'absorption des acides aminés." } }, { "@type": "Question", "name": "Le stress chronique affecte-t-il les niveaux d'acides aminés ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress peut modifier le métabolisme des acides aminés et leur utilisation." } } ] } ] }

Sous-catégories

148 au total
└─

Alanine

Alanine D000409 - D12.125.042
└─

Chlorométhyl cétones d'acides aminés

Amino Acid Chloromethyl Ketones D000590 - D12.125.065
└─

Acides aminés acides

Amino Acids, Acidic D024342 - D12.125.067
└─

Acides aminés basiques

Amino Acids, Basic D024361 - D12.125.068
└─

Acides aminés à chaine ramifiée

Amino Acids, Branched-Chain D000597 - D12.125.070
└─

Acides aminés cycliques

Amino Acids, Cyclic D000598 - D12.125.072
└─

Acides aminés diaminés

Amino Acids, Diamino D000599 - D12.125.095
└─

Acides aminés dicarboxyliques

Amino Acids, Dicarboxylic D000600 - D12.125.119
└─

Acides aminés essentiels

Amino Acids, Essential D000601 - D12.125.142
└─

Acides aminés neutres

Amino Acids, Neutral D021542 - D12.125.154
└─

Acides aminés soufrés

Amino Acids, Sulfur D000603 - D12.125.166
└─

Amino-butyrates

Aminobutyrates D000613 - D12.125.190
└─

Aminocaproates

Aminocaproates D000614 - D12.125.213
└─

Acide amino-lévulinique

Aminolevulinic Acid D000622 - D12.125.262
└─

Canavanine

Canavanine D002172 - D12.125.311
└─

Créatine

Creatine D003401 - D12.125.373
└─

Acides aminés excitateurs

Excitatory Amino Acids D018846 - D12.125.427
└─

Glycine

Glycine D005998 - D12.125.481
└─

Homosérine

Homoserine D006714 - D12.125.526
└─

Cynurénine

Kynurenine D007737 - D12.125.608
└─

Acide oxamique

Oxamic Acid D010072 - D12.125.730
└─

Acides phosphoaminés

Phosphoamino Acids D019606 - D12.125.740
└─

Acide quisqualique

Quisqualic Acid D016318 - D12.125.755
└─└─

bêta-Alanine

beta-Alanine D015091 - D12.125.042.070
└─└─

Mimosine

Mimosine D008898 - D12.125.042.500
└─└─

N-(5-Amino-1-chloroacétylpentyl)-para-toluènesulfonamide

Tosyllysine Chloromethyl Ketone D014107 - D12.125.065.850
└─└─

N-(1-Benzyl-3-chloroacétonyl)-para-toluènesulfonamide

Tosylphenylalanyl Chloromethyl Ketone D014108 - D12.125.065.930
└─└─

Acides aminés aromatiques

Amino Acids, Aromatic D024322 - D12.125.072.050
└─└─

Cycloleucine

Cycloleucine D003515 - D12.125.072.170
└─└─

Desmosine

Desmosine D003895 - D12.125.072.200
└─└─

Imino-acides

Imino Acids D007098 - D12.125.072.401
└─└─

Isodesmosine

Isodesmosine D007524 - D12.125.072.415
└─└─

Citrulline

Citrulline D002956 - D12.125.095.226
└─└─

Acide diamino-pimélique

Diaminopimelic Acid D003960 - D12.125.095.390
└─└─

Ornithine

Ornithine D009952 - D12.125.095.765
└─└─

Acide 2-amino-adipique

2-Aminoadipic Acid D015074 - D12.125.119.075
└─└─

Glutamates

Glutamates D005971 - D12.125.119.409
└─└─

Arginine

Arginine D001120 - D12.125.142.087
└─└─

Histidine

Histidine D006639 - D12.125.142.308
└─└─

Isoleucine

Isoleucine D007532 - D12.125.142.383
└─└─

Leucine

Leucine D007930 - D12.125.142.441
└─└─

Lysine

Lysine D008239 - D12.125.142.497
└─└─

Phénylalanine

Phenylalanine D010649 - D12.125.142.666
└─└─

Tryptophane

Tryptophan D014364 - D12.125.142.875
└─└─

Valine

Valine D014633 - D12.125.142.930
└─└─

Asparagine

Asparagine D001216 - D12.125.154.049
└─└─

Glutamine

Glutamine D005973 - D12.125.154.424
└─└─

Sérine

Serine D012694 - D12.125.154.800
└─└─

Thréonine

Threonine D013912 - D12.125.154.900
└─└─

Cystathionine

Cystathionine D003540 - D12.125.166.175
└─└─

Acide cystéique

Cysteic Acid D003544 - D12.125.166.215
└─└─

Cystéine

Cysteine D003545 - D12.125.166.230
└─└─

Éthionine

Ethionine D005001 - D12.125.166.388
└─└─

Homocystéine

Homocysteine D006710 - D12.125.166.498
└─└─

Homocystine

Homocystine D006711 - D12.125.166.554
└─└─

Méthionine

Methionine D008715 - D12.125.166.676
└─└─

Pénicillamine

Penicillamine D010396 - D12.125.166.786
└─└─

Acides amino-isobutyriques

Aminoisobutyric Acids D000621 - D12.125.190.055
└─└─

Acide gamma-amino-butyrique

gamma-Aminobutyric Acid D005680 - D12.125.190.350
└─└─

Acide 6-amino-caproïque

Aminocaproic Acid D015119 - D12.125.213.075
└─└─

Norleucine

Norleucine D009646 - D12.125.213.568
└─└─

Acide aspartique

Aspartic Acid D001224 - D12.125.427.040
└─└─

Acide glutamique

Glutamic Acid D018698 - D12.125.427.300
└─└─

Allylglycine

Allylglycine D000501 - D12.125.481.100
└─└─

Amino-2 phosphono-5 valérate

2-Amino-5-phosphonovalerate D015763 - D12.125.740.025
└─└─

Phosphocréatine

Phosphocreatine D010725 - D12.125.740.675
└─└─

Phosphosérine

Phosphoserine D010768 - D12.125.740.700
└─└─

Phosphothréonine

Phosphothreonine D010769 - D12.125.740.725
└─└─

Phosphotyrosine

Phosphotyrosine D019000 - D12.125.740.740
└─└─└─

Acide pantothénique

Pantothenic Acid D010205 - D12.125.042.070.500
└─└─└─

Dextrothyroxine

Dextrothyroxine D003918 - D12.125.072.050.342
└─└─└─

Thyroxine

Thyroxine D013974 - D12.125.072.050.767
└─└─└─

Tyrosine

Tyrosine D014443 - D12.125.072.050.875
└─└─└─

Ergothionéine

Ergothioneine D004880 - D12.125.072.329.269
└─└─└─

Méthylhistidines

Methylhistidines D008762 - D12.125.072.329.539
└─└─└─

Acide azétidine-2-carboxylique

Azetidinecarboxylic Acid D001383 - D12.125.072.401.200
└─└─└─

Proline

Proline D011392 - D12.125.072.401.623
└─└─└─

Acide pidolique

Pyrrolidonecarboxylic Acid D011761 - D12.125.072.401.761
└─└─└─

N-(((2,6-Diéthylphényl)carbamoyl)méthyl)iminodiacétate de technétium (99mTc)

Technetium Tc 99m Diethyl-iminodiacetic Acid D019784 - D12.125.072.401.830
└─└─└─

Disofénine de technétium (99mTc)

Technetium Tc 99m Disofenin D019785 - D12.125.072.401.840
└─└─└─

Lidofénine de technétium (99mTc)

Technetium Tc 99m Lidofenin D019780 - D12.125.072.401.900
└─└─└─

Acide arginino-succinique

Argininosuccinic Acid D001125 - D12.125.095.104.075
└─└─└─

Benzoylarginine-2-Naphthylamide

Benzoylarginine-2-Naphthylamide D001587 - D12.125.095.104.095
└─└─└─

Benzoylarginine nitroanilide

Benzoylarginine Nitroanilide D001586 - D12.125.095.104.100
└─└─└─

Homoarginine

Homoarginine D006709 - D12.125.095.104.400
└─└─└─

L-NAME

NG-Nitroarginine Methyl Ester D019331 - D12.125.095.104.525
└─└─└─

Nitroarginine

Nitroarginine D019335 - D12.125.095.104.587
└─└─└─

Nalpha-Tosyl-arginate de méthyle

Tosylarginine Methyl Ester D014106 - D12.125.095.104.900
└─└─└─

Proglumide

Proglumide D011377 - D12.125.095.461.700
└─└─└─

Hydroxylysine

Hydroxylysine D006901 - D12.125.095.647.478
└─└─└─

Lysinoalanine

Lysinoalanine D008241 - D12.125.095.647.575
└─└─└─

Eflornithine

Eflornithine D000518 - D12.125.095.765.340
└─└─└─

Acide D-aspartique

D-Aspartic Acid D026603 - D12.125.119.170.150
└─└─└─

Acide isoaspartique

Isoaspartic Acid D026581 - D12.125.119.170.275
└─└─└─

N-Méthyl-aspartate

N-Methylaspartate D016202 - D12.125.119.170.400
└─└─└─

Aspartate de magnésium et potassium

Potassium Magnesium Aspartate D011195 - D12.125.119.170.700
└─└─└─

Acide 1-carboxy-glutamique

1-Carboxyglutamic Acid D015055 - D12.125.119.409.174
└─└─└─

Pémétrexed

Pemetrexed D000068437 - D12.125.119.409.525
└─└─└─

oméga-N-Méthylarginine

omega-N-Methylarginine D019323 - D12.125.142.087.500
└─└─└─

Valsartan

Valsartan D000068756 - D12.125.142.930.500
└─└─└─

Azasérine

Azaserine D001377 - D12.125.154.800.500
└─└─└─

Cyclosérine

Cycloserine D003523 - D12.125.154.800.750
└─└─└─

Droxidopa

Droxidopa D015103 - D12.125.154.800.875
└─└─└─

Acétylcystéine

Acetylcysteine D000111 - D12.125.166.230.259
└─└─└─

Carbocystéine

Carbocysteine D002233 - D12.125.166.230.310
└─└─└─

5-((2-Amino-2-carboxyéthyl)sulfanyl)-3-hydroxy-tyrosine

Cysteinyldopa D003548 - D12.125.166.230.330
└─└─└─

Cystine

Cystine D003553 - D12.125.166.230.369
└─└─└─

Sélénocystéine

Selenocysteine D017279 - D12.125.166.230.700
└─└─└─

Racéméthionine

Racemethionine D064697 - D12.125.166.676.089
└─└─└─

N-Formyl-méthionine

N-Formylmethionine D009239 - D12.125.166.676.450
└─└─└─

Méthionine sulfoximine

Methionine Sulfoximine D008717 - D12.125.166.676.620
└─└─└─

Sélénométhionine

Selenomethionine D012645 - D12.125.166.676.900
└─└─└─

Vitamine U

Vitamin U D014814 - D12.125.166.676.950
└─└─└─

N-Acétyl-S-nitroso-pénicillamine

S-Nitroso-N-Acetylpenicillamine D026423 - D12.125.166.786.500
└─└─└─

Gabapentine

Gabapentin D000077206 - D12.125.190.350.225
└─└─└─

Prégabaline

Pregabalin D000069583 - D12.125.190.350.450
└─└─└─

Vigabatrine

Vigabatrin D020888 - D12.125.190.350.900
└─└─└─

6-Diazo-5-oxo-L-norleucine

Diazooxonorleucine D003980 - D12.125.213.568.175
└─└─└─

Acide glycocholique

Glycocholic Acid D006000 - D12.125.481.700.249
└─└─└─

Sarcosine

Sarcosine D012521 - D12.125.481.700.374
└─└─└─

Thiorphan

Thiorphan D015244 - D12.125.481.700.750
└─└─└─

Tiopronine

Tiopronin D008625 - D12.125.481.700.760
└─└─└─└─

Fenclonine

Fenclonine D010134 - D12.125.072.050.685.440
└─└─└─└─

Natéglinide

Nateglinide D000077715 - D12.125.072.050.685.448
└─└─└─└─

p-Fluorophénylalanine

p-Fluorophenylalanine D010135 - D12.125.072.050.685.450
└─└─└─└─

Melphalan

Melphalan D008558 - D12.125.072.050.685.500
└─└─└─└─

Thyronines

Thyronines D013970 - D12.125.072.050.767.741
└─└─└─└─

5-Hydroxytryptophane

5-Hydroxytryptophan D006916 - D12.125.072.050.850.479
└─└─└─└─

Bétalaïnes

Betalains D050858 - D12.125.072.050.875.064
└─└─└─└─

Dopa

Dihydroxyphenylalanine D004295 - D12.125.072.050.875.130
└─└─└─└─

Di-iodotyrosine

Diiodotyrosine D004105 - D12.125.072.050.875.262
└─└─└─└─

Méthyltyrosines

Methyltyrosines D008781 - D12.125.072.050.875.485
└─└─└─└─

Mono-iodotyrosine

Monoiodotyrosine D007470 - D12.125.072.050.875.496
└─└─└─└─

Tirofiban

Tirofiban D000077466 - D12.125.072.050.875.875
└─└─└─└─

Captopril

Captopril D002216 - D12.125.072.401.623.270
└─└─└─└─

Fosinopril

Fosinopril D017328 - D12.125.072.401.623.374
└─└─└─└─

Hydroxyproline

Hydroxyproline D006909 - D12.125.072.401.623.478
└─└─└─└─

Glutamate de sodium

Sodium Glutamate D012970 - D12.125.119.409.349.575
└─└─└─└─

Buthionine sulfoximine

Buthionine Sulfoximine D019328 - D12.125.166.676.620.125
└─└─└─└─

Acide glycodésoxycholique

Glycodeoxycholic Acid D006002 - D12.125.481.700.249.420
└─└─└─└─└─

Di-iodothyronines

Diiodothyronines D004104 - D12.125.072.050.767.741.180
└─└─└─└─└─

Tri-iodothyronine

Triiodothyronine D014284 - D12.125.072.050.767.741.894
└─└─└─└─└─

Tri-iodothyronine inverse

Triiodothyronine, Reverse D014285 - D12.125.072.050.767.741.947
└─└─└─└─└─

Bétacyanines

Betacyanins D050859 - D12.125.072.050.875.064.500
└─└─└─└─└─

Lévodopa

Levodopa D007980 - D12.125.072.050.875.130.500
└─└─└─└─└─

Méthyldopa

Methyldopa D008750 - D12.125.072.050.875.130.600
└─└─└─└─└─

alpha-Méthyltyrosine

alpha-Methyltyrosine D019805 - D12.125.072.050.875.485.050
└─└─└─└─└─

Acide glycochénodésoxycholique

Glycochenodeoxycholic Acid D005999 - D12.125.481.700.249.420.400

Sources (10000 au total)

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis.

To evaluate the value of combined detection of serum CA125, CA199, and HE4 in the diagnosis of ovarian cancer.... Relevant articles retrieved from PubMed, Elsevier Science, Springer, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases were screened strictly according to inclusion and exclus... The results of meta-analysis showed that there was a statistical difference in diagnostic specificity analysis of CA125 (OR = 1.91, 95% CI (1.58, 2.32),... In the clinical assisted diagnosis of ovarian cancer, combined detection of CA125, CA199, and HE4 has the stronger discriminant ability and higher accuracy than single detection of CA125, which can im...

BMI increase during early childhood in boys with cystic fibrosis and early adrenarche.

Increase in body mass index (BMI) in early childhood (1-6 years) was found to be a contributing factor for impaired final height in boys with Cystic Fibrosis (CF). Early adrenarche (before age 9 years... Boys with CF, aged 8-9 years, visiting the CF expertize center Utrecht were included. Since 2018, anthropomorphic, pubertal and endocrine data were collected. Early adrenarche in boys was defined as a... Thirteen boys (mean age 8.55 ± 0.27 years) were enrolled. The median (IQR) DHEAS-level was 1.3 µmol/L (0.71-2.40). Eight boys (61.5%) had an early rise in DHEAS-levels ≥ 1 µmol/L. Mean increase in BMI... In this small cohort, 61.5% of boys with CF between 8 and 9 years had an early rise of DHEAS, which was correlated to ΔBMI...

Promoting early childhood oral health and preventing early childhood caries on Instagram.

Early childhood caries (ECC) is prevalent worldwide. Oral health promotion effectively utilizes key messages to educate parents/caregivers and the public on how to prevent ECC. Instagram is one of the... This study used inductive content analysis to categorize, quantify, and interpret pictorial and textual data derived from Instagram posts containing the most commonly used ECC-related hashtags in thei... A total of 1,071 images and 3,228 comments were analyzed based on 13 hashtags. The most common types of images were those of people (57.5%) and graphics/memes (37.8%). Most people were older children ... As more people engage with social media, health professionals should consider the potential for Instagram as a tool to promote early childhood oral health and to prevent ECC. Our study shows that many...

Adjuvant and neoadjuvant therapy with or without CDK4/6 inhibitors in HR+/HER2- early breast cancer: a systematic review and meta-analysis.

The combination of cyclin-dependent kinases 4/6 (CDK4/6) inhibitors and endocrine therapy is the standard treatment for patients with hormone receptor-positive (HR+)/HER2-negative (HER2-) advanced bre... This study aimed to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy versus endocrine therapy alone in patients with HR+, HER2- early breast cancer. A systematic r... Eight randomized controlled trials (RCTs) were included in the study. CDK4/6 inhibitors combined with endocrine therapy showed a significant improvement in IDFS (hazard ratio (HR) = 0.81, 95% confiden... The addition of CDK4/6 inhibitors in HR+/HER2- early breast cancer patients significantly improved IDFS in adjuvant therapy and CCCA in neoadjuvant. However, CDK4/6 inhibitors also showed significant ... Identifier CRD42024530704....

Oncological outcomes after laparotomic, laparoscopic, and robot-assisted laparoscopic staging for early high-intermediate or high-risk endometrial cancer.

To compare oncological outcomes in patients with early-stage high-intermediate or high-risk endometrial cancer undergoing surgical staging by laparotomy, conventional laparoscopy, or robot-assisted la... Patients diagnosed between 2015 and 2021 with stage I-II (International Federation of Gynecology and Obstetrics 2009), high-intermediate or high-risk endometrial cancer who underwent staging surgery, ... In total 941 patients met the inclusion criteria, of whom 399 (42.4%) underwent staging surgery by laparotomy, 273 (29.0%) by laparoscopy, and 269 (28.6%) by robot-assisted laparoscopy. Baseline chara... Laparoscopic and robot-assisted laparoscopic staging surgery in women with early-stage high-intermediate or high-risk endometrial cancer are safe alternatives to laparotomic staging surgery....

Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study.

Childhood, teenage and young adult (CTYA, 0-24 years) cancers are rare and diverse, making timely diagnosis challenging. We aim to explore symptoms and symptom combinations associated with a subsequen... Using the QResearch Database, we carried out a matched nested case-control study. Associations between pre-specified symptoms encountered in primary care and a subsequent diagnosis of any cancer were ... 3186 cases and 50,576 controls were identified from a cohort of 3,424,771 CTYA. We identified 12 novel associations, of which hemiparesis [OR 90.9 (95%CI 24.7-335.1), PPV = 1.6%], testicular swelling ... Using the largest cohort to date, we provide novel information on the time-varying predictive utility of symptoms in the diagnosis of CTYA cancers. Our findings will help to raise clinical and public ...

Estimated Doses to the Heart, Lungs and Oesophagus and Risks From Typical UK Radiotherapy for Early Breast Cancer During 2015-2023.

Breast cancer radiotherapy can increase the risks of heart disease, lung cancer and oesophageal cancer. At present, the best dosimetric predictors of these risks are mean doses to the whole heart, lun... A systematic review and meta-analysis was conducted of planned or delivered mean doses to the whole heart, lungs or oesophagus from UK breast cancer radiotherapy in studies published during 2015-2023.... For whole heart, thirteen studies reported 2893 doses. Average mean doses were higher in left than in right-sided radiotherapy and increased with extent of clinical targets. For left-sided radiotherap... The typical doses to these organs may be combined with dose-response relationships to estimate radiation risks. Estimated 30-year absolute lung cancer mortality risks from modern UK breast cancer radi...