questionsmedicales.fr
Facteurs biologiques
Antigènes
Antigènes thymo-indépendants
Antigènes thymo-indépendants : Questions médicales fréquentes
Termes MeSH sélectionnés :
Interferon-gamma Release Tests
Diagnostic
5
Marqueurs immunologiques
Lymphocytes B
Symptômes
5
Symptômes
Réponse immunitaire
Réponse humorale
Anticorps
Prévention
5
Système immunitaire
Nutrition
Traitements
5
Immunomodulateurs
Réponse immunitaire
Antihistaminiques
Corticostéroïdes
Complications
5
Maladies auto-immunes
Lymphocytes B
Choc anaphylactique
Allergies
Suivi médical
Complications
Facteurs de risque
5
Immunodépression
Facteurs de risque
Antécédents familiaux
Allergies
Maladies chroniques
Facteurs de risque
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"description": "Comment identifier un antigène thymo-indépendant ?\nQuels tests sont utilisés pour évaluer la réponse immunitaire ?\nLes antigènes thymo-indépendants sont-ils visibles sur des biopsies ?\nPeut-on mesurer les niveaux d'anticorps spécifiques ?\nQuels marqueurs immunologiques sont associés ?",
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"name": "Comment identifier un antigène thymo-indépendant ?",
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"@type": "Answer",
"text": "Des tests immunologiques comme l'ELISA peuvent détecter ces antigènes."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la réponse immunitaire ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de prolifération des lymphocytes B et les dosages d'anticorps sont courants."
}
},
{
"@type": "Question",
"name": "Les antigènes thymo-indépendants sont-ils visibles sur des biopsies ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils ne sont pas directement visibles, mais leur effet peut être évalué par des tests."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer les niveaux d'anticorps spécifiques ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests sérologiques peuvent mesurer les anticorps contre ces antigènes."
}
},
{
"@type": "Question",
"name": "Quels marqueurs immunologiques sont associés ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs comme CD19 et CD20 sont souvent utilisés pour évaluer les lymphocytes B."
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},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réponse immunitaire ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la fièvre, la fatigue et des douleurs peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les antigènes thymo-indépendants causent-ils des allergies ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent provoquer des réactions allergiques, mais ce n'est pas systématique."
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{
"@type": "Question",
"name": "Y a-t-il des signes d'infection associés ?",
"position": 8,
"acceptedAnswer": {
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}
},
{
"@type": "Question",
"name": "Comment se manifeste une réponse humorale ?",
"position": 9,
"acceptedAnswer": {
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"text": "Une augmentation des anticorps spécifiques dans le sang est un signe clé."
}
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{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'antigène ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier en fonction de l'antigène et de l'individu."
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{
"@type": "Question",
"name": "Comment prévenir les infections liées aux antigènes ?",
"position": 11,
"acceptedAnswer": {
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"text": "Maintenir une bonne hygiène et se faire vacciner sont des mesures clés."
}
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{
"@type": "Question",
"name": "Les mesures d'hygiène sont-elles efficaces ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le lavage des mains et la désinfection réduisent le risque d'infection."
}
},
{
"@type": "Question",
"name": "Faut-il éviter certains aliments ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les aliments allergènes peut prévenir des réactions indésirables."
}
},
{
"@type": "Question",
"name": "Les vaccinations sont-elles recommandées ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations peuvent prévenir certaines infections associées aux antigènes."
}
},
{
"@type": "Question",
"name": "Comment renforcer le système immunitaire ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, l'exercice et le sommeil adéquat aident à renforcer l'immunité."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les infections ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antibiotiques et les antiviraux sont souvent utilisés selon l'infection."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des immunomodulateurs ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des immunomodulateurs peuvent aider à réguler la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Les vaccins sont-ils efficaces contre ces antigènes ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains vaccins ciblent des antigènes thymo-indépendants pour renforcer l'immunité."
}
},
{
"@type": "Question",
"name": "Comment traiter les réactions allergiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antihistaminiques et les corticostéroïdes sont souvent prescrits."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements préventifs ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des vaccins et des traitements prophylactiques peuvent réduire les risques d'infection."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des infections récurrentes et des allergies sévères peuvent être des complications."
}
},
{
"@type": "Question",
"name": "Les antigènes peuvent-ils causer des maladies auto-immunes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activation inappropriée des lymphocytes B peut mener à des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de choc anaphylactique ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des réactions allergiques sévères peuvent entraîner un choc anaphylactique."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications immunitaires ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un suivi médical régulier et des traitements appropriés sont essentiels."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles fréquentes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles varient selon l'individu et le type d'antigène, mais peuvent être sérieuses."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'infection ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'immunodépression, le stress et une mauvaise hygiène augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la réponse immunitaire ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les jeunes enfants et les personnes âgées ont une réponse immunitaire plus faible."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents d'allergies ou de maladies auto-immunes augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il l'immunité ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme, l'alcool et le manque d'exercice peuvent affaiblir l'immunité."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète ou l'asthme peuvent augmenter le risque d'infection."
}
}
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}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/04/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
3 publications dans cette catégorie
Affiliations :
Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
3 publications dans cette catégorie
Affiliations :
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joglekar@pitt.edu.
Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joglekar@pitt.edu.
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joglekar@pitt.edu.
Publications dans "Antigènes thymo-indépendants" :
3 publications dans cette catégorie
Affiliations :
Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. guidengl_ism@163.com.
Suzhou Institute of Systems Medicine, Suzhou, China. guidengl_ism@163.com.
Key Laboratory of Synthetic Biology Regulatory Element, Chinese Academy of Medical Sciences, Beijing, China. guidengl_ism@163.com.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Institute Curie, Université PSL, U932 INSERM, Integrative Analysis of T cell Activation Team, Paris, France.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Institute Curie, Université PSL, U932 INSERM, Integrative Analysis of T cell Activation Team, Paris, France.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Apitope International NV, Diepenbeek, Belgium.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. nathan.singh@wustl.edu.
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. nathan.singh@wustl.edu.
Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA. nathan.singh@wustl.edu.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Penn Institute for Biomedical Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Tumor Models, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China.
Publications dans "Antigènes thymo-indépendants" :
2 publications dans cette catégorie
Affiliations :
Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Publications dans "Antigènes thymo-indépendants" :
A mechanistic understanding of uncommon immune outcomes such as resistance to infection has led to the development of novel therapies. Using gene level analytic methods, we previously found distinct m...
Using transcript isoform analyses, we aimed to identify novel RSTR-associated genes hypothesizing that previous gene-level differential expression analysis obscures isoform-specific differences that c...
Monocytes from 49 RSTR versus 52 subjects with latent Mtb infection (LTBI) were infected with M. tuberculosis (H37Rv) or left unstimulated (media) prior to RNA isolation and sequencing. RSTR-associate...
We identified 81 differentially expressed transcripts (DETs) in 70 genes (FDR <0.05) comparing RSTR and LTBI phenotypes with the majority (n = 79 DETs) identified under Mtb-stimulated conditions. Seve...
Transcript isoform-specific analyses identify transcriptional associations, such as those associated with resistance to TST/IGRA conversion, that are obscured when using gene-level approaches. These f...
Heavy exposure to Mycobacterium tuberculosis, the etiologic agent of tuberculosis (TB) and among the top infectious killers worldwide, results in infection that is cleared, contained, or progresses to...
Establishing diagnosis of latent and active histoplasmosis is challenging. Interferon gamma-release assays (IGRAs) may provide evidence of latent and active infection. An enzyme-linked immunospot (ELI...
Diabetes mellitus (DM) patients with latent tuberculosis infection (LTBI) have an increased risk of developing active tuberculosis (TB) due to impaired immunity. The performance of currently available...
A prospective study was conducted to investigate the status of LTBI in patients with confirmed T2DM. At the baseline survey, the prevalence of LTBI was tested using interferon-gamma release assay (IGR...
A total of 404 participants with T2DM were included in the study. At baseline, after excluding active TB, the prevalence of LTBI identified by TST (≥ 10 mm), C-TST (≥ 5 mm) and IGRA (≥ 0.35 IU/ml) wer...
In studied patients with T2DM, C-TST showed higher consistency with IGRA as compared to TST. The present of conversion observed in serial testing suggested that boosting effect of skin testing should ...
The aim of this study was to evaluate the prevalence of latent Mycobacterium tuberculosis infection in hematopoietic stem cell transplantation candidates, using tuberculin skin test and QuantiFERON-TB...
The interferon-gamma (IFN-γ) release assay (IGRA) is an important laboratory diagnosis for latent Mycobacterium tuberculosis (TB) infection. The TB-IGRA measures the release of IFN-γ from peripheral b...
We have analyzed the clinical data of 776 children who are underwent TB-IGRA testing in the Department of Allergy and Rheumatology of Guangzhou Women and Children's Medical Center from 2018 to 2020. T...
The TB Ag-NL levels were significantly higher in patients with active SLE than those in inactive SLE (p = 0.0002). The TB Ag-NL levels were positively correlated with the SLE disease activity index (S...
The detection of IFN-γ release levels by the TB-IGRA may be useful to assess SLE disease activity in pediatric patients with active SLE....
Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have asse...
We searched PubMed, Embase, and Cochran databases. We obtained literature related to the diagnosis of OATB by IGRA, and the retrieval period was from the establishment of the database to June 2021. Th...
We included seven studies involving 643 subjects in diagnosing OATB by IGRA. The comprehensive sensitivity and specificity were 0.84 (95% CI, 0.70-0.92) and 0.78 (95% CI, 0.66-0.87), respectively. The...
In blood samples, the diagnostic accuracy of IGRAS is poor in patients with suspected OAT. We conclude that IGRA may not be appropriate for patients with OATB....
Latent tuberculosis is prevalent in HIV-infected people and has an impact on the progression of AIDS. The aim of this study is to match a more accurate IGRA method for the better detection of latent t...
Interferon-gamma release assays (IGRAs) are approved for children ≥2 years old to aid in diagnosis of Mycobacterium tuberculosis (TB) infection and disease. Tuberculin skin tests (TSTs) continue to be...
We performed a retrospective cohort study of IGRA use in patients <2 years old in 2 large Boston healthcare systems. The primary outcome was the proportion of valid versus invalid/indeterminate IGRA r...
A total of 321 IGRA results were analyzed; 308 tests (96%) were valid and 13 (4%) were invalid/indeterminate. Thirty-seven IGRAs were obtained in immunocompromised patients; the proportion of invalid/...
The high proportion of valid IGRA test results in patients <2 years of age in a low TB prevalence setting in combination with the known logistical and interpretation challenges associated with TSTs su...
To predict protective immunity to SARS-CoV-2, cellular immunity seems to be more sensitive than humoral immunity. Through an Interferon-Gamma (IFN-γ) Release Assay (IGRA), we show that, despite a mark...