Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Seattle Children's Research Institute, Seattle, WA 98101, USA. Electronic address: lili1@uw.edu.
Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Psychology, University of Washington, Seattle, WA 98105, USA.
State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.
Autonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland (D.G., G.C., P.S.); NIH Academy Enrichment Program, OD/NIH (G.C.); and Sackler Faculty of Medicine, Tel Aviv University, Israel (Y.S.) goldsteind@ninds.nih.gov.
Autonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland (D.G., G.C., P.S.); NIH Academy Enrichment Program, OD/NIH (G.C.); and Sackler Faculty of Medicine, Tel Aviv University, Israel (Y.S.).
Autonomic Medicine Section, CNP/DIR/NINDS/NIH, Bethesda, Maryland (D.G., G.C., P.S.); NIH Academy Enrichment Program, OD/NIH (G.C.); and Sackler Faculty of Medicine, Tel Aviv University, Israel (Y.S.).
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: karel@mail.nih.gov.
From the Department of Internal Medicine (C.D.C.C.v.d.H., L.G., S.T.K., M.P.N., S.K., A.H., L.A.B.J., H.J.L.M.T., M.G.N., N.P.R.), Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Department of Medicine, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany.
Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center, Madrid, Spain.
Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions....
To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population....
A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database....
Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/li...
The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone i...
Sorbitan sesquioleate (SSO) is a sorbitan fatty acid ester, an emulsifier used in topical products and certain patch test preparations. SSO may affect the patch test results. It has been debated wheth...
To report the prevalence and simultaneous reactions of SSO with other patch test preparations containing SSO as an emulsifier....
A retrospective analysis of 3539 dermatitis patients who underwent patch testing from 2016 to 2020 was performed....
The 5-year SSO contact allergy prevalence was 0.48%, and 1.3% had a doubtful reaction. Patients with a stronger positive reaction (2+, 3+) were more likely to react simultaneously to other allergen pr...
Patch testing with allergen preparations containing SSO affected the patch test interpretation. Fragrance contact allergy could not be ruled out when a patient simultaneously reacted to SSO and FM I. ...
Textile dye mix (TDM) is included in the European baseline series (EBS), but it is unknown if TDM identifies all patients with a textile dye allergy....
To assess the added value of performing patch testing with individual textile dyes in addition to TDM....
Two hundred and nine patients suspected to have a contact allergy to textile dyes were patch tested between January 2015 and December 2021 with the EBS, as well as an individual textile dye test serie...
Fifty-four patients (25.8%) tested positive for TDM or an individual textile dye. Disperse Orange 3 (9.6%) followed by Disperse Blue 106 (4.8%) were the most common individual textile dyes causing a p...
It is beneficial to test individual textile dyes in addition to TDM in patients suspected of having a textile dye allergy. Otherwise, 46.3% of the dye positive patients and 35.7% of the patients with ...
Dental workers are exposed to allergenic materials in the workplace....
To summarize patch test results in dental staff with work-related dermatitis....
Cross-sectional study of dental staff with dermatitis was conducted. Symptoms, clinical findings and results from patch tests with 40 dental allergens were summarized....
Of 329 participants, 155 (47.1%) had at least one positive patch reaction. The highest frequency of positive reactions was observed for metals (38.6%), acrylics (7.3%) and additives in acrylic resins ...
Almost half of the dental staff with dermatitis had at least one positive patch test and approximately 12% had current occupational relevance of the allergens. Our results underscore the importance of...
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease mainly affecting children. Similarly, Allergic contact dermatitis (ACD) is an inflammatory skin disease, but unlike AD it re...
In this cross-sectional transversal study, we performed a PT with 30 sensitizers in 26 children with AD, selected according to established criteria for suspected ACD, and treated at an AD center of a ...
In all, 23 (88.5%) patients reacted to at least one allergen, 21 (80.7%) had a relevant positive patch test, and 15 (57.7%) were polysensitized. The main positive sensitizers were nickel (38.5%), blue...
Our data underscore the importance of performing a PT in AD children whose eczema has atypical distribution. The expressive percentage of positive tests, especially of allergens in skincare products, ...
Celiac disease is one of the most common autoimmune disorders. This study aimed to evaluate the relationship between celiac disease and wheat sensitization....
In the current study, children aged < 18 years with confirmed celiac disease were included. Data were analyzed using SPSS....
Gastrointestinal problems were the most common indication for evaluation in terms of celiac disease. Prick and patch tests were positive in 43.4% and 34% respectively....
Prick test and patch test for wheat sensitization were positive in about 30-45% of the children for celiac disease....
Fragrance materials are widely used in various types of products in daily life and many of them can be contact sensitizers. Contact allergy to fragrances has been reported to be common worldwide. Unli...
Eugenol is a known contact sensitiser included in fragrance mix I....
To assess the allergic reactivity to eugenol in different concentrations using patch test as well as repeated open application test (ROAT)....
Overall 67 subjects from 6 European dermatology clinics participated in the study. The ROAT was performed for 21 days twice a day, applying 3 dilutions of eugenol (2.7%-0.5%) and a control. Before and...
Out of the 34 subjects with contact allergy to eugenol, 21 (61.8%) showed a positive patch test before ROAT was performed, the lowest positive concentration was 0.031%. The ROAT was positive in 19 (55...
Eugenol can provoke a positive patch test reaction in a very low dose; besides, this hypersensitivity may persist even if a former positive patch test is not reproduceable....
Critical to the evaluation of non-animal tests are reference data with which to assess their relevance. Animal data are typically used because they are generally standardized and available. However, w...
A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated....
The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations....
Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 1...
Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compar...
Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua....
