questionsmedicales.fr
Métabolisme
Désalkylation
Désalkylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Désalkylation
Tests biochimiques
Anomalies hépatiques
Désalkylation
Imagerie médicale
Désalkylation
Enzymes hépatiques
Désalkylation
Symptômes
5
Nausées
Douleurs abdominales
Effets neurologiques
Désalkylation
Éruptions cutanées
Désalkylation
Hépatotoxicité
Désalkylation
Prévention
5
Prévention
Substances chimiques
Contrôles médicaux
Désalkylation
Éducation des patients
Médicaments
Mode de vie
Complications
Professionnels de santé
Interactions médicamenteuses
Traitements
5
Antidotes
Soins de soutien
Antiémétiques
Analgésiques
Prévention
Substances toxiques
Complications
5
Lésions hépatiques
Troubles neurologiques
Maladies chroniques
Cirrhose
Réversibilité
Traitement précoce
Surveillance clinique
Tests de laboratoire
Facteurs de risque
5
Facteurs de risque
Antécédents hépatiques
Habitudes alimentaires
Toxines
Tabagisme
Substances nocives
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Désalkylation : Questions médicales les plus fréquentes",
"headline": "Désalkylation : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Désalkylation : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-05-28",
"dateModified": "2025-02-22",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Désalkylation"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Métabolisme",
"url": "https://questionsmedicales.fr/mesh/D008660",
"about": {
"@type": "MedicalCondition",
"name": "Métabolisme",
"code": {
"@type": "MedicalCode",
"code": "D008660",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G03"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Déméthylation",
"alternateName": "Demethylation",
"url": "https://questionsmedicales.fr/mesh/D000073398",
"about": {
"@type": "MedicalCondition",
"name": "Déméthylation",
"code": {
"@type": "MedicalCode",
"code": "D000073398",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G03.219.500"
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Déméthylation de l'ADN",
"alternateName": "DNA Demethylation",
"url": "https://questionsmedicales.fr/mesh/D000073399",
"about": {
"@type": "MedicalCondition",
"name": "Déméthylation de l'ADN",
"code": {
"@type": "MedicalCode",
"code": "D000073399",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G03.219.500.500"
}
}
}
]
}
],
"about": {
"@type": "MedicalCondition",
"name": "Désalkylation",
"alternateName": "Dealkylation",
"code": {
"@type": "MedicalCode",
"code": "D003640",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Michael R Baldwin",
"url": "https://questionsmedicales.fr/author/Michael%20R%20Baldwin",
"affiliation": {
"@type": "Organization",
"name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600."
}
},
{
"@type": "Person",
"name": "Suzanne J Admiraal",
"url": "https://questionsmedicales.fr/author/Suzanne%20J%20Admiraal",
"affiliation": {
"@type": "Organization",
"name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600."
}
},
{
"@type": "Person",
"name": "Patrick J O'Brien",
"url": "https://questionsmedicales.fr/author/Patrick%20J%20O%27Brien",
"affiliation": {
"@type": "Organization",
"name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu."
}
},
{
"@type": "Person",
"name": "Yusuke Suzuki",
"url": "https://questionsmedicales.fr/author/Yusuke%20Suzuki",
"affiliation": {
"@type": "Organization",
"name": "Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan."
}
},
{
"@type": "Person",
"name": "Takafumi Naito",
"url": "https://questionsmedicales.fr/author/Takafumi%20Naito",
"affiliation": {
"@type": "Organization",
"name": "Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. naitou@shinshu-u.ac.jp."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Surgical management of dermatofibrosarcoma protuberans.",
"datePublished": "2023-03-31",
"url": "https://questionsmedicales.fr/article/36999599",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/jso.27258"
}
},
{
"@type": "ScholarlyArticle",
"name": "Pigmented dermatofibrosarcoma (Bednar tumour) of scalp.",
"datePublished": "2023-09-27",
"url": "https://questionsmedicales.fr/article/37758662",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1136/bcr-2022-254473"
}
},
{
"@type": "ScholarlyArticle",
"name": "PRAME expression in fibrosarcomatous dermatofibrosarcoma protuberans.",
"datePublished": "2024-10-03",
"url": "https://questionsmedicales.fr/article/39362949",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41598-024-74556-5"
}
},
{
"@type": "ScholarlyArticle",
"name": "Oncological efficiency of wide local excision in dermatofibrosarcoma protuberans.",
"datePublished": "2022-11-25",
"url": "https://questionsmedicales.fr/article/36592535",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.bjps.2022.11.002"
}
},
{
"@type": "ScholarlyArticle",
"name": "Dermatofibrosarcoma protuberans challenges: a case series and review of the literature.",
"datePublished": "2023-01-19",
"url": "https://questionsmedicales.fr/article/36653860",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13256-022-03728-6"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Métabolisme",
"item": "https://questionsmedicales.fr/mesh/D008660"
},
{
"@type": "ListItem",
"position": 3,
"name": "Désalkylation",
"item": "https://questionsmedicales.fr/mesh/D003640"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Désalkylation - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Désalkylation",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-04",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Désalkylation",
"description": "Comment diagnostiquer une désalkylation ?\nQuels tests sont utilisés pour la désalkylation ?\nQuels signes indiquent une désalkylation ?\nLa désalkylation est-elle détectable par imagerie ?\nQuels marqueurs sont associés à la désalkylation ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Désalkylation",
"description": "Quels symptômes sont liés à la désalkylation ?\nLa désalkylation provoque-t-elle des effets neurologiques ?\nY a-t-il des symptômes cutanés associés ?\nLa désalkylation affecte-t-elle le foie ?\nQuels signes de toxicité sont observés ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Désalkylation",
"description": "Comment prévenir la désalkylation ?\nLes contrôles médicaux aident-ils à prévenir la désalkylation ?\nL'éducation des patients est-elle importante ?\nLes changements de mode de vie aident-ils ?\nLes professionnels de santé jouent-ils un rôle ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Désalkylation",
"description": "Quel traitement pour une désalkylation toxique ?\nLes médicaments peuvent-ils aider à la désalkylation ?\nComment gérer les symptômes de désalkylation ?\nY a-t-il des traitements préventifs ?\nLa désalkylation nécessite-t-elle une hospitalisation ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Désalkylation",
"description": "Quelles complications peuvent survenir ?\nLa désalkylation peut-elle entraîner des maladies chroniques ?\nY a-t-il des risques de surdosage ?\nLes complications sont-elles réversibles ?\nComment surveiller les complications ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Désalkylation",
"description": "Quels sont les facteurs de risque de désalkylation ?\nL'âge influence-t-il le risque de désalkylation ?\nLes habitudes alimentaires affectent-elles le risque ?\nLe tabagisme est-il un facteur de risque ?\nLes maladies préexistantes influencent-elles le risque ?",
"url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Dermatofibrosarcoma#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une désalkylation ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des tests biochimiques et des analyses de sang pour évaluer les métabolites."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour la désalkylation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de toxicologie et des analyses enzymatiques sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une désalkylation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes cliniques comme des anomalies hépatiques peuvent indiquer une désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation est-elle détectable par imagerie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la désalkylation est généralement évaluée par des tests biochimiques, pas par imagerie."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés à la désalkylation ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs comme les enzymes hépatiques peuvent être augmentés lors de la désalkylation."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à la désalkylation ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent inclure des nausées, des vomissements et des douleurs abdominales."
}
},
{
"@type": "Question",
"name": "La désalkylation provoque-t-elle des effets neurologiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets neurologiques comme des vertiges peuvent survenir en cas de désalkylation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes cutanés associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des éruptions cutanées peuvent apparaître en raison de réactions aux métabolites de désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation affecte-t-elle le foie ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des anomalies hépatiques et une hépatotoxicité."
}
},
{
"@type": "Question",
"name": "Quels signes de toxicité sont observés ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes de toxicité incluent fatigue, confusion et jaunisse dans les cas graves."
}
},
{
"@type": "Question",
"name": "Comment prévenir la désalkylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition à des substances chimiques et suivre les prescriptions médicales aide."
}
},
{
"@type": "Question",
"name": "Les contrôles médicaux aident-ils à prévenir la désalkylation ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des contrôles réguliers peuvent détecter des problèmes avant qu'ils ne deviennent graves."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les risques des médicaments et des toxines est crucial."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie aident-ils ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Adopter un mode de vie sain peut réduire le risque de désalkylation et de complications."
}
},
{
"@type": "Question",
"name": "Les professionnels de santé jouent-ils un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les professionnels de santé doivent surveiller les interactions médicamenteuses et les risques."
}
},
{
"@type": "Question",
"name": "Quel traitement pour une désalkylation toxique ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des soins de soutien et des antidotes spécifiques selon le toxique."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider à la désalkylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent faciliter le métabolisme et l'élimination des toxines."
}
},
{
"@type": "Question",
"name": "Comment gérer les symptômes de désalkylation ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des symptômes inclut des antiémétiques et des analgésiques pour le confort."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements préventifs ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les substances toxiques et surveiller les médicaments peut prévenir la désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation nécessite-t-elle une hospitalisation ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela dépend de la gravité des symptômes et de l'exposition aux toxines, parfois nécessaire."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des lésions hépatiques, des troubles neurologiques et des réactions allergiques."
}
},
{
"@type": "Question",
"name": "La désalkylation peut-elle entraîner des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une désalkylation sévère peut contribuer à des maladies chroniques comme la cirrhose."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de surdosage ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un surdosage de substances pouvant subir désalkylation peut être fatal."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement précoce, d'autres non."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "La surveillance clinique et les tests de laboratoire réguliers sont essentiels pour détecter les complications."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de désalkylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'exposition à des toxines, l'usage de certains médicaments et des antécédents hépatiques."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de désalkylation ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir un risque accru en raison d'une fonction hépatique diminuée."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires affectent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en toxines ou en médicaments peut augmenter le risque de désalkylation."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut augmenter le risque de désalkylation en raison de l'exposition à des substances nocives."
}
},
{
"@type": "Question",
"name": "Les maladies préexistantes influencent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme l'hépatite ou la cirrhose augmentent le risque de désalkylation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 22/02/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. naitou@shinshu-u.ac.jp.
Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. naitou@shinshu-u.ac.jp.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Kodikos Laboratories, Institut Cochin, Paris 75014, France.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Kodikos Laboratories, Institut Cochin, Paris 75014, France.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemical Engineering, Engineering and Technology Institute Groningen, University of Groningen, 9747 AG, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Drug Design, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemical Engineering, Engineering and Technology Institute Groningen, University of Groningen, 9747 AG, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Drug Design, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive cutaneous malignancy. Complete resection is the primary treatment but there is debate over the optimal method. Wide local exci...
Pigmented dermatofibrosarcoma protuberans (DFSP) also known as Bednar tumour is a very rare variant of DFSP which is considered to be of intermediate grade along with the presence of melanin-containin...
PRAME (PReferentially expressed Antigen in MElanoma) was first identified as a malignant melanoma-specific antigen. Recently, a few cases of fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) ...
Dermatofibrosarcoma protuberans (DFSP) is a slow-growing, low- to intermediate-grade malignant sarcoma. Its optimal treatment is resection with wide margins; the likelihood of local control associated...
We examined the clinical, epidemiological, and pathological features, the treatment types, and outcomes of patients to investigate the width of safe surgical margins (SM) and how the width of SMs affe...
We retrospectively examined the records of 60 patients who were initially operated on with wide local excision for DFSP in the period 2008-2019. Optimal cutoff points for SMs were calculated with the ...
During the mean 89.6-month follow-up, local recurrence was seen in 36.7% and distant metastasis in 20% of the patients. Recurrences were significantly related to peripheral resection margins. Analysis...
This study showed SMs >2.5 cm to be sufficiently safe for WLE and optimized the balance among safe margin width, reconstruction need, and surgical morbidity. In metastatic DFSP patients, tyrosine kina...
Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary st...
Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgi...
Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commo...
A 47-year-old woman presented with a 6-month history of palpable masses in the right hip. The patient was subsequently enrolled in our clinical trial of 68 Ga-FAPI PET/CT study on tumors. Intense 68 G...
Dermatofibrosarcoma protuberans (DFSP) is an aggressive tumour with multiple local recurrences and rare metastatic potential. Fibrosarcomatous transformation occurs in a few cases of DFSP which makes ...
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor with a low rate of metastatic disease. Previous series have shown a superiority of Mohs micrographic surgery (MMS) compared with wi...
The purpose of the current study was to examine the outcome of surgical treatment of primary DFSP of the trunk and extremities....
We reviewed 236 patients (115 females, 121 males, mean age 41 ± 15 years) undergoing MMS (n = 81, 34%) or WLE (n = 155, 66%) to treat a primary DFSP. Mean tumor size and follow-up was 4 ± 2 cm and 7 y...
There was no difference (p > 0.05) in patient age, sex, tumor size, negative margin excision, or history of a previous inadvertent excision between patients who underwent WLE and those undergoing MMS....
There was no difference in oncologic outcome comparing MMS with WLE for DFSP outside the head and neck. The goal of treatment for DFSP is to achieve a negative margin, regardless of surgical treatment...
Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor characterized by a high risk of local recurrence but a low risk of metastasis. A small subpopulation of DFSP undergoes fibrosarcomato...
Dermatofibrosarcoma protuberans (DFSP) is one of the most common dermal sarcomas, but facial DFSP is rare....
The clinicopathological characteristics of 34 facial DFSPs were reviewed. Additional immunostaining (CD34) and PDGFB/COL1A1-PDGFB fluorescence in situ hybridization (FISH) detection were performed....
Patients were aged from 24 to 64 years (mean 42.9 years), with a male-to-female ratio of 4.7 : 1. Morphologically, classic DFSP (25/34, 73.5 %), pigmented DFSP (2/34, 5.9 %), DFSP with myoid different...
Facial DFSP occurs predominantly in males, while FS-DFSPs are more likely to exhibit myxoid degeneration and a worse prognosis. Notably, negative surgical margin status determined a satisfactory progn...