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Métabolisme
Désalkylation
Désalkylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Désalkylation
Tests biochimiques
Anomalies hépatiques
Désalkylation
Imagerie médicale
Désalkylation
Enzymes hépatiques
Désalkylation
Symptômes
5
Nausées
Douleurs abdominales
Effets neurologiques
Désalkylation
Éruptions cutanées
Désalkylation
Hépatotoxicité
Désalkylation
Prévention
5
Prévention
Substances chimiques
Contrôles médicaux
Désalkylation
Éducation des patients
Médicaments
Mode de vie
Complications
Professionnels de santé
Interactions médicamenteuses
Traitements
5
Antidotes
Soins de soutien
Antiémétiques
Analgésiques
Prévention
Substances toxiques
Complications
5
Lésions hépatiques
Troubles neurologiques
Maladies chroniques
Cirrhose
Réversibilité
Traitement précoce
Surveillance clinique
Tests de laboratoire
Facteurs de risque
5
Facteurs de risque
Antécédents hépatiques
Habitudes alimentaires
Toxines
Tabagisme
Substances nocives
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"description": "Comment diagnostiquer une désalkylation ?\nQuels tests sont utilisés pour la désalkylation ?\nQuels signes indiquent une désalkylation ?\nLa désalkylation est-elle détectable par imagerie ?\nQuels marqueurs sont associés à la désalkylation ?",
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"name": "Comment diagnostiquer une désalkylation ?",
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}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour la désalkylation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de toxicologie et des analyses enzymatiques sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une désalkylation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes cliniques comme des anomalies hépatiques peuvent indiquer une désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation est-elle détectable par imagerie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la désalkylation est généralement évaluée par des tests biochimiques, pas par imagerie."
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{
"@type": "Question",
"name": "Quels marqueurs sont associés à la désalkylation ?",
"position": 5,
"acceptedAnswer": {
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"text": "Les marqueurs comme les enzymes hépatiques peuvent être augmentés lors de la désalkylation."
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{
"@type": "Question",
"name": "Quels symptômes sont liés à la désalkylation ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent inclure des nausées, des vomissements et des douleurs abdominales."
}
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{
"@type": "Question",
"name": "La désalkylation provoque-t-elle des effets neurologiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets neurologiques comme des vertiges peuvent survenir en cas de désalkylation."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes cutanés associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des éruptions cutanées peuvent apparaître en raison de réactions aux métabolites de désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation affecte-t-elle le foie ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des anomalies hépatiques et une hépatotoxicité."
}
},
{
"@type": "Question",
"name": "Quels signes de toxicité sont observés ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes de toxicité incluent fatigue, confusion et jaunisse dans les cas graves."
}
},
{
"@type": "Question",
"name": "Comment prévenir la désalkylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition à des substances chimiques et suivre les prescriptions médicales aide."
}
},
{
"@type": "Question",
"name": "Les contrôles médicaux aident-ils à prévenir la désalkylation ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des contrôles réguliers peuvent détecter des problèmes avant qu'ils ne deviennent graves."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les risques des médicaments et des toxines est crucial."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie aident-ils ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Adopter un mode de vie sain peut réduire le risque de désalkylation et de complications."
}
},
{
"@type": "Question",
"name": "Les professionnels de santé jouent-ils un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les professionnels de santé doivent surveiller les interactions médicamenteuses et les risques."
}
},
{
"@type": "Question",
"name": "Quel traitement pour une désalkylation toxique ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des soins de soutien et des antidotes spécifiques selon le toxique."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider à la désalkylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent faciliter le métabolisme et l'élimination des toxines."
}
},
{
"@type": "Question",
"name": "Comment gérer les symptômes de désalkylation ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des symptômes inclut des antiémétiques et des analgésiques pour le confort."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements préventifs ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les substances toxiques et surveiller les médicaments peut prévenir la désalkylation."
}
},
{
"@type": "Question",
"name": "La désalkylation nécessite-t-elle une hospitalisation ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela dépend de la gravité des symptômes et de l'exposition aux toxines, parfois nécessaire."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des lésions hépatiques, des troubles neurologiques et des réactions allergiques."
}
},
{
"@type": "Question",
"name": "La désalkylation peut-elle entraîner des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une désalkylation sévère peut contribuer à des maladies chroniques comme la cirrhose."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de surdosage ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un surdosage de substances pouvant subir désalkylation peut être fatal."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement précoce, d'autres non."
}
},
{
"@type": "Question",
"name": "Comment surveiller les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "La surveillance clinique et les tests de laboratoire réguliers sont essentiels pour détecter les complications."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de désalkylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'exposition à des toxines, l'usage de certains médicaments et des antécédents hépatiques."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de désalkylation ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir un risque accru en raison d'une fonction hépatique diminuée."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires affectent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en toxines ou en médicaments peut augmenter le risque de désalkylation."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut augmenter le risque de désalkylation en raison de l'exposition à des substances nocives."
}
},
{
"@type": "Question",
"name": "Les maladies préexistantes influencent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme l'hépatite ou la cirrhose augmentent le risque de désalkylation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 22/02/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. naitou@shinshu-u.ac.jp.
Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. naitou@shinshu-u.ac.jp.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
2 publications dans cette catégorie
Affiliations :
Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Kodikos Laboratories, Institut Cochin, Paris 75014, France.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Kodikos Laboratories, Institut Cochin, Paris 75014, France.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemical Engineering, Engineering and Technology Institute Groningen, University of Groningen, 9747 AG, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Drug Design, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Chemical Engineering, Engineering and Technology Institute Groningen, University of Groningen, 9747 AG, Groningen, The Netherlands.
Publications dans "Désalkylation" :
1 publication dans cette catégorie
Affiliations :
Department of Drug Design, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Publications dans "Désalkylation" :
Transcranial direct current stimulation (tDCS) is a promising tool to enhance therapeutic efforts, for instance, after a stroke. The achieved stimulation effects exhibit high inter-subject variability...
While brain anatomy in general and specifically atrophy as well as stroke lesions are deemed influential on the EF in simulation studies, the influence of the uncertainty in the change of the electric...
A group simulation study with 88 subjects assigned into four groups of increasing lesion load was conducted. Due to the lack of information about the electrical conductivity of WMLs, an uncertainty an...
The contribution of WMLs to the EF variance was on average only one tenth to one thousandth of the contribution of the other modeled tissues. While the contribution of the WMLs significantly increased...
Our results suggest that WMLs do not perturb the EF globally and can thus be omitted when modeling subjects with low to medium lesion load. However, for high lesion load subjects, the omission of WMLs...
Physical inactivity is associated with muscle atrophy and venous thromboembolism, which may be prevented by neuromuscular electrical stimulation (NMES). This study aimed to investigate the effect on d...
On eleven healthy participants (four females), calf-NMES via a TTE sock was applied with increasing intensity (mA) until ankle-plantar flexion at which point outcomes were compared when testing freque...
1 Hz yielded a median (inter-quartile range) NRS of 2.4 (1.0-3.4), significantly lower than both 3 Hz with NRS 2.8 (1.8-4.2), and 10 Hz with NRS 3.4 (1.4-5.4) (both p ≤ .014). Each increase in tested ...
LI-NMES applied via a TTE sock produces a relevant plantar flexion of the ankle with the best comfort and lowest energy consumption using 1 Hz and phase durations 150, 200 or 400 µs....
Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcra...
We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for imple...
The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weakness...
Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases....
We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES tr...
Intracranial electrodes are used clinically for diagnostic or therapeutic purposes, notably in drug-refractory epilepsy (DRE) among others. Visualization and quantification of the energy delivered thr...
To assess the efficacy of vaginal electrical stimulation (VS) versus transcutaneous tibial nerve electrical stimulation (TTNS) in women with overactive bladder syndrome (OAB)....
Sixty-nine patients were randomized to receive 12 sessions of VS versus TTNS, or no treatment (control group-CG), over 6 weeks. OAB impact according to international consultation on incontinence quest...
Both TTNS (mean difference = -4.2; 95% confidence interval [CI] = -6.5 to -1.9) and VS (-3.8; -6.0 to -1.6) were associated with significant reduction of ICIQ-OAB scores, as well as discomfort sensati...
Short-term interventions (6 weeks) of TTNS and VS were both effective in treating women with OAB. TTNS provided residual effects at one-month postintervention on ICIQ-OAB score....
Osteoporosis is mainly a geriatric disease with a high incidence, and the resulting spinal fractures and hip fractures cause great harm to patients. Anti-osteoporosis drugs are the main treatment for ...
Tooth loss during the lifetime of an individual is common. A strategy to treat partial or complete edentulous patients is the placement of dental implants. However, dental implants are subject to bact...
Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas inv...
We reviewed 12,088 bipolar stimulations performed in 203 patients during the presurgical evaluation of drug refractory epilepsy. Responses to stimulation were divided into viscero-sensitive, viscero-v...
In total, 543 stimulations evoked visceral and emotional sensations. Stimulations of operculo-insulolimbic structures (amygdala, anterior and posterior insula, anterior and mid-cingulate cortex, hippo...
Our data can help to guide SEEG explorations when visceral or emotional symptoms are part of the ictal semiology. They also bring some insights into the mechanisms of visceroception and the functional...
The application of biological methods in industrial saline wastewater treatment is limited, since the activities of microorganisms are strongly inhibited by the highly concentrated salts. Acclimatized...
Exercising intrinsic foot muscles (IFMs) can improve dynamic balance and foot posture. The exercises are not intuitive and electrotherapy (neuromuscular electrical stimulation [NMES]) has been suggest...
Randomized controlled trial....
Thirty-nine participants were randomized to control, TRAIN, or NMES. TRAIN and NMES performed IFM exercises daily for 4 weeks; NMES received electrotherapy during the first 2 weeks of training. The Y-...
A 4-week IFM training program demonstrated increases in Y-Balance (P = .01) for TRAIN and in arch height index (seated P = .03; standing P = .02) for NMES, relative to baseline. NMES demonstrated impr...
A 4-week IFM training program improved dynamic balance and foot posture. Adding NMES in early phases of training provided early improvement in dynamic balance and foot posture, but did not affect perc...