Quelle est l'importance de la formation continue ?
La formation continue est essentielle pour maintenir des compétences à jour et garantir des soins de qualité.
Formation médicaleCompétenceÉthique médicale
#4
Comment un médecin doit-il traiter les patients vulnérables ?
Il doit faire preuve de sensibilité, respecter leur dignité et adapter les soins à leurs besoins.
Patients vulnérablesÉthique médicaleDroits des patients
#5
Quelles sont les implications de la télémédecine en déontologie ?
La télémédecine doit respecter les mêmes principes éthiques, notamment la confidentialité et le consentement.
TélémédecineConfidentialitéÉthique médicale
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Clinical Ethics Service, Sydney Children's Hospital Network, Children's Hospital at Westmead and Sydney Children's Hospital, Randwick, Australia; Sydney Health Ethics, 92/94 Parramatta Rd, Camperdown, NSW 2050, Australia. Electronic address: davidisaacs@health.nsw.gov.au.
Clinical Ethics Service, Sydney Children's Hospital Network, Children's Hospital at Westmead and Sydney Children's Hospital, Randwick, Australia; Sydney Health Ethics, 92/94 Parramatta Rd, Camperdown, NSW 2050, Australia.
The State Budget Institution of the Republic of Dagestan "The Republican Clinical Hospital - the Center of Specialized Emergency Medical Care", 367000, Makhachkala, he Republic of Dagestan, Russia.
For randomized clinical trials, subjects' variance structures may vary over time among treatment groups, resulting in the heteroscedasticity of residuals in a regression analysis. Commonly used method...
Platform trials, with arms entering and leaving the trial over time, are complex. In addition to trial changes over time, certain arms in a platform may come with patient restrictions. Both of these i...
Covariate-adjusted randomization (CAR) can reduce the risk of covariate imbalance and, when accounted for in analysis, increase the power of a trial. Despite CAR advances, stratified randomization rem...
When running a randomized controlled trial (RCT), a clinical site may face a situation when an eligible trial participant is to be randomized to the treatment that is not available at the site. In thi...
We described four different IRT configurations with or without FR and illustrated them using a simple example. We discussed potential merits of FR and outlined some relevant theoretical risks and risk...
FR can eliminate refusals to randomize patients, which can cause frustration for patients and study site personnel, improve the study logistics, drug supply management, cost-efficiency, and recruitmen...
FR with a carefully chosen drug supply/re-supply strategy can result in quantifiable improvements in the patients' and site personnel experience, trial logistics and efficiency while preventing an und...
In stepped-wedge cluster randomized trials (SW-CRTs), clusters are randomized not to treatment and control arms but to sequences dictating the times of crossing from control to intervention conditions...
We used electronic searches to identify primary reports of SW-CRTs published between 2016 and 2022....
Across 160 identified trials, the median number of clusters randomized was 11 (Q1-Q3: 8-18). Sixty-three (39%) used restricted randomization-most often stratification based on a single cluster-level c...
SW-CRTs often randomize a small number of clusters using unrestricted allocation. Investigators need guidance on appropriate methods of randomization and assessment and reporting of balance at baselin...
In pre-post designs, analysis of covariance (ANCOVA) is a standard technique to detect the treatment effect with a continuous variable measured at baseline and follow-up. For measurements subject to a...
In this article, we report investigations of using multiple pre-treatment and post-treatment measurements in randomized clinical trials. We consider the sample size formula for ANCOVA under general co...
Theoretical formulas and simulation studies show the benefits of repeating the pre-treatment measurements in pre-post randomized studies. The optimal pre-post allocation derived from the ANCOVA extend...
Repeating baselines and follow-up assessments is a valuable and efficient technique in pre-post design. The proposed optimal pre-post allocation designs can minimize the sample size, i.e., achieve max...
An ongoing cluster-randomized trial for the prevention of arboviral diseases utilizes covariate-constrained randomization to balance two treatment arms across four specified covariates and geographic ...
We developed an algorithm that successfully identified a subset of clusters that maximized the average minimum pairwise distance between clusters in order to reduce contamination and balanced the spec...
Simulations were performed to explore some limitations of this algorithm. The number of selected clusters and eligible clusters were varied along with the method of selecting the final allocation patt...
The algorithm is presented here as a series of optional steps that can be added to the standard covariate-constrained randomization process in order to achieve spatial dispersion, cluster subsampling,...
Randomized trials of infectious disease interventions, such as vaccines, often focus on groups of connected or potentially interacting individuals. When the pathogen of interest is transmissible betwe...
The scientific role randomization plays in clinical research is universally recognized, but poorly understood. In stark contrast, the ethical role randomization plays in the proper care of patients in...
We review the introduction of randomization in the design of experiments, its first use in Britain, and its essential role in analysis of statistical results. We also review Thomas Chalmers' argument ...
Randomization is not only essential to the validity of statistical tests, it is also the best way to learn from experience. Although Chalmers' admonition to 'Randomize the first patient' pertained to ...
Randomized allocation plays crucial scientific and ethical roles both in research and practice. It is the most efficient way to learn from experience. Prior to this gain in knowledge, it is the way to...