Oui, certains antidépresseurs peuvent améliorer les symptômes liés au tRNA-Trp.
AntidépresseursTraitement médicamenteux
#3
Y a-t-il des thérapies alternatives ?
Des thérapies comme la méditation peuvent aider à gérer les symptômes.
Thérapies alternativesMéditation
#4
Le suivi médical est-il nécessaire ?
Oui, un suivi régulier est essentiel pour ajuster le traitement.
Suivi médicalAjustement thérapeutique
#5
Des changements de mode de vie sont-ils recommandés ?
Oui, une alimentation équilibrée et l'exercice régulier sont conseillés.
Mode de vie sainExercice physique
Complications
5
#1
Quelles complications peuvent survenir avec une carence en tRNA-Trp ?
Des troubles mentaux et des problèmes de croissance peuvent se développer.
ComplicationsTroubles mentaux
#2
Le tRNA-Trp est-il lié à des maladies chroniques ?
Oui, des déséquilibres peuvent contribuer à des maladies comme la dépression.
Maladies chroniquesDépression
#3
Des troubles métaboliques peuvent-ils être causés ?
Oui, une carence peut entraîner des troubles métaboliques et endocriniens.
Troubles métaboliquesEndocrinologie
#4
Y a-t-il un risque accru de maladies cardiovasculaires ?
Oui, des déséquilibres en acides aminés peuvent affecter la santé cardiaque.
Maladies cardiovasculairesAcides aminés
#5
Les complications neurologiques sont-elles possibles ?
Oui, des troubles neurologiques peuvent survenir en cas de carence prolongée.
Complications neurologiquesCarence prolongée
Facteurs de risque
5
#1
Quels sont les facteurs de risque de carence en tryptophane ?
Une alimentation déséquilibrée et des troubles digestifs augmentent le risque.
Facteurs de risqueTroubles digestifs
#2
Les personnes âgées sont-elles plus à risque ?
Oui, elles peuvent avoir des besoins nutritionnels accrus et une absorption réduite.
Personnes âgéesBesoins nutritionnels
#3
Les végétariens courent-ils un risque accru ?
Oui, ils doivent veiller à consommer suffisamment de sources de tryptophane.
VégétariensSources alimentaires
#4
Les troubles alimentaires augmentent-ils le risque ?
Oui, ils peuvent entraîner des carences en nutriments essentiels comme le tryptophane.
Troubles alimentairesCarences nutritionnelles
#5
Le stress peut-il affecter le tRNA-Trp ?
Oui, le stress chronique peut perturber le métabolisme des acides aminés.
StressMétabolisme des acides aminés
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Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan. Electronic address: mkashio@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. zong@uchc.edu.
Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT, 06269, USA. zong@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3, COL4A4 or COL4A5 gene mutations and characterized by abnormalities of glomerular basement membranes (GBMs). Due to a lack of c...
Liver fibrosis is one of the cardinal clinical features of chronic hepatitis C (CHC). However, the mechanisms underlying the evolution and reversion of liver fibrosis after hepatitis C virus (HCV) era...
Between October 2014 and September 2019, 418 patients with CHC or compensated cirrhosis with HCV were prospectively recruited in this observational study. 326 patients that were successfully eradicate...
Ten (3.1%) patients died during the observation period. 4COL7S-defined fibrosis progression (n = 97, 29.8%) at SVR was significantly correlated with worse all-cause mortality post-SVR (P = 0.0062) but...
Peri-treatment dynamics of serum 4COL7S, a non-invasive fibrosis marker, predict prognosis. Non-invasive fibrosis markers may be useful biomarkers for risk stratification post-SVR....
The glomerular basement membrane (GBM) consists of laminins, collagen IV, nidogens, and fibronectin and is essential for filtration barrier integrity in the kidney. Critically, structural and function...
Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive spirometry pattern without parenchymal opacities. The protein sign...
41 patients who had undergone LTX were enrolled. Of these, 27 developed BOS and 14 (control group) were considered stable at the time of serum sampling. Of BOS patients, serum samples were analysed at...
Serum concentrations of COL4A5 were higher in pre-BOS than in stable patients (40.5 ± 13.9 and 24.8 ± 11.4, respectively, p = 0.048). This protein is not influenced by comorbidities, such as acute rej...
Serum concentrations of COL4A5 can be considered a good prognostic marker due to their association with survival and correlation with functional parameters....
Children with persistent, isolated microscopic hematuria typically undergo a limited diagnostic workup and are monitored for signs of kidney disease in long-term longitudinal follow-up, which can dela...
To determine the clinical utility of genetic screening in this population, we performed targeted genetic testing using a custom, 32-gene next-generation sequencing panel for progressive kidney disease...
In cohort 1 33% of subjects (10/30) had pathogenic or likely pathogenic (P/LP) variants in the type IV collagen genes (COL4A3/A4/A5), and 10% (3/30) had variants of uncertain significance in these gen...
Children with persistent, isolated microscopic hematuria have a high likelihood of having pathogenic variants in type IV collagen genes and genetic screening should be considered. A higher resolution ...
The objective of this study was to develop a serum biochemical marker of the degradation of type III and IV collagens, as an index of synovium turnover, and evaluate its performance in patients with r...
Increased collagen remodelling is a key pathophysiological component underlying intestinal stricture and fistula development in Crohn's disease (CD)....
To investigate associations between serological biomarkers of collagen turnover and disease behaviour according to the Montreal classification in patients with CD....
Serological biomarkers of type III/IV collagen formation (PRO-C3, PRO-C4) and matrix metalloproteinase (MMP) or granzyme-B (GrzB)-mediated type I, III, IV and VI collagen degradation (C1M, C3M, C4M, C...
C1M, C3M and C4M were significantly reduced in patients with stricturing disease (Montreal B2) and accurately differentiated them from patients with either non-stricturing, non-penetrating (B1) or pen...
Elevated degradation of type I, III and IV collagen and excessive (relative) formation of type IV collagen strongly associates with stricturing CD. Type I and IV collagen fragments show predictive pot...
Escherichia coli (E. coli) is one of the main bacteria associated with preterm premature rupture of membranes by increasing pro-matrix metalloproteinase 9 (proMMP-9) and degradation of type IV collage...
Nine HFMi were mounted in a Transwell system. MDec was stimulated with P4 or E. coli for 3-, 6-, or 24-hours. proMMP-2, -9 and type IV collagen were assessed....
Gelatin zymography revealed an increase in proMMP-9 after 3, 6, and 24 h of stimulating MDec with E. coli. Using immunofluorescence, it was confirmed the increase in the HFMi tissue and a reduction on...
P4 modulates the activity of proMMP-9 induced by E. coli stimulation but it was unable to completely reverse the degradation of type IV collagen in human MDec tissue....
X-linked Alport syndrome is a genetic kidney disease caused by pathogenic COL4A5 variants, but little is known of the consequences of missense variants affecting the NC1 domain of the corresponding co...