Oui, certains antidépresseurs peuvent améliorer les symptômes liés au tRNA-Trp.
AntidépresseursTraitement médicamenteux
#3
Y a-t-il des thérapies alternatives ?
Des thérapies comme la méditation peuvent aider à gérer les symptômes.
Thérapies alternativesMéditation
#4
Le suivi médical est-il nécessaire ?
Oui, un suivi régulier est essentiel pour ajuster le traitement.
Suivi médicalAjustement thérapeutique
#5
Des changements de mode de vie sont-ils recommandés ?
Oui, une alimentation équilibrée et l'exercice régulier sont conseillés.
Mode de vie sainExercice physique
Complications
5
#1
Quelles complications peuvent survenir avec une carence en tRNA-Trp ?
Des troubles mentaux et des problèmes de croissance peuvent se développer.
ComplicationsTroubles mentaux
#2
Le tRNA-Trp est-il lié à des maladies chroniques ?
Oui, des déséquilibres peuvent contribuer à des maladies comme la dépression.
Maladies chroniquesDépression
#3
Des troubles métaboliques peuvent-ils être causés ?
Oui, une carence peut entraîner des troubles métaboliques et endocriniens.
Troubles métaboliquesEndocrinologie
#4
Y a-t-il un risque accru de maladies cardiovasculaires ?
Oui, des déséquilibres en acides aminés peuvent affecter la santé cardiaque.
Maladies cardiovasculairesAcides aminés
#5
Les complications neurologiques sont-elles possibles ?
Oui, des troubles neurologiques peuvent survenir en cas de carence prolongée.
Complications neurologiquesCarence prolongée
Facteurs de risque
5
#1
Quels sont les facteurs de risque de carence en tryptophane ?
Une alimentation déséquilibrée et des troubles digestifs augmentent le risque.
Facteurs de risqueTroubles digestifs
#2
Les personnes âgées sont-elles plus à risque ?
Oui, elles peuvent avoir des besoins nutritionnels accrus et une absorption réduite.
Personnes âgéesBesoins nutritionnels
#3
Les végétariens courent-ils un risque accru ?
Oui, ils doivent veiller à consommer suffisamment de sources de tryptophane.
VégétariensSources alimentaires
#4
Les troubles alimentaires augmentent-ils le risque ?
Oui, ils peuvent entraîner des carences en nutriments essentiels comme le tryptophane.
Troubles alimentairesCarences nutritionnelles
#5
Le stress peut-il affecter le tRNA-Trp ?
Oui, le stress chronique peut perturber le métabolisme des acides aminés.
StressMétabolisme des acides aminés
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "ARN de transfert du tryptophane : Questions médicales les plus fréquentes",
"headline": "ARN de transfert du tryptophane : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les ARN de transfert du tryptophane : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-04-17",
"dateModified": "2025-04-12",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "ARN de transfert du tryptophane"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "ARN de transfert spécifiques des différents acides aminés",
"url": "https://questionsmedicales.fr/mesh/D012345",
"about": {
"@type": "MedicalCondition",
"name": "ARN de transfert spécifiques des différents acides aminés",
"code": {
"@type": "MedicalCode",
"code": "D012345",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D13.444.735.757.700"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "ARN de transfert du tryptophane",
"alternateName": "RNA, Transfer, Trp",
"code": {
"@type": "MedicalCode",
"code": "D012364",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Makoto Tominaga",
"url": "https://questionsmedicales.fr/author/Makoto%20Tominaga",
"affiliation": {
"@type": "Organization",
"name": "Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp."
}
},
{
"@type": "Person",
"name": "Sudhanva S Kashyap",
"url": "https://questionsmedicales.fr/author/Sudhanva%20S%20Kashyap",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA."
}
},
{
"@type": "Person",
"name": "Alan P Robertson",
"url": "https://questionsmedicales.fr/author/Alan%20P%20Robertson",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA."
}
},
{
"@type": "Person",
"name": "Richard J Martin",
"url": "https://questionsmedicales.fr/author/Richard%20J%20Martin",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA. rjmartin@iastate.edu."
}
},
{
"@type": "Person",
"name": "Lixia Yue",
"url": "https://questionsmedicales.fr/author/Lixia%20Yue",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Recommendation on an updated standardization of serum magnesium reference ranges.",
"datePublished": "2022-06-10",
"url": "https://questionsmedicales.fr/article/35689124",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00394-022-02916-w"
}
},
{
"@type": "ScholarlyArticle",
"name": "Reference Standards to Support Quality of Synthetic Peptide Therapeutics.",
"datePublished": "2023-03-22",
"url": "https://questionsmedicales.fr/article/36949371",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s11095-023-03493-1"
}
},
{
"@type": "ScholarlyArticle",
"name": "Diagnosis of Genital Tuberculosis in Infertile Women by Using the Composite Reference Standard.",
"datePublished": "2022-08-16",
"url": "https://questionsmedicales.fr/article/36016849",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1155/2022/8078639"
}
},
{
"@type": "ScholarlyArticle",
"name": "Development of a glucose reference material in human serum for clinical assay standardization.",
"datePublished": "2023-02-15",
"url": "https://questionsmedicales.fr/article/36848767",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jpba.2023.115285"
}
},
{
"@type": "ScholarlyArticle",
"name": "The Delirium Interview as a new reference standard in studies on delirium assessment tools.",
"datePublished": "2023-02-21",
"url": "https://questionsmedicales.fr/article/36807119",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/jgs.18263"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides nucléiques, nucléotides et nucléosides",
"item": "https://questionsmedicales.fr/mesh/D009706"
},
{
"@type": "ListItem",
"position": 3,
"name": "Acides nucléiques",
"item": "https://questionsmedicales.fr/mesh/D009696"
},
{
"@type": "ListItem",
"position": 4,
"name": "ARN",
"item": "https://questionsmedicales.fr/mesh/D012313"
},
{
"@type": "ListItem",
"position": 5,
"name": "ARN de transfert",
"item": "https://questionsmedicales.fr/mesh/D012343"
},
{
"@type": "ListItem",
"position": 6,
"name": "ARN de transfert spécifiques des différents acides aminés",
"item": "https://questionsmedicales.fr/mesh/D012345"
},
{
"@type": "ListItem",
"position": 7,
"name": "ARN de transfert du tryptophane",
"item": "https://questionsmedicales.fr/mesh/D012364"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : ARN de transfert du tryptophane - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur ARN de transfert du tryptophane",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-15",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur ARN de transfert du tryptophane",
"description": "Comment diagnostiquer une anomalie du tRNA-Trp ?\nQuels tests sont utilisés pour évaluer le tRNA-Trp ?\nQuels symptômes peuvent indiquer un problème avec le tRNA-Trp ?\nLe dosage du tryptophane est-il utile ?\nPeut-on détecter des mutations dans le gène du tRNA-Trp ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur ARN de transfert du tryptophane",
"description": "Quels sont les symptômes d'une carence en tryptophane ?\nLes troubles de l'humeur sont-ils liés au tRNA-Trp ?\nY a-t-il des signes neurologiques associés ?\nComment le tRNA-Trp affecte-t-il l'appétit ?\nDes problèmes de croissance peuvent-ils survenir ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur ARN de transfert du tryptophane",
"description": "Comment prévenir une carence en tryptophane ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nY a-t-il des recommandations diététiques spécifiques ?\nL'éducation nutritionnelle est-elle importante ?\nLes suppléments sont-ils nécessaires pour tout le monde ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur ARN de transfert du tryptophane",
"description": "Comment traiter une carence en tryptophane ?\nLes médicaments peuvent-ils aider ?\nY a-t-il des thérapies alternatives ?\nLe suivi médical est-il nécessaire ?\nDes changements de mode de vie sont-ils recommandés ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur ARN de transfert du tryptophane",
"description": "Quelles complications peuvent survenir avec une carence en tRNA-Trp ?\nLe tRNA-Trp est-il lié à des maladies chroniques ?\nDes troubles métaboliques peuvent-ils être causés ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications neurologiques sont-elles possibles ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur ARN de transfert du tryptophane",
"description": "Quels sont les facteurs de risque de carence en tryptophane ?\nLes personnes âgées sont-elles plus à risque ?\nLes végétariens courent-ils un risque accru ?\nLes troubles alimentaires augmentent-ils le risque ?\nLe stress peut-il affecter le tRNA-Trp ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Reference+Standards#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une anomalie du tRNA-Trp ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses biochimiques peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le tRNA-Trp ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'électrophorèse et la spectrométrie de masse sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec le tRNA-Trp ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles neurologiques et des retards de développement peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le dosage du tryptophane est-il utile ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut aider à évaluer la fonction du tRNA-Trp dans l'organisme."
}
},
{
"@type": "Question",
"name": "Peut-on détecter des mutations dans le gène du tRNA-Trp ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques de séquençage peuvent identifier des mutations spécifiques."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une carence en tryptophane ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, dépression et troubles du sommeil peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Les troubles de l'humeur sont-ils liés au tRNA-Trp ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction du tRNA-Trp peut affecter la synthèse de neurotransmetteurs."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes neurologiques associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des convulsions et des troubles cognitifs peuvent être observés."
}
},
{
"@type": "Question",
"name": "Comment le tRNA-Trp affecte-t-il l'appétit ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il joue un rôle dans la régulation de la sérotonine, influençant l'appétit."
}
},
{
"@type": "Question",
"name": "Des problèmes de croissance peuvent-ils survenir ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence en tryptophane peut entraîner un retard de croissance."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en tryptophane ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en protéines et en acides aminés essentiels est clé."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent identifier les personnes à risque de troubles liés au tRNA-Trp."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques spécifiques ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consommer des aliments riches en tryptophane comme les noix et les produits laitiers."
}
},
{
"@type": "Question",
"name": "L'éducation nutritionnelle est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à comprendre l'importance des acides aminés dans l'alimentation."
}
},
{
"@type": "Question",
"name": "Les suppléments sont-ils nécessaires pour tout le monde ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils ne sont nécessaires que pour ceux qui ont des besoins accrus."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en tryptophane ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments de tryptophane et des modifications alimentaires sont recommandés."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains antidépresseurs peuvent améliorer les symptômes liés au tRNA-Trp."
}
},
{
"@type": "Question",
"name": "Y a-t-il des thérapies alternatives ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies comme la méditation peuvent aider à gérer les symptômes."
}
},
{
"@type": "Question",
"name": "Le suivi médical est-il nécessaire ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour ajuster le traitement."
}
},
{
"@type": "Question",
"name": "Des changements de mode de vie sont-ils recommandés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée et l'exercice régulier sont conseillés."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une carence en tRNA-Trp ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles mentaux et des problèmes de croissance peuvent se développer."
}
},
{
"@type": "Question",
"name": "Le tRNA-Trp est-il lié à des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres peuvent contribuer à des maladies comme la dépression."
}
},
{
"@type": "Question",
"name": "Des troubles métaboliques peuvent-ils être causés ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence peut entraîner des troubles métaboliques et endocriniens."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies cardiovasculaires ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres en acides aminés peuvent affecter la santé cardiaque."
}
},
{
"@type": "Question",
"name": "Les complications neurologiques sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir en cas de carence prolongée."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de carence en tryptophane ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation déséquilibrée et des troubles digestifs augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles plus à risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent avoir des besoins nutritionnels accrus et une absorption réduite."
}
},
{
"@type": "Question",
"name": "Les végétariens courent-ils un risque accru ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils doivent veiller à consommer suffisamment de sources de tryptophane."
}
},
{
"@type": "Question",
"name": "Les troubles alimentaires augmentent-ils le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent entraîner des carences en nutriments essentiels comme le tryptophane."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter le tRNA-Trp ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber le métabolisme des acides aminés."
}
}
]
}
]
}
Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan. Electronic address: mkashio@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. zong@uchc.edu.
Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT, 06269, USA. zong@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnose...
We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide....
Serum magnesium levels designating "hypomagnesemia" differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off val...
Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To ap...
Peptides are an important class of therapeutics. Their quality is evaluated using a series of analytical tests, many of which depend on well-characterized reference standards to determine identity, pu...
Discuss approaches to producing peptide reference standards, including vialing, lyophilization, analytical testing and stability studies....
Case studies are used to illustrate analytical approaches to characterize reference standards, including methods for value assignment, content uniformity, and identity testing. Methods described inclu...
This report describes the analytical strategy used to establish peptide reference standard and illustrates how results from multiple labs are integrated to assign a value to the final lyophilized vial...
The methods and case studies described provide a benchmark for best practices in establishing the preparation, analytical testing, handling, and storage of peptide reference standards for the pharmace...
Female genital tuberculosis (FGTB) can be asymptomatic or even masquerade as other gynecological conditions. Conventional methods of FGTB diagnosis include various imaging, bacteriological, molecular,...
Blood glucose is an important monosaccharide functioning as the main source of energy for the human body. The accurate measurement of blood glucose is crucial for the screening, diagnosis, and monitor...
Raw serum samples were collected from residual samples after clinical testing, filtered, and repackaged under mild stirring. The homogeneity and stability of the samples were examined according to ISO...
The developed RMs was homogeneous and commutable enough for clinical use. They were also stable for 24 h at 2-8 ℃ or 20-25 ℃ and for at least 4 years at - 70 ℃. The certified values were 5.20 ± 0.18 m...
The developed RM could be used for the standardization of reference and clinical systems with satisfactory performance and traceable values, providing strong support for the accurate measurement of bl...
The reference standard in studies on delirium assessment tools is usually based on the clinical judgment of only one delirium expert and may be concise, unstandardized, or not specified at all. This m...
We tested the diagnostic accuracy of our standardized Delirium Interview by comparing delirium assessments of the reported results with live assessments. Our reference, the live assessment, was perfor...
We included 98 patients (62% male, mean age 69 ± 12 years), of whom 56 (57%) intensive care units (ICUs) patients, 22 (39%) patients with a Richmond Agitation Sedation Scale (RASS) < 0 and 26 (27%) no...
The Delirium Interview is a feasible reference method for large study cohorts evaluating delirium assessment tools since experts could assess delirium with high accuracy without seeing the patient at ...
The US National Institute of Standards and Technology (NIST) developed a Standard Reference Material® (SRM®) 3949 Folate Vitamers in Frozen Human Serum to replace SRM 1955 Homocysteine and Folate in H...
Radiomics features (RFs) serve as quantitative metrics to characterize shape, density/intensity, and texture patterns in radiological images. Despite their promise, RFs exhibit reproducibility challen...
To explore the diagnostic performance of routine magnetic resonance imaging (MRI) for the cross-sectional assessment of osteophytes (OPs) in all three knee compartments using computed tomography (CT) ...
The Strontium Ranelate Efficacy in Knee Osteoarthritis (SEKOIA) trial explored the effect of 3 years of treatment with strontium ranelate in patients with primary knee OA. OPs were scored for the base...
Included were 74 patients with available MRI and CT data. Mean age was 62.9 ± 7.5 years. Altogether 1,332 locations were evaluated. For the PFJ, MRI detected 141 (72%) of 197 CT-defined OPs with a w-k...
MRI underestimates presence of osteophytes in all three knee compartments. CT may be helpful particularly regarding assessment of small osteophytes particularly in early disease....
National reference standards for anti-HIV-1 antibody are needed to evaluate the performance and maintain the quality control of anti-HIV-1 antibody assays. The aim of this study was to prepare a mixed...
Nineteen serum samples from different HIV patients were obtained, along with 15 units of fresh frozen plasma samples with negative anti-HIV-1 antibody results. Ten anti-HIV-1 antibody-positive candida...
In the collaborative study, results of all five anti-HIV-1 antibody assays were positive for all 10 candidate standards prepared using HIV patient samples. The CV of each assay for every candidate sta...
The overall results suggest that the 12 candidate standards could serve as national reference standards for anti-HIV-1 antibody....
Are age-normalized reference values for human ovarian cortical follicular density adequate for tissue quality control in fertility preservation?...
Published quantitative data on the number of follicles in samples without known ovarian pathology were converted into cortical densities to create reference values. Next, a sample cohort of 126 girls ...
No difference was observed between Z-scores in samples from untreated patients (0.3 ± 3.5, n = 30) and patients treated with (0.5 ± 2.9, n = 48) and without (0.1 ± 1.3, n = 6) alkylating chemotherapy....
Z-scores allow the estimation of genetic- and treatment-related effects on follicular density in cortical tissue from young patients stored for fertility preservation. Understanding the quality of cry...
