Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA.
Present address: Institute for Quantitative Biosciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 1130032, Japan.
Present address: Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 1538902, Japan.
Food Quality Perception & Society Team, iSENSE Lab, Department of Food Science, Aarhus University, Aarhus, Denmark; Sino-Danish College (SDC), University of Chinese Academy of Sciences, Beijing, China.
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213, USAuoszczap@andrew.cmu.edu, hellerl@andrew.cmu.edu, seojunj@andrew.cmu.edu, banance@andrew.cmu.edu.
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15213, USAuoszczap@andrew.cmu.edu, hellerl@andrew.cmu.edu, seojunj@andrew.cmu.edu, banance@andrew.cmu.edu.
Consultant Neurologist & Honorary Clinical Associate Professor of Neurology, Department of Neurology, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. Electronic address: melissamaguire@nhs.net.
International Islamic University Malaysia, Kulliyyah of Allied Health Sciences, Department of Audiology and Speech Language Pathology, Kuantan, Pahang, Malaysia.
International Islamic University Malaysia, Kulliyyah of Allied Health Sciences, Department of Audiology and Speech Language Pathology, Kuantan, Pahang, Malaysia. sarahrahmat@iium.edu.my.
International Islamic University Malaysia, Kulliyyah of Allied Health Sciences, Department of Audiology and Speech Language Pathology, Kuantan, Pahang, Malaysia.
International Islamic University Malaysia, Kulliyyah of Allied Health Sciences, Department of Optometry and Visual Sciences, Kuantan, Pahang, Malaysia.
The field of cardiac pacing has changed rapidly in the last several years. Since the initial description of His bundle pacing targeting the conduction system, recent advances in pacing the left bundle...
Dyssynchrony-associated left ventricular systolic dysfunction is a major contributor to heart failure in congenital heart disease (CHD). Although conventional cardiac resynchronization therapy (CRT) h...
The purpose of this study was compare the clinical outcomes of CSP vs conventional CRT in CHD with biventricular, systemic left ventricular anatomy....
Retrospective CSP data from 7 centers were compared with propensity score-matched conventional CRT control subjects. Outcomes were lead performance, change in left ventricular ejection fraction (LVEF)...
A total of 65 CSP cases were identified (mean age 37 ± 21 years, 46% men). The most common CHDs were tetralogy of Fallot (n = 12 [19%]) and ventricular septal defect (n = 12 [19%]). CSP was achieved a...
CSP can be reliably achieved in biventricular, systemic left ventricular CHD patients with similar improvement in LVEF and greater QRS narrowing for CSP vs conventional CRT at 1 year. Among CSP patien...
Heart block is rare in pediatrics with many possible causes. An association between complete heart block (CHB) and pathogenic titin (TTN) mutations have not been previously described. We report a 9-ye...
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV-CRT) is ineffective in approximately one-third of patients. CRT with Conduction system pacing (CSP-CRT) may achieve greater synch...
The PubMed, Embase, Web of Science, Scopus, and the Cochrane Library were systematically searched until August 19, 2023, for original studies including patients with reduced left ventricular ejection ...
This study found that CSP-CRT is associated with greater improvements in QRSd, echocardiographic, and clinical response. LBB-CRT was associated with lower pacing thresholds. Future randomized trials a...
Whether conduction system pacing (CSP) is an alternative option for cardiac resynchronization therapy (CRT) in patients with heart failure remains an area of active investigation....
The purpose of this study was to assess the echocardiographic and clinical outcomes of CSP compared to biventricular pacing (BiVP)....
This multicenter retrospective study included patients who fulfilled CRT indications and received CSP. Patients with CSP were matched using propensity score matching and compared in a 1:1 ratio to pat...
A total of 238 patients were included. Mean age was 69.8 ± 12.5 years, and 66 (27.7%) were female. Sixty-nine patients (29%) had His-bundle pacing, 50 (21%) had left bundle branch area pacing, and 119...
In patients with heart failure and reduced ejection fraction, CSP resulted in greater improvement in LVEF compared to BiVP. Large-scale randomized trials are needed to validate these outcomes and furt...
Conduction system pacing (CSP) is observed to produce greater improvements in echocardiographic and hemodynamic parameters as compared to conventional biventricular pacing (BiVP). However, whether the...
A systematic search of the Embase and PubMed database was performed for studies comparing CSP and BiVP for patients indicated to receive a CRT device. The coprimary endpoints were all-cause mortality ...
Twenty-one studies (4 randomized and 17 observational) were identified reporting either primary outcome and were included in the meta-analysis. In total 1960 patients were assigned to CSP and 2367 to ...
CSP was associated with a significant reduction in all-cause mortality and HFH when compared to conventional BiVP for CRT. Further large-scale randomized trials are needed to verify these observations...
Conduction system pacing (CSP), including His bundle and left bundle branch pacing are physiological pacing modalities, but lead deployment is often difficult mainly due to a lack of anatomical landma...
In patients receiving conduction system pacing (CSP), it is not well established how to program the sensed atrioventricular delay (sAVD), with respect to the type of capture obtained (selective, nonse...
Consecutive patients undergoing HB or LBB pacing were enrolled. The EP-guided sAVD was defined as the sAVD leading to a PR interval of 150 ms on surface electrocardiogram (ECG). In HB pacing patients,...
Seventy-one patients were enrolled: 12 with selective, 32 nonselective HB capture, and 27 LBB capture. Overall, the rate of concordance between the EP-guided and the echo-optimized sAVD was 71.8%, wit...
In CSP patients, an optimal sAVD can be programmed, in more than 70% of cases, considering only simple EGM intervals to obtain a physiological PR interval on surface ECG....
Pacing leads with extendable-retractable helix (EHL) are alternatives to fixed-helix leads (FHL) for conduction system pacing (CSP), but data on handling characteristics are limited. This study evalua...
Consecutive patients with His-bundle pacing (HBP) or left bundle branch pacing (LBBP) were evaluated for the primary outcome of lead failure, defined as structural damage to the lead necessitating lea...
Helix deformation and fracture were more frequent with EHL in CSP despite similar implant success. These findings have significant implications for lead selection during CSP and raises concerns about ...
Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with mor...
