questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines du sang
Immunoprotéines
Protéines du système du complément
Complément C3
Complément C3b
Complément C3c
Complément C3c : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Compléments
Tests de laboratoire
Compléments
Tests de laboratoire
Maladies auto-immunes
Inflammation
Marqueurs biologiques
Pathologies
Système du complément
Diagnostic
Symptômes
5
Système immunitaire
Symptômes
Prévention
5
Prévention
Maladies chroniques
Vaccins
Système immunitaire
Stress
Système immunitaire
Examens médicaux
Prévention
Traitements
5
Immunothérapie
Traitement
Médicaments immunosuppresseurs
Compléments
Suivi médical
Compléments
Alimentation
Système immunitaire
Transfusions sanguines
Compléments
Complications
5
Infections
Maladies auto-immunes
Complications
Inflammation
Maladies cardiovasculaires
Risques
Facteurs de risque
5
Facteurs de risque
Maladies auto-immunes
Antécédents familiaux
Maladies immunitaires
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"name": "Le vaccin influence-t-il le C3c ?",
"position": 12,
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"position": 13,
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"text": "Éviter le tabagisme et une mauvaise alimentation peut aider à maintenir un C3c normal."
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"@type": "Question",
"name": "Le stress affecte-t-il le C3c ?",
"position": 14,
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"name": "Des examens réguliers sont-ils nécessaires ?",
"position": 15,
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"text": "Oui, des examens réguliers peuvent aider à détecter des anomalies du C3c tôt."
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"name": "Comment traiter un faible C3c ?",
"position": 16,
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"name": "Des médicaments affectent-ils le C3c ?",
"position": 17,
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"name": "Le C3c nécessite-t-il un suivi ?",
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"name": "Les transfusions affectent-elles le C3c ?",
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"name": "Quelles complications peuvent survenir avec un C3c bas ?",
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"@type": "Question",
"name": "Un C3c élevé cause-t-il des complications ?",
"position": 22,
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"text": "Oui, un C3c élevé peut être lié à des complications inflammatoires et des maladies chroniques."
}
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{
"@type": "Question",
"name": "Le C3c affecte-t-il la guérison des blessures ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent retarder la guérison en perturbant l'inflammation."
}
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{
"@type": "Question",
"name": "Y a-t-il des risques de thrombose liés au C3c ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés de C3c peuvent être associés à un risque accru de thrombose."
}
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{
"@type": "Question",
"name": "Le C3c influence-t-il les maladies cardiovasculaires ?",
"position": 25,
"acceptedAnswer": {
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"text": "Oui, des niveaux anormaux de C3c peuvent être liés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de C3c anormal ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies auto-immunes, infections chroniques et certains médicaments augmentent le risque."
}
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{
"@type": "Question",
"name": "L'âge influence-t-il le C3c ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter les niveaux de C3c, souvent en raison de changements immunitaires."
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"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le C3c ?",
"position": 28,
"acceptedAnswer": {
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"text": "Oui, des différences hormonales peuvent influencer les niveaux de C3c entre les sexes."
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"@type": "Question",
"name": "Le mode de vie affecte-t-il le C3c ?",
"position": 29,
"acceptedAnswer": {
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"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter le C3c."
}
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"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le C3c ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de C3c anormal."
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 31/03/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA. mdalakas@med.uoa.gr.
Neuroimmunology Unit, Department of Pathophysiology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece. mdalakas@med.uoa.gr.
Publications dans "Complément C3c" :
4 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
4 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
3 publications dans cette catégorie
Affiliations :
Division of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute for Laboratory Animal Science, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Translational Bio-Nanosciences Laboratory, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Center, Aurora, CO, USA; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
BMT Unit, Hematology Department, G. Papanicolaou Hospital, Thessaloniki, Greece.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Centre de Recherche des Cordeliers, Inserm UMR S1138, Paris, France.
Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Centre de Recherche des Cordeliers, Inserm UMR S1138, Paris, France.
Service d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Publications dans "Complément C3c" :
Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life...
Neuromyelitis Optica Spectrum Disorders (NMOSD) is an antibody-mediated disorder of the Central Nervous System where a leading role of the complement system has been demonstrated....
To measure the levels of complement factors C3, C4 and C5a in serum and plasma of clinical remission patients with AQP4-IgG + NMOSD....
Twelve patients with NMOSD AQP4 + according to 2015 criteria from a General Hospital in Buenos Aires, Argentina, were included in the study, and 19 age- and sex-matched healthy volunteers as a control...
The complement factors, C3, C4, and C5a were measured in all samples. The mean concentration of C3 was 130.7 mg/dl (SD 16.1 mg/dl), and the mean concentration of C4 was 21.6 mg/dl (SD 4.8 mg/dl); both...
In conclusion, the present study demonstrates that plasma C5a may be interesting to investigate as a potential biomarker of disease activity in NMOSD, in a larger and prospective cohort....
Diabetic kidney disease (DKD) affects 30-40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserve...
Complement C5a is an important component of the innate immune system. An increasing number of reports have revealed the relevance of C5a in tumor progression; however, its exact role in metastatic ren...
We evaluated C5a expression in tumor tissue microarrays of 231 mRCC patients and analyzed the relationship between C5a levels and clinical outcomes, and the expression of epithelial-mesenchymal transi...
High C5a expression was associated with poor therapeutic responses, poor overall and progression-free survival, and high expression of EMT-related proteins and PD-1/PD-L1 in mRCC patients. Exogenous C...
Our findings indicate that elevated C5a expression is associated with poor outcomes in patients with mRCC, and this effect may be partly attributed to the ability of C5a to promote EMT and PD-1/PD-L1 ...
The clinical efficacy and safety of complement C5a inhibitors for patients with severe COVID-19 remains unclear....
The PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched from their inception to 27 September 2022. Only studies that assessed the usefulness of C5a inhibitors for the trea...
Six studies, including four randomized controlled trials (RCTs) and two non-RCTs, were included. The study group receiving C5a inhibitors had a significantly lower risk of mortality compared with the ...
C5a inhibitors could help reduce the risk of mortality in patients with severe COVID-19 infection while being as safe as placebos. These findings support the promising role of C5a inhibitors in the tr...
Involvement of lower gastrointestinal tract (LGI) occurs in 60% of patients with graft-versus-host-disease (GVHD). Complement components C3 and C5 are involved in GVHD pathogenesis. In this phase 2a s...
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients u...
To examine concentrations of circulating antibodies targeting C3a and C5a complement receptors in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) and analyze their associati...
Concentrations of antibodies against C3a and C5a complement receptors (anti-C3aR and anti-C5aR) and plasma complement fragments C3a and C5a were determined in patients with AAV (n = 110; granulomatosi...
In AAV, anti-C3aR and anti-C5aR antibodies were decreased (P = 0.0026 and P ≤ 0.0001, respectively). In remission, anti-C3aR antibody concentrations rose to values comparable to healthy donors, wherea...
Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk for relapse in AAV....
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement fa...
The conjunctiva has immune-responsive properties to protect the eye from infections. Its innate immune system reacts against external pathogens, such as fungi. The complement factor C5a is an importan...