Titre : Syndrome de Li-Fraumeni

Syndrome de Li-Fraumeni : Questions médicales fréquentes

Termes MeSH sélectionnés :

Paraphilic Disorders
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"url": "https://questionsmedicales.fr/mesh/D016864?mesh_terms=Paraphilic+Disorders&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Syndrome de Li-Fraumeni", "description": "Quelles complications peuvent survenir avec ce syndrome ?\nLes complications sont-elles prévisibles ?\nComment gérer les complications psychologiques ?\nLes complications peuvent-elles affecter la qualité de vie ?\nY a-t-il des complications spécifiques aux traitements ?", "url": "https://questionsmedicales.fr/mesh/D016864?mesh_terms=Paraphilic+Disorders&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Syndrome de Li-Fraumeni", "description": "Quels sont les principaux facteurs de risque ?\nLe mode de vie influence-t-il le risque ?\nLes femmes sont-elles plus à risque ?\nL'âge joue-t-il un rôle dans le risque ?\nLes facteurs environnementaux sont-ils impliqués ?", "url": "https://questionsmedicales.fr/mesh/D016864?mesh_terms=Paraphilic+Disorders&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment est diagnostiqué le syndrome de Li-Fraumeni ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'historique familial et des tests génétiques pour identifier des mutations." } }, { "@type": "Question", "name": "Quels tests génétiques sont utilisés ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests ciblent principalement les gènes TP53 et d'autres gènes associés au cancer." } }, { "@type": "Question", "name": "Quels critères cliniques sont utilisés pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les critères incluent des antécédents familiaux de cancers précoces et multiples." } }, { "@type": "Question", "name": "Le diagnostic peut-il être posé à tout âge ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le diagnostic peut être établi à tout âge, souvent après l'apparition de cancers." } }, { "@type": "Question", "name": "Les tests de dépistage sont-ils recommandés ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un dépistage régulier est conseillé pour détecter précocement les cancers." } }, { "@type": "Question", "name": "Quels sont les symptômes du syndrome de Li-Fraumeni ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes varient selon le type de cancer, incluant des douleurs, des masses et des changements de poids." } }, { "@type": "Question", "name": "Les symptômes apparaissent-ils à un âge précoce ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les cancers associés apparaissent souvent chez les jeunes adultes ou même les enfants." } }, { "@type": "Question", "name": "Y a-t-il des signes spécifiques à surveiller ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Surveillez les douleurs persistantes, les changements cutanés et les anomalies mammaires." } }, { "@type": "Question", "name": "Les symptômes sont-ils toujours liés à des cancers ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Pas toujours, mais tout symptôme persistant doit être évalué par un professionnel." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils varier d'une personne à l'autre ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'expression des symptômes peut varier en fonction des cancers développés." } }, { "@type": "Question", "name": "Comment prévenir le syndrome de Li-Fraumeni ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de prévention, mais un dépistage régulier peut aider à détecter les cancers tôt." } }, { "@type": "Question", "name": "Les personnes à risque doivent-elles se faire dépister ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes à risque élevé doivent suivre un programme de dépistage régulier." } }, { "@type": "Question", "name": "Y a-t-il des recommandations pour les familles touchées ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Les familles doivent consulter des conseillers en génétique pour des recommandations personnalisées." } }, { "@type": "Question", "name": "Les habitudes de vie peuvent-elles influencer le risque ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Adopter un mode de vie sain peut réduire le risque de certains cancers, mais pas tous." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils recommandés pour tous ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils sont recommandés principalement pour les personnes ayant des antécédents familiaux." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour ce syndrome ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent la chirurgie, la chimiothérapie et la radiothérapie selon le cancer." } }, { "@type": "Question", "name": "La prévention des cancers est-elle possible ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Une surveillance régulière et des interventions précoces peuvent aider à prévenir certains cancers." } }, { "@type": "Question", "name": "Les traitements sont-ils différents selon le cancer ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, chaque type de cancer peut nécessiter un traitement spécifique adapté." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux disponibles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques peuvent offrir des options de traitement innovantes pour les patients." } }, { "@type": "Question", "name": "Le suivi post-traitement est-il important ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier est crucial pour détecter toute récidive ou nouveaux cancers." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec ce syndrome ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des cancers multiples, des effets secondaires des traitements et des problèmes psychologiques." } }, { "@type": "Question", "name": "Les complications sont-elles prévisibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être anticipées, mais d'autres peuvent survenir de manière inattendue." } }, { "@type": "Question", "name": "Comment gérer les complications psychologiques ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Un soutien psychologique et des groupes de soutien peuvent aider à gérer l'anxiété et la dépression." } }, { "@type": "Question", "name": "Les complications peuvent-elles affecter la qualité de vie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications liées aux traitements et aux cancers peuvent altérer la qualité de vie." } }, { "@type": "Question", "name": "Y a-t-il des complications spécifiques aux traitements ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent entraîner des effets secondaires comme la fatigue, la nausée et l'immunosuppression." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux de cancers et les mutations génétiques, notamment TP53, sont des facteurs clés." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des facteurs comme le tabagisme et l'alimentation peuvent influencer le risque de cancer." } }, { "@type": "Question", "name": "Les femmes sont-elles plus à risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Non, le syndrome affecte également les hommes, bien que certains cancers soient plus fréquents chez les femmes." } }, { "@type": "Question", "name": "L'âge joue-t-il un rôle dans le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de développer des cancers augmente avec l'âge, surtout après 30 ans." } }, { "@type": "Question", "name": "Les facteurs environnementaux sont-ils impliqués ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs environnementaux peuvent contribuer au risque, mais le syndrome est principalement génétique." } } ] } ] }

Sources (10000 au total)

Functional Connectivity in Compulsive Sexual Behavior Disorder - Systematic Review of Literature and Study on Heterosexual Males.

Compulsive Sexual Behavior Disorder (CSBD) was recently included in ICD-11 as a new impulse control disorder. While this certainly improved the diagnosis of CSBD, the underlying brain mechanisms of th... Here we investigate patterns of resting-state brain functional connectivity (fc) in a group of CSBD patients compared to a group of healthy controls (HC).... A MATLAB toolbox named CONN functional connectivity toolbox was employed to study patterns of brain connectivity. Also correlation between fc and severity of CSBD symptoms and other psychological char... We collected resting-state functional magnetic resonance imaging data from 81 heterosexual males: 52 CSBD patients and 29 HC.... We found increased fc between left inferior frontal gyrus and right planum temporale and polare, right and left insula, right Supplementary Motor Cortex (SMA), right parietal operculum, and also betwe... Results from our study extend the knowledge of brain mechanisms differentiating CSBD from HC.... The study was the first large sample study showing 5 distinct functional brain networks differentiating CSBD patients and HC. However, the sample was limited only to heterosexual men, in the future a ... The identified functional brain networks differentiate CSBD from HC and provide some support for incentive sensitization as mechanism underlying CSBD symptoms. The correlation between psychological as...

Contradicting classification, nomenclature, and diagnostic criteria of Compulsive Sexual Behavior Disorder (CSBD) and future directions •.

Building on the conclusions of the debate papers by Gola et al. (2022) and Sassover and Weinstein (2022), the present commentary further addressed the contradictions between the current classification...

Compulsive sexual behavior disorder in 42 countries: Insights from the International Sex Survey and introduction of standardized assessment tools.

Despite its inclusion in the 11th revision of the International Classification of Diseases, there is a virtual paucity of high-quality scientific evidence about compulsive sexual behavior disorder (CS... Using data from the International Sex Survey (N = 82,243; Mage = 32.39 years, SD = 12.52), we evaluated the psychometric properties of the CSBD-19 and CSBD-7 and compared CSBD across 42 countries, thr... A total of 4.8% of the participants were at high risk of experiencing CSBD. Country- and gender-based differences were observed, while no sexual-orientation-based differences were present in CSBD leve... This study contributes to a better understanding of CSBD in underrepresented and underserved populations and facilitates its identification in diverse populations by providing freely accessible ICD-11...

Treatments and interventions for compulsive sexual behavior disorder with a focus on problematic pornography use: A preregistered systematic review.

Compulsive sexual behavior disorder (CSBD) which includes problematic pornography use (PPU) is a clinically relevant syndrome that has been included in the ICD-11 as impulse control disorder. The numb... The study was preregistered at Prospero International Prospective Register of Systematic Reviews (CRD42021252329). The literature search done in February 2022 at PubMed, Scopus, Web of Science, and Ps... Overall 24 studies were identified. Four of these studies were randomized controlled trials. Treatment approaches included settings with cognitive behavior therapy components, psychotherapy methods, a... There is first evidence for the effectiveness of treatment approaches such as cognitive behavior therapy. However, strong conclusions on the specificity of treatments should be drawn with caution. Mor...

Neural and behavioral correlates of sexual stimuli anticipation point to addiction-like mechanisms in compulsive sexual behavior disorder.

Compulsive sexual behavior disorder (CSBD) is characterized by persistent patterns of failure to control sexual impulses resulting in repetitive sexual behavior, pursued despite adverse consequences. ... We designed and applied a behavioral paradigm aimed at disentangling processes related to anticipation and viewing of erotic stimuli. In 22 male CSBD patients (age: M = 38.7, SD = 11.7) and 20 healthy... We found robust case-control differences on behavioral level, where CSBD patients showed larger response time differences between erotic and non-erotic trials than HC. The task induced reliable main a... Our results support the validity and applicability of the developed task and suggest that CSBD is associated with altered behavioral correlates of anticipation, which were associated with ventral stri...

Who feels affected by "out of control" sexual behavior? Prevalence and correlates of indicators for ICD-11 Compulsive Sexual Behavior Disorder in the German Health and Sexuality Survey (GeSiD).

The purpose of this study was to examine the prevalence and correlates of indicators consistent with Compulsive Sexual Behavior Disorder (CSBD)-defined and operationalized according to the ICD-11 guid... Participants were asked if they had ever experienced "intense and recurring sexual impulses or sexual urges that I had difficulty controlling and resulted in sexual behavior" over a period of several ... Overall, 4.9% of men [95% CI = 3.9-6.1] and 3.0% of women [95% CI = 2.3-3.9] reported experiences consistent with ICD-11 diagnostic requirements for lifetime diagnosis. In the 12 months preceding the ... The current study provides novel and important insights into the prevalence and characteristics of CSBD in the general population....