Comment diagnostiquer une dysfonction du néostriatum ?
Un diagnostic peut inclure des examens neurologiques et des imageries cérébrales.
Dysfonctionnement neurologiqueImagerie par résonance magnétique
#2
Quels tests sont utilisés pour évaluer le néostriatum ?
Les tests incluent l'IRM, la TEP et des évaluations neuropsychologiques.
Imagerie par résonance magnétiqueTomographie par émission de positons
#3
Quels signes cliniques indiquent une atteinte du néostriatum ?
Des signes incluent des troubles du mouvement, des changements cognitifs et des troubles émotionnels.
Troubles du mouvementTroubles cognitifs
#4
Le néostriatum peut-il être évalué par électroencéphalogramme ?
Non, l'EEG n'évalue pas directement le néostriatum, mais peut montrer des anomalies cérébrales.
ÉlectroencéphalogrammeAnomalies cérébrales
#5
Quels spécialistes évaluent le néostriatum ?
Les neurologues et les psychiatres sont les principaux spécialistes impliqués.
NeurologiePsychiatrie
Symptômes
5
#1
Quels symptômes sont associés à une lésion du néostriatum ?
Les symptômes incluent tremblements, rigidité, et troubles de la coordination.
TremblementsRigidité musculaire
#2
Comment le néostriatum affecte-t-il le comportement ?
Il influence la motivation, le plaisir et les comportements de récompense.
ComportementSystème de récompense
#3
Les troubles de l'humeur peuvent-ils être liés au néostriatum ?
Oui, des dysfonctionnements peuvent entraîner des troubles de l'humeur comme la dépression.
Troubles de l'humeurDépression
#4
Quels troubles cognitifs sont liés au néostriatum ?
Des troubles de la mémoire, de l'attention et de la planification peuvent survenir.
Troubles de la mémoireTroubles de l'attention
#5
Le néostriatum est-il impliqué dans la maladie de Parkinson ?
Oui, la maladie de Parkinson affecte le néostriatum, entraînant des symptômes moteurs.
Maladie de ParkinsonTroubles moteurs
Prévention
5
#1
Comment prévenir les troubles liés au néostriatum ?
Un mode de vie sain, l'exercice régulier et une alimentation équilibrée peuvent aider.
Mode de vie sainExercice physique
#2
Le stress peut-il affecter le néostriatum ?
Oui, le stress chronique peut altérer la fonction du néostriatum et aggraver les symptômes.
StressFonction cérébrale
#3
Y a-t-il des exercices spécifiques pour le néostriatum ?
Des exercices de coordination et d'équilibre peuvent être bénéfiques.
Exercices de coordinationÉquilibre
#4
La prévention des maladies neurodégénératives est-elle possible ?
Certaines stratégies, comme l'activité cognitive, peuvent réduire le risque.
Maladies neurodégénérativesActivité cognitive
#5
L'alimentation influence-t-elle la santé du néostriatum ?
Oui, une alimentation riche en antioxydants et oméga-3 peut être bénéfique.
AlimentationAntioxydants
Traitements
5
#1
Quels traitements sont disponibles pour les troubles du néostriatum ?
Les traitements incluent médicaments, thérapies physiques et interventions chirurgicales.
MédicamentsThérapie physique
#2
Les médicaments peuvent-ils améliorer la fonction du néostriatum ?
Oui, des médicaments comme les agonistes de la dopamine peuvent aider à améliorer la fonction.
Agonistes de la dopamineMédicaments
#3
La stimulation cérébrale profonde est-elle efficace pour le néostriatum ?
Oui, elle est utilisée pour traiter des troubles comme la maladie de Parkinson.
Stimulation cérébrale profondeMaladie de Parkinson
#4
Quels types de thérapies sont recommandés pour les troubles du néostriatum ?
Les thérapies comportementales et cognitives sont souvent recommandées.
Thérapie comportementaleThérapie cognitive
#5
Les interventions chirurgicales sont-elles courantes pour le néostriatum ?
Elles sont réservées aux cas graves, comme les troubles moteurs réfractaires.
ChirurgieTroubles moteurs
Complications
5
#1
Quelles complications peuvent survenir avec des troubles du néostriatum ?
Des complications incluent des troubles moteurs sévères et des problèmes cognitifs.
ComplicationsTroubles cognitifs
#2
Les troubles du néostriatum peuvent-ils entraîner des chutes ?
Oui, des troubles de l'équilibre et de la coordination augmentent le risque de chutes.
ChutesÉquilibre
#3
Comment les troubles du néostriatum affectent-ils la qualité de vie ?
Ils peuvent réduire l'autonomie, affecter les relations sociales et la santé mentale.
Qualité de vieSanté mentale
#4
Les complications peuvent-elles être réversibles ?
Certaines complications peuvent être atténuées avec un traitement précoce et approprié.
RéversibilitéTraitement précoce
#5
Les troubles du néostriatum peuvent-ils affecter le sommeil ?
Oui, ils peuvent entraîner des troubles du sommeil, comme l'insomnie ou des mouvements nocturnes.
Troubles du sommeilInsomnie
Facteurs de risque
5
#1
Quels sont les facteurs de risque pour les troubles du néostriatum ?
Les facteurs incluent l'âge, les antécédents familiaux et les traumatismes crâniens.
Facteurs de risqueTraumatismes crâniens
#2
Le mode de vie influence-t-il les troubles du néostriatum ?
Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques.
Mode de vie sédentaireAlimentation
#3
Les maladies cardiovasculaires sont-elles un facteur de risque ?
Oui, elles peuvent affecter la circulation sanguine vers le néostriatum, augmentant les risques.
Maladies cardiovasculairesCirculation sanguine
#4
Le stress chronique est-il un facteur de risque ?
Oui, le stress chronique peut contribuer à des dysfonctionnements du néostriatum.
Stress chroniqueDysfonctionnement
#5
Les infections peuvent-elles affecter le néostriatum ?
Certaines infections, comme l'encéphalite, peuvent endommager le néostriatum.
InfectionsEncéphalite
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{
"@type": "Question",
"name": "La stimulation cérébrale profonde est-elle efficace pour le néostriatum ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle est utilisée pour traiter des troubles comme la maladie de Parkinson."
}
},
{
"@type": "Question",
"name": "Quels types de thérapies sont recommandés pour les troubles du néostriatum ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les thérapies comportementales et cognitives sont souvent recommandées."
}
},
{
"@type": "Question",
"name": "Les interventions chirurgicales sont-elles courantes pour le néostriatum ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles sont réservées aux cas graves, comme les troubles moteurs réfractaires."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles du néostriatum ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles moteurs sévères et des problèmes cognitifs."
}
},
{
"@type": "Question",
"name": "Les troubles du néostriatum peuvent-ils entraîner des chutes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles de l'équilibre et de la coordination augmentent le risque de chutes."
}
},
{
"@type": "Question",
"name": "Comment les troubles du néostriatum affectent-ils la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'autonomie, affecter les relations sociales et la santé mentale."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être atténuées avec un traitement précoce et approprié."
}
},
{
"@type": "Question",
"name": "Les troubles du néostriatum peuvent-ils affecter le sommeil ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent entraîner des troubles du sommeil, comme l'insomnie ou des mouvements nocturnes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles du néostriatum ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'âge, les antécédents familiaux et les traumatismes crâniens."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il les troubles du néostriatum ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent affecter la circulation sanguine vers le néostriatum, augmentant les risques."
}
},
{
"@type": "Question",
"name": "Le stress chronique est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à des dysfonctionnements du néostriatum."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles affecter le néostriatum ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections, comme l'encéphalite, peuvent endommager le néostriatum."
}
}
]
}
]
}
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; Behavioural Neuroscience Institute (INeC), Ribeirão Preto, São Paulo, Brazil. Electronic address: ju.silva@usp.br.
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; São Paulo State University (UNESP), School of Science and Literature, Department of Biological Sciences, Assis, São Paulo, Brazil; Behavioural Neuroscience Institute (INeC), Ribeirão Preto, São Paulo, Brazil.
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; Behavioural Neuroscience Institute (INeC), Ribeirão Preto, São Paulo, Brazil; NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address: nccoimbr@fmrp.usp.br.
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; Behavioural Neuroscience Institute (INeC), Ribeirão Preto, São Paulo, Brazil.
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; Behavioural Neuroscience Institute (INeC), Ribeirão Preto, São Paulo, Brazil.
Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Department of Pharmacology, Laboratory of Neuroanatomy and Neuropsychobiology, Ribeirão Preto, São Paulo, Brazil; São Paulo State University (UNESP), School of Science and Literature, Department of Biological Sciences, Assis, São Paulo, Brazil.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark. chenhf@uestc.edu.cn wangjian_811@yahoo.com liuchen@aifmri.com.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark. chenhf@uestc.edu.cn wangjian_811@yahoo.com liuchen@aifmri.com.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark. chenhf@uestc.edu.cn wangjian_811@yahoo.com liuchen@aifmri.com.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark. chenhf@uestc.edu.cn wangjian_811@yahoo.com liuchen@aifmri.com.
From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical Genetics, College of Basic Medical Science (L.D.), and Department of Biomedical Engineering & Imaging Medicine (Q.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; and Department of Biomedical Engineering (B.B.B.), New Jersey Institute of Technology, Newark. chenhf@uestc.edu.cn wangjian_811@yahoo.com liuchen@aifmri.com.
Hand osteoarthritis is a disabling condition with few effective therapies. Hand osteoarthritis with synovitis is a common inflammatory phenotype associated with pain. We aimed to examine the efficacy ...
In this multisite, parallel-group, double-blind, randomised, placebo-controlled trial, participants (aged 40-75 years) with hand osteoarthritis (Kellgren and Lawrence grade ≥2 in at least one joint) a...
Between Nov 22, 2017, and Nov 8, 2021, of 202 participants who were assessed for eligibility, 97 (48%) were randomly assigned to receive methotrexate (n=50) or placebo (n=47). 68 (70%) of 97 participa...
Treatment of hand osteoarthritis and synovitis with 20 mg methotrexate for 6 months had a moderate but potentially clinically meaningful effect on reducing pain, providing proof of concept that methot...
National Health and Medical Research Council of Australia....
We aim to develop fMRI neurofeedback as a treatment for obsessive compulsive disorder (OCD). In prior work, we found that providing neurofeedback of activity in the anterior prefrontal cortex (aPFC) i...
This study aimed to establish the 95% effective dose (ED95) of esketamine in combination with propofol for hysteroscopy and then to evaluate its efficacy and safety profile....
This prospective, double-blind, randomized controlled trial consisted of two cohorts. In cohort 1, 45 women aged 18-65 years undergoing hysteroscopy were randomly assigned to either group E (esketamin...
The ED95 of esketamine was 0.254 mg/kg (95% CI: 0.214-1.004), while that of alfentanil was 9.121 μg/kg (95% CI: 8.479-13.364). The anesthesia success rate was 93.0% in group E and 95.2% in group A (p ...
This study determined the ED 95 dose of esketamine for intravenous general anesthesia during hysteroscopy. Esketamine showed less respiratory and hemodynamic depression, as well as fewer adverse effec...
www.chictr.org.cn, (ChiCTR2300077283); registered November 3, 2023....
Binge-eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence-based treatments exist for BED, particularly pharmacological options. This study tested the effica...
A randomized, double-blind, placebo-controlled, 12-week trial tested naltrexone/bupropion for BED with and without obesity. Eighty-nine patients (70.8% women, 69.7% White, mean age 45.7 y, mean BMI 35...
Mixed models of binge-eating frequency revealed significant reductions that did not differ significantly between naltrexone/bupropion and placebo. Logistic regression of binge-eating remission rates r...
Naltrexone/bupropion did not demonstrate effectiveness for reducing binge eating relative to placebo but showed effectiveness for weight reduction in patients with BED. Obesity status did not predict ...
Classic psychedelics have regained interest in research and therapy. Despite the long tradition of the human use of mescaline, modern data on its dose-dependent acute effects and pharmacokinetics are ...
In this double-blind placebo-controlled randomized investigation, we assessed the tolerability of glutamine in older adults recruited from three daycare centers. The relevance of studying glutamine su...
To determine the effectiveness of oral dydrogesterone in preventing miscarriage in threatened miscarriage....
A randomized, controlled trial study was conducted among pregnant Thai women at the gestational age of six to less than 20 weeks who visited King Chulalongkorn Memorial Hospital, Department of Obstetr...
A total of 100 pregnancies were recruited. Fifty of them were assigned to receive oral dydrogesterone and 50 were assigned to receive placebo. The rate of continuing pregnancy beyond 20 weeks of gesta...
Oral dydrogesterone 20 mg/day could not prevent miscarriages in women with threatened miscarriage....
This Phase IV placebo-controlled clinical trial was designed to demonstrate the efficacy and safety of the product Neurodoron (Kalium phosporicum comp., KPC) in patients with neurasthenia....
This monocenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial (registration number: DRKS00003261) was conducted in an outpatient German trial site. Women and men aged 18...
In total, 204 patients underwent screening, 78 were randomized in each treatment group, and 77 patients each received treatment (intention-to-treat (ITT) population = 154 patients). For none of the pr...
Trial treatment was well tolerated with only a few and minor AEs reported, confirming the markedly good safety of KPC. A significant improvement of neurasthenia was seen for the total study population...
The change in symptoms necessary to be clinically relevant in obsessive-compulsive disorder (OCD) is currently unknown. In this study, we aimed to create an empirically validated threshold for clinica...
We analyzed individual participant data from short-term, double-blind, placebo-controlled registration trials of selective serotonin reuptake inhibitors in adult OCD patients. Data were collected from...
We included 7 trials with a total of 1216 patients. The CGI-scores and YBOCS were moderately to highly correlated. The MID corresponded to 4.9 YBOCS points (95% CI 4.4-5.4) for the full sample, or a 2...
By linking the YBOCS to the CGI-I, this is the first study to propose an MID in OCD trials. Having a clearly defined MID can guide future clinical research and help interpretation of efficacy of exist...
Various nutritional supplements are available over the counter, yet few have been investigated in randomized controlled trials. The rationale for using the specific mix of nutritional substances inclu...