Targeted lateral pelvic lymph node excision in the setting of total neoadjuvant therapy for rectal cancer.
Targeted lateral pelvic node dissection in the era of total neoadjuvant therapy....
Phosphotransferases (Phosphate Group Acceptor) : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une déficience en phosphotransférases ?
Des tests enzymatiques et des analyses biochimiques sont utilisés pour évaluer l'activité des phosphotransférases.
#2
Quels tests sont utilisés pour évaluer l'activité des phosphotransférases ?
Les tests de dosage enzymatique et les analyses de métabolites sont couramment utilisés.
#3
Quels symptômes peuvent indiquer un problème avec ces enzymes ?
Des symptômes métaboliques, comme la fatigue ou des troubles énergétiques, peuvent survenir.
#4
Les tests génétiques sont-ils utiles pour le diagnostic ?
Oui, les tests génétiques peuvent identifier des mutations affectant les phosphotransférases.
#5
Peut-on diagnostiquer par imagerie des troubles liés aux phosphotransférases ?
L'imagerie n'est pas spécifique, mais peut aider à évaluer des complications métaboliques.
Symptômes 5
#1
Quels sont les symptômes d'une déficience en phosphotransférases ?
Fatigue, faiblesse musculaire, troubles de la croissance et anomalies métaboliques.
#2
Les troubles neurologiques sont-ils liés aux phosphotransférases ?
Oui, des troubles neurologiques peuvent survenir en raison d'un métabolisme énergétique altéré.
#3
Comment les symptômes varient-ils selon le type d'enzyme ?
Les symptômes dépendent de l'enzyme spécifique affectée et de son rôle métabolique.
#4
Les symptômes apparaissent-ils à la naissance ?
Certains symptômes peuvent apparaître à la naissance, tandis que d'autres se développent plus tard.
#5
Y a-t-il des symptômes spécifiques aux enfants ?
Oui, les enfants peuvent présenter des retards de développement et des troubles de la croissance.
Prévention 5
#1
Peut-on prévenir les déficiences en phosphotransférases ?
La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes.
#2
Les tests de dépistage néonatal sont-ils utiles ?
Oui, les tests de dépistage néonatal peuvent identifier certaines déficiences précocement.
#3
Y a-t-il des recommandations diététiques préventives ?
Des recommandations diététiques peuvent être établies pour les familles à risque.
#4
Les conseils génétiques sont-ils importants ?
Oui, les conseils génétiques peuvent aider les familles à comprendre les risques de transmission.
#5
Les vaccinations peuvent-elles aider à prévenir des complications ?
Les vaccinations ne préviennent pas directement les déficiences, mais protègent contre les infections.
Traitements 5
#1
Quels traitements sont disponibles pour les déficiences en phosphotransférases ?
Le traitement peut inclure des suppléments nutritionnels et une gestion diététique.
#2
La thérapie génique est-elle une option ?
La thérapie génique est en recherche, mais pas encore largement disponible pour ces déficiences.
#3
Les médicaments peuvent-ils aider à traiter ces déficiences ?
Certains médicaments peuvent aider à gérer les symptômes, mais ne corrigent pas la déficience.
#4
Y a-t-il des traitements expérimentaux en cours ?
Oui, des études cliniques explorent de nouvelles approches thérapeutiques pour ces conditions.
#5
Comment la gestion diététique aide-t-elle ?
Une gestion diététique peut aider à compenser les déficiences métaboliques et à améliorer la santé.
Complications 5
#1
Quelles complications peuvent survenir avec ces déficiences ?
Des complications métaboliques, neurologiques et de croissance peuvent se développer.
#2
Les troubles cardiaques sont-ils une complication possible ?
Oui, des troubles cardiaques peuvent survenir en raison d'un métabolisme énergétique altéré.
#3
Comment les complications affectent-elles la qualité de vie ?
Les complications peuvent réduire la qualité de vie en limitant les activités quotidiennes.
#4
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
#5
Y a-t-il un risque accru de maladies métaboliques ?
Oui, les personnes avec des déficiences en phosphotransférases peuvent avoir un risque accru de maladies métaboliques.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour ces déficiences ?
Les antécédents familiaux et certaines mutations génétiques sont des facteurs de risque connus.
#2
Les facteurs environnementaux jouent-ils un rôle ?
Oui, certains facteurs environnementaux peuvent influencer l'expression des déficiences enzymatiques.
#3
Les maladies auto-immunes sont-elles un facteur de risque ?
Certaines maladies auto-immunes peuvent affecter le métabolisme et augmenter le risque.
#4
L'alimentation peut-elle influencer le risque ?
Une alimentation déséquilibrée peut exacerber les symptômes chez les personnes à risque.
#5
Les infections peuvent-elles aggraver la condition ?
Oui, certaines infections peuvent déclencher ou aggraver les symptômes liés aux déficiences enzymatiques.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 27/04/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
6 au total
└─
Adenylate kinase
Adenylate KinaseD000263 -
D08.811.913.696.650.025
└─
ATP synthetase complexes
ATP Synthetase ComplexesD025181 -
D08.811.913.696.650.150
└─
Guanylate kinase
Guanylate KinasesD051528 -
D08.811.913.696.650.450
└─
Nucleoside diphosphate kinase
Nucleoside-Diphosphate KinaseD009701 -
D08.811.913.696.650.550
└─
Nucleoside phosphate kinase
Nucleoside-Phosphate KinaseD009703 -
D08.811.913.696.650.575
└─└─
NM23 Nucleoside Diphosphate kinases
NM23 Nucleoside Diphosphate KinasesD054778 -
D08.811.913.696.650.550.200
Auteurs principaux
Jean-Marc Jeckelmann
3 publications dans cette catégorie
Affiliations :
- Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland. jean-marc.jeckelmann@ibmm.unibe.ch.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Carbohydrate Transport by Group Translocation: The Bacterial Phosphoenolpyruvate: Sugar Phosphotransferase System.
Sub-cellular biochemistry
-
Structure and mechanism of a phosphotransferase system glucose transporter.
Nature communications 2024-09-12
-
The mannose phosphotransferase system (Man-PTS) - Mannose transporter and receptor for bacteriocins and bacteriophages.
Biochimica et biophysica acta. Biomembranes 2020-07-22
Zengqi Xie
3 publications dans cette catégorie
Affiliations :
- Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Effect of Nitro-Substituted Ending Groups on the Photovoltaic Properties of Nonfullerene Acceptors.
ACS applied materials & interfaces 2020-09-03
-
High-Performance Simple Nonfused Ring Electron Acceptors with Diphenylamino Flanking Groups.
ACS applied materials & interfaces 2021-08-12
-
Three Isomeric Non-Fullerene Acceptors Comprising a Mono-Brominated End-Group for Efficient Organic Solar Cells.
ACS applied materials & interfaces 2022-07-28
Bernhard Erni
2 publications dans cette catégorie
Affiliations :
- Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Carbohydrate Transport by Group Translocation: The Bacterial Phosphoenolpyruvate: Sugar Phosphotransferase System.
Sub-cellular biochemistry
-
The mannose phosphotransferase system (Man-PTS) - Mannose transporter and receptor for bacteriocins and bacteriophages.
Biochimica et biophysica acta. Biomembranes 2020-07-22
Yulin Zhu
2 publications dans cette catégorie
Affiliations :
- Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Effects of Halogenated End Groups on the Performance of Nonfullerene Acceptors.
ACS applied materials & interfaces 2021-01-27
-
End-Group Modifications with Bromine and Methyl in Nonfullerene Acceptors: The Effect of Isomerism.
ACS applied materials & interfaces 2021-06-15
Feng He
2 publications dans cette catégorie
Affiliations :
- Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
- Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Effects of Halogenated End Groups on the Performance of Nonfullerene Acceptors.
ACS applied materials & interfaces 2021-01-27
-
End-Group Modifications with Bromine and Methyl in Nonfullerene Acceptors: The Effect of Isomerism.
ACS applied materials & interfaces 2021-06-15
Lei Wang
2 publications dans cette catégorie
Affiliations :
- Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic University, 7098 Liuxian Blvd, District Nanshan, Shenzhen, 518055, P. R. China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Impact of Imine Bond Orientations and Acceptor Groups on Photocatalytic Hydrogen Generation of Donor-Acceptor Covalent Organic Frameworks.
Small (Weinheim an der Bergstrasse, Germany) 2024-09-09
-
Effects of intramolecular proton acceptors located near sulfhydryl groups on sulfhydryl compounds for acrylamide elimination.
Food chemistry 2023-01-12
Wenjun Zhang
2 publications dans cette catégorie
Affiliations :
- Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
- Center of Materials Science and Optoelectronics Engineer, University of Chinese Academy of Sciences, Beijing 100049, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Highly Efficient Nonfullerene Acceptor with Sulfonyl-Based Ending Groups.
ACS applied materials & interfaces 2020-10-26
-
A Fused-Ring Electron Acceptor with Phthalimide-Based Ending Groups for Efficient Ternary Organic Solar Cells.
ACS applied materials & interfaces 2024-01-17
Weijie Song
2 publications dans cette catégorie
Affiliations :
- Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
- Center of Materials Science and Optoelectronics Engineer, University of Chinese Academy of Sciences, Beijing 100049, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Highly Efficient Nonfullerene Acceptor with Sulfonyl-Based Ending Groups.
ACS applied materials & interfaces 2020-10-26
-
A Fused-Ring Electron Acceptor with Phthalimide-Based Ending Groups for Efficient Ternary Organic Solar Cells.
ACS applied materials & interfaces 2024-01-17
Nan Zheng
2 publications dans cette catégorie
Affiliations :
- Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Effect of Nitro-Substituted Ending Groups on the Photovoltaic Properties of Nonfullerene Acceptors.
ACS applied materials & interfaces 2020-09-03
-
End-Group Modifications with Bromine and Methyl in Nonfullerene Acceptors: The Effect of Isomerism.
ACS applied materials & interfaces 2021-06-15
Zheng Tang
2 publications dans cette catégorie
Affiliations :
- Center for Advanced Low-Dimension Materials, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Near-Infrared Acceptors with Imide-Containing End Groups for Organic Solar Cells.
ACS applied materials & interfaces 2023-02-23
-
High-Performance Simple Nonfused Ring Electron Acceptors with Diphenylamino Flanking Groups.
ACS applied materials & interfaces 2021-08-12
Jiadong Zhou
2 publications dans cette catégorie
Affiliations :
- Institute of Polymer Optoelectronic Materials and Devices and State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P. R. China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
High-Performance Simple Nonfused Ring Electron Acceptors with Diphenylamino Flanking Groups.
ACS applied materials & interfaces 2021-08-12
-
Three Isomeric Non-Fullerene Acceptors Comprising a Mono-Brominated End-Group for Efficient Organic Solar Cells.
ACS applied materials & interfaces 2022-07-28
Yasuhiro Horibata
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids.
Journal of lipid research 2020-06-23
-
Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids.
Journal of lipid research 2021-07-29
Hiroyuki Sugimoto
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan h-sugi@dokkyomed.ac.jp.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids.
Journal of lipid research 2020-06-23
-
Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids.
Journal of lipid research 2021-07-29
Debadatta Dhar Chanda
2 publications dans cette catégorie
Affiliations :
- Department of Microbiology, Assam University, Silchar, Assam, India.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Diverse aminoglycoside phosphotransferase types conferring aminoglycoside resistance in
Indian journal of medical microbiology
Alexei Gorelik
1 publication dans cette catégorie
Affiliations :
- Department of Biochemistry, McGill University, Montreal, QC H3G 0B1, Canada.
- Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proceedings of the National Academy of Sciences of the United States of America 2022-08-08
Katalin Illes
1 publication dans cette catégorie
Affiliations :
- Department of Biochemistry, McGill University, Montreal, QC H3G 0B1, Canada.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proceedings of the National Academy of Sciences of the United States of America 2022-08-08
Khanh Huy Bui
1 publication dans cette catégorie
Affiliations :
- Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proceedings of the National Academy of Sciences of the United States of America 2022-08-08
Bhushan Nagar
1 publication dans cette catégorie
Affiliations :
- Department of Biochemistry, McGill University, Montreal, QC H3G 0B1, Canada.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proceedings of the National Academy of Sciences of the United States of America 2022-08-08
Shuai Zhao
1 publication dans cette catégorie
Affiliations :
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Whole-Cell Display of Phosphotransferase in
Biomolecules 2022-01-15
Guoli Yang
1 publication dans cette catégorie
Affiliations :
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, China.
Publications dans "Phosphotransferases (Phosphate Group Acceptor)" :
-
Whole-Cell Display of Phosphotransferase in
Biomolecules 2022-01-15
Sources (7957 au total)
Prone position thoracoscopic-assisted total mesoesophageal excision: initial experiences and benefits of lymph node dissection.
Total mesoesophageal excision (TME) is a promising procedure. Prone position thoracoscopic-assisted TME might be a good choice, even without robust evidence yet. Therefore, it is necessary to explore ... We retrospectively analyzed the short-term outcomes regarding intraoperative unplanned events, postoperative complications, and lymphadenectomy in 61 patients who underwent prone position thoracoscopi... Of these sixty-one patients, there were 10, 24 and 27 cases of tumor in the upper, middle, and lower thoracic, respectively. Although there were five cases of unplanned events during surgery, no conve... The prone position thoracoscopic-assisted TME is a safe procedure that is more conducive to thoracic lymph node dissection, especially for middle and lower mediastinum....
Efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.
To study the efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.... Patients with more than 200 mL of lymph drained per day until postoperative day 3 after pelvic lymph node excision were enrolled. Of the 75 patients, 36 were managed by conservative methods without th... The total and mean daily amount of lymph produced per patient was significantly lower in the octreotide-treated group than in the untreated group. The duration of drain placement was shorter in the oc... The injection of octreotide is effective to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies....
Subcostal lymph nodes: An unusual sentinel lymph node basin in cutaneous melanoma.
Lymphatic drainage from subcostal nodes, along the costal groove, have not previously been characterized as sites for melanoma drainage and metastasis. This study reports a series of patients with sub... Patients who presented to our institution between 2005 and 2020 with documented cutaneous melanoma and sentinel lymph node biopsy of a subcostal node (sentinel = S), or metastases to subcostal nodes l... Six patients had subcostal sentinel nodes (SNs). Primary sites included the posterior trunk and lateral chest wall. Subcostal nodes were found under ribs 10-12. Subcostal SNs had at least one dimensio... Melanoma can metastasize to subcostal lymph nodes and be found at the time of SN biopsy or identified at recurrence. These small nodes are fed by lymphatic channels that run in the neurovascular bundl...
Lymph Node Positivity of Axillary Reverse Mapping Lymph Nodes at the Time of Axillary Lymph Node Dissection: Two-Site Prospective Trial.
Axillary reverse mapping (ARM) was introduced in 2007 to identify and selectively preserve upper-extremity lymphatics during axillary lymph node surgery to decrease the risk of lymphedema. The patient... Patients undergoing ALND with or without immediate lymphatic reconstruction (ILR) were enrolled in a prospective trial at two institutional sites between April 2018 and Decemeber 2022. This report ana... The inclusion criteria were met by 139 patients, who made up the study population (133 with breast cancer and 6 with other disease). Of the breast cancer patients, 99.2% were female, 35.3% (47/133) we... In the contemporary patient population undergoing ALND, the positivity rate of the ARM LN was relatively high, suggesting that leaving ARM LNs in patients undergoing ALND may not be oncologically safe...
Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography.
This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical ex... Seventy-nine subjects scheduled for breast cancer surgery with SLN excision completed this IRB-approved study, out of which 18 (23%) underwent neoadjuvant chemotherapy before surgery. Subjects underwe... Seventy-two SLNs were surgically excised from 18 subjects, 29 were positive for blue dye, 63 were positive for radioactive tracer and 57 were positive for Sonazoid. Comparison with blue dye showed tha... Lymphosonography achieved similar accuracy as radioactive tracer and higher accuracy than blue dye for identifying SLNs. The 15 SLNs positive for malignancy were all identified by lymphosonography....
Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes.
Metastasis in a nonsentinel lymph node (non-SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection... This retrospective study enrolled 656 cases of melanoma who underwent sentinel lymph node biopsy at Fudan University Shanghai Cancer Center from 2009 to 2017. We identified 81 SLN + AM patients who un... Ulceration, Clark level, number of deposits in the SLN (NumDep) and maximum size of deposits (MaxSize) are independent risk factors associated with non-SLN metastases. We developed a scoring system th... A scoring system that included ulceration, Clark level, MaxSize, and NumDep is reliable and effective for predicting non-SLN metastasis in SLN-positive AM....
Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer.
To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature.... Retrospective register-based study.... Copenhagen Oral Cavity Squamous Cell Carcinoma database.... Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival... In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve de... Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical q...
Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis.
The survival benefit of inguinal lymph node dissection (ILND) vs no ILND in patients with squamous cell carcinoma of the penis (SCCP) and the absence of lymph node invasion is unclear. We addressed th... We identified lymph node negative SCCP patients who either underwent ILND (pN0) or clinical examination only (cN0). We tested for the effect of ILND vs no ILND on cancer-specific mortality (CSM) in Ka... Of 2520 SCCP patients, 369 (15%) underwent ILND (pN0) vs 2151 (85%) did not (cN0). The pN0 vs cN0 distribution according to pT stages was as follows: 80 (7%) vs 1092 (93%) in pT1b, and 289 (21%) vs 10... In pT2-3 stage SCCP, a significantly lower CSM was recorded in lymph node negative patients treated with ILND than in their clinical lymph node negative counterparts who did not undergo ILND....
Predictive Value of Jugulo-omohyoid Lymph Nodes in Lateral Lymph Node Metastasis of Papillary Thyroid Cancer.
Jugulo-omohyoid lymph nodes (JOHLN) metastasis has proven to be associated with lateral lymph node metastasis (LLNM). This study aimed to reveal the clinical features and evaluate the predictive value... A total of 550 patients pathologically diagnosed with PTC between October 2015 and January 2020, all of whom underwent thyroidectomy and lateral lymph node dissection, were included in this study.... Thyroiditis, tumor location, tumor size, extra-thyroidal extension, extra-nodal extension, central lymph node metastasis (CLNM), and LLMM were associated with JOHLN. Male, upper lobe tumor, multifocal... JOLHN metastasis could be a clinically sensitive predictor of further LLM. A high-performance nomogram was established, which can provide an individual risk assessment of LNM and guide treatment decis...