questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Hémoprotéines
Cytochromes
Cytochrome P-450 enzyme system
Famille-1 de cytochromes P450
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A2 : Questions médicales fréquentes
Termes MeSH sélectionnés :
Sensitivity and Specificity
Diagnostic
5
Cytochrome P-450
Métabolisme des médicaments
Tests sanguins
Cytochrome P-450
Biomarqueurs
Cytochrome P-450
Médicaments
Cytochrome P-450
Tests génétiques
Polymorphisme génétique
Symptômes
5
Dysfonction hépatique
Effets indésirables
Toxicité médicamenteuse
Cytochrome P-450
Induction enzymatique
Efficacité médicamenteuse
Réactions indésirables
Troubles hépatiques
Maladies
Métabolisme des médicaments
Prévention
5
Interactions médicamenteuses
Cytochrome P-450
Éducation médicale
Surveillance médicale
Alimentation
Cytochrome P-450
Toxicité médicamenteuse
Cytochrome P-450
Traitements
5
Ajustement médicamenteux
Cytochrome P-450
Médicaments
Antidépresseurs
Induction enzymatique
Ajustement médicamenteux
Effets indésirables
Surveillance médicale
Traitements alternatifs
Cytochrome P-450
Complications
5
Complications médicales
Réactions indésirables
Maladies hépatiques
Cytochrome P-450
Gestion des complications
Surveillance médicale
Surdosage
Cytochrome P-450
Santé chronique
Dysfonction hépatique
Facteurs de risque
5
Facteurs de risque
Génétique
Tabagisme
Induction enzymatique
Alcool
Inhibition enzymatique
Antibiotiques
Antidépresseurs
Alimentation
Cytochrome P-450
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"@type": "Question",
"name": "Comment évaluer l'activité de CYP1A2 ?",
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"text": "L'activité peut être évaluée par des tests de métabolisme de médicaments spécifiques."
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{
"@type": "Question",
"name": "Quels tests sanguins sont utilisés pour CYP1A2 ?",
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"@type": "Question",
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{
"@type": "Question",
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{
"@type": "Question",
"name": "Quels symptômes indiquent une dysfonction de CYP1A2 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une dysfonction peut entraîner des effets indésirables liés à l'accumulation de médicaments."
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},
{
"@type": "Question",
"name": "Comment CYP1A2 affecte-t-il les symptômes de toxicité ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une activité réduite de CYP1A2 peut augmenter la toxicité des médicaments métabolisés."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes liés à l'induction de CYP1A2 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'induction peut réduire l'efficacité des médicaments, entraînant des symptômes de maladie."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques sont associés à CYP1A2 ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes peuvent inclure des réactions indésirables aux médicaments et des troubles hépatiques."
}
},
{
"@type": "Question",
"name": "CYP1A2 influence-t-il les symptômes de maladies ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, CYP1A2 peut influencer les symptômes de maladies en modifiant le métabolisme des médicaments."
}
},
{
"@type": "Question",
"name": "Comment prévenir les interactions médicamenteuses avec CYP1A2 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Évitez les médicaments connus pour interagir avec CYP1A2 et consultez un médecin."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives pour CYP1A2 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des mesures incluent l'éducation sur les médicaments et la surveillance des effets."
}
},
{
"@type": "Question",
"name": "Comment le mode de vie influence-t-il CYP1A2 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, y compris l'alimentation, peut influencer l'activité de CYP1A2."
}
},
{
"@type": "Question",
"name": "Quels aliments affectent CYP1A2 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des aliments comme le brocoli et le pamplemousse peuvent influencer l'activité de CYP1A2."
}
},
{
"@type": "Question",
"name": "Comment éviter la toxicité liée à CYP1A2 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Évitez les doses élevées de médicaments métabolisés par CYP1A2 pour prévenir la toxicité."
}
},
{
"@type": "Question",
"name": "Comment traiter une dysfonction de CYP1A2 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement implique l'ajustement des doses de médicaments métabolisés par CYP1A2."
}
},
{
"@type": "Question",
"name": "Quels médicaments affectent CYP1A2 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme la caféine et certains antidépresseurs peuvent influencer CYP1A2."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements pour l'induction de CYP1A2 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'induction peut nécessiter des ajustements de traitement pour éviter l'inefficacité."
}
},
{
"@type": "Question",
"name": "Comment gérer les effets indésirables liés à CYP1A2 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion implique la surveillance des effets indésirables et l'ajustement des doses."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements alternatifs pour CYP1A2 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements alternatifs peuvent inclure des médicaments non métabolisés par CYP1A2."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec CYP1A2 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des réactions indésirables graves aux médicaments métabolisés."
}
},
{
"@type": "Question",
"name": "CYP1A2 peut-il causer des maladies hépatiques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une dysfonction de CYP1A2 peut contribuer à des maladies hépatiques en altérant le métabolisme."
}
},
{
"@type": "Question",
"name": "Comment les complications sont-elles gérées ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des complications implique l'ajustement des traitements et la surveillance étroite."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de surdosage avec CYP1A2 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un métabolisme altéré peut augmenter le risque de surdosage de certains médicaments."
}
},
{
"@type": "Question",
"name": "Quels sont les effets à long terme de la dysfonction de CYP1A2 ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets à long terme peuvent inclure des problèmes de santé chroniques liés au métabolisme."
}
},
{
"@type": "Question",
"name": "Quels facteurs influencent l'activité de CYP1A2 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme la génétique, l'alimentation et l'usage de médicaments influencent l'activité."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme affecte-t-il CYP1A2 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme induit l'activité de CYP1A2, augmentant le métabolisme de certains médicaments."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques liés à l'alcool et CYP1A2 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "La consommation excessive d'alcool peut inhiber l'activité de CYP1A2, affectant le métabolisme."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont des facteurs de risque pour CYP1A2 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les antibiotiques et les antidépresseurs peuvent influencer CYP1A2."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle CYP1A2 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains aliments, comme le pamplemousse, peuvent inhiber ou induire l'activité de CYP1A2."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 07/03/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Rókus u. 2, Pécs H-7624, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs H-7624, Hungary. Electronic address: poor.miklos@pte.hu.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology and Experimental Therapeutics, and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology and Experimental Therapeutics, and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology and Experimental Therapeutics, and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Federal University of Minas Gerais, Av. Presidente Antonio Carlos, 667, Campus Pampulha, Belo Horizonte-MG, CEP: 31270-901, Brazil.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32611, United States.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Federal University of Sao Joao del-Rei, Av. Sebastiao Goncalves Coelho, 400, Campus Centro-Oeste, Chanadour, Divinopolis-MG, CEP: 35501-296, Brazil.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou 550025, P.R. China.
Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550025, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy, Affiliated Meitan People's Hospital of Zunyi Medical University, Zunyi, Guizhou 564100, P.R. China.
The Key Laboratory of Clinical Pharmacy of Zunyi City, Zunyi Medical University, Zunyi, Guizhou 563006, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
The Key Laboratory of Clinical Pharmacy of Zunyi City, Zunyi Medical University, Zunyi, Guizhou 563006, P.R. China.
Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Publications dans "Cytochrome P-450 CYP1A2" :
2 publications dans cette catégorie
Affiliations :
Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Publications dans "Cytochrome P-450 CYP1A2" :
The evaluation of deep-learning (DL) systems typically relies on the Area under the Receiver-Operating-Curve (AU-ROC) as a performance metric. However, AU-ROC, in its holistic form, does not sufficien...
The use of...
To estimate the summary sensitivity and specificity of...
Studies were included if PET/CT was performed for suspicion of PVE and IPD of both the PET/CT result and final diagnosis defined by a gold-standard assessment was available. There were 3 possible fina...
Seventeen studies were included with IPD available for 537 patients (from 538 scans). The summary sensitivity and specificity were 85% (95% CI 74.2%-91.8%) and 86.5% (95% CI 75.8%-92.9%) respectively ...
Developed as a plan-specific pre-treatment QA tool, Varian portal dosimetry promises a fast, high-resolution, and integrated QA solution. In this study, the agreement between predicted fluence and mea...
All patient plans and the corresponding verification plans were generated within the Eclipse treatment planning system. Four representative plans of different treatment sites (prostate, prostate with ...
Predicted and acquired portal dosimetry fluences demonstrated a high agreement evident by average gamma passing rates for the clinical patient plans of 99.90%, 96.64%, and 91.87% for γ...
Owing to the high achievable spatial resolution, portal dosimetry at the Halcyon can reliably be deployed as plan-specific pre-treatment QA tool to screen for errors. It is recommended to support the ...
Specific recognition and sensitive quantification of mRNA alternative splice variants have been a necessity for exploring the regulatory mechanism of RNA splicing and revealing the association between...
When evaluating potential new cancer screening modalities, estimating sensitivity, especially for early-stage cases, is critical. There are methods to approximate stage-specific sensitivity in asympto...
We fit natural history models to lung and ovarian cancer screening data that permitted estimation of stage-specific (early/late) true sensitivity, defined as the probability subjects screened in the g...
Stage-specific true sensitivities estimated by the lung cancer natural history model were 47% (early) and 63% (late). Simulation results for the prospective setting gave estimated sensitivities of 81%...
Existing methods for approximating stage-specific sensitivity in both prospective and retrospective scenarios are unsatisfactory; improvements are needed before they can be considered to be reliable....
Recombinant proteins in complex solutions are typically detected with tag-specific antibodies in Western blots. Here we describe an antibody-free alternative in which tagged proteins are detected dire...
Children with cancer often present with general and nonspecific symptoms leading to initial diagnostic workup inclusive of clinical imaging. Various sequences of magnetic resonance imaging (MRI) are b...
Enzyme-linked immunosorbent assays (ELISAs) are a cornerstone of modern molecular detection, but the technique still faces notable challenges. One of the biggest problems is discriminating true signal...
To evaluate the sensitivity and specificity of the ABCD progression display for keratoconus progression....
Data was collected from patients that underwent at least two Pentacam assessments 6 months apart. Sensitivity and specificity were calculated for the ABCD progression display. Progression was defined ...
Thirty eyes were evaluated over a median time of 10.3 months. Progression by criterion 1 resulted in a sensitivity of 61.9% and specificity of 88.9%. Progression by criterion 2 resulted in higher sens...
The ABCD progression display can assess keratoconus progression with high sensitivity and specificity, thus assisting the patients' decision-making process. The D parameter did not contribute to the s...
To systematically evaluate the evidence for the reliability, sensitivity and specificity of existing measures of vowel-initial voice onset....
A literature search was conducted across electronic databases for published studies (MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, PubMed Central, IEEE Xplore) and grey literature (ProQuest for unp...
The search retrieved 6,983 records. Titles and abstracts were screened against the inclusion criteria by two independent reviewers, with a third reviewer responsible for conflict resolution. Thirty-fi...
A range of vowel-initial voice onset measurements have been applied throughout the literature, however, there is a lack of evidence regarding their sensitivity, specificity and reliability in the dete...