Osteosarcoma.
Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in males. The key pathophysiolog...
Protéine p120 d'activation de la ras GTPase : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une anomalie de p120 GTPase ?
Des tests génétiques et des analyses protéomiques peuvent être utilisés pour diagnostiquer.
#2
Quels tests sont utilisés pour évaluer p120 GTPase ?
Les tests incluent l'immunoblotting et la PCR pour détecter les mutations.
#3
Y a-t-il des biomarqueurs associés à p120 GTPase ?
Des niveaux anormaux de p120 peuvent servir de biomarqueurs dans certaines pathologies.
#4
Quels symptômes peuvent indiquer un problème avec p120 ?
Des anomalies de croissance cellulaire ou des cancers peuvent indiquer un problème.
#5
Comment les mutations de p120 sont-elles détectées ?
Les mutations peuvent être détectées par séquençage génétique et analyses fonctionnelles.
Symptômes 5
#1
Quels symptômes sont liés à une dysfonction de p120 GTPase ?
Les symptômes peuvent inclure des troubles de croissance et des anomalies cellulaires.
#2
La dysfonction de p120 peut-elle causer des cancers ?
Oui, des mutations dans p120 sont associées à divers types de cancers.
#3
Quels types de cancers sont liés à p120 GTPase ?
Des cancers comme le cancer du poumon et le mélanome sont souvent associés.
#4
Y a-t-il des signes précoces de dysfonction de p120 ?
Des signes précoces peuvent inclure des anomalies dans le développement cellulaire.
#5
Comment p120 affecte-t-il la signalisation cellulaire ?
p120 régule la signalisation en activant les GTPases, influençant la prolifération.
Prévention 5
#1
Peut-on prévenir les mutations de p120 ?
La prévention des mutations est difficile, mais un mode de vie sain peut aider.
#2
Y a-t-il des mesures préventives pour le cancer lié à p120 ?
Des dépistages réguliers et un mode de vie sain peuvent réduire les risques.
#3
Comment l'alimentation influence-t-elle p120 ?
Une alimentation équilibrée peut influencer la santé cellulaire et réduire les risques.
#4
Le tabagisme affecte-t-il p120 GTPase ?
Oui, le tabagisme peut augmenter le risque de mutations et de cancers associés.
#5
L'exercice physique peut-il aider à prévenir les cancers ?
Oui, l'exercice régulier est associé à une réduction du risque de certains cancers.
Traitements 5
#1
Quels traitements ciblent p120 GTPase ?
Des thérapies ciblées et des inhibiteurs spécifiques sont en développement.
#2
Peut-on utiliser des médicaments pour moduler p120 ?
Oui, certains médicaments peuvent moduler l'activité de p120 dans les cellules.
#3
Y a-t-il des essais cliniques pour p120 ?
Des essais cliniques évaluent des traitements ciblant les anomalies de p120.
#4
Comment la thérapie génique peut-elle aider ?
La thérapie génique pourrait corriger les mutations de p120 dans certaines conditions.
#5
Quels sont les effets secondaires des traitements ciblés ?
Les effets secondaires peuvent inclure des réactions immunitaires et des toxicités cellulaires.
Complications 5
#1
Quelles complications peuvent survenir avec p120 ?
Les complications incluent des cancers avancés et des troubles métaboliques.
#2
Comment p120 affecte-t-il le pronostic du cancer ?
Les anomalies de p120 peuvent aggraver le pronostic et la réponse au traitement.
#3
Y a-t-il des complications liées aux traitements de p120 ?
Oui, des complications comme des effets secondaires graves peuvent survenir.
#4
Les mutations de p120 augmentent-elles le risque de récidive ?
Oui, les mutations peuvent augmenter le risque de récidive du cancer après traitement.
#5
Quelles sont les implications des anomalies de p120 ?
Les anomalies de p120 peuvent entraîner des troubles de croissance et des cancers.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les mutations de p120 ?
Les facteurs incluent des prédispositions génétiques et des expositions environnementales.
#2
L'âge est-il un facteur de risque pour p120 ?
Oui, le risque de mutations et de cancers associés augmente avec l'âge.
#3
Les antécédents familiaux influencent-ils p120 ?
Oui, des antécédents familiaux de cancer peuvent augmenter le risque de mutations.
#4
Le stress peut-il affecter p120 GTPase ?
Le stress chronique peut influencer la régulation de p120 et augmenter les risques.
#5
Y a-t-il des expositions environnementales à surveiller ?
Oui, l'exposition à des agents cancérigènes peut augmenter le risque de mutations.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 11/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
René Rasche
2 publications dans cette catégorie
Affiliations :
- Institute of Biochemistry, University Münster, Germany.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
κB-Ras proteins are fast-exchanging GTPases and function via nucleotide-independent binding of Ral GTPase-activating protein complexes.
FEBS letters 2024-04-11
-
The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
The Journal of cell biology 2024-03-27
Daniel Kümmel
2 publications dans cette catégorie
Affiliations :
- Institute of Biochemistry, University Münster, Germany.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
κB-Ras proteins are fast-exchanging GTPases and function via nucleotide-independent binding of Ral GTPase-activating protein complexes.
FEBS letters 2024-04-11
-
The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
The Journal of cell biology 2024-03-27
Manil Kanade
2 publications dans cette catégorie
Affiliations :
- Indian Institute of Science Education and Research, Pune, India.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Dual specificity of a prokaryotic GTPase-activating protein (GAP) to two small Ras-like GTPases in Myxococcus xanthus.
The FEBS journal 2020-09-03
-
Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer.
The Journal of biological chemistry 2024-03-18
Pananghat Gayathri
2 publications dans cette catégorie
Affiliations :
- Indian Institute of Science Education and Research, Pune, India.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Dual specificity of a prokaryotic GTPase-activating protein (GAP) to two small Ras-like GTPases in Myxococcus xanthus.
The FEBS journal 2020-09-03
-
Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer.
The Journal of biological chemistry 2024-03-18
Qingqing Dai
2 publications dans cette catégorie
Affiliations :
- Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
- Else Kröner Graduate School for Medical Students "Jena School for Ageing Medicine (JSAM)", Jena University Hospital, Jena, Germany.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma.
Frontiers in oncology 2022-06-16
-
Comprehensive analysis of the expression and prognosis for IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma.
BMC cancer 2022-11-01
Fei Song
2 publications dans cette catégorie
Affiliations :
- Department of Urology, Jena University Hospital, Jena, Germany.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma.
Frontiers in oncology 2022-06-16
-
Comprehensive analysis of the expression and prognosis for IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma.
BMC cancer 2022-11-01
Jun Matsuda
2 publications dans cette catégorie
Affiliations :
- Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Rho GTPase regulatory proteins in podocytes.
Kidney international 2020-10-26
-
Monitoring of Rho GTPase Activity in Podocytes.
Methods in molecular biology (Clifton, N.J.)
Tomoko Takano
2 publications dans cette catégorie
Affiliations :
- Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: tomoko.takano@mcgill.ca.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Rho GTPase regulatory proteins in podocytes.
Kidney international 2020-10-26
-
Monitoring of Rho GTPase Activity in Podocytes.
Methods in molecular biology (Clifton, N.J.)
Qiaojia Zheng
2 publications dans cette catégorie
Affiliations :
- Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Zhi Yu
2 publications dans cette catégorie
Affiliations :
- Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
- College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Yanping Yuan
2 publications dans cette catégorie
Affiliations :
- College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Danli Sun
2 publications dans cette catégorie
Affiliations :
- Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Yakubu Saddeeq Abubakar
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Jie Zhou
2 publications dans cette catégorie
Affiliations :
- College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Zonghua Wang
2 publications dans cette catégorie
Affiliations :
- Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
- College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Huawei Zheng
2 publications dans cette catégorie
Affiliations :
- Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-01-21
-
Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in
Frontiers in microbiology 2021-03-08
Lorna O'Donoghue
1 publication dans cette catégorie
Affiliations :
- UCD School of Medicine, University College Dublin, UCD Conway Institute, Belfield, Dublin 4, Ireland.
- Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green 123, Dublin 2, Ireland.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Roles of G proteins and their GTPase-activating proteins in platelets.
Bioscience reports
Albert Smolenski
1 publication dans cette catégorie
Affiliations :
- UCD School of Medicine, University College Dublin, UCD Conway Institute, Belfield, Dublin 4, Ireland.
- Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green 123, Dublin 2, Ireland.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
-
Roles of G proteins and their GTPase-activating proteins in platelets.
Bioscience reports
Yu Huang
1 publication dans cette catégorie
Affiliations :
- Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
Shuangquan Yan
1 publication dans cette catégorie
Affiliations :
- Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China.
Publications dans "Protéine p120 d'activation de la ras GTPase" :
Sources (1994 au total)
Advances in Osteosarcoma.
This article gives a brief overview of the most recent developments in osteosarcoma treatment, including targeting of signaling pathways, immune checkpoint inhibitors, drug delivery strategies as sing... Osteosarcoma is one of the most common primary malignant bone tumors in children and young adults, with a high risk of bone and lung metastases and a 5-year survival rate around 70% in the absence of ...
Primary osteosarcoma of the ribs: A report from the Cooperative Osteosarcoma Study Group.
Primary rib osteosarcoma has not been investigated extensively, and clinical characteristics and optimal therapeutic strategies have not been defined. The authors used the database of the Cooperative ... The COSS database was searched for treatment-naive, high-grade osteosarcomas of the rib. Affected patients were analyzed for demographic and tumor-related factors, treatments, and outcomes.... A total of 44 patients (23 males, 21 females; median age, 23 years [range, 6-59]) were identified. Primary metastases were detected in six of 44 (14%) patients. Surgery was performed in 40 of 44 (91%)... This large series provides evidence that patients with costal primaries are older than the average osteosarcoma patient, but appear to share the similar tumor biology and-if treated according to stand...
Osteosarcomas in older adults: A report from the Cooperative Osteosarcoma Study Group.
Osteosarcoma is typically a disease of the young, but may affect any age. Little is known about the disease in older patients beyond retirement age. We aim to describe the characteristics, treatment, ... The database of the Cooperative Osteosarcoma Study Group (COSS) was searched for osteosarcoma patients diagnosed from 1980 to 2020 who were aged 65 years or older at diagnosis. Affected individuals we... Fifty-five eligible patients were detected (median age 68 [range: 65-84] years; male:female = 25:30). Among these patients, 15/55 (27%) tumors were secondary malignancies, 41/55 (75%) were high-grade ... Osteosarcomas can occur in older individuals. It is more often secondary, axially located, or extraosseous than in younger patients. However, the same treatment principles seem to apply, and selected ...
Effects of microenvironment in osteosarcoma on chemoresistance and the promise of immunotherapy as an osteosarcoma therapeutic modality.
Osteosarcoma (OS) is one of the most common primary malignant tumors originating in bones. Its high malignancy typically manifests in lung metastasis leading to high mortality. Although remarkable adv...
Chondroblastoma-like osteosarcoma: a clinicopathological and molecular study of a rare osteosarcoma variant.
Chondroblastoma-like osteosarcoma (CBLOS) is a rare and poorly understood variant of OS. We examined the clinicopathological, immunohistochemical and molecular features of six CBLOSs to highlight the ... We performed histone 3.3 mutation analysis by gene sequencing and/or immunohistochemistry in all cases, while whole exome sequencing (WES) was performed on two CB-like osteosarcomas and 11 conventiona... CBLOSs were predominantly localised at acral sites and involved mainly male subjects with a mean age of 29 years. One patient who had metastases at presentation died of disease, while another patient ... CBLOS presents a different genetic background and a less aggressive clinical behaviour in comparison with CHGOS. Search of the H3F3B K36M mutation is useful in the differential diagnosis with CB....
Osteosarcoma in the Thyroid Gland.
Primary osteosarcomas are rarely seen in areas other than bone, although they can occur in sites such as the thigh, anal region, hand, etc. We present a case of primary extraskeletal osteosarcoma of t...
Osteosarcoma in a ceRNET perspective.
Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by great heterogeneity of genomic aberrations, mutated genes, and cell types contribution, making therapy and ...
FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma.
Osteosarcoma has become the most common bone malignancy in adolescents. Although the clinical treatment of osteosarcoma has advanced considerably in recent years, the 5-year survival rate has not impr... We selected prognostic genes that are closely associated with osteosarcoma clinical features by obtaining osteosarcoma patient information from the GTEx and TARGET databases, and then we developed a r... In conclusion, we validated that the prognostic factor FKBP11 is closely associated with osteosarcoma. Additionally, we identified a novel mechanism by which FKBP11 ameliorates the malignant propertie...
Management of osteosarcoma of the head and neck.
There is no clear consensus guideline that specifies the optimum course of treatment for adult head and neck osteosarcoma (HNO) because of its rarity. The review's goal is to examine the most recent r... Due to overlapping symptoms with various benign disorders of the lower jaw and midface bone, these patients present with a noticeable delay. The greatest results for these malignancies can be achieved... Multimodality treatments seem to yield better results for advanced HNO with adverse features and incomplete resections....