Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
RéversibilitéGestion des complications
Facteurs de risque
5
#1
Quels sont les facteurs de risque pour les anomalies des motifs EF Hands ?
Les facteurs incluent des prédispositions génétiques et des expositions environnementales.
Facteurs de risquePrédispositions génétiques
#2
L'âge influence-t-il les motifs EF Hands ?
Oui, le vieillissement peut affecter la fonction des motifs EF Hands et la signalisation calcique.
ÂgeVieillissement
#3
Le mode de vie joue-t-il un rôle dans les risques ?
Un mode de vie sédentaire et une mauvaise alimentation augmentent les risques.
Mode de vieAlimentation
#4
Les antécédents familiaux sont-ils un facteur de risque ?
Oui, des antécédents familiaux de maladies génétiques peuvent augmenter le risque.
Antécédents familiauxMaladies génétiques
#5
Les infections peuvent-elles affecter les motifs EF Hands ?
Certaines infections peuvent perturber la signalisation calcique, affectant ces motifs.
InfectionsSignalisation calcique
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"position": 2,
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"position": 6,
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"@type": "Question",
"name": "Les motifs EF Hands sont-ils liés à des maladies ?",
"position": 7,
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"@type": "Question",
"name": "Comment les motifs EF Hands affectent-ils la signalisation cellulaire ?",
"position": 8,
"acceptedAnswer": {
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"name": "Y a-t-il des signes cliniques de dysfonction des motifs EF Hands ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes indirects peuvent apparaître, comme des troubles neurologiques ou musculaires."
}
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"@type": "Question",
"name": "Les motifs EF Hands influencent-ils le métabolisme ?",
"position": 10,
"acceptedAnswer": {
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"text": "Oui, ils jouent un rôle dans le métabolisme cellulaire en régulant le calcium."
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"@type": "Question",
"name": "Peut-on prévenir les anomalies des motifs EF Hands ?",
"position": 11,
"acceptedAnswer": {
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"text": "La prévention est difficile, mais un mode de vie sain peut réduire les risques associés."
}
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"name": "Y a-t-il des facteurs environnementaux à considérer ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines peut affecter la fonction des motifs EF Hands."
}
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{
"@type": "Question",
"name": "Comment le stress influence-t-il les motifs EF Hands ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress peut perturber la signalisation calcique, affectant indirectement ces motifs."
}
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{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact sur ces motifs ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régule la signalisation calcique, ce qui peut soutenir la fonction des motifs."
}
},
{
"@type": "Question",
"name": "Les suppléments de calcium sont-ils bénéfiques ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments peuvent aider à maintenir un bon équilibre calcique, soutenant la fonction."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent les motifs EF Hands ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de traitements spécifiques pour les motifs EF Hands."
}
},
{
"@type": "Question",
"name": "Peut-on modifier les motifs EF Hands par thérapie génique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique pourrait potentiellement corriger des mutations affectant ces motifs."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer les motifs EF Hands ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains médicaments modulent la signalisation calcique, indirectement affectant ces motifs."
}
},
{
"@type": "Question",
"name": "Y a-t-il des approches expérimentales pour traiter les anomalies ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours sur des peptides et des inhibiteurs ciblant les motifs EF Hands."
}
},
{
"@type": "Question",
"name": "Comment la nutrition peut-elle influencer les motifs EF Hands ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une nutrition adéquate en calcium et en magnésium peut soutenir leur fonction."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des motifs EF Hands défectueux ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications peuvent inclure des troubles neurologiques et musculaires."
}
},
{
"@type": "Question",
"name": "Les motifs EF Hands sont-ils liés à des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent un lien potentiel entre des anomalies et certains types de cancer."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner des limitations fonctionnelles et des douleurs chroniques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de maladies cardiovasculaires ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dysfonctionnements calciques peuvent contribuer à des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les anomalies des motifs EF Hands ?",
"position": 26,
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"text": "Les facteurs incluent des prédispositions génétiques et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il les motifs EF Hands ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des motifs EF Hands et la signalisation calcique."
}
},
{
"@type": "Question",
"name": "Le mode de vie joue-t-il un rôle dans les risques ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sédentaire et une mauvaise alimentation augmentent les risques."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies génétiques peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles affecter les motifs EF Hands ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
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}
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RG Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Leibniz Group 'Dendritic Organelles and Synaptic Function', University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology, ZMNH, Hamburg, Germany.
Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia. epermyak@yandex.ru.
Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, 142290 Pushchino, Russia. epermyak@yandex.ru.
Perfusion weighted imaging (PWI) is critical for determining whether stroke patients presenting in an extended time window are candidates for mechanical thrombectomy. However, PWI is not always availa...
The National Institutes of Health (NIH) FHV score was developed to quantify the burden of FHV and applied to magnetic resonance imaging scans of stroke patients with fluid-attenuated inversion recover...
There were 101 patients included in the analysis, of whom 78% had a perfusion deficit detected on PWI with a mean lesion volume of 47 (±59) mL. The NIH-FHV score was strongly associated with the PWI l...
The NIH-FHV score provides an estimate of the PWI lesion volume and, when combined with diffusion weighted imaging, may be helpful when trying to determine whether there is a clinically relevant diffu...
Although hypothermic machine perfusion (HMP) is associated with improved kidney graft viability and function, the underlying biological mechanisms are unknown. Untargeted metabolomic profiling may ide...
This letter responds to the article "Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion," by Adam Omelianchuk et al., in the July-August 2024 issue of the Hastings Center R...
Type 2 diabetes mellitus (T2DM) is associated with altered cerebral vasoreactivity, cognitive impairment, and functional decline. Magnetic Resonance (MR) perfusion can be used to assess cerebral blood...
The study included 52 patients diagnosed with T2DM and 39 healthy individuals. The diabetic patients were classified into three groups (PRP: proliferative retinopathy, NPRP: non-proliferative retinopa...
The comparison between the T2DM group and the control group revealed that rCBF values of bilateral frontal lobes, cingulate gyrus, medial temporal lobe, thalami and right occipital lobe were measured ...
Regional hypoperfusion was encountered in most of the lobes in the T2DM group when compared with the healthy group. However, in terms of rCBF values, there was no significant difference among the thre...
Pulmonary blood flow can be assessed on ventilation-perfusion (VQ) scan with relative lung perfusion, with a 55% to 45% (or 10%) right-to-left differential considered normal. We hypothesized that wide...
We conducted a retrospective cohort study on all patients who underwent double-lung transplant in our program between 2005 and 2016, identifying patients with a wide perfusion differential of >10% on ...
Of 340 patients who met inclusion criteria, 169 (49%) had a relative perfusion differential of ≥ 10% on a 3-mo VQ scan. Patients with increased perfusion differential had increased risk of death or re...
Wide lung perfusion differential was common after lung transplant in our cohort and associated with increased risk of death, poor lung function, and CLAD onset. The nature of this abnormality and its ...
Although COVID-19 infection is associated with the increased risk of pulmonary thromboembolism (PTE), COVID-19 pulmonary lesions cause ventilation-perfusion (V/Q) patterns other than PTE. Although ext...
This article describes fabrication of a customizable bioreactor, which comprises a perfusion system and coverslip-based tissue culture chamber that allow centimeter-scale vascularized or otherwise can...
Anterograde or retrograde cerebral perfusion can protect the brain from ischemic injury during hypothermic circulatory arrest (HCA), but neither type of perfusion provides blood flow to the abdominal ...
We aimed at examining both the incidence and extent of different lung perfusion abnormalities as well as the relationship between them on Tc-99m macroaggregated albumin (MAA) perfusion-only SPECT/CT s...
Ninety-one patients (71.4 ± 13.9 years; range: 29-98 years, median age: 74 years; 45 female and 46 male) with confirmed SARS-CoV-2 virus infection were included in this retrospective study. After perf...
Moderately severe parenchymal lesions were detected in 87 (95.6%) patients. Although, 50 (54.95%) patients were depicted to have MM lesions, the whole patient cohort was mildly affected by this abnorm...
Heterogeneous perfusion abnormalities were found in most of COVID-19 patients: parenchymal lesions with normal, decreased or increased perfusion and perfusion defects in healthy lung areas. These phen...
Liver transplantation is the only chance of cure for people with end-stage liver disease and some people with advanced liver cancers or acute liver failure. The increasing prevalence of these conditio...
To evaluate the effects of different methods of machine perfusion (including hypothermic oxygenated machine perfusion (HOPE), normothermic machine perfusion (NMP), controlled oxygenated rewarming, and...
We used standard, extensive Cochrane search methods. The latest search date was 10 January 2023....
We included randomised clinical trials which compared different methods of machine perfusion, either with each other or with SCS. Studies comparing HOPE via both hepatic artery and portal vein, or via...
We used standard Cochrane methods. Our primary outcomes were 1. overall participant survival, 2. quality of life, and 3. serious adverse events. Secondary outcomes were 4. graft survival, 5. ischaemic...
We included seven randomised trials (1024 transplant recipients from 1301 randomised/included livers). All trials were parallel two-group trials; four compared HOPE versus SCS, and three compared NMP ...
In situations where the decision has been made to transplant a liver donated after circulatory death or donated following brain death, end-ischaemic HOPE will provide superior clinically relevant outc...
