questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Hydrolases
Peptide hydrolases
Metalloproteases
Metalloproteases : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Métalloprotéases
Biopsie
Tests sanguins
Marqueurs biologiques
Métalloprotéases
Sérum
Imagerie médicale
Métalloprotéases
Tissus
Tests génétiques
Métalloprotéases
Mutations
Activité enzymatique
Métalloprotéases
Échantillons biologiques
Symptômes
5
Inflammation
Métalloprotéases
Douleurs articulaires
Métalloprotéases
Symptômes
Tissus
Cicatrisation
Métalloprotéases
Matrice extracellulaire
Asymptomatique
Métalloprotéases
Dysfonction
Âge
Métalloprotéases
Symptômes dégénératifs
Prévention
5
Prévention
Métalloprotéases
Mode de vie sain
Suppléments nutritionnels
Métalloprotéases
Antioxydants
Alimentation
Métalloprotéases
Inflammation
Stress
Métalloprotéases
Gestion du stress
Examens médicaux
Métalloprotéases
Déséquilibres enzymatiques
Traitements
5
Inhibiteurs
Métalloprotéases
Traitements
Thérapie génique
Métalloprotéases
Mutations
Anti-inflammatoires
Métalloprotéases
Inflammation
Médecine personnalisée
Métalloprotéases
Traitements
Effets secondaires
Inhibiteurs
Métalloprotéases
Complications
5
Complications
Métalloprotéases
Arthrite
Réversibilité
Métalloprotéases
Traitement
Qualité de vie
Métalloprotéases
Douleurs chroniques
Prévisibilité
Métalloprotéases
Surveillance
Complications
Métalloprotéases
Cicatrisation
Facteurs de risque
5
Facteurs de risque
Métalloprotéases
Mode de vie
Antécédents familiaux
Métalloprotéases
Risque
Tabagisme
Métalloprotéases
Maladies
Stress chronique
Métalloprotéases
Risque
Toxines
Métalloprotéases
Environnement
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"name": "Prévention",
"headline": "Prévention sur Metalloproteases",
"description": "Comment prévenir les maladies liées aux métalloprotéases ?\nLes suppléments nutritionnels sont-ils utiles ?\nL'évitement de certains aliments est-il recommandé ?\nLe contrôle du stress est-il important ?\nLes examens réguliers sont-ils nécessaires ?",
"url": "https://questionsmedicales.fr/mesh/D045726?mesh_terms=Pectoralis+Muscles#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Metalloproteases",
"description": "Quels traitements ciblent les métalloprotéases ?\nLes thérapies géniques sont-elles une option ?\nComment les anti-inflammatoires aident-ils ?\nLes traitements sont-ils personnalisés ?\nQuels sont les effets secondaires des inhibiteurs ?",
"url": "https://questionsmedicales.fr/mesh/D045726?mesh_terms=Pectoralis+Muscles#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Metalloproteases",
"description": "Quelles complications peuvent survenir avec une suractivité ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles la qualité de vie ?\nLes complications sont-elles prévisibles ?\nQuelles sont les complications liées à une déficience ?",
"url": "https://questionsmedicales.fr/mesh/D045726?mesh_terms=Pectoralis+Muscles#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Metalloproteases",
"description": "Quels facteurs augmentent le risque de dysfonction ?\nLes antécédents familiaux jouent-ils un rôle ?\nLe tabagisme est-il un facteur de risque ?\nLe stress chronique influence-t-il le risque ?\nL'exposition à des toxines est-elle un facteur ?",
"url": "https://questionsmedicales.fr/mesh/D045726?mesh_terms=Pectoralis+Muscles#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des métalloprotéases ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des biopsies tissulaires peuvent évaluer l'activité des métalloprotéases."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les niveaux de métalloprotéases dans le sérum ou les tissus peuvent servir de marqueurs diagnostiques."
}
},
{
"@type": "Question",
"name": "Les imageries sont-elles utiles pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'imagerie peut aider à visualiser les tissus affectés par des déséquilibres enzymatiques."
}
},
{
"@type": "Question",
"name": "Quels tests génétiques sont disponibles ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent identifier des mutations affectant la production de métalloprotéases."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'activité enzymatique ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques spécifiques mesurent l'activité des métalloprotéases dans les échantillons."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une surproduction de métalloprotéases ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une inflammation, des douleurs articulaires et des lésions tissulaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type de métalloprotéases ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, différents types de métalloprotéases peuvent causer des symptômes variés selon les tissus affectés."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques sont associés à une déficience ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une cicatrisation lente et des anomalies dans la matrice extracellulaire peuvent être observées."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils toujours visibles ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certaines dysfonctions peuvent être asymptomatiques jusqu'à des stades avancés."
}
},
{
"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'activité des métalloprotéases peut augmenter avec l'âge, aggravant les symptômes dégénératifs."
}
},
{
"@type": "Question",
"name": "Comment prévenir les maladies liées aux métalloprotéases ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels sont-ils utiles ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains suppléments, comme les antioxydants, peuvent soutenir la fonction des métalloprotéases."
}
},
{
"@type": "Question",
"name": "L'évitement de certains aliments est-il recommandé ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, réduire les aliments pro-inflammatoires peut aider à réguler l'activité des métalloprotéases."
}
},
{
"@type": "Question",
"name": "Le contrôle du stress est-il important ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut influencer l'activité des métalloprotéases, donc sa gestion est cruciale."
}
},
{
"@type": "Question",
"name": "Les examens réguliers sont-ils nécessaires ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers peuvent aider à détecter précocement des déséquilibres enzymatiques."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent les métalloprotéases ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques des métalloprotéases sont utilisés pour traiter certaines maladies."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques sont-elles une option ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique peut corriger des mutations affectant la production de métalloprotéases."
}
},
{
"@type": "Question",
"name": "Comment les anti-inflammatoires aident-ils ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'inflammation causée par une suractivité des métalloprotéases."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du type de métalloprotéases impliqué."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires des inhibiteurs ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les inhibiteurs peuvent causer des effets secondaires comme des troubles gastro-intestinaux."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une suractivité ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies dégénératives, comme l'arthrite, peuvent résulter d'une suractivité des métalloprotéases."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner des douleurs chroniques et une mobilité réduite, affectant la qualité de vie."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles prévisibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être prévisibles en surveillant les niveaux d'activité enzymatique."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications liées à une déficience ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une cicatrisation lente et des infections peuvent survenir en raison d'une déficience en métalloprotéases."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de dysfonction ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, le mode de vie sédentaire et une alimentation déséquilibrée augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies liées aux métalloprotéases peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut exacerber l'activité des métalloprotéases et augmenter les maladies associées."
}
},
{
"@type": "Question",
"name": "Le stress chronique influence-t-il le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber l'équilibre des métalloprotéases, augmentant le risque de maladies."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines est-elle un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines environnementales peut affecter l'activité des métalloprotéases."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
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The pectoralis major muscle is located in the anterior chest wall. In most cases, it is divided into clavicular, sternal (sternocostal) and abdominal heads. The aim of this study is to demonstrate and...
Classical anatomical dissection was performed on 35 human fetuses aged 18-38 weeks of gestation at death were examined. (17 female, and 18 male, 70 sides; fixed in 10% formalin solution). The fetuses ...
Five types of morphology (based on number of bellies) were observed in the fetuses. Type I was characterized by a single claviculosternal belly (10% of all samples). Type II comprised the clavicular a...
Due to its embryological development, the PM demonstrates great variability in the numbers of its parts. The most common type was the PM with two bellies, in line with previous studies which also dist...
Low muscle mass is associated with numerous adverse outcomes independent of other associated comorbid diseases. We aimed to predict and understand an individual's risk for developing low muscle mass u...
Computed tomography (CT) defined muscle mass can be used as a surrogate parameter for sarcopenia. The present study used thoracic CT to assess pectoralis muscle area and density as an imaging biomarke...
Overall, 981 patients (440 female, 44.9%) with a mean age of 63.5 ± 15.9 years were included into the study and 144 patients (14.6%) died within the 30-days period. Every pectoral muscle value was hig...
Parameters of the pectoralis musculature are associated with 30-day mortality in patients with acute PE. These findings should lead to an independent validation study and ultimately to the inclusion i...
Sarcopenia is associated with a poor prognosis in patients with breast cancer (BC). Currently, there are few quantitative assessments carried out between muscle biomarkers and distant metastasis using...
To assess the predictive value of the pectoralis muscle for BC distant metastasis, we developed a deep learning radiomics nomogram model (DLR-N) in this study....
A total of 493 patients with pathologically confirmed BC were registered. Image features were extracted from computed tomography (CT) images for each patient. Univariate and multivariate Cox regressio...
The developed DLR-N combined multiple radiomic features and clinicopathological factors and demonstrated excellent predictive performance. The C-index of the training cohort was 0.983 (95% confidence ...
DLR-N verified that there were biomarkers at the level of the fourth thoracic vertebra (T4) that affected distant metastasis. Multimodal prediction models based on deep learning could be a potential m...
Physiological and prognostic associations of centrilobular emphysema (CLE) and paraseptal emphysema (PSE) in smokers with and without chronic obstructive pulmonary disease (COPD) have been increasingl...
The aim of the study was to investigate whether CLE was associated with extrapulmonary abnormalities independent of concomitant PSE in smokers without airflow limitation....
This retrospective study consecutively enrolled current smokers without airflow limitation who underwent lung cancer screening with computed tomography and spirometry. CLE and PSE were visually identi...
Of 310 current smokers without airflow limitation, 83 (26.8%) had CLE. The PSE prevalence was higher (67.5% vs. 23.3%), and PM area, SAT area, and BMD were lower in smokers with CLE than in those with...
The observed association between CLE and lower PM area suggests that susceptibility to skeletal muscle loss could be high in smokers with CLE even without COPD....
We aimed to investigate whether sarcopenia measured from pectoralis muscles is a risk factor for long-term mortality in left ventricular assist device patients....
Patients aged >18 years implanted with a left ventricular assist device in a single center between 2013 and 2019 were retrospectively included. Patients without a thoracic computed tomography scan per...
The study was conducted on 64 left ventricular assist device patients who met the inclusion criteria. Notably, 21 (32.8%) of the study patients were sarcopenic. Diabetes mellitus and sarcopenia were m...
Sarcopenia defined by low pectoralis muscle index increases the risk for 2-year mortality in left ventricular assist device patients....
To investigate the possible relationship between pectoralis muscle (PM) measurement and frailty in older women with breast cancer (BC) (preoperatively defined as stage 1, 2, and 3 diseases)....
This retrospective, observational study was conducted at Konya Training and Research Hospital between June and December 2020. A total of 102 patients [median age 62.5 years, median follow-up period tw...
The nonrobust patients had lower pectoralis major muscle index (PMaMI) (p = 0.041) and pectoralis major muscle density(PMaD) (p = 0.020) levels than robust patients in the whole study sample. PMI (p =...
In the study, it has been shown that pectoralis muscle assessment might be a related parameter to frailty in older women with breast cancer....
Pectoralis Major ruptures normally occur in activities and sports such as powerlifting and American football or rugby. It is a rarely reported phenomena in professional footballers. Surgery is normall...
A 27-year-old professional footballer sustained a left pectoralis major rupture after falling to the floor. A subsequent MRI reported a 5cm retraction of the pectoralis major tendon from its attachmen...
This case study demonstrates a successful return to professional football following a pectoralis major rupture and supports the notion that surgical repair of these injuries produces a favourable outc...
We report the case of a healthy 17-year-old female softball player with a subacute full-thickness intramuscular tear of the pectoralis major (PM) muscle. A successful muscle repair was obtained using ...
Despite initially being a rare injury pattern, the incidence of PM muscle rupture is likely to increase as interest in sports and weight training increases, and although this injury pattern is more co...
To explore the association between CT-derived pectoralis muscle index (PMI) and COVID-19 induced lung injury....
We enrolled 116 elderly COVID-19 patients linked to the COVID-19 outbreak in Nanjing Lukou international airport. We extracted three sessions of their CT data, including one upon admission (T1), one d...
The maximum CT scores in low PMI patients were higher than those of normal PMI patients, including CTSS1 (7, IQR 6-10 vs. 5, IQR 3-6, p < 0.001), CTSS2 (8, IQR 7-11 vs. 5, IQR 4-7, p < 0.001) and POS ...
PMI can be easily assessed on chest CT images and can potentially be used as one of the markers to predict the severity of lung injury in elderly COVID-19 patients....
